• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.46 no.4
• /
• pp.37-44
• /
• 2009

A novel phase-locked loop(PLL) architecture with resistance and capacitance scaling scheme has been proposed. The proposed PLL has three charge pumps. The effective capacitance and resistance of the loop filter can be scaled up/down according to the locking status by controlling the direction and magnitude of each charge pump current. This architecture makes it possible to have a narrow bandwidth and low resistance in the loop filter, which improves phase noise and reference spur characteristics. It has been fabricated with a 3.3V $0.35{\mu}m$ CMOS process. The measured locking time is $25{\mu}s$ with the measured phase noise of -105.37 dBc/Hz @1MHz and the reference spur of -50dBc at 851.2MHz output frequency

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.42 no.4 s.334
• /
• pp.37-44
• /
• 2005

In this paper, a new type of the TC-to-BC encoder for high speed flash ADC's, called the Successive Selection Encoder (SSE), is proposed. In contrast to the conventional fat tree encoder based on OR operations, the W- outputs, in the new design, are obtained directly from TC inputs through simple MUX operations. The detailed structure of the SSE has been determined systematically by the method of the logical effort and the simulation oil Hynix 0.25um process. The theoretical and experimental results show that (1) it is not required to generate one-out-of-n signals, (2) the number of gates is reduced by the factor of 1/3, and (3) the speed is improved more than 2-times, compared to the fat tree encoder. It is speculated that the SSE proposed in this study is an effective solution for bottleneck problems in high speed ADCs.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.3
• /
• pp.1453-1461
• /
• 2016

Regarding 'mate' intake (infusion of Ilex paraguariensis herb, a staple beverage in temperate South American regions), most epidemiologic studies showed positive associations with risk of some cancers, (e.g. upper aerodigestive tract), but evidence on breast cancer (BC) risk is limited to a previous multi-site study, which reported a non significant odds ratio [OR]=0.85, 95% confidence interval [95% CI] 0.67-1.09, p for trend=0.31) for the highest quartile of intake. The present study was conducted in order to further assess associations of 'mate' intake with BC risk. We combined two databases of women belonging to public and private healthcare hospitals. The sample included 572 BC incident cases and 889 controls interviewed with a specific questionnaire featured by socio-demographic, reproductive and lifestyle variables, and a food frequency questionnaire of 64 items, also analyzing 'mate' intake (consumer status, daily intake, age at start, age at quit, duration of habit, intensity of intake). ORs and their 95%CI were calculated through unconditional logistic regression, adjusting for relevant potential confounders. The highest quartile of 'mate' intake was inversely associated with BC risk (OR=0.40, 95%CI 0.26-0.57, p for trend <0.001). Stratified analyses also displayed strong significant inverse associations for 'mate' in frequent tea drinkers (OR=0.22), high energy intake (OR=0.23), high body mass index (OR=0.29) and in postmenopausal women (OR=0.36), among other results. As conclusions, we found evidence of a significant inverse association for 'mate' intake and BC risk.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.16
• /
• pp.6519-6524
• /
• 2014

The aim of this study was to evaluate the clinical outcomes of radical cystectomy (RC) and concurrent chemoradiotherapy (CRT) with methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) in patients with locally advanced bladder cancer (BC). From December 2000 to February 2012, 72 patients with locally advanced BC (T3-4a, N0 or N+, M0) received either RC or CRT. RC with bilateral pelvic lymph node dissection including the common iliac region as the standard procedure. Patients in the CRT group received one cycle of MVAC followed by radiotherapy with a half dose of MVAC and then two more cycles of MVAC. Standard fractionation at a daily dose of 1.8-2.0 Gy was used, with a median total dose of 50 Gy (range, 45-60 Gy). The 3-year progression-free survival (PFS) rates in the RC and CRT groups were 56.2% and 25.6%, respectively (p=-0.015) and the 3-year overall survival (OS) rates were 63.5% and 48.1% (p=0.272). Multivariate Cox proportional hazards regression analysis with application of a propensity score indicated that RC was a significant predictor of PFS (p=0.033) but not of OS (p=0.291). Among patients with locally advanced BC, PFS was significantly prolonged in the RC group compared with the CRT group. However, RC was not a significant predictor of OS. Although the sample size in this study was small, the results suggest that patient background and postoperative quality of life should be considered when choosing treatment strategy for locally advanced BC.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.49 no.5
• /
• pp.37-42
• /
• 2012

In this paper, a new charge pump is proposed to reduce the timing mismatch in the conventional current-steering charge pumps. Conventional current-steering charge pumps used NMOS input stages both for UP and DOWN signals, which resulted in different numbers of stage for UP and DOWN delay paths. The proposed charge pump has equalized the numbers of stages for UP and DOWN signals by using a PMOS stage for the DOWN signal. The simulation results show that the conventional current-steering charge pump has 14ns and 6ns for optimized timing mismatches between UP and DOWN signals for turn-on and turn-off, respectively. On the other hand, the proposed charge pump has improved timing mismatches of 6ns and 5ns for turn-on and turn-off, respectively. As a result, the reference spurs are reduced from -26dBc to -39dBc for the proposed charge pump. The proposed charge pump was designed by using $0.18{\mu}m$ CMOS technology. The measurement results show that the maximum variation of the charging and discharging current over the charge pump output voltage range of 0.3~1.5V is approximately 1.5%.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.38 no.5
• /
• pp.413-417
• /
• 1993

This study was conducted to breed various cytoplasmic genetic male sterile (CGMS) and restorer lines with backgrounds of Korean japonica rice varieties. The CGMS line BT-CMS was crossed with the restorer line AR-3. The fertile $F_1 was emasculated and crossed with the Korean japonica rice varieties of the early maturing Sobaegbyeo, Odaebyeo, Gwanagbyeo and Daeseongbyeo, and of the medium maturing Hwajinbyeo, Paldal, Suwon 224 and Iri 386, and of the late maturing Nagdongbyeo, Palkweng, Hwacheongbyeo and Milyang 97. Each of the three way cross $F_{1S} was segregated into fertile and sterile individuals. The sterile individuals in each cross were discarded and the fertile individuals were emasculated and backcrossed with the Korean japonica rice varieties. The same process was applied from BC$_1$F$_1$ to BC$_4$F$_1$ generation. In the ${BC_4}{F_1}of each cross, the male sterile individual was crossed with the recurrent Korean japonica variety which was maintainer of male sterility. The male sterile lines of ${BC_6}{F_1}were named as Sobaegbyeo R, Odaebyeo R, Gwanagbyeo R, etc. The fertile individuals homozygous in pollen fertility were selected from the ${BC_4}{F_2}generation and named as Sobaegbyeo R, Odaebyeo R, Gwanagbyeo R, etc. Agronomic characteristics of the CGMS, restorer lines with backgrounds of Korean japonica, and the recurrent Korean japonica rice varieties grown in the field condition were compared. Culm length of the CGMS lines tended to be shorter than that of the recurrent parent, however no significant differences in heading date, panicle length and yield component were found among the CGMS, restorer and recurrent lines.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.31 no.7B
• /
• pp.602-607
• /
• 2006

A subscriber-oriented service became necessary for the QoS management due to the development of network. BcN(Broadband convergence Network) which incorporates communication, broadcasting and internet not only improves the quality of the communication and broadcasting service but also. aims at broadband service. Therefore, QoS management for each subscriber becomes more important. Not yet, however, the discussion for the subscriber oriented QoS management is not activated. Although, there are several techniques for subscriber distinction using flow information, IP information or MAC information, but they are only processed in layer 3 network. Actually, it is impossible to manage QoS of all subscriber's in layer 3 network. In this paper, we propose a method for QoS management scheme that does not need additional processes or large hardware in layer 2 network and analyze efficiency and overheads. We propose the first subscriber-oriented service method in layer 2 network that is applicable to either existing network or BcN.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.14 no.9
• /
• pp.967-973
• /
• 2003

This paper presents a new predistortion method which injects the 2nd low-frequency intermodulation signal of RF signals into the input bias line of the amplifier. New 2nd intermodulation signal extraction circuit is also proposed. We have shown that this method can suppress the 3rd IM apparently and sometimes do the 5th IM, through mathematical analysis, then confirmed it with simulation and verified it on the desk test. When the input signal CDMA IS-95 lFA is applied, measured ACPR improvements are 25 dBc, 22.5 dBc, and 6 dBc at 0.885 MHz, l.25 MHz and 2.25 MHz offset respectively. Also, when applying the CDMA IS-95 3FA, the measured ACPR improvement is 20 dBc at 0.885 MHz offset.

• Biomolecules & Therapeutics
• /
• v.26 no.3
• /
• pp.328-334
• /
• 2018

Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary substances and botanical products. Studies have shown that Panduratin A (PA) possesses many health benefits, including anti-inflammatory, anti-bacterial, anti-oxidant and anticancer activities. In the present study, we provide evidence that PA treatment of MCF-7 BC cells resulted in a time- and dose-dependent inhibition of cell growth with an $IC_{50}$ of $15{\mu}M$ and no to little effect on normal human MCF-10A breast cells. To define the mechanism of these anti-proliferative effects of PA, we determined its effect critical molecular events known to regulate the cell cycle and apoptotic machinery. Immunofluorescence and flow cytometric analysis of Annexin V-FITC staining provided evidence for the induction of apoptosis. PA treatment of BC cells resulted in increased activity/expression of mitochondrial cytochrome C, caspases 7, 8 and 9 with a significant increase in the Bax:Bcl-2 ratio, suggesting the involvement of a mitochondrial-dependent apoptotic pathway. Furthermore, cell cycle analysis using flow cytometry showed that PA treatment of cells resulted in G0/G1 arrest in a dose-dependent manner. Immunoblot analysis data revealed that, in MCF-7 cell lines, PA treatment resulted in the dose-dependent (i) induction of $p21^{WAF1/Cip1}$ and p27Kip1, (ii) downregulation of Cyclin dependent kinase (CDK) 4 and (iii) decrease in cyclin D1. These findings suggest that PA may be an effective therapeutic agent against BC.

• International journal of advanced smart convergence
• /
• v.10 no.1
• /
• pp.12-23
• /
• 2021

This paper proposes a low power radio frequency receiver front-end where, in a single stage, single-balanced mixer and voltage-controlled oscillator are stacked on top of low noise amplifier and re-use the dc current to reduce the power consumption. In the proposed topology, the voltage-controlled oscillator itself plays the dual role of oscillator and mixer by exploiting a series inductor-capacitor network. Using a 65 nm complementary metal oxide semiconductor technology, the proposed radio frequency front-end is designed and simulated. Oscillating at around 2.4 GHz frequency band, the voltage-controlled oscillator of the proposed radio frequency front-end achieves the phase noise of -72 dBc/Hz, -93 dBc/Hz, and -113 dBc/Hz at 10KHz, 100KHz, and 1 MHz offset frequency, respectively. The simulated voltage conversion gain is about 25 dB. The double-side band noise figure is -14.2 dB, -8.8 dB, and -7.3 dB at 100 KHz, 1 MHz and 10 MHz offset. The radio frequency front-end consumes only 96 ㎼ dc power from a 1-V supply.