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NEW ANTIDEPRESSANTS IN CHILD AND ADOLESCENT PSYCHIATRY (소아청소년정신과영역의 새로운 항우울제)

  • Lee, Soo-Jung
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.14 no.1
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    • pp.12-25
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    • 2003
  • Objectives:As increasing number of new antidepressants have been being introduced in clinical practice, pharmacological understanding has been broadened. These changes mandate new information and theories to be incorporated into the treatment process of children with depressive disorders. In light of newly coming knowledge, this review intended to recapitulate the characteristics of new antidepressants and to consider the pivotal issues to develope guidelines for the treatment of depression in childhood and adolescence. Methods:Searching the Pub-Med online database for the articles with the key words of 'new', 'antidepressants' and 'children' ninety-seven headings of review articles were obtained. The author selected the articles of pertinent subjects in terms of either treatment guideline or psychopharmacology of new antidepressants. When required, articles about the clinical effectiveness of individual antidepressants were separatedly searched. In addition, the safety information of new antidepressants was acquired by browsing the official sites of the United States Food and Drugs Administration and Department of Health and Human Services. Results:1) For the clinical course, treatment phase, and treatment outcome, the reviews or treatment guidelines adopted the information from adult treatment guidelines. 2) Systematic and critical reviews unambiguously concluded that selective serotonin reuptake inhibitors(SSRIs) excelled tricyclic antidepressants( TCAs) for both efficacy and side effect profiles, and were recommend for the first-line choice for the treatment of children with depressive disorders. 3) New antidepressants generally lacked treatment experiences and randomized controlled clinical trials. 4) SSRIs and other new antidepressants, when used together, might result in pharmacokinetic and/or pharmacodynamic drug-to-drug interaction. 5) The difference of the clinical effectiveness of antidepressants between children and adults should be addressed from developmental aspects, which required further evidence. Conclusion:Treatment guidelines for the pharmacological treatment of childhood and adolescence depression could be constructed on the basis of clinical trial findings and practical experiences. Treatment guidelines are to best serve as the frame of reference for a clinician to make reasonable decisions for a particular therapeutic situation. In order to fulfill this role, guidelines should be updated as soon as new research data become available.

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Experiment of Flexural Behavior of Composite Beam with Steel Fiber Reinforced Ultra High Performance Concrete Deck and Inverted-T Steel Girder (강섬유로 보강된 초고성능 콘크리트 바닥판과 역T형 강거더 합성보의 휨거동 실험)

  • Yoo, Sung-Won;Ahn, Young-Sun;Cha, Yeong-Dal;Joh, Chang-Bin
    • Journal of the Korea Concrete Institute
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    • v.26 no.6
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    • pp.761-769
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    • 2014
  • Ultra high performance concrete (UHPC) has been developed to overcome the low strengths and brittleness of conventional concrete. Considering that UHPC, owing to its composition and the use of steel fibers, develops a compressive strength of 180 MPa as well as high stiffness, the top flange of the steel girder may be superfluous in the composite beam combining a slab made of UHPC and the steel girder. In such composite beam, the steel girder takes the form of an inverted-T shaped structure without top flange in which the studs needed for the composition of the steel girder with the UHPC slab are disposed in the web of the steel girder. This study investigates experimentally and analytically the flexural behavior of this new type of composite beam to propose details like stud spacing and slab thickness for further design recommendations. To that goal, eight composite beams with varying stud spacing and slab thickness were fabricated and tested. The test results indicated that stud spacing running from 100 mm to 2 to 3 times the slab thickness can be recommended. In view of the relative characteristic slip limit of Eurocode-4, the results showed that the composite beam developed ductile behavior. Moreover, except for the members with thin slab and large stud spacing, most of the specimens exhibited results different to those predicted by AASHTO LRFD and Eurocode-4 because of the high performance developed by UHPC.

A Study on the Teaching·Learning Management Status and Improvement Plan about 'Creative Engineering Design' Lesson of 'Technology·Home Economics Subject' for High School Teachers (고등학교 기술·가정 교과 '창의 공학 설계' 단원 수업에 대한 교수·학습 운영 실태 분석 및 개선 방안)

  • Kim, SeongIl;Lim, YunJin
    • 대한공업교육학회지
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    • v.41 no.1
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    • pp.128-146
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    • 2016
  • The purpose of this study was to provide a basic research data for increasing the quality of 'creative engineering design' lesson and the teaching learning capability of high school teachers by analyzing the teaching learning management status and improvement plan of 'technology home economics subject' lesson for high school teachers. In order to investigate the teaching learning management status, the survey questionnaires from 63 teachers were collected from high school teachers who teach technology home economics subject currently and analyzed by statistical program SPSS 20. The main results of this study were as follows: First, for the contents of 'creative engineering design' lesson, the highest mean of response was 'creative thinking method'(M=4.22). In the learning activities, the teachers perceived the importance of the 'idea concept' highly. Second, in the management of 'creative engineering design' lesson, the teachers perceived the importance of the secure of tool, material budget, and practice space for the lesson highly. In the teaching capabilities, the teacher perceived the importance of the preparing teaching learning strategy most($$M{\frac{._-}{.}}4.14$$). Third, the teachers preferred to product for making uncomfortable things better in life and the other production outside from the content of textbook. Fourth, in the ratio of practice:theory lesson, they perceived the ratio of 3:7(36.5%), 4:6(25.4%), and 2:8(23.8%) are appropriate. In the assessment, the combination of production, portfolio, and presentation was preferred most. Fifth, there were statistically significant difference in teachers' interest and satisfaction and contents about 'creative engineering design' lesson between groups divided by the existence of practice space, certification held(technology teacher, non technology teacher), etc. Therefore, in order to improve the interest and satisfaction about the 'creative engineering design' lesson, the secure of space for technology practice and material budget were required. In addition, training and seminars program for improving the teaching capability for 'creative engineering design' lesson were required.

The Use of Landscape Greenery Surrounding Commercial Buildings in Seoul (서울시 일부 상업용 건물 수목의 입지환경)

  • Lee, Eun-Heui;Jang, Ha-Kyung;Ahn, Geun-Young
    • Journal of the Korean Institute of Landscape Architecture
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    • v.36 no.5
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    • pp.73-81
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    • 2008
  • The purpose of this study is to create a database of the use of landscape greenery that surrounds commercial buildings in Seoul. The method of this study was: to review preceding studies and related laws, survey areas, measure trees, and analyze the results. The 20 representative sites were specifically investigated to measure the width, direction, and environment of planting conditions. To analyze the greens adjacent to the building, the greens were divided into three types: front greenery, side greenery, and rear greenery. The study surveyed the distance from trees to adjacent buildings, and their planting conditions. The results of this study are as follows. First, 45% of the front greenery and 30% of the rear greenery were not established, but 19 of the 20 side greens were. Second, 13 of the 44 green areas adjacent to commercial buildings were under 1m in width. Most side greenery was belt -shape and unrelated to the features of the site or building. Third, the average distance from trees to buildings was 0.76m, indicating that most trees were planted too close to the buildings. Fourth, of the 30 trees utilized, the species breakdown was: 8 evergreen trees, 15 deciduous trees, and 7 shrubs. For the most part, planting patterns were similar for all species. Fifth, most sites were ill-suited to tree growth, because crown shape, planting conditions, and light conditions, etc., had not been considered. Based on these results, it is suggested that more specific, subdivided standards for planting conditions should be established. For example, building plans should include a green area that is at least one meter in width. In addition, according to the location and type(closing/opening) of the greenery adjacent to the buildings, suitable management programs and supervision protocol should be adopted.

An Analysis of the Visual Characteristics and Preference Factors of Traditional Landscape of Rivers in Kangnam Region of China - With a Case of River in Zhouzhuang, Jiangsu Province of China - (중국 강남 전통 수향(水鄕) 하천 경관의 시각적 특성 및 선호요인 분석 - 중국 강수성 주장(周莊) 하천경관을 중심으로 -)

  • Kim, Dong-Chan;Song, Mei-Jie
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.28 no.3
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    • pp.122-130
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    • 2010
  • The Study takes the rivers in Zhouzhuang - traditional Chinese Kangnam watery landscape as the object. The purpose of this study is to grasp the relationships between visual characteristics and the preference. The following is the research process: Firstly, the theoretical study of Zhouzhuang, the traditional Kangnam region in China, is conducted, the watery landscape is taken pictures, and 22 photos are selected. Secondly, in order to grasp the visual preference and landscape characteristics of the watery landscape in Zhouzhuang, 22 pictures and 25 pairs of adjectives are adopted for the questionnaire survey. Thirdly, in order to have a better understanding on the physical properties and effects of physical quantity on the preference, the occupation ratios of buildings and sculptures, natural elements, footpaths, bank revetments and other landscape elements are calculated, and the mean analysis, dispersion analysis and regression analysis are conducted. In order to grasp the landscape characteristics and preference factors, 25 pairs of adjectives are used to conduct the factor analysis. In order to grasp the effects of characteristics of visual factors on the preference, the dispersion analysis and regression analysis are carried out. The results are as follows: From the results of the landscape preference analysis, in the No.22 photo with the top preference, 11 pairs of adjectives, namely, "harmonious-disharmonious", "beautiful-ugly", "rural-urban", "soft-rough", "stable-instable", "romantic-realistic", "cheerful-gloomy", "brilliant-simple", "natural-artificial", "familiar-strange", and "clean-dirty" have positive effects on watery landscape. It can be viewed as the relatively important factor in the visual preference. In terms of the results of visual physical quantity analysis of traditional Chinese Kangnam watery landscape, the landscape with high occupation ratio of buildings and sculptures has positive effects on visual preference. The results of analysis of visual physical quantity and preference show that the preference degree increases as the occupation ratio of footpath area increases. The analysis results of visual characteristics of traditional Chinese Kangnam watery landscape identify four factors, namely psychological factor, cultural factor, condition factor and physical factor. It can be concluded from the results of analysis of the relationships between visual preference and visual characteristics that the return coefficient B of the psychological factor is +0.936. It can significantly affect the watery landscape, so it can be identified as the most important factor among the visual preference factors of Chinese Kangnam watery landscape.

Measurement of the Quantity of Hydrogen Peroxide Produced in the Ultrasound-irradiated Aqueous Solution of Organic Compounds (초음파를 조사(照射)한 유기화합물 수용액 속에서의 과산화수소 생성량의 측정)

  • Mo, Se-Young;Chang, Hong-Ki;Lee, Kyung-Jae;Jang, Gun-Eik;Sohn, Jong-Ryeul
    • Journal of Korean Society of Environmental Engineers
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    • v.22 no.1
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    • pp.61-71
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    • 2000
  • When irradiate the power ultrasound into the aqueous solutions, water vapor is decomposed by the heat of very high temperature in the cavitation bubble to produce OH (hydroxyl radical) and H (hydrogen radical), and these radicals play a role in decomposing the substances in aqueous solution by oxidation and/or reduction, and in producing the hydrogen peroxide. Accordingly it is possible to predict that the quantity of hydrogen peroxide produced may correlate with the sonolysis mechanism of the substance in aqueous solution. Thus to confirm this prediction, the quantities of hydrogen peroxide produced from each of the air saturated distilled water and three aqueous solutions of TCE, benzene, and 2,4-DCP that are prepared by dissolving them into distilled water are measured. As a result, it showed that the quantity of hydrogen peroxide produced from the distilled water and three aqueous solutions are increased in order of distilled water>TCE solution>2,4-DCP solution>benzene solution, and decrease with decrease in concentration of organic substance, which coincide with the sonolysis mechanisms reported that TCE in aqueous solution is decomposed directly by the pyrolysis in and around the cavitation bubbles when its concentration is high and by the radical reaction when low, however, benzene and 2,4-DCP are decomposed not only by the pyrolysis but also by the radical reactions. Effects of such experimental parameters as the acoustic frequency and power and as the concentration showed that the higher the acoustic frequency and the lower the acoustic power, the less the quantity of hydrogen peroxide was produced. This result coincide with the theory of ultrasound for the relation between the cavitation that is the energy source of the power ultrasound in aqueous solution and these experimental parameters.

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A Fast Algorithm for Computing Multiplicative Inverses in GF(2$^{m}$) using Factorization Formula and Normal Basis (인수분해 공식과 정규기저를 이용한 GF(2$^{m}$ ) 상의 고속 곱셈 역원 연산 알고리즘)

  • 장용희;권용진
    • Journal of KIISE:Computer Systems and Theory
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    • v.30 no.5_6
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    • pp.324-329
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    • 2003
  • The public-key cryptosystems such as Diffie-Hellman Key Distribution and Elliptical Curve Cryptosystems are built on the basis of the operations defined in GF(2$^{m}$ ):addition, subtraction, multiplication and multiplicative inversion. It is important that these operations should be computed at high speed in order to implement these cryptosystems efficiently. Among those operations, as being the most time-consuming, multiplicative inversion has become the object of lots of investigation Formant's theorem says $\beta$$^{-1}$ =$\beta$$^{2}$sup m/-2/, where $\beta$$^{-1}$ is the multiplicative inverse of $\beta$$\in$GF(2$^{m}$ ). Therefore, to compute the multiplicative inverse of arbitrary elements of GF(2$^{m}$ ), it is most important to reduce the number of times of multiplication by decomposing 2$^{m}$ -2 efficiently. Among many algorithms relevant to the subject, the algorithm proposed by Itoh and Tsujii[2] has reduced the required number of times of multiplication to O(log m) by using normal basis. Furthermore, a few papers have presented algorithms improving the Itoh and Tsujii's. However they have some demerits such as complicated decomposition processes[3,5]. In this paper, in the case of 2$^{m}$ -2, which is mainly used in practical applications, an efficient algorithm is proposed for computing the multiplicative inverse at high speed by using both the factorization formula x$^3$-y$^3$=(x-y)(x$^2$+xy+y$^2$) and normal basis. The number of times of multiplication of the algorithm is smaller than that of the algorithm proposed by Itoh and Tsujii. Also the algorithm decomposes 2$^{m}$ -2 more simply than other proposed algorithms.

A Construction of TMO Object Group Model for Distributed Real-Time Services (분산 실시간 서비스를 위한 TMO 객체그룹 모델의 구축)

  • 신창선;김명희;주수종
    • Journal of KIISE:Computer Systems and Theory
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    • v.30 no.5_6
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    • pp.307-318
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    • 2003
  • In this paper, we design and construct a TMO object group that provides the guaranteed real-time services in the distributed object computing environments, and verify execution power of its model for the correct distributed real-time services. The TMO object group we suggested is based on TINA's object group concept. This model consists of TMO objects having real-time properties and some components that support the object management service and the real-time scheduling service in the TMO object group. Also TMO objects can be duplicated or non-duplicated on distributed systems. Our model can execute the guaranteed distributed real-time service on COTS middlewares without restricting the specially ORB or the of operating system. For achieving goals of our model. we defined the concepts of the TMO object and the structure of the TMO object group. Also we designed and implemented the functions and interactions of components in the object group. The TMO object group includes the Dynamic Binder object and the Scheduler object for supporting the object management service and the real-time scheduling service, respectively The Dynamic Binder object supports the dynamic binding service that selects the appropriate one out of the duplicated TMO objects for the clients'request. And the Scheduler object supports the real-time scheduling service that determines the priority of tasks executed by an arbitrary TMO object for the clients'service requests. And then, in order to verify the executions of our model, we implemented the Dynamic Binder object and the Scheduler object adopting the binding priority algorithm for the dynamic binding service and the EDF algorithm for the real-time scheduling service from extending the existing known algorithms. Finally, from the numerical analyzed results we are shown, we verified whether our TMO object group model could support dynamic binding service for duplicated or non-duplicated TMO objects, also real-time scheduling service for an arbitrary TMO object requested from clients.

Results of Extracardiac Pericardial-flap Lateral Tunnel Fontan Operation (자가심낭막절편을 이용한 심외외측통로 Fontan 수술의 결과)

  • Park Han-Ki;Youn Young-Nam;Yang Hong-Seok;Yoo Byoung-Won;Choi Jae-Young;Park Young-Hwan
    • Journal of Chest Surgery
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    • v.39 no.4 s.261
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    • pp.281-288
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    • 2006
  • Background: Extracardiac pericardial-flap lateral tunnel Fontan operation has theoretical advantage of growth potentiality of the extracardiac tunnels. The mid-term results of this technique and morphologic change of the lateral tunnel were studied. Material and Method: Clinical data was reviewed in 42 patients who underwent extracardiac pericardial-flap lateral tunnel Fontan operation between November 1993 and December 2004. The age was $2.8{\pm}1.5$ years and the body weight was $12.3{\pm}3.2$ kg. Extracardiac tunnel was constructed using the pedicled pericardium with the base undetached. By reviewing the follow-up cardiac angiograms, the diameter and the cross-sectional area of the lateral tunnel was compared to those of inferior vena cava. Result: There were four operative mortality cases (9.8%) and the causes of death were low cardiac output for all four cases. Postoperatively, five patients had prolonged pleural effusion longer than two weeks and one patient required a permanent pacemaker due to complete heart block. Follow-up was possible in 37 patients and the follow up duration was $3.8{\pm}2.2$ years. During that period, one patient died, of upper gastrointestional bleeding combined with heart failure and one patient died a sudden death of unknown cause. Two patients required reoperation due to subaortic stenosis and anastomosis site stenosis between inferior vena cava and lateral tunnel. In one patient, bradyarrhythmia was anew but there was no thromboembolic complication. The lateral tunnel showed growth in proportion to the size of the inferior vena cava. Conclusion: Extracardiac pericardial-flap lateral tunnel Fontan operation is relatively simple and safe. The mid-term result was favorable and the extracardiac tunnel showed potential for growth.

Understanding the Response Characteristics of X-ray Verification Film (X-선 Verification 필름의 반응 특성에 관한 연구)

  • Yeo Inhwan;Seong Jinsil;Chu Sung Sil;Kim Gwi Eon;Suh Chang Ok;Burch Sandra E.;Wang Chris K.
    • Radiation Oncology Journal
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    • v.16 no.4
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    • pp.505-515
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    • 1998
  • Purpose : This study is intended to understand the sensitometric characteristics and the emulsion properties of the commercially available CEA TVS film in comparison with the Kodak X-Omat V film. Materials and Methods : For this purpose, we have formulated an analytic expression of the characteristic curves for x-ray film exposed to mixed radiation of electrons, photons, and visible light. This mathematical expression was developed based on reaction-rate and target-hit theories. Unlike previous expressions. it relates optical density to emulsion properties such as grain size and silver bromide content We have also developed a quantity which characterizes the film response to visible light relative to that to photons and electrons. This quantity could be expressed as a function of grain area. Thus, we have developed mathematical expressions and quantities with which the emulsion properties of the films can be revealed based on the sensitometric characteristics. Demonstrating the use of this analytical study, we exposed CEA and Kodak verification films to the mixed radiation of electrons, photons, and visible light, and interpreted the experimental results accordingly. Results : We have demonstrated that: (1) the saturation density increases as the silver bromide content increases, (2) the time required to reach the threshold dose (to which the film begins to respond) when films are exposed to visible light decreases as the grain size increases, and (3) the CEA film contains more silver bromide. whereas the Kodak film contains larger grains. These findings were supported by the data provided by the manufacturers afterward. Conclusion : This study presented an analytical and experimental basis for understanding the response of X-ray film with respect to the emulsion properties.

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