• Toxicological Research
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• v.22 no.2
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• pp.109-116
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• 2006

Safety pharmacology studies are conducted to investigated the potential undesirable pharmacodynamic effects of a substance on physiological functions in relation to exposure in the therapeutic range and above. In the International Conference on Harmonisation (ICH), the guideline 'S7A: Safety Pharmacology Studies for Human Pharmaceuticals' has been developed and reached Step 5 of the ICH process in 2001. Now the Korea Food and Drug Administration (KFDA) are going to transfer 'The Guideline for General Pharmacology' into 'The Guideline for Safety Pharmacology'. Safety pharmacology studies should be performed in compliance with Good Laboratory Practice (GLP). Thus, the present paper reviews the Japanese GLP guidelines for pharmaceuticals to help the conduct and inspection of safety pharmacology studies in compliance with GLP. We also reviewed the ICH guidelines 'S7B revised : The Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals' and 'E14 : The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-antiarrhythmic Drugs' to apply our drug approval systems.

• Proceedings of the KOR-KST Conference
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• 1995.05a
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• pp.239-250
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• 1995

With speeding up the process of being international municipality, the gravity of lacking parking lots in Shanghai urban area, which directly blocks the traffic in the city, has been revealed. This thesis analyses present automobiles parking capability and forecasts the future's needs for the city. To solve the problem, the concept could be to expand parking areas in city center recently to relax the tention and to do thoughtful planning in the near future on the foundation of fully consideration the trend. The municipal government has to set up policy properly, amplify regulations, strenthern the administration and open up a path to raise founds. Berween road system administration which is dynamic and parking lot system administration which is static, there are a knot on macroscopic meaning and an interference as well. The coordination of these two systems would be reflested on the effects of whole municipal traffic adminisration. Basically, public parking lots are city's foundal facilities, just like roads, bridges, etc. The main problems now in Shanghai are large parking space demands, insufficient facilities, cheap parking expenses comparing with the cost of parking lots construcion and poor administration. According to the forecast on social economy development, there will be 580 thousand automobiles in Shanghai by the year 2000, and the amount of private cars will increase greatly. The frequency of automobiles going out will be 1.45 million per day. Public parking lots being able to afford 105 thousand units are needed. To satisfy the demands, the recent aim of planning should be speed up the parking lots construction, the planning objective in next period should be developing reasonably and exceed the demands properly. In order to realize the planning objective, the government has to formulate correct policy and amplify administration regulations. The government has to adopt both administration and economy means, including charging parking people reasonably, collect necessary taxes, bringing the parking lots planning into general municipality planning, opening up an effective path to raise founds, such as set up founds for parking lots construction, issue bonds and stocks, get loans at home and abroad, etc.

• Archives of Pharmacal Research
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• v.22 no.5
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• pp.474-478
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• 1999

Modulation of unscheduled DNA synthesis by dehydroepiandrosterone (DHEA) after exposure to various chemical carcinogens was investigated in the primary rat hepatocytes. Unscheduled DNA synthesis was induced by treatment of such direct acting carcinogens as methly methanesulfonate (MMS) and ethyl methanesulfonate (EMS) or procarcinogens including benzo(a)pyrene (BaP) and 7, 12-dimethylbenz(a)anthracene (DMBA). Unscheduled DNA synthesis was determined by measuring [methyl-3H]thymidine radioactivity incorporated into nuclear DNA of hepatocytes treated with carcinogens in the presence or absence of DHEA. Hydroxyurea $(5{\times}10^{-3} M)$was added to growth medium to selectively suppress normal replication. DHEA at concentrations ranging from $(1{\times}10^{-6} M)$ to$(5{\times}10^{-4} M)$ did not significantly inhibit unscheduled DNA synthesis induced by either MMS $(1{\times}10^{-4} M)$ or EMS $(1{\times}10^{-2} M)$. In contrast, DHEA-significantly inhibited unscheduled DNA synthesis induced by BaP $(6.5{\times}10^{-5} M)$ and DMBA.$(2{\times}10^{-5} M)$. DHEA-induced hepatotoxicity in rats was examined using lactate dehydrogenase (LDH) release as an indicator of cytotoxicity. DHEA exhibit no significant increase in LDH release compared with the control at 18 h. These data suggest that nontoxic concentration of DHEA does not affect the DNA excision repair process, but it probably influence the enzymatic system responsible for the metabolic activation of procarcinogens and thereby decreases the amount of the effective DNA adducts formed by the ultimate reactive carcinogenic species.

• Journal of Drive and Control
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• v.20 no.4
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• pp.64-70
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• 2023

Garlic is classified as one of the three essential seasoning vegetables in Korea. In 2023, it was reported that the area under garlic cultivation was 24,700 ha, and the production stood at 318,220 tons. Garlic harvesting mechanization currently stands at 43.8%, and garlic is still collected manually after digging out using diggers, so the process is labor intensive. To reduce garlic production costs and enhance competitiveness, it is necessary to develop a high-performance gathering type harvester in place of the digging type harvester. Therefore, in this study, a gathering-type garlic harvester that can dig and collect simultaneously was designed and manufactured, and the harvest performance by factor was analyzed through a harvest performance test. As a result of the performance test, it was analyzed to perform optimally at a driving speed of 0.11m/s and a transfer speed of 85rpm. Work performance was calculated using the results obtained from the factor performance test.

• Journal of the Korea Society of Computer and Information
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• v.22 no.10
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• pp.159-166
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• 2017

This study is a discussion of business process reengineering for the next generation information system. To be concrete, we analyze and reengineer the current business process in administration of academic, general and research. This reengineering is conformed by 5 steps, as analyzing environmental status that figures out factors of inside or outside (environmental analyzing), analyzing current condition that diagnoses AS-IS process (current situation analysis), establishing information-oriented vision with strategic accomplishing goals accordingly (visioning), deducing detailed improving tasks (defining tasks), and engineering TO-BE process comprehending improving matters (engineering model). This paper shows BPR model for next generation information system.

• Management & Information Systems Review
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• v.31 no.1
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• pp.183-203
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• 2012

This paper investigates how small-medium firms deploy organizational culture, job stability and environmental uncertainty for technological innovation(product and process innovation). This paper suggests that organizational culture has significant effects on technological innovation, that job stability and environmental uncertainty moderate relationship between organizational culture and technological innovation. To test the hypotheses, data were collected from small-medium firms. The survey data of 258 firms were collected and integrated as the empirical base for testing the hypotheses. Major results are as follows: Firstly, when organizational culture as well as control variables are considered, organizational culture had significant and positive effects on product innovation. This result implies that organizational culture is an important means by which small-medium firms can promote innovation. Secondly, the interaction between organizational culture and job stability had a positive and significant effects on product innovation. Thirdly, the interaction between organizational culture and environmental uncertainty had a positive and significant effects on product innovation and process innovation. This paper suggests implications and several future researches need to overcome the limitations of this paper.

• Atmosphere
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• v.15 no.1
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• pp.59-68
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• 2005

United Nations Development Programme (UNDP) introduced the Adaptation Policy Framework (APF) to support the developing countries in order to help to make adaptation policy and strategy to climate change. This study provides the summary of the APF and will help for preparing policy regarding the impact of climate change and its adaptation. APF consists of five basic and two cross-cutting steps. Five basic steps are made of (a) defining project scope and design, (b) assessing current vulnerability and adaptation, (c) assessing future climate-related risks, (d) developing an adaptation strategy, and (e) continuing the adaptation process. Cross-cutting steps consist of engaging stakeholder and enhancing adaptive capacity. The project scope and design process includes four major tasks: scope the project and define its objectives, establish the project team, review and synthesize existing information on vulnerability and adaptation, and design the APF project. The main purpose of assessing current vulnerability and adaptation is to understand the characteristics of current climate-related vulnerability in priority systems and the scope of adaptive responses. Future climate-related risks are assessed in order to characterize future climate-related risks, so that adaptation policies and measures can be designed to reduce the system's exposure to future climate hazard. In developing an adaptation strategy, all of the preceding APF-related work is synthesized into a well-considered strategy that can direct real adaptation action. Continuing the adaptation process is in order to implement and sustain the APF-strategy, polices, and measure. The purpose of involvement of stakeholders is to communicate between individuals and groups about projects. Finally, enhancing adaptive capacity provides guidance on how adaptive capacity can be assessed and enhanced.

• Information Systems Review
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• v.8 no.1
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• pp.287-303
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• 2006

Recently, Investment on HRM, particularly, on training and development, in companies has been increased. Therefore, HR managers pay attention to action learning that has the practical effect on performance. The purpose of this study is to introduce action learning as an efficient training method and simultaneously to raise operational issues from the case study. This study analyses a training and development program applying action learning for team manager candidates in corporate Hyosung from September, 2005 to January, 2006. The findings are as follows: First, inefficient processes are thrown out by the process reengineering applying action learning. Second, the training and development activity is maximized by the integrated use of internal and external facilitators. Third, the steady support of executives and the driving force of HRD managers are considered as main success factors.

• Journal of Periodontal and Implant Science
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• v.24 no.3
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• pp.649-660
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• 1994

The purpose of this study was to evaluate the effects of administration of Zea Mays L. on the healing process after periodontal surgery as adjuntives. Authors used 3 kinds of different clinical criteria, depth of periodontal pocket by using the Goldman Fox periodontal probe, degree, of tooth mobility by Periotest, and amount of occlusal force with electronic device. In this comparative clinical study, 30 patients who were divided into two group, 15 ZML administrated group and 15 placebo adminstrated group, were participated. All the examined teeth were isolated with gauze and air spray, and measured each clinical critera on the day of before surgery, 1, 2, 4, 8 weeks after surgery. The results were as follows. 1. The changes of the periodontal pocket depth, on the both of Zea Mays L. administrated group and placebo adminstrated group, revealed the decreasing tendency, and it was shown the time dependent tendency. But there was no statistically significant differences between the two group. 2. In the case of tooth mobility, both group showed the highest severe mobility on the 1 week after surgery. It was observed that experimental group had more effects on decreasing the mobility. But there was no statistically significant differences between the two group. 3. In the case of experimental group, the recovery trend of occlusal forces after periodontal surgery on the molar teeth revealed higher than the control group. But there was no statistically significant differences between the two group. In conclusion, Zea Mays L. may play a favorable role in the healing process after periodontal surgery. It was suggested that further study to evaluate the effects of selective administration on the patient who have systemic diseases should be needed.

• Journal of the Society of Disaster Information
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• v.17 no.3
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• pp.500-511
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• 2021

Purpose: This study seeks to draw out implications that must be considered in the process of establishing measures to evacuate residents in preparation for domestic nuclear disasters by conducting an investigation about the disaster situation at the time of the Fukushima nuclear power plant explosion, emergency warning situation for residents protection, evacuation situation and In addition to investigating problems and measures raised in the resident protection system at that time. Method: A literature survey was conducted focusing on reports published by Japan's national, parliament, local governments and related agencies from right after the Great East Japan Earthquake to the present. Result: Found out what needs to be considered in the process of establishing domestic radiation disaster measures through the results of the survey on the problems and countermeasures derived from the process of evacuation of residents at the time of the Fukushima nuclear power plant explosion. Conclusion: The reviews were classified into four categories and detailed reviews were presented.