• Title/Summary/Keyword: Active Extension

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Evaluation of in-vitro Anti-thrombosis and Anti-oxidation Activity of Lees of Takju (Wookukseng) (우국생 탁주 주박의 항혈전 및 항산화 활성)

  • Kim, Mi-Sun;Lee, Ye-Seul;Kim, Jong Sik;Shin, Woo-Chang;Sohn, Ho-Yong
    • Journal of Life Science
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    • v.25 no.4
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    • pp.425-432
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    • 2015
  • This study was performed to develop high-value-added biomaterials for health and beauty products. Extracts of ethanol and hot water and their subsequent organic solvent fractions were prepared from Lees of Wookukseng (LW), a commercialized Korean traditional rice wine. We investigated their activities on blood coagulation, platelet aggregation, hemolysis against human red blood cells (hRBCs), and anti-oxidation. The water content, pH and brix of the LW were 80.3%, 3.94 and 13.0°, respectively. The yield of ethanol extraction (6.62%) was 3.15 times higher than that of hot-water extraction (2.1%), and the ethyacetate fraction (EAF) of ethanol extract showed the highest content of total polyphenol (128 mg/g) among the various fractions. In anticoagulation activity assay, the EAF of ethanol extract showed a 15-fold extension in TT, PT, and aPTT, indicating that the EAFs contain various inhibitory substances against thrombin, prothrombin and coagulation factors. In anti-platelet aggregation activity assay, the butanol fraction and water residue of ethanol extract showed significant inhibition activity. The activities were comparable to aspirin, a commercial anti-thrombosis agent. The above extracts and fractions did not show hemolysis activity against hRBC up to 5 mg/ml, and had radical scavenging activity against DPPH anion, ABTS cation and nitrite. Our results suggest that the active fractions prepared from LW, which has no specific usage until now, have a high potential as novel resources for anti-thrombosis agents.

Developing Aged-Housing Remodeling Technology for Improving Structural and Equipment performance;Introduction of Center for Aged-housing Remodeling Technology (노후 공동주택 구조 및 설비성능개선 기술 개발;2차년도 실적 및 차년도 연구계획 소개)

  • Han, Ju-Yeoun;Kim, Kyung-Rai
    • Proceedings of the Korean Institute Of Construction Engineering and Management
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    • 2007.11a
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    • pp.190-196
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    • 2007
  • As the number of aged-housing has been rapidly increased, many kinds of defects and problems such as degeneration of housing environment, structural performance, and equipment performance have been appeared. The reconstruction as the way to improve the aged-housing has been used mostly because the legal process of the reconstruction is relatively easy. On the other hand, it has caused problems such as the lack of natural aggregates, the environmental damages owing to construction wastes, the loss of national resources, and the lack of the housing for rent nearby the reconstruction area. This problems limit active tying into the reconstruction business at present in the industrial and political perspective. In this context, it is necessary to revitalize the remodeling rather than the reconstruction. In order to reach this objective, this research aims at identifying the user-oriented performance for the housing and deducing the core technology. It is expected that the result of this research can contribute to more revitalize the remodeling as tying researches in terms of design, structure, equipment, and construction.

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A Comparative Study of Housing Culture of Korean Immigrants through Analysis of Living Arrangement in Australia and Canada (해외거주 한인의 주공간 사용 및 주생활 분석을 통해 본 주거문화의 비교 고찰 - 호주(Australia)와 캐나다(Canada)를 중심으로 -)

  • Lee, Young-Shim
    • Journal of the Korean Home Economics Association
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    • v.46 no.1
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    • pp.47-61
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    • 2008
  • The purpose of this study is to provide information about domestic living of Korean immigrants in Australia and Canada who have the same cultural background for comparative study. For this, usage of domestic space and living style in housing of 52 Korean households in Melbourne of Australia and 32 Korean households in the region of Waterloo of Canada were analyzed. Ethnographic research with questionnaire were used. Results of the research were as follows. 1. Korean immigrants in each countries were living in houses which was built by company of Australia and Canada. 44.2% of Korean immigrants in Australia were using L+D K and 53.1% of Korean immigrants in Canada were using L D K. 2. Laundry was indispensable for Korean immigrants in both countries and they all wanted to use the laundry as a utility room which could dry, ironing and so on. 3. Drain hole on the floor of the bathroom was not indispensable for most Korean immigrants in both countries for hygienic reason. 4. Korean immigrants in both countries were ironing in master bedroom and they all wanted to separate it from there through renovation and extension and so on. 5. Korean immigrants in Canada were more active to use the formal lounge which has been planned as a traditional element of western house. 6. The seating style of Korean immigrants in both countries belong to chair-seating style mostly. But it was clear that they were making Kimchi with floor seating style in both countries. 7. A level of satisfaction about using carpet was not high for Korean immigrants in both countries cause of uneasiness to clean and it was considered to relate to the floor seating style of them. 8. Almost Korean immigrants were took off the shoes inside of the house and they had shoes cabinet beside the entrance or basement usually. 9. The most popular heating system was ducted heating in both countries. The level of satisfaction about this was different for Korean immigrants in Australia and Canada but most desirable heating system was Ondol for them in both countries commonly.

Computational Optimization of Bioanalytical Parameters for the Evaluation of the Toxicity of the Phytomarker 1,4 Napthoquinone and its Metabolite 1,2,4-trihydroxynapththalene

  • Gopal, Velmani;AL Rashid, Mohammad Harun;Majumder, Sayani;Maiti, Partha Pratim;Mandal, Subhash C
    • Journal of Pharmacopuncture
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    • v.18 no.2
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    • pp.7-18
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    • 2015
  • Objectives: Lawsone (1,4 naphthoquinone) is a non redox cycling compound that can be catalyzed by DT diaphorase (DTD) into 1,2,4-trihydroxynaphthalene (THN), which can generate reactive oxygen species by auto oxidation. The purpose of this study was to evaluate the toxicity of the phytomarker 1,4 naphthoquinone and its metabolite THN by using the molecular docking program AutoDock 4. Methods: The 3D structure of ligands such as hydrogen peroxide ($H_2O_2$), nitric oxide synthase (NOS), catalase (CAT), glutathione (GSH), glutathione reductase (GR), glucose 6-phosphate dehydrogenase (G6PDH) and nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) were drawn using hyperchem drawing tools and minimizing the energy of all pdb files with the help of hyperchem by $MM^+$ followed by a semi-empirical (PM3) method. The docking process was studied with ligand molecules to identify suitable dockings at protein binding sites through annealing and genetic simulation algorithms. The program auto dock tools (ADT) was released as an extension suite to the python molecular viewer used to prepare proteins and ligands. Grids centered on active sites were obtained with spacings of $54{\times}55{\times}56$, and a grid spacing of 0.503 was calculated. Comparisons of Global and Local Search Methods in Drug Docking were adopted to determine parameters; a maximum number of 250,000 energy evaluations, a maximum number of generations of 27,000, and mutation and crossover rates of 0.02 and 0.8 were used. The number of docking runs was set to 10. Results: Lawsone and THN can be considered to efficiently bind with NOS, CAT, GSH, GR, G6PDH and NADPH, which has been confirmed through hydrogen bond affinity with the respective amino acids. Conclusion: Naphthoquinone derivatives of lawsone, which can be metabolized into THN by a catalyst DTD, were examined. Lawsone and THN were found to be identically potent molecules for their affinities for selected proteins.

Total Elbow Arthroplasty after Failed Surgical Treatment for Elbow Fracture or Dislocation (주관절 골절 혹은 탈구의 실패한 수술적 치료 후 시행한 주관절 전 치환술의 결과)

  • Yi, Jin-Woong;Roh, Jun-Ha;Song, Jong-Hoon;Rhee, Yong-Girl
    • Clinics in Shoulder and Elbow
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    • v.10 no.2
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    • pp.190-198
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    • 2007
  • Purpose: The current study reports the clinical results of total elbow arthroplasties (TEA) which were Performed on patients with poor clinical and radiological results after initial surgeries for elbow fractures or dislocations. Materials and Methods: The clinical outcomes of twelve consecutive patients who underwent TEA after failed surgeries for elbow fractures or dislocations from january, 1995 to December, 2005 were evaluated. The initial diagnoses were distal humeral fractures in 8 cases and fracture-dislocations in 4 cases. The Mean period from the initial operations to the TEAs was 12 months. The mean folloow up period after TEA was 43 months. Results: The mean range of motion, in terms of active extension, activeflexion, supination, and pronation, improved from $14.2^{\circ}$, $96.7^{\circ}$, $50.8^{\circ}$ and $53.3^{\circ}$ to $5.4^{\circ}$, $122.1^{\circ}$, $63.3^{\circ}$ and $67.5^{\circ}$, respectively (p<0.05). RAdiolucent lines were found in 3 cases, which were 1 case of type 3, and 2 cases of type 4. All three loosening cases underwent revision TEAs. The mean postoperative Mayo elvow performance score was 79 point. There were 6 cases of excellent, 2 cases of good, and 4 cases in poor. Conclusion: Good clinical results were obtained after TEA performed in failed surgeries for elbow fractures of dislocations.

Activation plans of the Cultural Exchanges between Korea' and the Czech Republic's Animation (한국과 체코의 애니메이션 교류를 통한 문화교류 활성화 연구)

  • Park, Ki Bok
    • Cartoon and Animation Studies
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    • s.36
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    • pp.619-641
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    • 2014
  • Animation is an important tool to establish the identity of mutually related countries, as cultural contents with the economic value. That is, it is necessary that the Korean animation should extend the previous boundary of exchange, for the status of representative cultural industry in the 21st century global market. Especially, to overcome the regionally prejudiced and unbalanced cultural exchange, the possibility of extension with Czech animation, which has not had an active exchange with Korea, will be considered and the efficient method will be proposed. The Czech Republic is geopolitically located in the center of Europe and its infrastructure like industrial construction, investment environment, human resources is outstanding among Visegrad Group. The Czech Republic has a remarkable cultural border-crossing phenomenon, and as a complex country of cultural and religious characteristics of eastern and western European, it is a powerful nation leading Central Europe. Therefore, the animation exchange of Czech and Korea is valuable in culture and economy of both nations. Through such an animation exchange of both nations, not only Korean animation secures the diversity of exchange but also insignificant cultural exchange after formal establishment of diplomatic relations in 1990, will be revitalized and international firm relationship of both nations will be established. Therefore, as an activation plan or cultural exchange of Korea and the Czech Republic, concrete plan like Stop Motion Animation Workshop is proposed.

Storage-life and Palatability Extension of Betula platyphylla Sap Using Lactic Acid Bacteria Fermentation (유산균 발효를 이용한 자작나무 수액의 저장성 및 기호성 증진 기술)

  • Kim, Jong-Ho;Lee, Woon-Jong;Cho, Youn-Won;Kim, Kwang-Yup
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.38 no.6
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    • pp.787-794
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    • 2009
  • In this study, a new method for extending storage-life and palatability of Betula platyphylla sap by applying lactic acid bacteria fermentation was developed. The fluids of saps were filtered through 0.22 ${\mu}m$ membrane filter and each fermented by 8 different lactic acid bacteria which are Lactobacillus acidophilus, Lactobacillus brevis, Leuconostoc mesenteroides, Leuconostoc lactis, Lactococcus lactis, Pediocossus pentosaceus, Pediococcus dextrinicus, Streptococcus thermophilus. All the tested lactic acid bacteria except P. dextrinicus grew fast up to $10^6{\sim}10^7cfu/mL$ levels and lowered pH down to about pH 4 levels in 48 hours in both saps. The produced organic acids and lowered pH level inhibited the growth of spoilage microorganisms almost completely for 2 weeks during storage at room temperature. Addition of xylitol in the saps before fermentation accelerated the growth of lactic acid bacteria and increased the sweetness and overall taste of final product. The filtration process did not affect the mineral compositions of Betula platyphylla saps. Also the compositions and amounts of minerals showed very minor differences before and after fermentation in Betula platyphylla saps inoculated with L. acidophilus. By applying lactic acid fermentation to extend storage-life of tree saps instead of heat treatment, it was possible to keep natural minerals in active forms without any modifications.

Intraspecific Zonation of the Benthic Amphipod Pontogeneia rostrata in Relation to Diel and Tidal Cycles (저서성 단각류 Pontogeneia rostrata의 종내 대상분포와 주야-조석주기)

  • YU Ok Hwan;SUH Hae-Lip;SOH Ho Youn
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.31 no.4
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    • pp.500-507
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    • 1998
  • Using a sledge net, the benthic amphipods were taken over one cycle of the neap and spring tides in January 1993 at the sandy shore surf zone of Dolsando, southern Korea. From these samples, we investigated the diel and tidal effects on the intraspecific zonation of Pontogeneia rostrata. The density of p. rostrata was higher during neap tide than spring. Of three categories (adult males and females and juveniles), juveniles and males attained to its highest density during neap and spring tides, respectively. Length- frequency data show that the high mortality of juveniles seemed to occur in winter. In the surface at night, it is significant that juveniles were significantly more abundant during neap tide than spring, whereas both adult males and females were more abundant during spring tide than neap. This suggests that the vortical migration patterns of juveniles and adults vary with the type of tides. During flood of spring tide, more than $90\%$ of population collected at the area above the mean sea level (MSL) were adults. With a decrease of female/male ratio, size of males increased there but that of female did not change, indicating an active migration of large males. This behavior can provide an extension of distribution area far large males, and also give a competitive advantage to large male against small one for mate and feeding. Although adult p. rostrata was collected at 100 cm above MSL at night during spring tide, a major portion of population as usually present on the shore below MSL. The center of zonation was restricted from 50 cm to 250 cm below MSL.

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"Poor Theatre, Poor Art" - Jerzy Grotowsky's Play and Arte Povera ('가난한 연극, 가난한 미술' - 그로토프스키 연극이론과 아르테 포베라)

  • Kang, Young-Joo
    • The Journal of Art Theory & Practice
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    • no.5
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    • pp.109-133
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    • 2007
  • What a concept of theatricality in modern art became more controversial is through a review "art and object-hood" on Michael Fried's minimal art, as having been already known broadly. As he had been concerned, the art following the minimalism is accepting as the very important elements such as the introduction of temporality, the stage in the exhibition space, and the audience's positive participation, enough to be no exaggeration to say that it was involved in almost all the theatricality. Particularly even in the installation art and the environment art, which have substantially positioned since the 1970s, the space is staged, and the audience's participation is greatly highlighted due to the temporal character and the site-specific in works. In such way, the theatricality in art work is today regarded as one of the most important elements. In this context, it is thought to have significance to examine theatricality, which is shown in the works of Arte Povera artists, who had been active energetically between 1967-1971. That is because the name of this group itself is what was borrowed from "Poor Theatre" in Jerzy Grotowski, who is a play director and theorist coming from Poland, and because of having many common points in the aspect of content and form. It reveals that the art called Arte Povera is sharing many critical minds in the face of commanding the field called a play and other media. Grotowski's theatre theory is very close to the theory and substance in Arte Povera in a sense that liberates a play, which was locked in literature, above all, renews the relationship between stage and seat and between actor and audience, and pursues a human being's change in consciousness through this. That is because Arte Povera also emphasizes the communication with the audience through appealing to a human being's perception and through the direct and living method, not the objective art concept of centering on the work. In addition, the poor play or poor art all has tendency that denies a system, which relies upon economic and cultural system, and seeks for what is anti-cultural, elemental, and fundamental. It is very similar even in a sense that focuses on the exploration process itself rather than the result, excludes the transcendental concept, and attaches importance to empiricism. However, Arte Povera accepts contradictoriness and complexity, and suggests eclecticism and tolerance, thereby being basically the nomadic art and the art difficult to be captured constitutively. On the other hand, there is difference in a sense that the poor play is characterized by purity, asceticism, seriousness, and solemnity. If so, which significance does this theatricality, which was introduced to art, ultimately have? As all the arts desire to be revealed with invisible things beyond the visual thing, theatricality comes to play a very important role at this time. If all the artists and audiences today came to acquire actual or virtual freedom much more, that can be said to be a point attributable to that art relied upon diverse conditions in a play.

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SOURCE-FREQUENCY PHASE-REFERENCING OBSERVATION OF AGNS WITH KAVA USING SIMULTANEOUS DUAL-FREQUENCY RECEIVING

  • Zhao, Guang-Yao;Jung, Taehyun;Sohn, Bong Won;Kino, Motoki;Honma, Mareki;Dodson, Richard;Rioja, Maria;Han, Seog-Tae;Shibata, Katsunori;Byun, Do-Young;Akiyama, Kazunori;Algaba, Juan-Carlos;An, Tao;Cheng, Xiaopeng;Cho, Ilje;Cui, Yuzhu;Hada, Kazuhiro;Hodgson, Jeffrey A.;Jiang, Wu;Lee, Jee Won;Lee, Jeong Ae;Niinuma, Kotaro;Park, Jong-Ho;Ro, Hyunwook;Sawada-Satoh, Satoko;Shen, Zhi-Qiang;Tazaki, Fumie;Trippe, Sascha;Wajima, Kiyoaki;Zhang, Yingkang
    • Journal of The Korean Astronomical Society
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    • v.52 no.1
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    • pp.23-30
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    • 2019
  • The KVN(Korean VLBI Network)-style simultaneous multi-frequency receiving mode is demonstrated to be promising for mm-VLBI observations. Recently, other Very long baseline interferometry (VLBI) facilities all over the globe start to implement compatible optics systems. Simultaneous dual/multi-frequency VLBI observations at mm wavelengths with international baselines are thus possible. In this paper, we present the results from the first successful simultaneous 22/43 GHz dual-frequency observation with KaVA(KVN and VERA array), including images and astrometric results. Our analysis shows that the newly implemented simultaneous receiving system has brought a significant extension of the coherence time of the 43 GHz visibility phases along the international baselines. The astrometric results obtained with KaVA are consistent with those obtained with the independent analysis of the KVN data. Our results thus confirm the good performance of the simultaneous receiving systems for the nonKVN stations. Future simultaneous observations with more global stations bring even higher sensitivity and micro-arcsecond level astrometric measurements of the targets.