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Antimicrobial Activities of the Anti-acne Compounds from Natural Sources  

Kim, Na-Rae (Department of Clinical Laboratory Science, College of Health Science, Korea University)
Lim, Young-Hee (Department of Clinical Laboratory Science, College of Health Science, Korea University)
Park, Sul-Woong (SD Biotechnologies Co., Ltd.)
Nam, Eun-Sil (SD Biotechnologies Co., Ltd.)
Publication Information
Microbiology and Biotechnology Letters / v.37, no.1, 2009 , pp. 80-84 More about this Journal
Abstract
The in vitro antibacterial activities of anti-acne agents prepared from the extracts of natural sources were investigated against several bacteria including antibiotic-susceptible and -resistant Propionibacterium acnes. SD-1 and SD-2 were prepared with different formulations and they showed strong antibacterial activities. The anti-acne agents completely inhibited the growth of the tested strains at the concentration of 0.5%. There was no difference in antibacterial activity between antibiotic-susceptible and -resistant P. acnes. The inhibitory activities of two agents showed time-dependent manner. In S. aureus, time-kill curve demonstrated 2.8- and 3.4-$log_{10}$-unit killing after 8 h with SD-1 and SD-2, respectively. In P. acnes, time-killing curve demonstrated 5.1- and 6.1-$log_{10}$-unit killing after 24 h with SD-1 and SD-2, respectively. SD-2 showed stronger antimicrobial activity than SD-1. From these results, we expect that SD-1 and SD-2 have strong antibacterial activities and have advantages for treating acne.
Keywords
Anti-acne; Propionibacterium acnes; antimicrobial activity;
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