• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7785-7792
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• 2014

Background: Valproic acid (VPA) is a potent anticancer and antiangiogenic agent. However, design and synthesis of chemical derivatives with improved antiangiogenic and anticancer activities are still necessary. In this study a library of novel derivatives of VPA was synthesized and tested. Methods: A human liver cancer cell line (HepG2) and a human normal embryonic kidney cell line (HEK 293) were exposed to various concentrations of VPA derivatives for 24 hours and cell viability was checked by MTT colorimetric assay. Anti-angiogenic properties were evaluated in transgenic zebrafish embryos. Results: N-valproylglycine derivatives suppressed survival almost 70% (p value 0.001) in HepG2 cells but only 10-12% in HEK 293 cells (p value 0.133). They also suppressed angiogenic blood vessel formation by 80% when used between $2-20{\mu}M$ in zebrafish embryos. Valproic acid hydrazides showed moderate level of anticancer activity by affecting 30-50% (p value 0.001) of cell viability in HepG2 cells and 8-10% in HEK293 cells (p value 0.034). Conclusion: The majority of compounds in this study showed potent and stronger antiangiogenic and anticancer activity than VPA. They proved selectively toxic to cancer cells and safer for normal cells. Moreover, these compounds inhibited developmental angiogenesis in zebrafish embryos. Based on the fact that liver is a highly vascularized organ, in case of liver carcinoma these compounds have the potential to target the pathological angiogenesis and could be an effective strategy to treat hepatocellular carcinoma.

• 한국도로학회논문집
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• 제19권1호
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• pp.45-52
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• 2017

PURPOSES : The main purpose of this study is to develop a high elastic modulus and low-shrinkage roller-compacted concrete base (RCCB) in order to prevent fatigue cracking and reflective cracking in the asphalt surface layer of composite pavement. Using a rigid base material with low shrinkage can be a solution to this problem. Moreover, a strong rigid base with high elastic modulus is able to shift the location of critical tensile strain from the bottom of the asphalt layer to the bottom of the rigid base layer, which can prevent fatigue cracking in the asphalt layer. METHODS : Sensitivity analysis of composite pavement via numerical methods is implemented to determine an appropriate range of elastic modulus of the rigid base that would eliminate fatigue cracking. Various asphalt thicknesses and elastic moduli of the rigid base are used in the analysis to study their respective influences on fatigue cracking. Low-shrinkage RCC mixture, as determined via laboratory testing with various amounts of a CSA expansion agent (0%, 7%, and 10%), is found to achieve an appropriate low-shrinkage level. Shrinkage of RCC is measured according to KS F 2424. RESULTS : This study shows that composite pavements comprising asphalt thicknesses of (h1) 2 in. with E2 > 19 GPa, 4 in. with E2 > 15 GPa, and 6 in. with E2 > 11 GPa are able to eliminate tensile strain in the asphalt layer, which is the cause of fatigue cracking in this layer. Shrinkage test results demonstrate that a 10% CSA RCC mixture can reduce shrinkage by 84% and 93% as compared to conventional RCC and PCC, respectively. CONCLUSIONS : According to the results of numerical analyses using various design inputs, composite pavements are shown to be able to eliminate fatigue cracking in composite pavement. Additionally, an RCC mixture with 10% CSA admixture is able to reduce or eliminate reflective cracking in asphalt surfaces as a result of the significant shrinkage reduction in the RCC base. Thus, this low-shrinkage base material can be used as an alternative solution to distresses in composite pavement.

• Asian-Australasian Journal of Animal Sciences
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• 제19권7호
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• pp.1004-1009
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• 2006

Four male crossbred native beef cattle (average body weight of 427.7 kg) were randomly allocated to four types of cassoy-urea pellet as a source of protein in concentrate according to a $4{\times}4$ Latin square design to determine effect of diets on ruminal fermentation and nutrient digestibility. The four types of cassoy-urea pellets contained cassava hay, soybean meal, urea and binding agent at 79.2:19.8:0:1 (27.9% CP dry matter), 78.4:19.6:1:1 (30.4% CP), 77.6:19.4:2:1 (33.0% CP) and 99:0:0:1 (23.8% CP) for dietary treatments; 1, 2, 3 and 4, respectively. All four concentrate mixtures contained similar crude protein levels (11% CP) and were fed to animals in two equal parts (0.5% of body weight per day) while urea-treated rice straw (5% urea) was given ad libitum. The experiment revealed that dietary concentrate treatments had no effect on dry matter intake while digestibilities of neutral-detergent fiber and crude protein were higher (p<0.05) in cattle fed dietary treatments 1, 2 and 3 than in cattle fed dietary treatment 4. Ruminal ammonia-nitrogen ($NH_3$-N), was higher and acetic acid concentration (C2) and ratio of C2 to propionic acid (C3) were lower (p<0.05) in cattle fed dietary treatments 1, 2 and 3 than in those on treatment 4. It is concluded that use of cassoy-urea pellet as a protein source in concentrates for cattle resulted in improvement of digestibility, ruminal fermentation and rumen ecology. Further research using cassoy-urea pellet in feeding trials with milking cows and fattening beef should be undertaken.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2009-2014
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• 2012

Objective: Taspine, isolated from Radix et Rhizoma Leonticis has demosntrated potential proctiective effects against cancer. Tas13D, a novel taspine derivative synthetized by structure-based drug design, have been shown to possess interesting biological and pharmacological activities. The current study was designed to evaluate its antiproliferative activity and underlying mechanisms. Methods: Antiproliferative activity of tas13D was evaluated by xenograft in athymic mice in vivo, and by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and cell migration assays with human liver cancer (SMMC-7721) cell lines in vitro. Docking between tas13D and VEGFR and EGFR was studied by with a Sybyl/Surflex module. VEGF and EGF and their receptor expression was determined by ELISA and real-time PCR methods, respectively. Results: Our present study showed that tas13D inhibited SMMC-7721 xenograft tumor growth, bound tightly with the active site of kinase domains of EGFR and VEGFR, and reduced SMMC-7721 cell proliferation (IC=34.7 ${\mu}mol/L$) and migration compared to negative controls. VEGF and EGF mRNAs were significantly reduced by tas13D treatment in a dose-dependent manner, along with VEGF and EGF production. Conclusion: The obtained results suggest that tas13D inhibits tumor growth and cell proliferation by inhibiting cell migration, downregulating mRNA expression of VEGF and EGF, and decreasing angiogenic factor production. Tas13D deserves further consideration as a chemotherapeutic agent.

• 한국전자거래학회지
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• 제8권2호
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• pp.63-76
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• 2003

e-비즈니스 프레임워크에서 가장 핵심적인 역할을 담당하는 것은 e-비즈니스 수행에 필요한 모든 메타데이타 정보들을 관리하는 레지스트리이다. 그러나, 실제적인 e-비즈니스 적용은 아직까지 어렵다. 즉 e-비즈니스 정보들은 물리적 또는 논리적으로 분산되고 이질적인 레지스트리들 안에 저장/관리되며 , 저장된 정보에 대해서는 키워드 기반의 검색 방법을 이용한다. 이것은 실제 e-비즈니스 수행에 있어서 거래에 필요한 비즈니스 정보 검색의 어려움을 제공한다. 이러한 문제점에 대한 인식은 확산되고 있으며, 이를 해결하기 위한 분산된 다양한 레지스트리의 통합과 체계적인 e-비즈니스 정보의 정의 및 지능적인 발견 기술의 적용이 요구된다. 본 논문에서는 이러한 문제점을 해결하기 위해 지능형 통합 e-비즈니스 레지스트리 시스템을 제안하였으며, 레지스트리 시스템들간의 통합 기능을 제공하는 레지스트리 통합 질의 관리기를 구현하였다. 또한, 향후 개발 할 지능형 레지스트리 에이전트 시스템의 구조를 정의하였다.

• 복식문화연구
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• 제15권1호
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• pp.127-136
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• 2007

Modern society shares new culture derived from the fusion of various cultures unlike the past culture regulating one phenomenon of certain field as the representative icon of the era. Especially, the phenomenon of globalization acts as the catalytic agent to receive coexistence of variousness easily. Especially, in fashion industry, these flows and the view of naturalism are harmonized and new fashion trend called 'Ethnic' was embossed. As it reflects internal spirit of human being that wants to return to the memory due to expansion of material civilization, the interest in the designer pursuing it is increasing. This study tries to consider the Ethnic style displayed by Chinese American designer, Anna Sui, who pursues the eastern style with full wit and individuality. Anna Sui, who was praised by New York Times for 'the superb harmony of houte couture style and up-to-date style', created another fashion trend, romanticism in New York and she is the worldwide designer representing Ethnic. Like it, the consideration on her Ethnic style reanalyzing as eastern style provides guidance to check how designer's fashion philosophy appears in one category of America and China and new study material that enables us to understand the third world culture code as well as Anna Sui. This confirmation has the meaning as the basic material for the endless challenge to the new style that fashion will go on in the future. Anna Sui was confirmed to have been recognized as a designer who represented the ethnic collection in the United States, exerting the influence with her unique oriental background. Moreover, her design could identify the pivotal point of ethnic image by developing her unique style which is distinct from other designers in terms of silhouette, color, fabric, detail, and so on. This kind of study can provide the basic data required to understand the fashion world of designer in the future.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2006년도 정기학술발표대회 논문집
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• pp.37-44
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• 2006

가톨릭중앙의료원 새병원 건립공사는 건설에 대한 전문적인 지식이 부족한 발주처를 대신하여 병원기획 단계부터 개원에 이르기까지 CM사가 발주처의 대리인으로 프로젝트 전 과정을 관리하는 대형병원건립 프로젝트이다. 본 사업은 병원건립 프로젝트에서 국내최초로 CM을 도입한 사례로서 그 의미를 찾을 수 있다. 즉, 건설본부조직을 구성하여 많은 인원을 병원의 직원으로 고용하지 않고서도 대형 프로젝트를 성공적으로 수행할 수 있다는 가능성을 보여준 최초의 사례이다. 이에 본 사례연구에서는 CM사가 참여하면서 Pre-Con.단계에서 적용된 건설사업관리 업무를 기준으로 작성하였으며, 이를 통하여 병원공사에 있어서 CM 도입의 필요성을 검토하고, CM적용 효과를 분석함으로써 향후 병원공사에서의 CM의 확대 적용에 기여하고자 한다.

• 정보처리학회논문지D
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• 제10D권1호
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• pp.167-174
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• 2003

현재 B2B 및 B2C 등 다양한 형태의 비즈니스가 진행되고 있으며 여기서 카탈로그 정보는 상품 구매 의사를 결정짓는 중요한 요소이다. 현재, 쇼핑몰과 경매사이트 등 전자상거래 관련 시스템을 구축하는 기업들이 증가하고 있으나 전자카탈로그의 명확한 개념과 일관된 구성요소 등이 없고 서로 상이한 내용, 포맷 등을 이용하여 개별적으로 구축하고 있다. 이처럼 현재 각 기업이 보유하고 있는 카탈로그 정보는 표준화되지 않은 상호 이질적인 구조를 이루고 있으며 이를 해결하기 위해 기존 데이터베이스 시스템과 연동한 플랫폼 독립적이고 이질적인 데이터를 통합할 수 있는 시스템의 구축이 절실히 요구된다. 이에 본 연구에서는 Mall 시스템, 가상 카탈로그 시스템으로 구성된 E-Catalog 시스템을 개발하여 표준화되고 정형화된 카탈로그 체제를 구축하고 제공된 네트워크 구조의 검색 시스템을 통해 구매자에게 원하는 물품을 제공함으로써 CRT(Customer Relation Management)을 지원하는 효율적인 marketplace를 이루는데 방향을 두고자 한다.

• 한국건설순환자원학회논문집
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• 제2권2호
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• pp.166-171
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• 2014

기포콘크리트의 재료 중 시멘트는 제조과정 중에 $CO_2$를 다량 발생시키기 때문에 지구 환경적인 측면에서 커다란 문제가 되고 있지만, 아직까지 시멘트를 대체할 수 있는 대체재에 대한 연구 개발이 미흡한 실정이다. 또한, 발포제는 압축강도가 낮고 고가인 단점이 있다. 이 때문에 강도와 경량 등의 성능 개선과 친환경적인 재료의 사용이 필요한 실정이다. 이에 본 연구에서는 시멘트와 발포제를 대체하기 위해 고로슬래그와 제지애시를 사용하여 경량 경화체를 제조하고자 하였으며, 강도 및 경량성을 보완하기 위해 플라이애시와 폴리실리콘 슬러지를 사용하여 실험을 실시하였다. 그 결과, 플라이애시를 사용한 경화체는 Plain 보다 낮은 밀도를 나타내었으나 강도보완에는 취약하였으며, 폴리실리콘 슬러지를 사용한 경우는 3%치환한 경화체가 압축강도는 Plain보다 다소 낮지만 겉보기 밀도의 감소가 큰 것으로 나타났다.

• 한국의류학회지
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• 제34권5호
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• pp.754-764
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• 2010

Most silk fabrics are produced only after the degumming process to make the best use of the properties and have restricted silk processing that do not hinder their performance. However, considering the highly increased preference for natural fibers and the shortage of raw silk, high-quality upgraded silk product functions are required by the development of a processing technology and a good design. This study analyzes the changes with the samples by the functional finish such as softening finishing, wash and wear, tannin weighting by measuring the objective hand of scoured silk and three finished ones using KES-FB. As a result, the change of objective hand of finished silk fabrics that improves functionality was analyzed and compared. The increase of KOSHI after the finish became stiffer show that the silk fabric samples are appropriate for summertime clothes with the retention of a certain clothing climate for the body. The stiffness of finished fabrics for the normal had a closer relationship with the density of fabrics than the type of finishing. The samples (after the softening finishes) maintain better elasticity according to the properties of the softener and the finishing agent. Although the specimens of this study were thin fabrics, their elasticity against compression increased after the softening finishes and became softer than degummed silk. The surface properties of georgette were changed by all types of finishing.