• Journal of Korea Technology Innovation Society
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• v.4 no.2
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• pp.224-241
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• 2001

This paper is an inquiry into the patterns of technological innovation of bio - industry in Korea in comparison with the worldwide patterns. In another words, this study wants to check whether the patterns of technological innovation of bio - industry in Korea differ front those in advanced countries or not. The comparison is based on the theory of science - based industry asserted by Seol (2001) and Cho (2001). There are no specific difference in the patterns of technological innovation such as science - based innovation, capitalization of science, industries leading by scientific fields, the importance of venture firms for commercialization, high level of R&D expense to sales. Also the order of fields by size is similar to worldwide patterns. But the size of microbiology is bigger than that of worldwide patterns. The strength in microbiology may be the country specific features of Korea, like platform technology of Germany.

• Asian Journal of Innovation and Policy
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• v.2 no.1
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• pp.1-19
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• 2013

As the catch-up innovation system was exposed to a new competition environment in which second-tier catch-up countries reduced the gap with Korea and advanced Korean firms entered into the frontier product market, it is experiencing system delay in terms of organizational and policy change. Therefore, innovation policy needs to be reorganized from a dynamic perspective to analyze the problems in the transition period and enable the system to overcome organizational and institutional delays. This article investigates the characteristics of transition periods in terms of external environment changes and internal socio-economic pressures. Based on the analysis of environment changes and catch-up system characteristics, it suggests the framework for policy intervention, direction, and practical principles for post catch-up innovation policy. In particular, it suggests the network-based developmental state and policy implementation in order to overcome the limitation of centralized developmental state of catch-up periods.

• Proceedings of the Korean Society of Crop Science Conference
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• 2005.10b
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• pp.278-279
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• 2005

• Journal of Korea Technology Innovation Society
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• v.7 no.1
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• pp.130-158
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• 2004

This paper aims at renewing the regional innovation system being embossed increasingly as a new paradigm to develop the regional area, using the innovational cluster based on the industrial properties and innovative base in Chungbuk province. As shown in the results of many researches, Chungbuk province is evaluated highly in regional innovation capability and is satisfied with the level of speciality in technical industry so that it has a potential capability to build the regional innovation system. However the clustering competition is growing in intensity between regional groups and there is a possible situation centralized by the high-tech industry into the metropolitan, so building the specialized innovation cluster requires advanced policy decisions and efforts in our won way. Ultimately, for the purpose of structuring the regional innovation system, the specialized innovation cluster reflected in regional industry and capability would be essential. It is time for Chungbuk province to prepare policies in order to make the Chungbuk-type innovation cluster which is neither uniform nor omnipresent.

• Journal of Korea Technology Innovation Society
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• v.6 no.4
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• pp.492-507
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• 2003

Material is enabling technology that creates the product performance and the service of most industrial sectors and fields of technology. However, compared to the other fields such as IT, BT, and NT etc., relatively little attention has been paid to the research on strategy and innovation of materials technology. This bias should have resulted in the misfit of policy and less than enough investment in materials innovation. This paper discusses the characteristics, process, and future of the materials innovation. The process and status of materials technology in Korea are analyzed based on the discussions above. Finally, some suggestions for R＆D strategies of Korea are presented on the basis of the nature, trend and barriers of materials innovation.

• Asian Journal of Innovation and Policy
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• v.9 no.2
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• pp.106-132
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• 2020

This study intends to add a factor to the discussion on the sectoral systems of innovation through Korea's response to the COVID-19 pandemic. The Korean approach is summarized as follows: the first response centers on technology and innovation. These include the development of diagnostic test methods and accurate test kits, first in the world, the use of ICT technology in epidemiological investigations, the technical response in the field, and the competitive edge in the development of medicine and vaccines that were behind the developed countries. The second response is an aggressive effort implemented just after the Chinese announcement, before the domestic outbreak; the third response is the open policy that induces voluntary participation of all subjects and people by opening all information. More important is the leadership at the national level shown in the past Korean experience and most advanced countries. National leadership must be the missing factor.

• Journal of Microbiology and Biotechnology
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• v.27 no.4
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• pp.856-867
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• 2017

Supplement of dietary fibers (DF) is regarded as one of the most effective way to prevent and relieve chronic diseases caused by long-term intake of a high-fat diet in the current society. The health benefits of soluble dietary fibers (SDF) have been widely researched and applied, whereas the insoluble dietary fibers (IDF), which represent a higher proportion in plant food, were mistakenly thought to have effects only in fecal bulking. In this article, we proved the anti-obesity and glucose homeostasis improvement effects of IDF from pear pomace at first, and then the mechanisms responsible for these effects were analyzed. The preliminary study by real-time PCR and ELISA showed that this kind of IDF caused more changes in the gut microbiota compared with in satiety hormone or in hepatic metabolism. Further analysis of the gut microbiota by high-throughput amplicon sequencing showed IDF from pear pomace obviously improved the structure of the gut microbiota. Specifically, it promoted the growth of Bacteroidetes and inhibited the growth of Firmicutes. These results are coincident with previous hypothesis that the ratio of Bacteroidetes/Firmicutes is negatively related with obesity. In conclusion, our results demonstrated IDF from pear pomace could prevent high-fat diet-induced obesity in rats mainly by improving the structure of the gut microbiota.

• Journal of Microbiology and Biotechnology
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• v.30 no.6
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• pp.903-911
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• 2020

Addition of probiotics to yogurt with desired health benefits is gaining increasing attention. To further understand the effect of probiotic Lactobacillus plantarum on the quality and function of fermented milk, probiotic fermented milk (PFM) made with probiotic L. plantarum K25 and yogurt starter (L. delbrueckii ssp. bulgaricus and Streptococcus thermophilus) was compared with the control fermented milk (FM) made with only the yogurt starter. The probiotic strain was shown to survive well with a viable count of 7.1 ± 0.1 log CFU/g in the PFM sample after 21 days of storage at 4℃. The strain was shown to promote formation of volatiles such as acetoin and 2,3-butanediol with milk fragrance, and it did not cause post-acidification during refrigerated storage. Metabolomics analysis by GC-MS datasets coupled with multivariate statistical analysis showed that addition of L. plantarum K25 increased formation of over 20 metabolites detected in fermented milk, among which γ-aminobutyric acid was the most prominent. Together with several other metabolites with relatively high levels in fermented milk such as glyceric acid, malic acid, succinic acid, glycine, alanine, ribose, and 1,3-dihydroxyacetone, they might play important roles in the probiotic function of L. plantarum K25. Further assay of the bioactivity of the PFM sample showed significant (p < 0.05) increase of ACE inhibitory activity from 22.3% at day 1 to 49.3% at day 21 of the refrigerated storage. Therefore, probiotic L. plantarum K25 could be explored for potential application in functional dairy products.

• Journal of Microbiology and Biotechnology
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• v.28 no.11
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• pp.1791-1799
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• 2018

Weaning stress can affect the growth performance and intestinal health of piglets. Dietary alternatives to antibiotics, such as dietary probiotics, especially those containing multiple microbial species, are a preventive strategy for effectively controlling post-weaning diarrhea. In this study, we investigated forty-eight crossbred piglets in three treatment groups for 21 days: the control and experimental groups were supplemented with Enterococcus faecium DSM 7134, Bacillus subtilis AS1.836 plus Saccharomyces cerevisiae ATCC 28338 (EBS) or Lactobacillus paracasei L9 CGMCC No. 9800 (EBL). On day 21, weaned piglets supplemented with two kinds of probiotic complexes showed increased growth performance and significantly reduced post-weaning diarrhea (p < 0.05). The EBS treatment increased acetic acid and propionic acid in the feces (p < 0.05), and the EBL treatment increased fecal acetic acid, propionic acid, butyrate and valerate (p < 0.05). Moreover, the fecal microbiota of the piglets changed markedly in EBL treatment. The addition of EBS and EBL may have similar effects on the prevention of diarrhea by improving the intestinal morphology and regulating the microbiota during the weaning period.

• Metals and materials international
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• v.24 no.6
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• pp.1202-1212
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• 2018

The effects of Nickle (Ni) addition on bainitic transformation and property of ultrahigh strength bainitic steels are investigated by three austempering processes. The results indicate that Ni addition hinders the isothermal bainite transformation kinetics, and decreases the volume fraction of bainite due to the decrease of chemical driving force for nucleation and growth of bainite transformation. Moreover, the product of tensile strength and total elongation (PSE) of high carbon bainitic steels decreases with Ni addition at higher austempering temperatures (220 and $250^{\circ}C$), while it shows no significant difference at lower austempering temperature ($200^{\circ}C$). For the same steel (Ni-free or Ni-added steel), the amounts of bainite and RA firstly increase and then decrease with the increase of the austempering temperature, resulting in the highest PSE in the sample austempered at temperature of $220^{\circ}C$. In addition, the effects of austempering time on bainite amount and property of high carbon bainitic steels are also analyzed. It indicates that in a given transformation time range of 30 h, more volume of bainite and better mechanical property in high carbon bainitic steels can be obtained by increasing the isothermal transformation time.