• Journal of the Korea Safety Management & Science
• /
• v.15 no.2
• /
• pp.1-7
• /
• 2013

Based on a literature review regarding shift work, it is recognized that it has an adverse effect on workers' health. Especially, the night shift rather than the day shift imposes severe disorders on workers, which are indicated to dyssomnia, maladaptation to social life, and health problems such as gastroenteric trouble, cardiovascular diseases and depression. As the shift work can be explainable by using workers' labor ability necessarily to maintain company business consistently, it does not consider biorhythm, active mass and health condition of workers Actually duration of shit work would deprive workers of fundamental life rights by causing physical and mental effects. As a result of reviewing previous case studies related to effect of work pattern (day shift and night shift) on workers' health, an incidence of physical diseases like dyssomnia, gastroenteric trouble, cardiovascular diseases and premature delivery was higher in shift workers than normal workers. Additionally the incidence of mental disorders such as busy brain, social isolation, depression and work stress was also higher in shift workers than normal workers. These adverse physical and mental problems were intensified to night shift workers compared to day shift workers. Considering current various reports and study results, it is recommended that the shift work, especially the night work pattern, should not apply to contemporary work situation for sustaining workers' health condition constantly.

• Journal of IKEEE
• /
• v.20 no.3
• /
• pp.251-259
• /
• 2016

This paper describes that how to enhance the robustness of semiconductor TRM(Transmitter and Receiver Module) through the bias sequencing and tuning the switching time. Previous circuit designs focused on improving the MDS(Minimum Detection Signal) performance. Because TRM has critical problem which transmission output signal leak into receiver by it's compact design. Under this condition, TRM was frequently broken down within the MTBF(Mean Time Between Failure). This study proposes the bias sequencing and tuning the switching time to improve above problem. At first, we collected major failure symptom and infer it's cause. Second, we demonstrated it's effect by derive the improvement method and apply it to our system. And finally we can convinced that the proposed method clear the frequent failure problem with its lack of isolation.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.4 no.4
• /
• pp.817-824
• /
• 2000

This paper presents circuit DQ modeling and analysis of operating characteristics of hybrid cascade multilevel PWM rectifier, especially five-level, without isolation transformers. The circuit DQ transformation changes the original three-phase time varying circuit to stationary equivalent one by employing the synchronously rotating transformation matrix. As a result of circuit DQ modeling, the operating characteristics and some useful design relationships for the system are obtained with ease. That is, the analytic equations for DC voltages and active/reactive power supplied by source with respect to control variables are Presented. Moreover, the DC voltages for the multilevel output generation may be directly built up from AC utility source and the important control equation ensuring 5-level output voltage is obtained. Finally, to confirm the validity of the analysis, MATLAB simulations are carried out and the simulation results show good agreements between analytic predictions and the simulated waveforms.

• Earthquakes and Structures
• /
• v.20 no.1
• /
• pp.39-53
• /
• 2021

By means of installing sloped rolling-type seismic isolators (SRI), the horizontal acceleration transmitted to the to-be-protected object above can be effectively and significantly reduced under external disturbance. To prevent the maximum horizontal displacement response of SRI from reaching a threshold, designing large and conservative damping force for SRI might be required, which will also enlarge the transmitted acceleration response. In a word, when adopting seismic isolation, minimizing acceleration or displacement responses is always a trade-off. Therefore, this paper proposes that by exploiting the possible information provided by an earthquake early warning system, the damping force applied to SRI which can better control both acceleration and displacement responses might be determined in advance and accordingly adjusted in a semi-active control manner. By using a large number of ground motion records with peak ground acceleration not less than 80 gal, the numerical results present that the maximum horizontal displacement response of SRI is highly correlated with and proportional to some important parameters of input excitations, the velocity pulse energy rate and peak velocity in particular. A control law employing the basic form of hyperbolic tangent function and two objective functions are considered in this study for conceptually developing suitable control algorithms. Compared with the numerical results of simply designing a constant, large damping factor to prevent SRI from pounding, adopting the recommended control algorithms can have more than 60% reduction of acceleration responses in average under the excitations. More importantly, it is effective in reducing acceleration responses under approximately 98% of the excitations.

• Korean Journal of Medicinal Crop Science
• /
• v.11 no.2
• /
• pp.115-121
• /
• 2003

Essential oils from Fennel fruit(Foeniculum vulgare Mill), Olibanum resin(Boswellia carteii Birew) and Needl Juniperus stem(Juniperus rigida Sieb.) were extracted by a supercritical fluid extraction system(SFE) and biological activity of each essential oils were observed. SFE technique was applied for the isolation and purification of nonpolar biologically active essential oils from each samples. The quantitative analysis of essential oils was carried out by gas chromatography-mass spectrometer(GC/MS). About 60% of the growth of AGS and A549 cells were inhibited by adding 1.0g/l of the crude essential oils and below 40% was observed by the control. Cytotoxicity on human normal lung cell(HEL299) was scored as $15{\sim}18%$ for the crude essential oils and 12% for control, respectively. It meant that the essential oils were more effective than the control in anti-mutagenecity tested by CHO V79 cells. The effect of the essential oils on the growth of nerve cells, PC12 was observed as follows: The viable cell density was about two times higher than control.

• Herbal Formula Science
• /
• v.16 no.1
• /
• pp.117-130
• /
• 2008

Korean traditional medicine has been used for the treatment of the various diseases based on both oriental medicinal theory and clinical trials. Thus, the prescriptions of Korean traditional medicine would be useful for the development of new therapeutics. This research focuses on the fundamental study in Korean traditional prescriptions for the development of new hepatoprotective agents. We found two prescriptions. Injinho-Tang and Osumogwa-Tang, showed the significant DPPH free radical scavenging and hepatoprotective effect, respectively. It is well-known that free radical scavenging effect is related to the prevention of various pathological events including liver injury. This paper deals with hepatoprotective effects on tacrine-induced cytotoxicity in Hep G2 cells, free radicals scavenging on both DPPH and superoxide of above two prescriptions. Hot water extract of Injinho-Tang did not show the significant hepatoprotective effect on tacrine-induced cytotoxicity in Hep G2 cells, however, it shows the significant scavenging effects for both DPPH and superoxide radicals. On the other hand, all of the hot water extracts of constituent herbal drugs in Injinho-Tang exhibited the promising protective effect on tacrine-induced cytotoxicity in Hep G2 cells. Of these, water extract of Rhei Rhizoma showed the most prominent effect on tacrine-induced cytotoxicity in Hep G2 cells. Bioassay-guided fractionation of Rhei Rhizoma extract has furnished four compounds, and their chemical structures have been identified by comparison of their spectral data with those of literature as chrysophanol (1), emodin (2), 3,5-dihydroxy-4'- methoxystilbene (3), and rhapontigenin (4), respectively. Among the isolated compounds, compounds 2-4 revealed the significant hepatoprotective effect in vitro when their $EC_{50}$ values compare with that of silybin, as a positive control. It also exhibited that emodin possessed the most hepatoprotective effect among these active compounds. In case of Osumogwa-Tang, its hot water extract showed the moderate protective effect on tacrine-induced cytotoxicity in Hep G2 cells. Hot water extract of Chaenomelis Fructus, one of the constituent herbal drug of this prescription, exhibited the significant hepatoprotective effect with $EC_{50}$ value of $7.8{\pm}0.1\;{\mu}g/ml$, however, it showed strong cytotoxicity in Hep G2 cells above the concentration of $25\;{\mu}g/ml$. It was revealed that both hot water extract of Evodiae Fructus and its butanol soluble fraction showed the moderate hepatoprotective effect but concentration-dependent activity in Hep G2 assay system. Two quinolone alkaloids, evocarpine and dihydroevocarpine, also tested for their hepatoprotective effects on tacrine-induced cytotoxicity in Hep G2 cells, however, these two compounds derived from the Evodiae Fructus as the major constituents did not show in vitro hepatoprotective effect. From these results, it would be necessary to further isolation of its hepatoprotective compounds from the butanol soluble fraction of the hot water extract of Evodiae Fructus.

• Nuclear Engineering and Technology
• /
• v.45 no.5
• /
• pp.605-612
• /
• 2013

Removal of decay heat from an operating reactor during a prolonged station blackout condition is a big concern for reactor designers, especially after the recent Fukushima accident. In the case of a prolonged station blackout condition, heat removal is possible only by passive means since no pumps or active systems are available. Keeping this in mind, the AHWR has been designed with many passive safety features. One of them is a passive means of removing decay heat with the help of Isolation Condensers (ICs) which are submerged in a big water pool called the Gravity Driven Water Pool (GDWP). The ICs have many tubes in which the steam, generated by the reactor core due to the decay heat, flows and condenses by rejecting the heat into the water pool. After condensation, the condensate falls back into the steam drum of the reactor. The GDWP tank holds a large amount of water, about 8000 $m^3$, which is located at a higher elevation than the steam drum of the reactor in order to promote natural circulation. Due to the recent Fukushima type accidents, it has been a concern to understand and evaluate the capability of the ICs to remove decay heat for a prolonged period without escalating fuel sheath temperature. In view of this, an analysis has been performed for decay heat removal characteristics over several days of an AHWR by ICs. The computer code RELAP5/MOD3.2 was used for this purpose. Results indicate that the ICs can remove the decay heat for more than 10 days without causing any bulk boiling in the GDWP. After that, decay heat can be removed for more than 40 days by boiling off the pool inventory. The pressure inside the containment does not exceed the design pressure even after 10 days by condensation of steam generated from the GDWP on the walls of containment and on the Passive Containment Cooling System (PCCS) tubes. If venting is carried out after this period, the decay heat can be removed for more than 50 days without exceeding the design limits.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.33 no.5
• /
• pp.769-777
• /
• 2004

A Helicobacter pylori urease inhibitor from Rubus coreanus Miquel has been isolated and partially characterized for aiming to Prevent H. pylori growth and decrease harmful accumulation of ammonia in human gastric mucosa. We screened urease inhibitory activities in 519 extracts library prepared by solvent extraction from 173 kinds of edible plants, medicinal herbs, herbs and seaweeds using a colorimetric urease assay system. As results of primary and secondary screening, 70% acetone extract of Rubus coreanus Miquel was selected as potent candidate, showing about 24% inhibitory activity. The acetone extract was sequentially partitioned into RCE/RCWI and RCB/RCW2 layers with ethyl acetate and butanol. The major active component in RCW2, water layer from butanol fractionation was revealed to be peptidic or proteinous substance by inhibitory activity determination after pronase digestion and periodate oxidation. RCW2-IIIc a was isolated by sequential column chromatography on DEAE-Toyopearl 650C, Butrl-Toyopearl 650M and Sephadex LH-20. The isolated urease inhibitor RCW2-IIIc $\alpha$, was highly pure proteinous substance with molecular weight of 13kDa by high-performance gel permeation liquid chromatography. RCW2-IIIc$\alpha$ has about 5 times higher inhibitory activity than 70％ acetone extract, showing high stability against heat treatment and peptic digestion.

• Korean Journal of Optics and Photonics
• /
• v.21 no.3
• /
• pp.123-128
• /
• 2010

Sum frequency generation was utilized to obtain a yellow laser with the wavelength of 578.4 nm for a probe laser of an Yb lattice clock. The output of an Nd:YAG laser with wavelength of 1319 nm and that of an Yb-fiber laser with wavelength of 1030 nm were passed through a waveguided periodically-poled lithium niobate (WG-PPLN) for sum frequency generation. It is required that the probe laser has a linewidth of the order of 1 Hz to fully resolve the Yb lattice clock transition. Thus, the linewidth of the probe laser was reduced by stabilizing the frequency to a super-cavity. This was made of ULE with a low thermal expansion coefficient, and was mounted on an active vibration-isolation table at the optimal point for the reduced sensitivity to vibration. Also, this was installed in a vacuum chamber, and the temperature was stabilized to 1 mK level. This system was installed in an acoustic enclosure to block acoustic noise. The finesse of the super-cavity was measured to be 380 000 from the photon life time of the cavity.

• Food Science and Preservation
• /
• v.11 no.1
• /
• pp.63-70
• /
• 2004

The antimicrobial substances from Rhodiola sachalinensis were extncted, isolated and identified. The highest level of antimicrobial activity and its yield were obtained in methanol extract. The minimum inhibition concentrations of the methanol extract were 500 $\mu\textrm{g}$mL on agar plate and 100 $\mu\textrm{g}$mL in broth media for four gram positive and four gram negative microbials. The methanol extract was fractionated by n-hexane, chloroform, ethyl ether, ethyl acetate, and butanol, orderly. The separate was developed on the TLC plate with different solvent system ratio of chloroform and methanol. Nine substances were isolated from chloroform and methanol mixture(9:1, v/v). Among them, three isolates showed antimicrobial activity. Three substances separated by HPLC were identified by GC/MS(EI) spectrum and $^1$H, /sup13/C-NMR spectrum. They were gallic acid, (-)-epicatechin and kaempferol. The antimicrobial activities of each substances were shown gallic acid, (-)-epicatechin, kaempferol orderly.