• Korean Journal of Radiology
• /
• v.24 no.3
• /
• pp.235-246
• /
• 2023

Objective: It is difficult to predict the treatment response of tissue after stereotactic radiosurgery (SRS) because radiation necrosis (RN) and tumor recurrence can coexist. Our study aimed to predict tumor recurrence, including the recurrence site, after SRS of brain metastasis by performing a longitudinal tumor habitat analysis. Materials and Methods: Two consecutive multiparametric MRI examinations were performed for 83 adults (mean age, 59.0 years; range, 27-82 years; 44 male and 39 female) with 103 SRS-treated brain metastases. Tumor habitats based on contrast-enhanced T1- and T2-weighted images (structural habitats) and those based on the apparent diffusion coefficient (ADC) and cerebral blood volume (CBV) images (physiological habitats) were defined using k-means voxel-wise clustering. The reference standard was based on the pathology or Response Assessment in Neuro-Oncologycriteria for brain metastases (RANO-BM). The association between parameters of single-time or longitudinal tumor habitat and the time to recurrence and the site of recurrence were evaluated using the Cox proportional hazards regression analysis and Dice similarity coefficient, respectively. Results: The mean interval between the two MRI examinations was 99 days. The longitudinal analysis showed that an increase in the hypovascular cellular habitat (low ADC and low CBV) was associated with the risk of recurrence (hazard ratio [HR], 2.68; 95% confidence interval [CI], 1.46-4.91; P = 0.001). During the single-time analysis, a solid low-enhancing habitat (low T2 and low contrast-enhanced T1 signal) was associated with the risk of recurrence (HR, 1.54; 95% CI, 1.01-2.35; P = 0.045). A hypovascular cellular habitat was indicative of the future recurrence site (Dice similarity coefficient = 0.423). Conclusion: After SRS of brain metastases, an increased hypovascular cellular habitat observed using a longitudinal MRI analysis was associated with the risk of recurrence (i.e., treatment resistance) and was indicative of recurrence site. A tumor habitat analysis may help guide future treatments for patients with brain metastases.

• ETRI Journal
• /
• v.39 no.2
• /
• pp.145-150
• /
• 2017

As wearable devices are powered by batteries, they need to consume as little energy as possible. To address this challenge, in this article, we propose a synergistic technique for energy-efficient approximate speech signal processing (ASSP) for wearable devices. More specifically, to enable the efficient trade-off between energy consumption and sound quality, we synergistically integrate an approximate multiplier and a successive approximate register analog-to-digital converter using our enhanced conversion algorithm. The proposed ASSP technique provides ~40% lower energy consumption with ~5% higher sound quality than a traditional one that optimizes only the bit width of SSP.

• Journal of Veterinary Clinics
• /
• v.30 no.4
• /
• pp.320-323
• /
• 2013

Spinal cord infarction is becoming recognized as an important cause of acute myelopathy in cats. Although the definitive diagnosis is confirmed through postmortem histopathologic examination, MR imaging features provide valuable informations for the diagnosis of spinal cord infarction. The aim of this report is to describe MR findings of acute spinal cord infarction in two cats and to evaluate usefulness of low field MRI (0.3Tesla) as a potential diagnostic tool of acute spinal cord infarction. A cat (unknown age, neutered male mixed breed cat) was referred one day after the acute onset of non-ambulatory spastic tetraparesis and the other cat (a 9-year-old, neutered female domestic short hair cat) was presented due to the acute onset of non-ambulatory paraparesis and one day later paraplegia. The lesions of the MR images were shown on the spinal cord parenchyma over C2 to C6 in case 1 and L2 to L5 in case 2. The MR images in these two cases were characterized by focal intramedullary lesions, mainly involving grey matter which were hyperintense T2 weighted and FLAIR images and hyperintense on DWI and hypointense on ADC map. The MR findings in both cases were highly suggestive of acute spinal cord infarctions, based upon previous reported small animal cases and human cases. In conclusion, based on MR features, together with the history and clinical examination findings, MRI modality can be used as an antemortem tool for the diagnosis of acute spinal cord infarction in cats.

• ETRI Journal
• /
• v.31 no.6
• /
• pp.717-724
• /
• 2009

This paper describes a 1.2 V 12 b 60 MS/s CMOS analog front-end (AFE) employing low-power and flexible design techniques for image signal processing. An op-amp preset technique and programmable capacitor array scheme are used in a variable gain amplifier to reduce the power consumption with a small area of the AFE. A pipelined analog-to-digital converter with variable resolution and a clock detector provide operation flexibility with regard to resolution and speed. The AFE is fabricated in a 0.13 ${\mu}m$ CMOS process and shows a gain error of 0.68 LSB with 0.0352 dB gain steps and a differential/integral nonlinearity of 0.64/1.58 LSB. The signal-to-noise ratio of the AFE is 59.7 dB at a 60 MHz sampling frequency. The AFE occupies 1.73 $mm^2$ and dissipates 64 mW from a 1.2 V supply. Also, the performance of the proposed AFE is demonstrated by an implementation of an image signal processing platform for digital camcorders.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.26 no.6
• /
• pp.87-93
• /
• 2012

In this paper, we propose an analog-to-digital converter to set the address of a I2C slave chip. The proposed scheme converts a fixed voltage between 0 and VDD to the digital value which can be used as the address of the slave chip. The rising time and the falling time are measured with digital counter in a serially connected RC circuit, while the circuit is being charged and discharged with the voltage to be measured. The ratio of the two measured values is used to get the corresponding digital value. This scheme gives a strong point which is to be implementable all the parts except comparator using digital logic. Although the method utilizes RC circuit, it has no relation with the RC value if the quantization error is disregarded. Experimental result shows that the proposed scheme gives 32-level resolution thus it can be used to configure the address of the I2C slave chip.

• Journal of Electrical Engineering and Technology
• /
• v.10 no.4
• /
• pp.1589-1596
• /
• 2015

A novel control method of a three-phase PWM inverter with LC filter is proposed. The transfer function of LC filter is the same as that of 2nd order low pass filter(2nd LPF) which has a zero damping ratio. A simple method of implementing 2nd LPF with damping ratio is to add resistor to inductor or capacitor of LC filter. In an industrial application, it is not practical to adopt damping resistor because it results in losses being proportional to square of current flowing through resistor. Instead of using damping resistors, the proposed active damping control(ADC) utilizes all pass filter(APF) and considers inherent processing delay of digital controller. The overall transfer function of the proposed method is the same as a 2nd LPF and its damping ratio is also controllable via control variables. Detailed design and implementation of controller is also presented. Experiments are conducted with a 7.5kVA induction motor drive system controlled by PWM converter and inverter. Test waveforms are also presented to verify the proposed LC filter control algorithm.

• Investigative Magnetic Resonance Imaging
• /
• v.17 no.2
• /
• pp.101-109
• /
• 2013

Objective: To investigate roles of dynamic contrast enhanced magnetic resonance (DCE MR) and diffusion-weighted (DW) imaging in preoperative prediction of underestimation of ductal carcinoma in situ (DCIS) ${\geq}2cm$ on US guided core needle biopsy. Materials and Methods: Twenty two patients with DCIS on US-guided 14 gauge core needle biopsy were included. Patients were divided into a group with and without DCIS underestimation based on histopathology. MR images including DCE and DW imaging were obtained with a 3.0-T MR. The lesion type (mass or non-mass), enhancement pattern, peak enhancement, and apparent diffusion coefficient (ADC) values of proven malignant masses were generated using software of CADstream and compared between two groups using Fisher's exact test and Mann Whitney test. Results: Eight patients were in the group with underestimation and 14 patients were in the group without underestimation. The lesion type and enhancement pattern were not different between two groups (P values = 1.000 and 0.613, respectively). The median peak enhancement of lesions with underestimation was 159.5%, higher than 133.5% of those without underestimation, but not significant (P value = 0.413). The median ADC value of lesions with underestimation was $1.26{\times}10^{-3}mm^2/sec$, substantially lower than $1.35{\times}10^{-3}mm^2/sec$ of those without underestimation (P value = 0.094). Conclusion: ADC values had the potential to preoperatively predict DCIS underestimation on US-guided core needle biopsy, although a large prospective series study should be conducted to confirm these results.

• Proceedings of the KIEE Conference
• /
• 2002.07b
• /
• pp.1114-1116
• /
• 2002

The characteristics of voltage drop and THD for parallel operating 11 PCRs (Phase Controlled Rectifiers) are analysed. The PCRs are used to drive high current (1.6 kA ${\sim}$ 3.7 kADC) electromagnetic coils for electromagnets. All the PCRs operate simultaneously in pulsed mode, and the pulse shot occurs every 150 seconds. During the pulse operation the PCR output current ramps up for 4 seconds, and then keeps flat top state for 2 seconds, and finally ramps down for 4 seconds. For the flat top mode a severe voltage drop and distortion appear in the power system because transformers for the PCRs are designed considering pulsed mode operation. It is expected that the analysis method can be applied to improve the system performance including power factor and design of high power pulsed mode operating power supply systems.

• Journal of IKEEE
• /
• v.21 no.3
• /
• pp.260-263
• /
• 2017

Based on several CPU cores, an SoC including ADCs, DC-DC converter and 2M-byte SRAM is proposed in this paper. The CPU core consists of a 12-bit MENSA, a 32-bit Symmetric multi-core processor, as well as 16-bit CDSP. To eliminate the external SDRAM memory, internal 2M-byte SRAM is implemented. Because the SRAM normally occupies huge area, the parasitic components reduce the speed of SoC. In this work, the SRAM blocks are divided into small pieces to reduce the parasitic components. The proposed SoC is developed in a standard 55nm CMOS process and the speed of SoC is 200MHz.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.14 no.8
• /
• pp.1887-1894
• /
• 2010

This paper proposes a new switched-capacitor sigma-delta modulator for automotive radars. Developed modulator is used to perform high-resolution analog-to-digital conversion (ADC) of high frequency band signal in a radar system. It has supply voltage of 2.7V, and has body-effect compensated switch configuration with low voltage and low distortion. The modulator has been implemented in a $0.25{\mu}m$ double-poly and triple-metal standard CMOS process, and it has die area of $1.9{\times}1.5mm^{2}$. It showed better total harmonic distortion of 20dB than the conventional bootstrapped circuit at the supply voltage of 2.7V.