• Journal of Elementary Mathematics Education in Korea
• /
• v.18 no.1
• /
• pp.1-17
• /
• 2014

Instructions for the commutative property of multiplication at elementary schools tend to be based on checking the equality between the quantities of 'a times b 'and b' times a, ' for example, $3{\times}4=12$ and $4{\times}3=12$. This article critically examined the approaches to teach the commutative property of multiplication from Kant's perspective of mathematical knowledge. According to Kant, mathematical knowledge is a priori. Yet, the numeric exploration by checking the equality between the amounts of 'a groups of b' and 'b groups of a' does not reflect the nature of apriority of mathematical knowledge. I suggest we teach the commutative property of multiplication in a way that it helps reveal the operational schema that is necessarily and generally involved in the transformation from the structure of 'a times b' to the structure of 'b times a.' Distributive reasoning is the mental operation that enables children to perform the structural transformation for the commutative property of multiplication by distributing a unit of one quantity across the other quantity. For example, 3 times 4 is transformed into 4 times 3 by distributing each unit of the quantity 3, which results in $3{\times}4=(1+1+1){\times}4=(1{\times}4)+(1{\times}4)+(1{\times}4)+(1{\times}4)=4+4+4=4{\times}3$. It is argued that the distributive reasoning is also critical in learning the subsequent mathematics concepts, such as (a whole number)${\times}10$ or 100 and fraction concept and fraction multiplication.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.5
• /
• pp.2805-2809
• /
• 2013

Objective: This study aimed at investigating whether the orphan nuclear receptor NR4A2 is significantly associated with clinicopathologic features and overall survival of patients with nasopharyngeal carcinoma (NPC). Methods: Immunohistochemistry was performed to determine NR4A2 protein expression in 84 NPC tissues and 20 non-cancerous nasopharyngeal (NP) tissues. The prognostic significance of NR4A2 protein expression was evaluated using Cox proportional hazards regression models and Kaplan-Meier survival analysis. Results: We did not find a significant association between total NR4A2 expression and clinicopathological variables in 84 patients with NPC. However, we observed that high cytoplasmic expression of NR4A2 was significantly associated with tumor size (T classification) (P = 0.006), lymph node metastasis (N classification) (P = 0.002) and clinical stage (P = 0.017). Patients with higher cytoplasmic NR4A2 expression had a significantly lower survival rate than those with lower cytoplasmic NR4A2 expression (P = 0.004). Multivariate Cox regression analysis analysis suggested that the level of cytoplasmic NR4A2 expression was an independent prognostic indicator for overall survival of patients with NPC (P = 0.033). Conclusions: High cytoplasmic expression of NR4A2 is a potential unfavorable prognostic factor for patients with NPC.

• Molecules and Cells
• /
• v.42 no.7
• /
• pp.546-556
• /
• 2019

Protein phosphatase 4 (PP4) is a crucial protein complex that plays an important role in DNA damage response (DDR), including DNA repair, cell cycle arrest and apoptosis. Despite the significance of PP4, the mechanism by which PP4 is regulated remains to be elucidated. Here, we identified a novel PP4 inhibitor, protein phosphatase 4 inhibitory protein (PP4IP) and elucidated its cellular functions. PP4IP-knockout cells were generated using the CRISPR/Cas9 system, and the phosphorylation status of PP4 substrates (H2AX, KAP1, and RPA2) was analyzed. Then we investigated that how PP4IP affects the cellular functions of PP4 by immunoprecipitation, immunofluorescence, and DNA double-strand break (DSB) repair assays. PP4IP interacts with PP4 complex, which is affected by DNA damage and cell cycle progression and decreases the dephosphorylational activity of PP4. Both overexpression and depletion of PP4IP impairs DSB repairs and sensitizes cells to genotoxic stress, suggesting timely inhibition of PP4 to be indispensable for cells in responding to DNA damage. Our results identify a novel inhibitor of PP4 that inhibits PP4-mediated cellular functions and establish the physiological importance of this regulation. In addition, PP4IP might be developed as potential therapeutic reagents for targeting tumors particularly with high level of PP4C expression.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2017.05a
• /
• pp.317-320
• /
• 2017

S4A (Scratch For Arduino) is a program that controls to Arduino with scratch. In this paper, We developed a simple game form for learning contents and using touch sensor that composed of scratch language based on S4A. We used background music and scores to motivate and interest that beginning to learn English for students.

• Parasites, Hosts and Diseases
• /
• v.33 no.4
• /
• pp.341-348
• /
• 1995

Genetic status of Acnnthamoebc sap. were tested on the basis of random amplified polymorphic DNA (RAPD) marker analysis. Four previously established Accnthcmoebn species, 4 Korean isolates of Acnnthamoeba sp., and one American isolate of Acanthcmoebc sp. were analyzed by RAPD-PCR using an arbitrary decamer primers. Amplification products were fractionated by agarose gel electrophoresis and slainrd by ethidium bromide . Eighteen primers produced DNA amplification profiles revealing clear differences among 4 species. Nine of them also produced DNA amplification profiles which included some isolate-specific amplification products. On the basis of amplified fragments by 18 primers, the pairwise similarity indices between A. culbensoni and other species (i.e. A. hntchetti, A. trinngularis, A. polyphaga) were 0.300, 0.308, and 0.313, respectively. Similarity index between A. hctchetti and A. triansulcris was 0.833. The mean similarity index among the 3 Korean isolates (YM-2, -3, -4) was 0.959 and 0.832 among them and 2 other species (A. hatchetti and A. triongulnris). The mean similarity index among YM-5 and other Korean isolates (YM-2, -3, -4) was 0.237. However, the similarity index between YM-5 and A. culbeksoni was 0.857, which suggests that YM-5 is genetically more similar to A. culbertsoni than other Korean isolates. Phonogram reconstructed by UPGMA method revealed that there are two groups: one group consists of A. hctchetti, A. tlonsulcns, and 3 Korean isolates (YM-2, -3, -4) , and the other group consists of A. cuLbensoni. A. polwphosc, HOV, and YM-5.

• The Plant Pathology Journal
• /
• v.21 no.1
• /
• pp.64-67
• /
• 2005

The biocontrol agent Serratia plymuthica A21-4 readily colonized on the root of pepper plant and the bacterium moves to newly emerging roots continuously. The colonization of A21-4 on the pepper root was influenced by the presence ofPhytophthora capsici in the soil. When P. capsici was introduced in advance, the population density of A21-4 on the root of pepper plant was sustained more than $10^6$ cfu/g root until 3 weeks after transplanting. On the other hand, in the absence of P. capsici, the population density of A21-4 was reduced continuously and less than $10^5$ cfu/g root at 21 days after transplanting. S. plymuthica A21-4 inhibited successfully the P. capsici population in pepper root and rhizosphere soil. In the rhizosphere soil, the population density of P. capsici was not increased more than original inoculum density when A21-4 was treated, but it increased rapidly in non-treated control. Similarly, the population density of P. capsici sharply increased in the non-treated control, however the population of P. capsici in A21-4 treated plant was not increased in pepper roots. The incidence of Phytophthora blight on pepper treated with A21-4 was 12.6%, while that of non-treated pepper was 74.5% in GSNU experimental farm experiment. And in farmer's vinyl house experiment, the incidence of the disease treated with the fungicide was 27.3%, but treatment of A21-4 resulted in only 4.7% of the disease incidence, showing above 80% disease control efficacy.

• Journal of the Korean Data and Information Science Society
• /
• v.21 no.2
• /
• pp.231-240
• /
• 2010

If only fixed effects exist in a 4 $\times$ 4 balanced incomplete block design, powers of FR statistic for testing a main effect show the highest level with a few replications. Under the exponential and double exponential distributions, FR statistic shows relatively high powers with big differences as compared with the F statistic. Further in a traditional balanced incomplete block design, powers of FR statistic having a fixed main effect and a random block effect show superior preference for all situations without regard to the effect size of a main effect, the parameter size and the type of population distributions of a block effect. Powers of FR statistic increase in a high speed as replications increase. Overall power preference of FR statistic for testing a main effect is caused by unique characteristic of a balanced incomplete block design having one main and block effect with missing observations, which sensitively responds to small increase of main effect and sample size.

• Archives of Pharmacal Research
• /
• v.17 no.3
• /
• pp.194-198
• /
• 1994

The antitumor effects of the 2E4 and anti--Tac, monoclonal antibodies directed to Il-2 receptor (IL-2R) conjugated with .alpha.-particle emitting radionuclide bismuth-212., were compared. The $^{212}Bi-2E4$ demonstratedspecific cytotocicity to EL4J3, 4, a I$L-2R^+$ cell line, than to EL4J, a $IL-2R^-$ cell line in thymidine incorporation assy. TEX>$^{212}Bi-2E4$ exerted the maximal antitumor effect in that % T/C in C57BL/6 mice implanted with EL4J3.4 ascitic tumor was 331% at the concentration of $50{\;}{\mu}Ci$, while that of $^{212}Bi-anti-Tac$ was 258% at $100{\;}{\mu}Ci$.

• Journal of Oriental Neuropsychiatry
• /
• v.28 no.3
• /
• pp.157-164
• /
• 2017

Objectives: The purpose of this study is the research of the 2D:4D ratio and its correlation with the Sasang constitution and the MBTI preference types. Methods: A measurement of the 2D:4D ratios of 101 South Korean medical students was performed, the QSCC-II and PSSC-2004 were used to diagnose the Sasang constitution, and MBTI testing was performed to classify the preference types. Results: In the relationship between the Sasang constitution and the 2D:4D ratios, a statistically significant difference is absent in the 2D:4D ratios of the group comprising both sexes in the order of Taeumin, Soyangin, and Soeumin. A statistically significant difference is also lacking in the 2D:4D ratios of the male-only group in the order of Taeumin, Soyangin, and Soeumin. The 2D:4D ratios are higher in the female group only, but again a statistically significant difference is absent. In the 2D:4D ratios according to the MBTI preference type, the 2D:4D ratios of the I, S, F, and P types are higher in the unisex group, but a significant difference is not evident. The 2D:4D ratios of the E, N, F, and P types are higher in the male-only group, but again a significant difference is not evident. In the female-only group, the mean of the 2D:4D ratios of the I, S, F, and P types is higher, but a significant difference is not identifiable. Conclusions: The Sasang constitution and the MBTI preference types did not show statistically significant differences regarding the 2D:4D ratios of the male, female, and unisex groups.

• Journal of Broadcast Engineering
• /
• v.20 no.5
• /
• pp.676-686
• /
• 2015

A 4D light field image is represented in traditional 2D spatial domain and additional 2D angular domain. The 4D light field has a resolution limitation both in spatial and angular domains since 4D signals are captured by 2D CMOS sensor with limited resolution. In this paper, we propose a dictionary learning-based superresolution algorithm in 4D light field domain to overcome the resolution limitation. The proposed algorithm performs dictionary learning using a large number of extracted 4D light field patches. Then, a high resolution light field image is reconstructed from a low resolution input using the learned dictionary. In this paper, we reconstruct a 4D light field image to have double resolution both in spatial and angular domains. Experimental result shows that the proposed method outperforms the traditional method for the test images captured by a commercial light field camera, i.e. Lytro.