• Communications for Statistical Applications and Methods
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• v.4 no.2
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• pp.581-588
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• 1997

Univariate F test is based on the multisample sphericity assumption. Robustness for tests of a main effect of the within-subjects factor was investigated when the assumptions of the onmibus F tests are violated in a split-plot design with one between-subjects factor using untrimmed data and trimmed data. The results indicate that when sample sizes are unbalanced and dispersion matrices are heterogeneous, the CIGA and the $CIGA_T$ tests better control Type I error rates than do the $F_T$test and the$\widetilde{\xi_T}$test.

• Bulletin of the Korean Mathematical Society
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• v.53 no.4
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• pp.1113-1122
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• 2016

Let (M, g(t)) be a compact Riemannian manifold and the metric g(t) evolve by the Yamabe flow. In the paper we derive the evolution for the first eigenvalue of geometric operator $-{\Delta}_{\phi}+{\frac{R}{2}}$ under the Yamabe flow, where ${\Delta}_{\phi}$ is the Witten-Laplacian operator, ${\phi}{\in}C^2(M)$, and R is the scalar curvature with respect to the metric g(t). As a consequence, we construct some monotonic quantities under the Yamabe flow.

• Journal of Korean Neurosurgical Society
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• v.53 no.5
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• pp.305-308
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• 2013

Myositis ossificans (MO) is a benign condition of non-neoplastic heterotopic bone formation in the muscle or soft tissue. Trauma plays a role in the development of MO, thus, non-traumatic MO is very rare. Although MO may occur anywhere in the body, it is rarely seen in the lumbosacral paravertebral muscle (PVM). Herein, we report a case of non-traumatic MO in the lumbosacral PVM. A 42-year-old man with no history of trauma was referred to our hospital for pain in the low back, left buttock, and left thigh. On physical examination, a slightly tender, hard, and fixed mass was palpated in the left lumbosacral PVM. Computed tomography showed a calcified mass within the left lumbosacral PVM. Magnetic resonance imaging (MRI) showed heterogeneous high signal intensity in T1- and T2-weighted image, and no enhancement of the mass was found in the postcontrast T1-weighted MRI. The lack of typical imaging features required an open biopsy, and MO was confirmed. MO should be considered in the differential diagnosis when the imaging findings show a mass involving PVM. When it is difficult to distinguish MO from soft tissue or bone malignancy by radiology, it is necessary to perform a biopsy to confirm the diagnosis.

• BMB Reports
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• v.57 no.7
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• pp.318-323
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• 2024

Regulation of cell fate and lung cell differentiation is associated with Aminoacyl-tRNA synthetases (ARS)-interacting multifunctional protein 2 (AIMP2), which acts as a non-enzymatic component required for the multi-tRNA synthetase complex. In response to DNA damage, a component of AIMP2 separates from the multi-tRNA synthetase complex, binds to p53, and prevents its degradation by MDM2, inducing apoptosis. Additionally, AIMP2 reduces proliferation in TGF-β and Wnt pathways, while enhancing apoptotic signaling induced by tumor necrosis factor-α. Given the crucial role of these pathways in tumorigenesis, AIMP2 is expected to function as a broad-spectrum tumor suppressor. The full-length AIMP2 transcript consists of four exons, with a small section of the pre-mRNA undergoing alternative splicing to produce a variant (AIMP2-DX2) lacking the second exon. AIMP2-DX2 binds to FBP, TRAF2, and p53 similarly to AIMP2, but competes with AIMP2 for binding to these target proteins, thereby impairing its tumor-suppressive activity. AIMP2-DX2 is specifically expressed in a diverse range of cancer cells, including breast cancer, liver cancer, bone cancer, and stomach cancer. There is growing interest in AIMP2-DX2 as a promising biomarker for prognosis and diagnosis, with AIMP2-DX2 inhibition attracting significant interest as a potentially effective therapeutic approach for the treatment of lung, ovarian, prostate, and nasopharyngeal cancers.

• Bulletin of the Korean Mathematical Society
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• v.53 no.2
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• pp.601-614
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• 2016

Let $N_{g,s}$ denote the nonorientable surface of genus g with s boundary components. Recently Paris and Szepietowski [12] obtained an explicit finite presentation for the mapping class group $\mathcal{M}(N_{g,s})$ of the surface $N_{g,s}$, where $s{\in}\{0,1\}$ and g + s > 3. Following this work, we obtain a finite presentation for the subgroup $\mathcal{T}(N_{g,s})$ of $\mathcal{M}(N_{g,s})$ generated by Dehn twists.

• Bulletin of the Korean Chemical Society
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• v.15 no.1
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• pp.53-57
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• 1994

A comparison study on asymmetric borane reduction of ketoxime ethers and N-substituted ketimines possesing C = N double bond mediated by the selected chiral oxazaborolidines (1-6) was investigated. Thus, an aromatic ketoxime O-alkyl ether acetophenone oxime O-methyl ether was reduced to the corresponding amine (1-phenylethylamine 8a) with optical yields, such as 58% ee with 1, 86% ee with 2, 3% ee with 3, 99% ee with 4, 60% ee with 5, and 73% ee with 6. However, the reduction of an aliphatic ketoxime derivative 2-heptanone oxime O-methyl ether provided low optical inductions (7-13% ee). For ketoxime O-trimethylsilyl ethers, the reduction of acetophenone O-trimethylsilyl ether afforded 8a with optical yields which were 90% ee with 1, 40% ee with 2, 2% ee with 3, 62% ee with 4, 5% ee with 5, and 60% ee with 6. The reduction of 2-heptanone O-trimethylsilyl ether also gave the product amine with low optical yields (10-40% ee). In the case of N-substituted ketimines, the reduction of acetophenone N-phenylimine afforded the corresponding amine with 79% ee, 78% ee, 9% ee, 73% ee, 78% ee and 67% ee using 1, 2, 3, 4, 5, and 6, respectively, whereas low optical inductions (5-18% ee) for 2-heptanone N-phenylimine were achieved.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.17 no.1
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• pp.11-17
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• 2017

Purpose: Phenylketonuria (PKU) results from a deficiency of phenylalanine hydroxylase (PAH). The mutation of the PAH gene results in decreased phenylalanine hydroxylase enzyme activity in hyperphenylalaninemia (HPA) patients. This study reports ten cases of patients with the benign HPA genotype c.158G>A (p.Arg53His, R53H) variant in the PAH gene and aims to evaluate the clinical significance of the R53H variant. Methods: Ten Korean patients with the HPA genotype the R53H variant were included in this study. A retrospective medical record review was conducted. We characterized the phenotypes of the patients with HPA with the R53H variant using the following system: classic PKU, moderate PKU, mild PKU, Mild HPA, and benign HPA. Results: Five patients had the R53H variant with the "Pathogenic" variants (R413P, R241C, $Y356^*$, c.442-1G>A, $Y325^*$), Two patients had the "Likely pathogenic" variants ($W187^*$, A259T), Two patients had the "Uncertain significance" variants (R53H, G344D), and One patient had the "Not provided" variant (c.1066-14C>G). Nine patients genotyped with the R53H variant were the patient with benign HPA and One patient genotyped with the R53H homozygote was within normal range of plasma phenylalanine. None of the ten patients required dietary restriction of phenylalanine or pharmacotherapy to maintain their plasma phenylalanine levels and showed no clinical symptoms of HPA. Conclusion: Ten patients with HPA genotype the R53H variant were the patient with benign HPA and showed no clinical symptoms of HPA. Thus, the R53H variant, which was previously classified as an "Uncertain significance" mutation in HPA patients, should be re-classified as "Benign."

• Korean Journal of Radiology
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• v.23 no.11
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• pp.1078-1088
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• 2022

Objective: To develop and validate a model using radiomics features from apparent diffusion coefficient (ADC) map to diagnose local tumor recurrence in head and neck squamous cell carcinoma (HNSCC). Materials and Methods: This retrospective study included 285 patients (mean age ± standard deviation, 62 ± 12 years; 220 male, 77.2%), including 215 for training (n = 161) and internal validation (n = 54) and 70 others for external validation, with newly developed contrast-enhancing lesions at the primary cancer site on the surveillance MRI following definitive treatment of HNSCC between January 2014 and October 2019. Of the 215 and 70 patients, 127 and 34, respectively, had local tumor recurrence. Radiomics models using radiomics scores were created separately for T2-weighted imaging (T2WI), contrast-enhanced T1-weighted imaging (CE-T1WI), and ADC maps using non-zero coefficients from the least absolute shrinkage and selection operator in the training set. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of each radiomics score and known clinical parameter (age, sex, and clinical stage) in the internal and external validation sets. Results: Five radiomics features from T2WI, six from CE-T1WI, and nine from ADC maps were selected and used to develop the respective radiomics models. The area under ROC curve (AUROC) of ADC radiomics score was 0.76 (95% confidence interval [CI], 0.62-0.89) and 0.77 (95% CI, 0.65-0.88) in the internal and external validation sets, respectively. These were significantly higher than the AUROC values of T2WI (0.53 [95% CI, 0.40-0.67], p = 0.006), CE-T1WI (0.53 [95% CI, 0.40-0.67], p = 0.012), and clinical parameters (0.53 [95% CI, 0.39-0.67], p = 0.021) in the external validation set. Conclusion: The radiomics model using ADC maps exhibited higher diagnostic performance than those of the radiomics models using T2WI or CE-T1WI and clinical parameters in the diagnosis of local tumor recurrence in HNSCC following definitive treatment.

• Bulletin of the Korean Mathematical Society
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• v.53 no.5
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• pp.1385-1394
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• 2016

Let (R, m) be a Noetherian local ring, I, J two ideals of R, and A an Artinian R-module. Let $k{\geq}0$ be an integer and $r=Width_{>k}(I,A)$ the supremum of lengths of A-cosequences in dimension > k in I defined by Nhan-Hoang [9]. It is first shown that for each $t{\leq}r$ and each sequence $x_1,{\cdots},x_t$ which is an A-cosequence in dimension > k, the set $$\Large(\bigcup^{t}_{i=0}Att_R(0:_A(x_1^{n_1},{\ldots},x_i^{n_i})))_{{\geq}k}$$ is independent of the choice of $n_1,{\ldots},n_t$. Let r be the eventual value of $Width_{>k}(0:_AJ^n)$. Then our second result says that for each $t{\leq}r$ the set $\large(\bigcup\limits_{i=0}^{t}Att_R(Tor_i^R(R/I,\;(0:_AJ^n))))_{{\geq}k}$ is stable for large n.

• The Korea Journal of Herbology
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• v.37 no.6
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• pp.53-59
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• 2022

Objectives : Cleanser is the most basic tools used in daily skin care. I made a cold process soap using Castanea crenata inner shell (CCIS). I'd like to study the effect of face wash using CCIS cold process (CP) soap on the skin. Methods : The same water and towel were used at the same place in order to examine the skin change state immediately before and after washing face. The skin test was performed before and after 10 minutes washing the face in order to remove these external environmental factors, such as lifestyle, alcohol, tobacco, and stress etc. As a control group, the cases of washing with water and foam cleanser (F/C), which is a popular commercial product, were set. Three cases were compared and analyzed. Results : In the case of water washing, there was a significant decrease in oil (U-zone) but that was not good effect. In the case of F/C and CCIS washing, there were significant decrease in oil (T-zone), pores and pigmentation, but the significance was bigger in CCIS washing. In the case of pores, there was a significant decrease in all three cases. Conclusion : In the case of F/C and CCIS washing, it showed the effect of reducing T-zone oil, pores and pigmentation. But the significance was greater in CCIS case than in F/C case. CCIS cp soap is considered as a form of face wash that is suitable for skin care.