• Title/Summary/Keyword: A${\beta}_{25-35}$

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Comparative Study on the Mixed Micellizations of Anionic Surfactant (DBS) with Nonionic Surfactnats (Brij 30 and Brij 35) (음이온성 계면활성제(DBS)와 비이온성 계면활성제(Brij 30과 Brij 35)와의 혼합미셀화에 대한 비교연구)

  • Park, In-Jung;Lee, Byung-Hwan
    • Journal of the Korean Chemical Society
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    • v.53 no.5
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    • pp.491-498
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    • 2009
  • The critical micelle concentration (CMC) and the counter ion binding constant (B) for the mixed micellizations of DBS (sodium dodecylbenzenesulfonate) with Brij 30 (polyoxyethylene(4) lauryl ether) and Brij 35 (polyoxyethylene (23) lauryl ehter) at 25 ${^{\circ}C}$ in pure water and in aqueous solutions of n-butanol were determined as a function of $\alpha$1 (the overall mole fraction of DBS) by the use of electric conductivity method. Various thermodynamic parameters (Xi, $\gamma$i, Ci, aiM, $\beta$, and ${\Delta}H_{mix}$) were calculated and compared for each mixed surfactant system by means of the equations derived from the nonideal mixed micellar model. There sults show that the molecules of DBS interact more strongly with Brij 35 than Brij 30 and that the DBS/Brij35 mixed system has greater negative deviation from the ideal mixed micellar model than the DBS/Brij 30mixed system.

Study on the Micellization of TTAB/Brij 35 Mixed Systems in Aqueous Solutions of n-Butanol (n-부탄올 수용액에서 TTAB/Brij 35 혼합계면활성제의 미셀화에 대한 연구)

  • Gil, Han-Nae;Lee, Byung-Hwan
    • Applied Chemistry for Engineering
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    • v.18 no.3
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    • pp.267-272
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    • 2007
  • The critical micelle concentration (CMC) and the counterion binding constant (B) in a mixed micellar state of the trimethyltetradecylammonium bromide (TTAB) with the polyoxyethylene (23) lauryl ether (Brij 35) at $25^{\circ}C$ in water and in aqueous solutions of n-butanol (0.1 M, 0.2 M, and 0.3 M) were determined as a function of ${\alpha}_1$ (the overall mole fraction of TTAB) by the use of electric conductivity method and surface tensiometer method. Various thermodynamic parameters ($X_i$, ${\gamma}_i$, $C_i$, ${a_i}^M$, ${\beta}$, and ${\Delta}H_{mix}$) were calculated by means of the equations derived from the nonideal mixed micellar model. The effects of n-butanol on the micellization of TTAB/Brij 35 mixtures have been also studied by analyzing the measured and calculated thermodynamic parameters.

Extraction of ${\beta}$-carotene from Ascidian Tunic [Halocynthia roretzi] using Supercritical Carbon Dioxide and Co-solvent (초임계 이산화탄소를 이용만 우렁쉥이 껍질로부터 ${\beta}$-carotene 추출)

  • Kang, In-Sook;Youn, Hyun-Seok;Park, Ji-Yeon;Chun, Byung-Soo
    • KSBB Journal
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    • v.21 no.3
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    • pp.194-198
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    • 2006
  • Dried raw Ascidians(Halocynthia roretzi) shells harvested from fish farms in southern coast area in Korea were used to extract ${\beta}$-carotene using supercritical carbon dioxide($SCO_2$) and with ethanol as a co-solvent at the range of temperatures and pressures, from 25 to $65^{\circ}C$ and 100 to 350 bar respectively. The size of the dried Ascidians shells was around $850{\mu}m$. The system used this study was a semi-batch flow type high pressure unit. The efficiency of ${\beta}$-carotene extraction using $SCO_2$ with and without co-solvent, ethanol, influenced to pressure and temperature changes. The highest solubility of ${\beta}$-carotene in $SCO_2$ was 1.35 mg/g for ${\beta}$-carotene at $35^{\circ}C$ and 350 bar. With addition of 2(v/v%) ethanol the recovery of ${\beta}$-carotene was 93%. As a result of using n-hexane and methanol for rinse, at $35^{\circ}C$ and 350 bar the amount of ${\beta}$-carotene by methanol rinse was 5 times higher than that of n-hexane rinse.

The Protective Effects of the Ethyl Acetate Fraction and Flavonoids from Taraxacum coreanum against Oxidative Stress in Neuronal Cells Induced by Hydrogen Peroxide and Amyloid Beta (흰민들레 Ethyl Acetate 분획물 및 Flavonoid 화합물의 Hydrogen Peroxide와 Amyloid Beta에 의한 신경세포의 산화적 스트레스 보호 효과)

  • Lee, Ah Young;Choi, Ji Myung;Lee, Sullim;Kim, Hyun Young;Lee, Sanghyun;Cho, Eun Ju
    • Korean Journal of Pharmacognosy
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    • v.44 no.3
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    • pp.263-268
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    • 2013
  • The protective role against oxidative stress under cellular system using C6 glioma cells was studied using the ethyl acetate (EtOAc) fraction, luteolin (1), and luteolin-7-glucoside (2) of Taraxacum coreanum. C6 glioma cells showed low cell viability and high generation of reactive oxygen species (ROS) by the treatment with generator of hydrogen peroxide ($H_2O_2$) and amyloid beta ($A{\beta}_{25-35}$). However, the treatment of the EtOAc fraction attenuated the cellular oxidative stress, resulting in significant elevation of cell viability. In addition, the production of ROS formation was also decreased by the treatment of the EtOAc fraction. Compounds 1 and 2 were isolated from the EtOAc fraction, and the protective effect was evaluated. Compounds 1 and 2 led to the increase of cell viability and decrease of production of ROS against oxidative stress by $H_2O_2$ and $A{\beta}_{25-35}$. The present study indicated that the EtOAc fraction, compounds 1 and 2 from T. coreanum demonstrated protective effects against oxidative stress, suggesting the preventive role against neurodegenerative diseases.

Emission Properties of Volatile Compounds from Medicine Herb Residues Board (한약재 찌꺼기로 제조한 한방보드의 휘발성 성분의 방출 특성)

  • Roh, JeongKwan
    • Journal of the Korean Wood Science and Technology
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    • v.44 no.3
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    • pp.430-439
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    • 2016
  • Medicine herb residues boards were manufactured by using medicine herb residues, and emission properties of volatile compounds from boards were examined under various temperature conditions. The volatile compounds were identified with analysis of TD GC/MS by absorbing their flavor components in Tenax tubes. Total 88 volatile compounds were identified from the board. The number of identified compounds at temperature conditions of $25^{\circ}C$, $35^{\circ}C$, and $45^{\circ}C$ were 44, 55, and 65 kinds, respectively. The number of volatile compounds and the total peak area tended to increase with an increase in the temperature. The number of the flavor components detected in all temperature conditions were 34 kinds. Hydrocarbon compounds showed 93% of the detected flavor compounds at $25^{\circ}C$, 92% at $35^{\circ}C$, and 90% at $45^{\circ}C$. Ether compounds accounted for 4% and ketone, aldehyde, and acid-type compounds were detected in a small quantity. The hydrocarbons were composed of 17 kinds of monoterpenes and 39 kinds of sesquiterpenes, which accounted for 11% and 80%, respectively. The most detected compound of monoterpene was limonene, and the major flavor components of sesquiterpenes were ${\alpha}-curcumene$, zingiberene, ${\beta}-elemene$, ${\beta}-selinene$, ${\alpha}-amorphene$, and ${\alpha}-copaene$. Anethole (3.26%) known for ether compounds was detected considerably in all temperature conditions. The results suggest that the manufactured medicine herb residues board include various types of flavor compounds and the flavor compounds might be useful for the manufacture of various products.

Effects of Cordyceps ophioglossoides extracts on the neuronal death and memory dificits

  • Park, Byung-Chul;Jin, Da-Qing;Beak, Sung-Mok;Lee, Jae-Sung;Choi, Hee-Don;Kim, Jung-Ae
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.124.1-124.1
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    • 2003
  • We investigated whether the mushroom extracts can protect neuronal death and ameliorate memory deficits in Alzheimer"s disease induced by $\beta$-amyloid peptide[A$\beta$(25-35)]. Cellular model of Alzheimer"s disease was produced by using SK-N-SH human neuronal cells treated with $A\beta$. Treatment with 40uM $A\beta$ for 48hours caused a 46% loss of cell viability. First, we examined the effects of 22 mushroom extracts on neuronal death using MTT assay. We found that 3 mushroom extracts increased viability of the cells from 46% to 87%. (omitted)

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Isolation of Biopolymer-producing Bacterium and Its Growth Pattern (Biopolymer 생산세균의 분리 및 증식패턴)

  • Yoo, Jin-Young;Chung, Dong-Hyo
    • Microbiology and Biotechnology Letters
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    • v.17 no.5
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    • pp.421-428
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    • 1989
  • A soil bacterium synthesizing an extremely viscous biopolymer was isolated and identified as Pseudomonas delafieldii. The optimal pH and temperature for the growth were 6.5 and 3$0^{\circ}C$, respectively. Maximum specific growth rate was 0.24 h$^{-1}$. The specific polysaccharide productivity, growth yield and product yield were 6.25 mg/g-cell/h, 54.5% and 38.39%, respectively. The polysaccharide was presumed to be $\beta$-glucan containing glucose and gluconolactone (1.9:1.0 in molar ratio) and 1.35 % acetyl group, Element analysis showed that it contained carbon (31.85%) and hydrogen (5.15%). The weight average molecular weight by GPC was 5.64$\times$10$^7$. The intrinsic viscosity was 42.84 dl/g.

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Comparative Studies on Protein Composition of Whey from Raw and Pasteurized Milk by Polyacrylamide Gel Electrophoresis (Polyacrylamide Gel 전기영동법에 의한 생유 및 살균처리유의 Whey 단백질 조성에 관한 비교 연구)

  • 남궁석;우세홍;조종후
    • Journal of Food Hygiene and Safety
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    • v.5 no.4
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    • pp.219-228
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    • 1990
  • Whey proteins in milk were analyzed by polyacrylamide gel electrophoresis and compared with respect to electrophoregrams, densitograms and concentrations of whey proteins in raw and market milk classified according to 3 kinds of pasteurization by low temperature long time. high temperature short time and ultra-high temperature short time. Relative composition of major whey protein constituents such as bovine serum albumin, ${\alpha}\;-\;lactalbumin\;and\;{\beta}-lactoglobulin$ in raw milk were 3.71:11.44:84.85 and not affected by low temperature long time and high temperature short time pasteurization, even though there were the tendencies of some declining in the actual concentrations. But by ultra-high temperature short time pasteurization compositions of whey protein were changed to 0: 64.75: 35 in which reflected the disapprearance of bovine serum albumin and the extensive decrease of ${\beta}-lactoglobulin$. Storage of low temperature pasteurized milk at $5^{\circ}C$ resulted in a slight decrease of ${\alpha}\;-\;lactalbumin\;a\;{\beta}-lactoglobulin$, but storage at $25^{\circ}C$ did not make any changes until3rd days of storage. Most of whey proteins in high temperature short time pasteurized milk were not affected during storage at $5^{\circ}C\;and\;25^{\circ}C$, but bovine serum albumin and ${\alpha}\;-lactalbumin$ diminished in 2-3 days of storage. Whey proteins of milk treated with ultra-high temeperature were not affected during storage at $5^{\circ}C\;and\;25^{\circ}C$ except a slight decrease of ${\alpha}\;-lactalbumin$ in 2nd day of storage at $5^{\circ}C$.

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The Influence of Job Satisfaction and Perfectionism on Burnout in Clinical Nurses (임상 간호사의 직무만족과 완벽주의 성향이 소진에 미치는 영향)

  • Lee, In Sook;Kim, Kyoung Ja;Choi, Yoon Jong
    • Journal of Home Health Care Nursing
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    • v.25 no.1
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    • pp.37-46
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    • 2018
  • Purpose: This descriptive study was conducted to identify burnout and factors influencing burnout in clinical nurses. Methods: A cross-sectional survey design was conducted by administering a structured questionnaire to 195 nurses working at hospitals, from August to September 2017. This study used scales to measure burnout (20 items), job satisfaction (16 items), and perfectionism (40 items). Data were analyzed using SPSS 22.0, descriptive statistics, t-test, ANOVA, Pearson's correlation coefficients, and multiple regression analysis. Results: Burnout of participants was correlated with job satisfaction and perfectionism. Factors identified to have influence on burnout were job satisfaction (${\beta}=-.35$, p<.001), perfectionism-fail avoidance (${\beta}=.26$, p=.001), perceived health status (${\beta}=-.26$, p<.001), and intention of department relocation (${\beta}=-.23$, p<.001). The regression model explained approximately 48% of nurses' burnout. Conclusion: Based on the results of this study, it is necessary to improve job satisfaction and organizational support to decrease dysfunctional perfectionism that could cause burnout in nurses. It is also necessary to establish a psychological support program in hospitals.

Synthesis of $\beta$-Sitosterol Esters with Conjugated Linoleic Acid and Medium Chain Fatty Acids by Using Lipase as Catalyst

  • Vu, Phuong-Lan;Lee, Ki-Teak
    • Proceedings of the Korean Society of Postharvest Science and Technology of Agricultural Products Conference
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    • 2003.04a
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    • pp.104.2-105
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    • 2003
  • Plant steryl esters have good effects on plasma cholesterol level and are used as functional food ingredient. Conjugated linoleic acid (CLA) presents mainly in animal foods and has a good benefit and medium chain fatty acids (MCFAs) are a rapid energy source for human. In this study, we produced the ${\beta}$-sitosterol esters from CLA and MCFAs using various lipases as catalysts. Among lipases, AYS (from Candida rugosa) was the most effective for synthesis of ${\beta}$-sitosterol esters in the presence of water (24.35% conversion) or hexane (25.33% conversion). The second esterification extent was obtained by lipase AK (from Pseudomonas sp), showing 10.26% conversion in water and 15.94% conversion in hexane, respectively. The reaction condition was 1:3 molar ratio (${\beta}$-sitosterol:fatty acid, 1:3) and stirred (175 rpm) at 55$^{\circ}C$ in water bath shaker for 48h.

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