• Journal of Life Science
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• v.23 no.2
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• pp.324-331
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• 2013

The addition and removal of N-acetylglucosamine (GlcNAc) molecules on serine or threonine residues of a protein is called O-GlcNAcylation. This post-translational modification occurs on both cytoplasmic and nuclear protein, and is fast and reversible as comparable to phosphorylation. In contrast to the phospho-signaling cycles, this emerging moon-lightening signaling is cycled by only two enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). The simple machinery is a good evolutionary adaptation of a cell for quick accommodation to continuously fluctuating intra- and extracellular microenvironments. Rather than "switching" on or off a specific proteins - this would be done by phosphorylation where numerous specific kinases and phosphatases are involved - O-GlcNAcylation would play a "rheostat" which would be much more delicately increase or decrease the efficacy of signal transductions in response to cellular nutrient and stress conditions. Interestingly, recent evidence indicates that O-GlcNAc is further modified by phosphorylation. The O-GlcNAc-P will upgrade the modulation efficiency of cellular processes to continuous 'analogue' level. So far, only one protein AP180 was reported to have O-GlcNAc-P on Thr310. But, proteomic data from our laboratory indicate that there are multiple O-GlcNAc-P proteins, constituting "O-GlcNAc-P'om". This will focus on the possibility of existence of "O-GlcNAc-P'om".

• The Journal of Korean Academic Society of Nursing Education
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• v.8 no.1
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• pp.108-119
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• 2002

This paper as the basic study aiming the establishment of nursing theory according to Korean culture, is made to reveal the types of recognition about concepts of health immanent in Korean who have the health view, completely mixed with traditional oriental medicine and Confucianism and Buddhism and Shamanism and european scientific medicine, etc. This paper is using the Q-method, which is greatly effective in measuring the individual subjectivity, to collect rightly the concepts of health of objects. This analysis shows us the 4 types of recognition about concepts of health immanent in Korean as follows. Type Ⅰ: modern self-searching type(現代的 自己 追求型), Type Ⅱ: nature-sharing type(自然 共有型), Type Ⅲ: meaning-intentional altruism(意味 指向的 他者 中心型), Type Ⅳ: oriental adaptational type(東洋的 順應型). The men belonging to type Ⅰ have positive and self-searching view of health. They are not only interpreting the concept of health scientifically, but also positively accepting the oriental concept of health. The men belonging to type Ⅱ have strong tendency of down-to-earth. They not only have the naturalistic view of health as Taoist, but also carry the weight in the family and neighbour and regard co-sharing as excellent virtue. The men belonging to type Ⅲ are positive altruists, pursuing the meaning of life and at the same time setting the importance to the good value system. Naturally they care more the family and neighbour than themselves. The men belonging to type Ⅳ have oriental view of the world characterized by nature-adaptation. They positively agree to the Shamanism, Buddhism, Confucianism and Oriental concept of health. In conclusion, in all types we can see that Korean understand the harmony of man and nature as fundamental principle of heath and carry the more importance to the mind(心) than body(身) and at the same time esteem more the family-centric, oriental and organic community than individual. All above facts is immersed in the concepts of health of Korean as a common denominator.

• Journal of Digital Convergence
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• v.16 no.1
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• pp.357-369
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• 2018

This study is to determine health related to Quality of Life(QOL) of married immigrant women in multicultural families, factors of predictors, and influence of these factors to develop and verify the structural model for development of an effective nursing mediation strategy for improved QOL. The participants were 254 women who immigrated to Korea for marriage. The hypothetical model is based on the health improvement model by Pender. Immigrant women's perceived barriers, perceived benefits, self-esteem, and perceived health had an impact on their health promotion behavior(HPB). These variables explained 55.2% of the QOL regarding health, and perceived health conditions, self-efficacy, self-worth, and level of cultural adaptation explained 29.3% of acts towards improving health. The results of this study suggest that development of efficient policy considering factors affecting health related to QOL of married immigrant women in multicultural families.

• Journal of Life Science
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• v.27 no.9
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• pp.1078-1085
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• 2017

Free radicals have long been considered damaging to various tissues. An excessive amount of reactive oxygen species (ROS) is known to have detrimental effects on the body and to be linked to numerous pathological conditions, such as cardiovascular disease, cancer, diabetes, and skeletal muscle atrophy. On the other hand, recent findings suggest that ROS is important for maintenance and development of cellular activity. Cells respond to increased oxidative stress by adaptive changes in the expression of a variety of proteins involved in the maintenance of cellular integrity. ROS is also essential for skeletal muscle function and metabolism. It is well known that physical exercise has many health benefits. Paradoxically, physical exercise also stimulates the production of ROS, which result in oxidative stress. Based on evidence amassed in the past decade, exercise itself may be considered an antioxidant because training increases the expression of antioxidant enzymes. In this review, we discuss the processes underlying the generation of ROS and its role in exercise-induced adaptation based on recent evidence. Furthermore, we discuss the possible role of NADPH oxidase in exercise-induced activation of insulin signaling and its effect on longevity.

• Journal of Haehwa Medicine
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• v.21 no.2
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• pp.21-36
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• 2013

Jeol-sik, (festive seasons every 15 days based on sun cycle), refers to both Korean Traditional Festival food(jeol-sik), intertwined between months, and in-season meals(si-jeol-sik) in which the ingredients used are produced in each and one of the four season. Si-jeol-sik is a kind of recommendatory food, which is combined to seasonal changes. I found that ingredients in Si-jeol-sik of spring are helpful for strengthening one's life force. Moreover, the ingredients also reflects seasonal changes. The main ingredient of Si-jeol-sik in January(in lunar year) is rice. Rice is good for upgrading one's stomach qi(energy). Rice continues to be used in February. In addition, some greens are included in February Si-jeol-sik as to help defecation. In March, the ingredients become diverse and abundant. The main concern in the ingredients found in March is not limited to stomach qi. These changes of ingredients are in line with the concept of 'health maintenance', which is written in Huangdi Neijing. The writing teaches the wisdom of adaptation to nature. Si-jeol-sik's basic idea is maybe giving people some food, which includes useful elements to help them survive through a season or the next season. They can be also explained properly by the help of five flavours theory. According to Huangdi Neijing liver is main organ of spring. So liver is more important than other organs in spring. And the most efficient way for liver is supplying sweet or sour food. Interestingly, there are many sweet elements in Si-jeol-sik of spring.

• Korean Journal of Agricultural and Forest Meteorology
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• v.17 no.2
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• pp.156-164
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• 2015

High temperature stress would affect rice production in the future as heat wave is expected to occur frequently under climate change conditions. The objective of this study was to obtain rudimentary information to assess the impact of heat stress on rice yield and its yield component in Korea. Two rice cultivars "Hwaseongbyeo" (Japonica) and "Dasanbyeo" (Tongil-type) were grown at different nitrogen fertilization levels in two seasons. These cultivars were grown in 1/5000a Wagner pot placed within four plastic houses where temperature was controlled at ambient, ambient$+1.5^{\circ}C$, ambient$+3^{\circ}C$ and ambient$+5^{\circ}C$ throughout the rice growing season in Suwon ($37^{\circ}16^{\prime}N$, $128^{\circ}59^{\prime}E$), Korea. The degree of temperature change affected grain yield whereas the level of nitrogen had little impact on grain yield. The number of panicle per pot and spikelet per panicle were not significantly different among temperature treatments in both cultivars tested. In contrast, 1000-grain weight and ripened grain ratio were decreased significantly under the treatments raising the air temperature to the level of $5.0^{\circ}C$ and $1.5^{\circ}C$ above the ambient air temperature in Dasanbyeo and Hwaseongbyeo, respectively. Reduction of 1000-grain weight and ripened grain ratio under the temperature treatments of $3.0^{\circ}C$ and $5.0^{\circ}C$ above the ambient air temperature resulted in significantly less grain yield for Dasanbyeo and Hwaseongbyeo, respectively. The greater sensitivity of grain yield to temperature increase in Dasanbyeo was attributable to the sharp decrease of 1000-grain weight and ripened grain ratio with the temperature rise above $23^{\circ}C$ during ripening period. On the other hand, Hwaseongbyeo had little variation of them in the temperature range of $23-27^{\circ}C$. These results suggested that grain yield would decrease under future climate conditions due to grain weight decreased by shorter grain filling period as well as the ripened grain ratio reduced by spikelet sterility and early abortion of rice kernel development. Thus, it would be essential to use cultivars tolerant to heat stress for climate change adaptation, which merits further studies for developing varieties that have traits to avoid spikelet sterility and early abortion of rice kernel, e.g., early morning flowering, under heat wave.

• Weed & Turfgrass Science
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• v.3 no.3
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• pp.174-182
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• 2014

This paper provides some of the scientific background on how projected environmental conditions could affect weeds and weed management in crops. Elevated $CO_2$ levels may have positive effects on crop competitiveness with $C_4$ weeds, but these are generally outnumbered by $C_3$ species in weed populations. Moreover, higher temperatures and drought will favor $C_4$ over $C_3$ plants. The implementation of climate change adaptation technologies, such as drought-tolerant germplasm and water-saving irrigation regimes, will have consequences for crop-weed competition. Rainfed production systems are thought to be most vulnerable to the direct effects of climate change and are likely to face increased competition from $C_4$ and parasitic weeds. Biotic stress-tolerant crop cultivars to be developed for these systems should encompass weed competitiveness and parasitic-weed resistance. In irrigated systems, indirect effects will be more important and weed management strategies should be diversified to lessen dependency on herbicides and mechanical control, and be targeted to perennial rhizomatous ($C_3$) weeds. Water-saving production methods that replace a weed-suppressive floodwater layer by intermittent or continuous periods of aerobic conditions necessitate additional weed management strategies to address the inherent increases in weed competition. Thus, climatic conditions have a great effect on weed population dynamics all over the world.

• Journal of Digital Convergence
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• v.16 no.11
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• pp.433-440
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• 2018

The purpose of the study to investigate the effect of self-efficacy and communication ability to self-leadership of nursing students. The study conducted among 320 nursing students on May 2018 at one university. Data were analyzed by t-test, one-way ANOVA, pearson's correlation coefficient, stepwise multiple regression by using SPSS 18.0 program. The results of the study showed that there was a significant different according to the general characteristics in communication skills in the grade, self leadership in age and grade. However, Self-efficacy, communication skills and Self-leadership. showed a statistically positive correlation with self-leadership and communication skills (r = .376, p = .000) and self leadership and communication skills were 14.1% exhibited by nursing students. The study findings suggested that there is a need to develop multidimensional strategies to improve self-efficacy and self-leadership. Also, it is recommended that develop and implement various programs to understand the college life adaptation for nursing students.

• Korean Journal of Ecology and Environment
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• v.36 no.3 s.104
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• pp.369-374
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• 2003

Nonylphenol (NP), an well known aquatic contaminant, has been known to induce abnormalities in various aquatic animals. In an effort to develop proteome in the study of aquatic contamination of NP and its impact on the amphibia, protein changes in liver tissues of Korean red bellied frog, Bombina orientalis was investigated following the NP exposure. NP was administered intraperitoneally to male B. orientalis at 10 mg/kg body weight. At 48 and 96h after the treatment, the frog livers were sampled, and the protein fraction was separated using two dimensional gel electrophoresis (2D/E) and visualized with Coomassie brilluant blue staining. The 2D/E Images of the tissue from the animals treated with NP showed marked changes of protein spots (about 20% of total protein spots). Analysis of the 50-60 separated spots allowed identification of the major protein changes in the overall pattern for the stressor (NP) by time (0,48 and 96 h). At 48h after treatment, 8 spots were increased and 12 spots were reduced. Then, at 96h after treatment, 10 spots were increased and 8 spots were reduced. In total, approximately 29% of liver proteins showed the altered expression following the NP treatment. It is suggested that protein expression was repressed by blocking of certain metabolisms at 48 hand induced by the synthesis of new proteins for adaptation at 96 h following NP exposure. This application for 2D/E analysis may show promise in searching biomarkers for environmental proteomics in amphibians.

• The Korea Journal of Herbology
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• v.33 no.6
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• pp.35-42
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• 2018

Objectives : The aim of this study was to investigate whether the extract of Coptidis Rhizoma inhibits inflammation in chronic cold stress (CCS)-exposed mice or not. Methods : Coptidis Rhizoma extract (CRE) was made by reflux with distilled water. Male ICR mice (7 weeks old) were divided randomly into 5 groups: (1) control, (2) CCS, (3) CCS+CRE 100 mg/kg, (4) CCS+CRE 300 mg/kg, (5) CCS+CRE 1,000 mg/kg groups. Mice were orally administered once a day for 14 days starting from 1 day before CCS. Group (2)-(5) were exposed to CCS conditions that maintained at $4^{\circ}C$ for 2 h once a day for 14 days. The levels of serum cortisol and hypothalamic prostaglandin E1 (PGE1) and PGE2 were measured by enzyme-linked immunosorbent assay kit. The expression levels of several pro-inflammatory factors like heat shock protein 70 (HSP70), c-fos, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) were measured by western blot analysis in mouse hypothalamus. Results : Oral administration of CRE 1,000 mg/kg significantly suppressed the increase of serum cortisol levels in mice exposed to CCS. CCS-exposed mice had significantly increased the expression of HSP70, c-fos, and NF-kB in hypothalamus, while CRE treatment significantly attenuated the elevation of these pro-inflammatory factors. The ratio of PGE2/PGE1 was also higher in CCS-exposed mice than control group. CRE treatment significantly reduced the increase of PGE2/PGE1 ratio induced by CCS. Conclusion : These findings suggest that Coptidis Rhizoma may work as a potential agent to modulate inflammatory responses under the condition of cold adaptation formed by CCS.