• Title/Summary/Keyword: Adjacent Cell

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Mycoplasma exploits mammalian tunneling nanotubes for cell-to-cell dissemination

  • Kim, Bong-Woo;Lee, Jae-Seon;Ko, Young-Gyu
    • BMB Reports
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    • v.52 no.8
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    • pp.490-495
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    • 2019
  • Using tunneling nanotubes (TNTs), various pathological molecules and viruses disseminate to adjacent cells intercellularly. Here, we show that the intracellular invasion of Mycoplasma hyorhinis induces the formation of actin- and tubulin-based TNTs in various mammalian cell lines. M. hyorhinis was found in TNTs generated by M. hyorhinis infection in NIH3T3 cells. Because mycoplasma-free recipient cells received mycoplasmas from M. hyorhinis-infected donor cells in a mixed co-culture system and not a spatially separated co-culture system, direct cell-to-cell contact via TNTs was necessary for the intracellular dissemination of M. hyorhinis. The activity of Rac1, which is a small GTP binding protein, was increased by the intracellular invasion of M. hyorhinis, and its pharmacological and genetic inhibition prevented M. hyorhinis infection-induced TNT generation in NIH3T3 cells. The pharmacological and genetic inhibition of Rac1 also reduced the cell-to-cell dissemination of M. hyorhinis. Based on these data, we conclude that intracellular invasion of M. hyorhinis induces the formation of TNTs, which are used for the cell-to-cell dissemination of M. hyorhinis.

Memory Circuit of Nonvolatile Single Transistor Ferroelectric Field Effect Transistor (비휘발성 단일트랜지스터 강유전체 메모리 회로)

  • 양일석;유병곤;유인규;이원재
    • Proceedings of the IEEK Conference
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    • 2000.11b
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    • pp.55-58
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    • 2000
  • This paper describes a single transistor type ferroelectric field effect transistor (1T FeFET) memory celt scheme which can select one unit memory cell and program/read it. To solve the selection problem of 1T FeEET memory cell array, the row direction common well is electrically isolated from different adjacent row direction column. So, we can control voltage of common well line. By applying bias voltage to Gate and Well, respectively, we can implant IT FeEET memory cell scheme which no interface problem and can bit operation. The results of HSPICE simulations showed the successful operations of the proposed cell scheme.

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A Case of Primary Squamous Cell Carcinoma of The Thyroid Gland (갑상선에서 발생한 원발성 편평상피세포암 1예)

  • Kang, Sihyung;Park, Gi Cheol
    • Korean Journal of Head & Neck Oncology
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    • v.37 no.2
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    • pp.91-95
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    • 2021
  • Primary squamous cell carcinoma of thyroid is a very rare malignant tumor with poor prognosis. It is usually diagnosed as an advanced disease infiltrating adjacent organs, and characterized by aggressive clinical course with an average postoperative survival time of less than 1 year. Recently, we had a 79- year-old woman with a painful neck mass who was diagnosed as primary squamous cell carcinoma of thyroid gland. She underwent total thyroidectomy and selective neck dissection(level III, VI) with no further postoperative managements such as radiation therapy or chemotherapy; she died of poor general condition and pneumonia resulting from rapid progression of the lesion on the 38th day after surgery. We report this case with a review of relevant literatures.

A Study on the Automatic Placement System for Standard Cell (스텐다드 셀의 자동배치 시스템에 관한 연구)

  • Kang, Gil Soon;Kyung, Chong Min;Park, Song Bai
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.23 no.4
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    • pp.557-564
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    • 1986
  • This paper describes a standard cell placement strategy which consists of three kconsecutive steps` initial placement, iterative placement improvement, and string placement. In the initial placement step, cell placement was done by solving the linear ordering problem for a one-dimensional layout of standard cells and then zigzaging the resultant linear order width in the chip plane. The iterative placement improvement step is based on the iterative pairwise interchange using the estimated total routing length as a figure-or -merit. The string placement is used to reorder cells and terminals in each etandard cell row such that channel routing in the adjacent channels is not blocked by cyclic constraints and needs fewer routing tracks. The placement program is coded in PASCAL and kimplemented on a VAX-11/750 computer. Experimental results for several examples are included.

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A Cell Selection Technique Considering MIMO Precoding (MIMO 프리코딩을 고려한 셀 탐색 기법)

  • Kim, Han Seong;Hong, Tae Howan;Cho, Yong Soo
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.37A no.12
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    • pp.1076-1084
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    • 2012
  • In the CS/CB(Coordinated Scheduling/Beamforming) scheme, the cell edge user throughput is increased by selecting MIMO (Multiple Input Multiple Output) precoders which can minimize the interferences from adjacent base stations (BSs). However, in current LTE(Long Term Evolution) systems, the serving cell is selected in the initialization stage by using the synchronization signals and cell specific reference signals transmitted by adjacent BSs with a single antenna. The selected BS in the initialization stage may not be the best one since the MIMO precoding gain has not been considered in the cell selection stage. In this paper, a new cell selection technique is proposed for LTE systems with MIMO precoder by taking into account the effect of the precoder in the initialization stage. The proposed technique enables a user equipment (UE) in the cell boundary to select the serving BS by using the information (channel rank, effective channel capacity, and effective SINR(Signal to Interference plus Noise Ratio)) acquired from cell specific reference signals of candidate BSs. It is verified by computer simulation that the proposed technique can increase the channel capacity significantly in the multi-cell environments, compared with the conventional CS/CB scheme.

An Improved Snake Algorithm Using Neighbouring Edges (근접 에지를 이용한 개선된 스네이크 알고리즘)

  • Jang, Seok-Woo;On, Jin-Wook;Kim, Gye-Young
    • Journal of KIISE:Software and Applications
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    • v.37 no.11
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    • pp.866-870
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    • 2010
  • This paper presents an improved Snake algorithm that contains additional energy term related to adjacent edges. The suggested algorithm represents the distance between an adjacent edge and the current cell as energy, and extracts object contours more effectively by including the energy tenn to the whole energy function. The adjacent edge-based snake algorithm not only make it possible to detect object boundaries which are concave, but also can detect the boundaries of complex objects without weight adjustment. Experimental results show that the proposed method extracts object boundaries more accurately than other existing methods without loss of speed.

EVIDENCE OF INTRAEPITHELIAL CGRP IMMUNOREACTIVE NERVE FIBERS DURING REEPITHELIALIZATION OF EXTRACTION WOUND OF RAT (흰쥐의 발치와 재상피화에 따른 상피내 CGRP 면역양성 신경섬유의 분포변화)

  • Byeon, Ki-Jeong;Kim, Chin-Soo
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.26 no.4
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    • pp.369-372
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    • 2000
  • The purpose of this study was to investigate the distribution pattern of CGRP immunoreactive nerve fibers in the healing mucosa of extracion wound. Maxillary 1st molars of rats were extracted. All extraction sites and adjacent tissues of 3 groups of rats(1-week, 2-week and 4-week groups) were removed en bloc and processed for immunostaining and were subjected to light microscopic examination. The results obtained were as follows; In 1-week group, there was no difference in the distribution pattern of CGRP immunoreactive nerve fiber between epithelial margin adjacent to extraction socket and normal gingival epithelium. In 2-week group, some CGRP-immunoreactive nerve fibers were seen in epithelial layer. In 4-week group, many intercellular CGRP immunoreactive nerve fibers were abundant in all layers of immature epithelium characterized by scab on the mucosa and thick keratinized cell layer with irregular surface. Intraepithelial CGRP immunoreactive nerve fibers were reduced to normal level in adjacent mature epithelium. These results suggest that density of CGRP immunoreactive nerve fibers are increased transiently in epithelium during reepithelialization process and CGRP released from these nerve fibers may play an important role in the reepithelialization in the wound healing.

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Fine Structure of Cardiac Sarcomeres in the Black Widow Spider Latrodectus mactans

  • KIM, Hoon;MOON, Myung-Jin
    • Entomological Research
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    • v.48 no.5
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    • pp.429-438
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    • 2018
  • Fine structural characteristics of the cardiac muscle and its sarcomere organization in the black widow spider, Latrodectus mactans were examined using transmission electron microscopy. The arrangement of cardiac muscle fibers was quite similar to that of skeletal muscle fibers, but they branched off at the ends and formed multiple connections with adjacent cells. Each cell contained multiple myofibrils and an extensive dyadic sarcotubular system consisting of sarcoplasmic reticulum and T-tubules. Thin and thick myofilaments were highly organized in regular repetitive arrays and formed contractile sarcomeres. Each repeating band unit of the sarcomere had three apparent striations, but the H-zone and M-lines were not prominent. Myofilaments were arranged into distinct sarcomeres defined by adjacent Z-lines with relatively short lengths of $2.0{\mu}m$ to $3.3{\mu}m$. Cross sections of the A-band showed hexagon-like arrangement of thick filaments, but the orbit of thin filaments around each thick filament was different from that seen in other vertebrates. Although each thick filament was surrounded by 12 thin filaments, the filament ratio of thin and thick myofilaments varied from 3:1 to 5:1 because thin filaments were shared by adjacent thick filaments.

Performance of cellular CDMA systems using orthogonal spreading codes in rayleigh fading channels (레일레이 페이딩 채널에서 직교확산부호를 이용한 셀룰러 CDMA 시스팀의 성능)

  • 조현욱;조용석;박상규
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.35S no.2
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    • pp.22-30
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    • 1998
  • In this paper, we analyze CDMA systems using M-orthogonal spreading codes. We assume that each user one set of M-orthogonal spreading codes allocated randomaly. The effect of multiple access interference from the reference and adjacent cells is considered slowly frequency selective rayleigh fading channels. and the adjacent cells interference is considered toanalyze the system performance. We calculate bit error rate and the maximum number of users whoe can communicate simulaneously within a cell by suing Rake receiver. By comparing CDMA systemwhich transmits 1 bit/spreding code, our system shows bit error rate decreases as M increases under the same bandwidth and infromation rate.

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A New Systolic Array Architecture for the OS CFAR Processor (OS CFAR 프로세서에 대한 새로운 시스톨릭 어레이 구조)

  • 송재필
    • Proceedings of the Acoustical Society of Korea Conference
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    • 1991.06a
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    • pp.163-168
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    • 1991
  • In this paper, we propose a new systolic architecture for the order statistics(OS) constant false alarm rate(CFAR) processor. In the proposed architecture, each processing element(PE) can compare two reference data cells with one test cell simultaneously in each clock cycle. So the utilization of each PE in this architecture is 100% whereas the utilization of each PE in the systolic architecture previously reported by Ritcey and Hwang is 50% because of one clock delay between two adjacent PE's active in computation. This can speed up the data processing rate by a factor of two. With this architecture, we can obtain the reduced number of communication links between adjacent PE's and reduction of the latency by half in comparison with the one proposed by Ritcey and Hwang.

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