• Microbiology and Biotechnology Letters
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• v.37 no.1
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• pp.80-84
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• 2009

The in vitro antibacterial activities of anti-acne agents prepared from the extracts of natural sources were investigated against several bacteria including antibiotic-susceptible and -resistant Propionibacterium acnes. SD-1 and SD-2 were prepared with different formulations and they showed strong antibacterial activities. The anti-acne agents completely inhibited the growth of the tested strains at the concentration of 0.5%. There was no difference in antibacterial activity between antibiotic-susceptible and -resistant P. acnes. The inhibitory activities of two agents showed time-dependent manner. In S. aureus, time-kill curve demonstrated 2.8- and 3.4-$log_{10}$-unit killing after 8 h with SD-1 and SD-2, respectively. In P. acnes, time-killing curve demonstrated 5.1- and 6.1-$log_{10}$-unit killing after 24 h with SD-1 and SD-2, respectively. SD-2 showed stronger antimicrobial activity than SD-1. From these results, we expect that SD-1 and SD-2 have strong antibacterial activities and have advantages for treating acne.

• Journal of Korean Medicine for Obesity Research
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• v.7 no.2
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• pp.95-103
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• 2007

Objectives The purpose of this study was to investigate the clinical effect of acre improved by oriental medical weight management. Methods We treated 2 cases of obese and acne patients with dietetic therapy, electro-acupuncture therapy and herb medication. Results After $5{\sim}6$weeks of oriental medicine therapy of obesity, a remarkable improvement was made for not only obesity but also acne. Conclusion The study suggests that oriental medicine therapy of obesity also effects acne. We think that it need further study and clinical trial for obesity and acne.

• Korean Journal of Pharmacognosy
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• v.42 no.1
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• pp.98-101
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• 2011

Acne, one of the most common skin disease, is a chronic inflammatory disease and is caused by uncertain and multiple factors. Propionibacterium acnes belongs to the human cutaneous normal flora and is a major etiologic agent of acne vulgaris. In this study, we evaluated the antibacterial effect of 19 medicinal plants. Antibacterial activity of extracts prepared from the 19 medicinal plants was investigated against bacteria related to acnes, Propionibacterium acnes. Among them, some medicinal plants inhibited the growth of the P. acnes. Minimum inhibitory concentration (MIC) of Polygonum aviculare (Herb) was 0.2 mg/ml against P. acnes. MIC of Dianthus chinensis (Aerial Part), Forsythia viridissima (Fruit), Lygodium japonicum (Spore) and Sophora flavescens (Root) were 0.4 mg/ml. Based on these results, Polygonum aviculare (Herb), Dianthus chinensis (Aerial Part), Forsythia viridissima (Fruit), Lygodium japonicum (Spore) and Sophora flavescens (Root) may be considered as a candidate for a good medicine for acne.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.3
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• pp.153-158
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• 2017

As social interest in acne treatment has grown, various external preparations have been developed and studied. So, we investigated the external prescription which can treat acne in medical classics, then reviewed and divided it by dynasty. The data for analysis of Herbal formula was taken from 'medicine Dictionary of traditional Chinese medicine prescriptions(中醫方劑大辭典)'. 31 external medicines were searched, 3 were before song(宋) dynasty, 11 were Song(宋) dynasty, 11 were Yuan(元) dynasty, 7 were Ming(明) dynasty and 7 were Qing(淸) dynasty. The recipe and usage were only making them pill(丸) and paste(膏) using grinded medicinal herbs, then rubbing to face. As the age developed, unique manufacturing process(i.e fermentation method), and usage(i.e time-based usage, herbal medicine extracts for wash) were proposed. The external application with oriental medicine for acne used with Angelicae Gahuricae Radix(n=12), Bletillae Rhizoma(n=8), Syzygii Flos, Saposhnikoviae Radix(n=7) and so on. In particular, Bletillae Rhizoma was searched with high frequency in this study, but it was not included or studied in patent composition. The results of this study will provide basic data for future experiments and clinical studies.

• 대한상한금궤의학회지
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• v.9 no.1
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• pp.59-73
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• 2017

Objectives : The purpose of this case report is to report the effect of Daesiho-tang on adult acne by Shanghanlun provisions with extrusion therapy. Methods : According to diagnostic system based on Shanghanlun provisions, the patient was diagnosed with Taeyang-byung Gyeolhyung and treated by Daesiho-tang with extrusion therapy. The result of administrations were evaluated by Korean Acne Grading System(KAGS), Korean Skindex-29, and change of clinical symptoms. Results : After administration of Daesiho-tang for 150 days with weelky extrusion therapy, KAGS improved from grade 4 to grade 1, Skindex-29 improved from 67.93 to 15.51, and patient was very satisfied with the treatment. No serius treatment-related adverse events were reported. Limitations : This case is only one case that the level of evidence is weak. Two interventions were used together and the duration of photo was uneven. Conclusions : The patient almost recovered from acne treated by Daesiho-tang according to diagnostic system based on Shanghanlun provisions with extrusion therapy. This is the first case report that suggests '熱結在裏' on the number 136 provision of Shanghanlun means fever that is always present in chronic skin lesions.

• The Korea Journal of Herbology
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• v.25 no.2
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• pp.11-19
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• 2010

Objective : I want to examine the antimicrobial activity of Samhwangsasimtang against pseudomonas aeruginosa 38 isolated from an acne patient. Method : Antimicrobial activity was assayed through the hot water extract from Samhwangsasimtang against pseudomonas aeruginosa 38 isolated from an acne patient. Result : The size of inhibition zone of Samhwangsasimtang extract was $12.6\;{\pm}\;0.04\;mm$. The optimal pH and temperature for the growth of isolated pseudomonas aeruginosa 38 were 6.0 and $37^{\circ}C$, respectively. The minimum inhibitory concentration of Samhwangsasimtang extract was $10\;{\pm}\;0.06\;{\mu\ell}$ and the antimicrobial activity of Samhwangsasimtang extract was not destroyed by the heat ($121^{\circ}C$ for 15 min) and not affected by pH. Conclusion : Reviewing this experimental result, it appeared that Samhwangsasimtang had efficacy against pseudomonas aeruginosa 38 isolated from an acne patient.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.23 no.3
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• pp.236-246
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• 2010

Background & Objective : Microneedle therapy system(MTS) is popular these days. However, there are few reports about it in oriental medicine academia. This study is performed to evaluate the effect of MTS on acne patients. Methods : This study was conducted to evaluate the effect of MTS. Seven patients were treated for 7 weeks. Follow-up was performed after the treatment with Janus facial analysis system, skindex-29 and Digital Infrared Thermographic Imaging machine. Satisfaction degree and inconvenience were asked from the patients. Results and Conclusions : Microneedle therapy system(MTS) was good for acne like pore, wrinkle, spot(polarised), sebum, porphyrin and skin tone. Especially it had excellent effects on sebum and porphyrin.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.6
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• pp.905-908
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• 2006

The purpose of this research was to study the effects of kefir whey (kefir whey, peptides, lactic acid) on skin care properties including skin lightening effect and acne treatment. The final aim was to develop a new cosmetic product and enhance the value of dairy products. The results of skin lightening tests showed that all three kefir whey components (kefir whey, peptides and lactic acid) had inhibitory ability against melanin synthesis. Furthermore, copper chelating analysis demonstrated that both kefir whey and kefir whey peptides could chelate the copper in tyrosinase, which might explain the mechanism of inhibition. The ability for acne treatment indicated that lactic acid level higher than 60 mg/ml could inhibit the growth of Propionibacterium acne, whereas no inhibition was found with other components.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.16 no.1
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• pp.154-158
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• 2003

Objectives : The purpose of this study was to search liquid that mixing with powder drug on acnes disease. Conclusions : Out of acne patients who visited Oriental Medicine Hospital of Han-Seo University during December 2002 - February 2003, four female and five male were treated over four weeks. The average age were 21.44 years old. Before treatment, acne patients were sparsely with papules at the forehead, cheeks, lower jaw. After treatment during four weeks, seven acne patients change for the better, 77.8$\%$(mild improved 55.5$\%$, improved 11.1$\%$, much improved 11.1$\%$)

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.26 no.3
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• pp.1-19
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• 2013

Objective : The primary purpose of present study is to evaluate the effect of herbal cosmetics containing Cortex Betulae Platyphyllae extract complex on acne. The second is to comparatively evaluate safety of this cosmetics. Methods : We opened collecting of applicant that men and women(the 18~35-year-old) with acne on face. We selected subjects who came up to entire inclusion criteria and were not included in the exclusion criteria. We checked changes of Acne Global score, skin sebum, moisture, pores counts, Skindex-29 for 8 weeks. Results : 1. Comparison of changes in Global score, it declined in both experimental group and control group. But Experimental group showed a statistically significant decline than control group. 2. Comparison of changes in sebum and moisture, it declined in both experimental group and control group. But there was no statistically significant difference between those two groups. 3. Comparison of changes in erythema normal area, it declined in both experimental group and control group. But there was no statistically significant difference between those two groups. 4. Comparison of changes in pore counts, it increased statistically significantly in both experimental group and control group. 5. Comparison of changes in Skindex-29, it declined in both experimental group and control group. But there was no statistically significant difference between those two groups. Conclusion : Considering the above experiments, it is suggested that herbal cosmetics containing Cortex Betulae Platyphyllae extract complex have a positive effect on acne.