• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2243-2248
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• 2013

Background: To compare the dosimetric coverage of target volumes and organs at risk in the radical treatment of nasopharyngeal carcinoma (NPC) between intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT). Materials and Methods: Data from 10 consecutive patients treated with IMRT from June-October 2011 in Penang General Hospital were collected retrospectively for analysis. For each patient, dose volume histograms were generated for both the IMRT and 3DCRT plans using a total dose of 70Gy. Comparison of the plans was accomplished by comparing the target volume coverage (5 measures) and sparing of organs at risk (17 organs) for each patient using both IMRT and 3DCRT. The means of each comparison target volume coverage measures and organs at risk measures were obtained and tested for statistical significance using the paired Student t-test. Results: All 5 measures for target volume coverage showed marked dosimetric superiority of IMRT over 3DCRT. V70 and V66.5 for PTV70 showed an absolute improvement of 39.3% and 24.1% respectively. V59.4 and V56.4 for PTV59.4 showed advantages of 18.4% and 16.4%. Moreover, the mean PTV70 dose revealed a 5.1 Gy higher dose with IMRT. Only 4 out of 17 organs at risk showed statistically significant difference in their means which were clinically meaningful between the IMRT and 3DCRT techniques. IMRT was superior in sparing the spinal cord (less 5.8Gy), V30 of right parotid (less 14.3%) and V30 of the left parotid (less 13.1%). The V55 of the left cochlea was lower with 3DCRT (less 44.3%). Conclusions: IMRT is superior to 3DCRT due to its dosimetric advantage in target volume coverage while delivering acceptable doses to organs at risk. A total dose of 70Gy with IMRT should be considered as a standard of care for radical treatment of NPC.

• Asian-Australasian Journal of Animal Sciences
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• 제16권2호
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• pp.180-184
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• 2003

The intrauterine inseminator (IUI) was developed to provide the method of depositing dog semen into the uterine body instead of the vagina. The IUI consists of a vaginal endoscope, a balloon sheath, and injection catheter. When the endoscope is inserted into the vagina and the balloon expanded with air, the cervical os becomes visible so a injection catheter can be inserted through the cervix for deposition of the frozen-thawed semen. The efficacy of the IUI device was compared to intra-vaginal artificial insemination using semen that had been collected and frozen from pooled sperm-rich fraction of ejaculates collected from two Jindo dog donors. Aliquots of semen were extended with a Tris-egg yolk diluent, centrifuged, the seminal plasma removed, the pellet resuspended with the same diluent, and cooled to $5^{\circ}C$ over a 2 h period. A Tris-egg yolk-glycerol extender was added at $5^{\circ}C$; after 1 h, semen was loaded into 0.5 ml straws, and straws were frozen in LN vapor for 5 min, and immersed in LN for storage. The final sperm concentration for freezing was approximately $100{\times}10^{6}cells/ml$. The straws were thawed at $70^{\circ}C$ for precisely 6 sec, 1.5 ml Tris-egg yolk buffer at $38^{\circ}C$ added, and the 2 ml of thawed semen was used for a single insemination using the IUI device. Each bitch was inseminated at optimal insemination point, which was estimated by vaginal epithelial cells staining and progesterone concentration analysis. Use of the IUI device resulted in 21 of 26 females giving birth to 89 pups ($4.2{\pm}1.6$ pups per litter), while intra-vaginal AI resulted in 6 of 15 females whelping a total of 17 pups ($2.8{\pm}1.2$ pups per litter). We believe the IUI device is easier to use than previously described devices used for intrauterine insemination. In our experience the expansion of the balloon has a calming effect on the bitch that aids the inseminator. These results indicate that the IUI device was able to provide high fertility with 50 million frozen sperm per insemination and two inseminations.

• 대한간호학회지
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• 제29권2호
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• pp.225-237
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• 1999

The purpose of this study was to analyze the relationship among the health promoting behaviors, self-reported climacteric symptoms and depression on a cross-sectional survey desist The subjects were 108 middle-aged women who were nonhystrectomized and ranged in age from 40 to 60. They were selected in Seoul and Kyoung-ki province. Korea. Data were collected from Oct. 25 to Nov. 10, 1997 by a structured Questionnaire. The instrument used for this study was the revised Health Promotion Lifestyle Profile(HPLP) developed by Walker, Sechrist and Pender, revised Climacteric Symptoms Scale developed by Chi, Sung Ai, and the Beck's Depression Inventory(BID). The data were analyzed by the SPSS /PC$^{＋}$ program using t-test, ANOVA and Scheffe test as a post hoc and Pearson Correlation Coefficient. The results of the study were as follows ; 1. The mean score of health promoting behaviors was low(2.42$\pm$0.35). There were statistically significant difference in the score of health promoting behaviors according to the educational background. family income, marital satisfaction, and whether or not taking a restoraitve food(t ＝－2.07, F＝2.60~7.57, p＜0.05). 2. The mean score of self-reported climacteric symptoms was 1.69 ; 99% of middle-aged women had symptoms. There were statistically significant difference in the score of middle-aged women's self-reported climacteric symptoms according to the age, number of children, educational background, occupation, family income, marital satisfaction, whether or not receiving hormone replacement therapy(HRT) or consultation experience with a professional, and perceived health status(t＝－2.04~3.69. F＝2.87~11.63, p＜0.05). 3. The mean score of depression was 10.84. There were statistically significant differences in the score of the depression according to the age, number of children, educational background, occupation, marital satisfaction, whether or not receiving menopausal treatment or consultation by a professional, and perceived health status(t ＝－2.25~3.00, F＝3.50~9.24, p＜0.05). 4. Women's degree of health promoting behaviors was a negative correlation with the degree of climacteric symptoms(r＝－0.19, p＝0.03) and the degree of depression(r＝－0.23, p＝0.01). The degree of climacteric stmptoms was a positive correlation with the degree of depression(r＝0.64 p＝0.01). In conclusion. health promoting behavior should be considered when developing nursing strategies for middle-aged women. especially when dealing with climacteric symptoms and depression.

• Clinical and Experimental Pediatrics
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• 제53권6호
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• pp.705-710
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• 2010

Purpose: To determine the clinical manifestations and outcomes of patients with tracheoesophageal fistula (TEF) and esophageal atresia (EA) born at a single neonatal intensive care unit. Methods: A retrospective analysis was conducted for 97 patients with confirmed TEF and EA who were admitted to the neonatal intensive care unit between 1990 and 2007. Results: The rate of prenatal diagnosis was 12%. The average gestational age and birth weight were $37^{+2}$ weeks and $2.5{\pm}0.7kg$, respectively. Thirty-one infants were born prematurely (32%). Type C was the most common. The mean gap between the proximal and distal esophagus was 2 cm. Esophago-esophagostomy was performed in 72 patients at a mean age of 4 days after birth; gastrostomy or duodenostomy were performed in 8 patients. Forty patients exhibited vertebral, anorectal, cardiac, tracheoesophageal, renal, limb (VACTERL) association with at least 2 combined anomalies, and cardiac anomaly was the most common. The most common post-operative complications were esophageal stricture followed by gastroesophageal reflux. Balloon dilatation was performed for 1.3 times in 26 patients at a mean age of 3 months. The mortality and morbidity rates were 24% and 67%, respectively, and the most common cause of death was sepsis. The weight of approximately 40% patients was below the 10th percentile at 2 years of age. Conclusion: Mortality and morbidity rates of patients with TEF and EA are high as compared to those of infants with other neonatal surgical diseases. Further efforts must be taken to reduce mortality and morbidity and improve growth retardation.

• 한국콘텐츠학회논문지
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• 제20권10호
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• pp.190-198
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• 2020

스마트폰 기술의 발전은 인간의 생활에 편리를 가져왔으나, 과도한 스마트폰 사용은 다양한 사고의 원인이 되기도 한다. 이 중 생명과 직결되는 대표적인 위험한 사고가 보행 중 부주의로 인한 안전사고이다. 본 연구에서는 보행 중 스마트폰을 사용할 때, 이러한 사고를 방지할 수 있도록 하는 애플리케이션 서비스 'Smombie Safe Go' UI(user interface)를 제안하고자 하였다. 이를 위해, 자료 조사와 사용자 관찰을 통해 보행자 여정맵을 작성하고 사용자 보행 중 안전에 필요한 주요 기능을 도출하였는데, 투명한 인터페이스를 비롯하여 장애물 위치 알림, 위험에 대한 주의와 경고 기능이 필요한 것으로 나타났다. 서비스 내용을 구체화하기 위하여 사용자 관찰을 통해 스마트폰을 사용하면서 보행 시에 맞닥뜨리는 위험상황을 세 가지로 - ① 전방에 장애물이 나타날 경우, ② 횡단보도에 신호등이 있는 경우, ③ 횡단보도에 신호등이 없는 경우- 구분하였다. 위험상황별 시나리오를 작성하고, 각 상황에서 위험을 경고하는 앱서비스 flow와 UI를 설계하였다. 또한 이 서비스 구현을 위해 V2N(Vehicle to Network), AI 3D 물체인식기술, 비콘(Beacon) 등의 기술들을 검토하고 활용방식을 제안하였다. 나아가 연구의 심화를 통해, 'Smombie Safe Go'는 일반 보행자 뿐 만 아니라, 시각 장애인들에게 안전한 보행을 지원할 수 있는 앱서비스로 활용이 가능할 것으로 예측된다.

• 기독교교육논총
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• 제67권
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• pp.377-414
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• 2021

슈밥(Schwab)이 2016년 다보스 포럼에서 4차 산업혁명을 언급하면서 많은 이들이 4차 산업혁명과 미래사회에 대하여 논하였다. 4차 산업혁명은 기술의 발달을 넘어서서 우리의 사회, 문화, 생활양식 전반에 영향을 주고 있으며, 우리는 코로나19 상황을 맞이하며 더욱더 실감을 하고 있다. 우리는 4차 산업혁명은 분명 인간의 삶을 증진시키며, 문명의 발달을 이루게 할 것이라 희망하지만, 인간소외나 양극화의 문제를 우려하게 된다. 이러한 때에 기독교가 어떻게 공적 영역에서 기여하며 교육의 방향을 설정할 것인가. 본 연구는 이러한 4차 산업혁명시대의 기독교의 역할과 교육방향에 관하여 연구한 논문이다. 먼저 4차 산업혁명시대에 일어날 개인과 공동체의 내면과 외면의 문제를 다각도로 조명하고자 심리학자 미첼(Mitchell), 사회학자 벨라(Bellah), 신학자 맥그래스(McGrath), 철학자 보스트롬(Bostrom)의 견해를 통해 접근하였다. 이들의 이론을 통해 4차 산업혁명시대의 현실 세계와 가상 세계, 초월적 세계에 사는 개인의 삶을 바라보았다. 그리고 이러한 세계에 기독교가 초월적 규범을 제시하고, 의미를 부여하며, 개인과 세계의 변화를 일으킬 수 있다고 보며, 교육의 방향을 "상징을 만들고 표현하는 교육"으로 보았다. 이를 위하여 관찰하기, 들어가기, 발견하기, 참여하기, 상징 만들기의 5단계를 제시하여, 이를 통해 현실 세계 안에서 하나님 나라를 이뤄갈 수 있도록 하였다.

• 디지털산업정보학회논문지
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• 제17권3호
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• pp.63-83
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• 2021

The appearance of education is also rapidly changing in social changes represented by social networks. And the development of information and communication technology is also having a widespread effect on the education field. In the era of untact caused by Covid-19, education through smart learning is having a greater effect on students as well as adult learners more quickly and broadly. In addition, smart learning is not just limited to learning content, but is developing into personalized, convergence, and intelligent. The purpose of this study is to identify the factors of ARCS motivation theory that can determine the learning motivation of smart learning users, and to empirically study the casual relationship between these factors on education achievement through practical value and hedonic value. Specifically, I would like to examine how the independent variables ARCS motivation factors (attention, relevance, confidence, and satisfaction) affect learners' education achievement through the parameters of practical value and hedonic value. To this end, a research model was presented that applied the main variables of attention, relevance, confidence, and satisfaction, which are four elements of ARCS motivation theory, a specific and systematic motivational strategy to induce and maintain learners' motivation. In order to empirically verify the research model of this study, a survey was carried out on learners with experience using smart learning. As a result of the study, first attention was found to have a positive effect on the hedonic value. Second, relevance was found to have a positive effect on the hedonic value. Third, it was found that confidence did not have a positive effect on the practical value and the hedonic value. Forth, satisfaction was found to have a positive effect on the practical value and the hedonic value. Fifth, practical value was found to have a positive effect on the education achievement. Sixth, hedonic value was found to have a positive effect on the education achievement. Through this, it can be seen that the intrinsic motivation of learners using smart learning affects the education achievement of users through intrinsic and extrinsic value. A variety of smart learning that combines advanced IT technologies such as AI and big data can contribute to improving learners' education achievement more effectively and efficiently. Furthermore, it can contribute a lot to social development.

• 문화기술의 융합
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• 제7권4호
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• pp.857-862
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• 2021

최근 급격한 기후변화로 인해 꿀벌의 생태계에도 많은 영향을 주고 있다. 꿀벌의 개체수 감소, 개화기의 변화로 인한 양봉 농가의 채밀에 막대한 영향을 주고 있다. 이에 따라 양봉에도 IoT 기술을 도입한 스마트 양봉에 관심이 집중되고 있다. 양봉의 특성에 따라 벌통안의 벌집을 육안으로 지속적 관찰이 불가능하고, 벌집안의 상태에 대하여 대부분 경험에 의한 지식에 의존하고 있는 실정이다. 특히, 벌통 내부에 꿀벌의 이동 경로와 이동량을 측정하는 부분에 대한 연구는 전무한 상황이다. 벌통 내부의 꿀벌의 이동에 대한 부분은 양봉에서 가장 중요한 분봉 시기를 예측할 수 있는 기본적인 정보를 제공할 수 있다. 본 연구에서는 꿀벌의 이동 경로를 파악하고 벌집(소비)간 입·출입 데이터를 실시간 측정하고 기록하는 장치를 제안한다. 본 연구에서 제안한 장치를 양봉 농가에서 활용할 수 있도록 기존 벌통의 벌집(소비) 규격에 맞춰서 개발했다. 개발방법은 꿀벌의 이동을 감지할 수 있는 포토 디텍터를 활용하여 16개의 이동통로를 구성하고 꿀벌의 이동상황을 실시간 감지할 수 있도록 했다. 이렇게 측정한 꿀벌의 이동상황을 활용하게 된다면 분봉시기를 놓치지 않기 위해 육안으로 봉군을 직접 관찰해야하는 문제를 해결할 수 있다. 나아가 꿀벌의 벌집 간 입출입 기록 데이터를 AI 알고리즘을 적용하면 자동으로 봉군 확장 시기를 예측할 수 있는 시스템 구현도 가능할 것이다.

• Genomics & Informatics
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• 제20권3호
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• pp.29.1-29.12
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• 2022

Several studies have shown associations between irinotecan toxicity and UGT1A genetic variations in colorectal and lung cancer, but only limited data are available for gastric cancer patients. We evaluated the frequencies of UGT1A polymorphisms and their relationship with clinicopathologic parameters in 382 Korean gastric cancer patients. Polymorphisms of UGT1A1*6, UGT1A1*27, UGT1A1*28, UGT1A1*60, UGT1A7*2, UGT1A7*3, and UGT1A9*22 were genotyped by direct sequencing. In 98 patients treated with irinotecan-containing regimens, toxicity and response were compared according to the genotype. The UGT1A1*6 and UGT1A9*22 genotypes showed a higher prevalence in Korean gastric cancer patients, while the prevalence of the UG1A1*28 polymorphism was lower than in normal Koreans, as has been found in other studies of Asian populations. The incidence of severe diarrhea after irinotecan-containing treatment was more common in patients with the UGT1A1*6, UGT1A7*3 and UGT1A9*22 polymorphisms than in controls. The presence of the UGT1A1*6 allele also showed a significant association with grade III-IV neutropenia. Upon haplotype and diplotype analyses, almost every patient bearing the UGT1A1*6 or UGT1A7*3 variant also had the UGT1A9*22 polymorphism, and all severe manifestations of UGT1A polymorphism-associated toxicity were related to the UGT1A9*22 polymorphism. By genotyping UGT1A9*22 polymorphisms, we could identify high-risk gastric cancer patients receiving irinotecan-containing chemotherapy, who would experience severe toxicity. When treating high-risk patients with the UGT1A9*22 polymorphism, clinicians should closely monitor them for signs of toxicity such as severe diarrhea or neutropenia.

• 한국수학교육학회지시리즈A:수학교육
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• 제62권2호
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• pp.289-302
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• 2023

지식정보사회의 비약적인 발전에 힘입어 빅데이터를 분석하여 가치있는 결과물을 도출하고 유용한 정보를 추출하는 역량이 학교 수학의 주요 목표 중 하나로 급부상하고 있다. 고등학교 수학 진로 선택 과목 중 하나인 <인공지능 수학>은 디지털 기술을 활용한 통계 프로젝트를 통해 빅데이터에 기반한 새로운 통계 교육의 기회를 제공할 수 있다. 이 연구에서는 효과적인 빅데이터 통계 프로젝트 기반 과제를 설계하기 위한 일련의 가이드라인을 제안하고, 이 기준에 따라 5종의 인공지능 수학 교과서에 실린 최적화 단원 과제들을 평가하였다. 인공지능 수학 교과에서 빅데이터 통계 프로젝트 과제를 설계 시 고려하도록 도출된 가이드라인은 다음과 같다: (1) 지식과 기술을 국가 학교 수학 교육과정에 맞추고, (2) 전처리된 대규모 데이터 세트를 사용하며, (3) 데이터 과학자의 문제 해결 방법을 사용하고, (4) 의사 결정을 장려하며, (5) 공학도구를 활용하고, (6) 협업 학습을 촉진한다. 분석 결과에 따르면 가이드라인에 완전히 부합하는 과제는 드물었고, 특히 대부분의 교과서에서 가이드라인 2에 해당하는 요소를 프로젝트 과제에서 통합하지 못하고 있는 것으로 나타났다. 또한 소규모 데이터 세트나 빅데이터를 전처리 없이 직접 사용하는 경우가 많아 학생들의 빅데이터의 개념에 대한 오해를 불러일으킬 것이 우려된다. 본 연구에서는 결과를 토대로 인공지능에 필요한 관련 수학 지식과 기술을 밝히고, 이것이 빅데이터 과제에 통합될 때 얻을 수 있는 잠재적 이점과 교육적 고려사항에 대해 논의하였다. 이 연구는 수학적 개념과 머신러닝 알고리즘과의 연계 및 빅데이터를 사용하는 통계 교육에서의 효과적인 공학적 도구 사용에 대한 통찰을 제공하고자 하였다.