• 한국결정성장학회지
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• 제13권4호
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• pp.199-204
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• 2003

전기로 더스트, 석탄회, 석분 등 폐기물을 재활용한 소성벽돌의 미세구조 및 조성분포를 SEM과 EBS로 분석하였다. 소성벽돌 시편 중 일부에서 갈색 매트릭스 위에 노란색 영역이 발견되었고 내부에는 갈색 영역 외에 흑색 black-core 영역이 존재하였다. 표면의 노란색 영역은 Zn이 주성분이었으며 흑색 black-core 영역은 매트릭스와 조성차이는 보이지 않았다. 소성벽돌 시편의 전 부분에 걸쳐 1$\mu\textrm{m}$ 크기의 mullite 결정상이 분포하고 있었으며 유리질에 의해 둘러싸여져 있었다. 이는 고령토와 석탄회 내의 alumino-silicate 화합물이 소성과정에서 meta-kaolinite를 거쳐 mullite로 전이된 것으로 사료된다. 시편 외부는 산화분위기가 조성되나 내부는 석탄회 및 더스트에 함유되어 있는 미연탄소분에 의해 환원분위기가 조성 되면서 발생한 가스에 의해 발포되어 흑색 black-core 영역에서는 수십 fm 크기의 구형 기공이 발견되었다. 벽돌 내부는 Al과 Si가 주성분이었고 소량의 Fe, K, Ca, Na를 포함하고 있었다 특히 Fe는 비정질상 표면에 원판형 Fe-rich 결정상으로 석출되어 존재하고 있었다. 시편 내부에서는 상대적으로 적은 양의 Zn이 발견되었고 외부에서는 내부에 있던 Zn이 환원되면서 표면으로 확산되어 Zn-rich 결정상을 표면에 형성하여 노란색 표피층을 형성하였다.

• 대한화학회지
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• 제64권5호
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• pp.277-290
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• 2020

이 연구에서는 전라남도 소재의 국립대학교 과학영재교육원 소속 중학교 2학년 4명의 영재 학생을 대상으로 탐구적 과학 글쓰기 수업을 적용한 과학 수업의 효과에 대한 학생들의 인식을 메타인지와 2015개정 과학과 교육과정의 목표의 관점에서 조사하였다. 과학 영재 학생들 대상의 설문과 면담을 통해, 과학 영재 학생들은 탐구적 과학 글쓰기를 적용한 과학 수업을 통해 메타인지의 계획, 모니터, 조절, 평가 네 가지 하위 영역에서 긍정적인 영향을 주었다고 인식하고 있었다. 그 이유로 과학 영재학생들은 자기주도적으로 실험을 설계하는 경험, 수집한 실험 자료를 지속적으로 점검하는 활동, 피드백 과정, 결론을 작성하는 과정에서 반성 경험 등을 제시하였다. 과학 영재 학생들은 탐구적 과학 글쓰기를 적용한 과학 수업을 통해 2015 개정 과학과 교육과정의 목표에 해당하는 태도, 탐구, 지식, 과학·기술·사회(STS), 과학학습의 즐거움과 유용성 영역에서 긍정적 인식을 가지고 있었다. 그 이유로 과학 영재 학생들은 자기주도적으로 탐구를 진행하는 경험, 동일한 주제의 연속적 실험 경험, 각 탐구의 단계에서 사고하는 과정, 탐구과정에서 학습하는 경험, 탐구의 전 과정 경험, 실생활과 밀접한 현상에 대한 탐구 등을 제시하였다. 따라서 효과적인 과학 수업을 위하여 과학 영재 학생들이 응답한 탐구적 과학 글쓰기를 적용한 과학 수업의 특징을 추후 과학 영재 수업뿐만 아니라 일반 학교 과학 수업에도 적용할 필요가 있다.

• Journal of Periodontal and Implant Science
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• 제37권4호
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• pp.719-732
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• 2007

Purpose: Various bone graft materials are being used for periodontal tissue regeneration. Th materials are being developed continuously for ideal clinical effects. Therefore, it is necessary to identify the clinical characteristics of each bone graft material through comparing the various bone graft materials statistically and in doing so, proposing a more efficient bone graft material. In this study, the following results were attained through comparing the clinical effects among the bone graft materials, using the statistical method based on the clinical studies published at the department of periodontology of Yonsei hospital. Materials and Method: 6 selected studies of department of Periodontology at Yonsei University Hospital were based on clinical study of bone grafting in intrabony defects. It was compared the clinical parameters among the 6 clinical studies, using the statistical META analysis. Result: When comparing the probing depth reduction, there was a relatively great amount of decease when using the xenograft, Anorganic Bovine Derived Hydroxapatite Bone Matrix/Cell Binding Peptide(ABM/P-15: PepGen $P-15^{(R)}$) and the autogenous bone and absorbable membrane, d, 1-alctide/glycolide copolymer(GC: $Biomesh^{(R)}$). The allogfrafts showed a relatively low decrease in the probing depth and clinical attachment change. It also showed a slight decrease in the bone probing depth. The allografts showed various results according to different bone graft materials. When comparing the ABM/P-15 and bovine bone $powder(BBP^{(R)})$, ABM/P-15 showed a relatively high clinical attachment level and the bovine bone powder showed a relatively high clinical attachment level. The probing depth change and gingival recession change showed a lower value than the mean value between the two bone graft materials. The synthetic bone showed a relatively high decrease in clinical attachment level and periodontal probing depth change. There was a relatively larger amount of gingival recession when using Bioactive Glass(BG) but a relatively low bone regeneration effect was seen. Conclusion: Good restorative results of the periodontal tissue can be attained by applying the various bone graft materials being used today after identifying the accurate clinical effects.

• 물과 미래
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• 제14권4호
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• pp.73-81
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• 1981

암반 지하수의 개발이 현재 국내에서 활발히 진행되고 있으나, 이들 심부 지하수를 배태하고 있는 각종 암류에 대한 그 수리 지질학적인 산출상태를 규명키 위한 연구가 전무한 상태였다. 대체적으로 심부 지하수는 지하 심부에서 발원 형성된 지질학적인 일 및 이차 공극내에 저유된 것으로 그 산출상태가 가장 양호한 암류는 화산암류, 퇴적암류, 변성퇴적암 및 편암, 안산암류, 편마암류 및 화강암의 순이다. 특히 규모가 큰 단층, 파쇄대와 같은 이차 공극이 잘 발달되어 있는 저지대에서의 암반, 지하수의 산출상태는 규모가 적은 절리, 층리와 같은 일 및 이차 공극이 발달된 고지대보다 그 산출상태가 각 암류별로 310% 이상 높다. 특히 결정질암에 대한 적정정호 심도를 구해 본 결과 그 심도는 80m이였다.

• Journal of Genetic Medicine
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• 제14권1호
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• pp.8-17
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• 2017

Purpose: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and is considered a marker of vascular damage. However, a genome-wide association study analyzing single nucleotide polymorphisms (SNPs) associated with brachial-ankle PWV (baPWV) has not been conducted in healthy populations. We performed this study to identify SNPs associated with baPWV in healthy populations in Korea. Materials and Methods: Genomic SNPs data for 2,407 individuals from three sites were analyzed as part of the Korean Genomic Epidemiologic Study. Without replication samples, we performed multivariable analysis as a post hoc analysis to verify the findings in site adjusted analysis. Healthy subjects aged between 40 and 70 years without self-reported history or diagnosis of hypertension, diabetes, hyperlipidemia, heart disease, cerebrovascular disease and cancer were included. We excluded subjects with a creatinine level >1.4 mg/dL (men) and 1.2 mg/dL (women). Results: In the site-adjusted association analysis, significant associations (P<$5{\times}10^{-8}$) with baPWV were detected for only 5 SNPs with low minor allele frequency. In multivariable analysis adjusted by age, sex, height, body mass index, mean arterial pressure, site, smoking, alcohol, and exercise, 11 SNPs were found to be associated (P<$5{\times}10^{-8}$) with baPWV. The 5 SNPs (P<$5{\times}10^{-8}$) linked to three genes (OPCML, PRR35 and RAB40C) were common between site-adjusted analysis and multivariable analysis. However, meta-analysis of the result from three sites for the 11 SNPs showed no significant associations. Conclusion: Using the recent standard for genome-wide association study, we did not find any evidence of significant association signals with baPWV.

• 비교교육연구
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• 제18권4호
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• pp.141-162
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• 2008

우리 주변에서 접할 수 있는 대부분의 이러닝 프로그램들은 강의법을 주된 교수방법으로 활용하고 있다. 이러닝 환경에서 강의법은 가장 효과적이지 못한 교수방법이라는 메타분석 연구결과 및 학습자의 능동적 참여만이 이러닝 프로그램의 성공을 보장할 수 있다는 학자들의 주장은 강의법 위주의 이러닝 프로그램의 학습효과에 의문을 제기하게 한다. 결국, 이러닝 프로그램의 질적 수준과 그 효과는 어떠한 페다고지를 적용하느냐에 따라 결정된다고 할 수 있다. 이 연구는 설계 연구(design research)를 통해 질적 개선을 추구하고 있는 미국의 이러닝 프로그램들이 어떠한 심리적 특성들을 공통적으로 반영하고 있는 지에 대한 분석을 통해 국내 이러닝 프로그램들의 개선을 위한 시사점을 제시하고자 하였다. 분석된 미국의 이러닝 프로그램들은 공통적으로 구성주의 교육철학의 배경을 가지고 반성적 사고, 협력적 상호작용 공간, 지식 구성, 맥락적 행위, 외적 표상의 활용 등의 심리적 특성들을 강조하고 있었다. 즉, 경험주의 학습, 상황학습, 협력학습, 복합표상 학습 등은 국내 이러닝 프로그램의 개선을 위해서 고려해야 할 학습원칙들일 것이다.

• 한방재활의학과학회지
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• 제32권3호
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• pp.13-27
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• 2022

Objectives This study investigated the trends in domestic and international clinical research in craniosacral therapy, classified as a type of Chuna manual therapy, and suggested further directions in Korean medicine. Methods This scoping review was performed using the Arksey and O'Malley methodological framework and preferred reporting items as per the preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews checklist. Eight electronic databases (PubMed, EMBASE, Cochrane Library, Koreanstudies Information Service System [KISS], KMBASE, Oriental Medicine Advanced Searching Integrated System [OASIS], Research Information Sharing Service [RISS], ScienceON) were searched to identify articles with the search terms "craniosacral therapy" and "cranial osteopathy" until December 2021. Results Forty-five studies were eligible as per our inclusion criteria. Most research studies (n=44) were conducted in the field of medicine and pharmacy, especially in rehabilitation medicine (n=16). As a result of the study design, randomized controlled trials (n=20) were the most common, and chronic pain (n=9) was the most frequently targeted disease, followed by headache (n=7). Thirty-two studies suggested interventions and 20 studies used Upledger's 10-step protocol. The average duration of craniosacral therapy was 41 min per session, administered 1.4 times per week. Outcome measurements were analyzed and categorized with the examination procedure for the patient. Conclusions This is the first scoping review of craniosacral therapy in Korea, and we believe that our findings could support its utility as Chuna. In the future, more studies should be conducted to establish the evidence of clinical efficacy of craniosacral therapy and develop standard techniques in Korean medicine.

• Journal of Korean Neurosurgical Society
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• 제65권4호
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• pp.539-548
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• 2022

Objective : Although full-endoscopic lumbar interbody fusion (Endo-LIF) has been tried as the latest alternative technique to minimally invasive transforaminal lumbar interobody fusion (MIS-TLIF) since mid-2010, the evidence is still lacking. We compared the clinical outcome and safety of Endo-LIF to MIS-TLIF for lumbar degenerative disease. Methods : We systematically searched electronic databases, including PubMed, EMBASE, and Cochrane Library to find literature comparing Endo-LIF to MIS-TLIF. The results retrieved were last updated on December 11, 2020. The perioperative outcome included the operation time, blood loss, complication, and hospital stay. The clinical outcomes included Visual analog scale (VAS) of low back pain and leg pain and Oswestry disability index (ODI), and the radiological outcome included pseudoarthosis rate with 12-month minimum follow-up. Results : Four retrospective observational studies and one prospective observational study comprising 423 patients (183 Endo-LIF and 241 MIS-TLIF) were included, and the pooled data analysis revealed low heterogeneity between studies in our review. Baseline characteristics including age and sex were not different between the two groups. Operation time was significantly longer in Endo-LIF (mean difference [MD], 23.220 minutes; 95% confidence interval [CI], 10.669-35.771; p=0.001). However, Endo-LIF resulted in less perioperative blood loss (MD, -144.710 mL; 95% CI, 247.941-41.478; p=0.023). Although VAS back pain at final (MD, -0.120; p=0.586), leg pain within 2 weeks (MD, 0.005; p=0.293), VAS leg pain at final (MD, 0.099; p=0.099), ODI at final (MD, 0.141; p=0.093) were not different, VAS back pain within 2 weeks was more favorable in the Endo-LIF (MD, -1.538; 95% CI, -2.044 to -1.032; p<0.001). On the other hand, no statistically significant group difference in complication rate (relative risk [RR], 0.709; p=0.774), hospital stay (MD, -2.399; p=0.151), and pseudoarthrosis rate (RR, 1.284; p=0.736) were found. Conclusion : Relative to MIS-TLIF, immediate outcomes were favorable in Endo-LIF in terms of blood loss and immediate VAS back pain, although complication rate, mid-term clinical outcomes, and fusion rate were not different. However, the challenges for Endo-LIF include longer operation time which means a difficult learning curve and limited surgical indication which means patient selection bias. Larger-scale, well-designed study with long-term follow-up and randomized controlled trials are needed to confirm and update the results of this systematic review.

• Animal Bioscience
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• 제35권11호
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• pp.1808-1816
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• 2022

Objective: The study of Hanwoo (Korean native cattle) has mainly been focused on meat quality and productivity. Recently the field of microbiome research has increased dramatically. However, the information on the microbiome in Hanwoo is still insufficient, especially relationship between vagina and feces. Therefore, the purpose of this study is to examine the microbial community characteristics by analyzing the 16S rRNA sequencing data of Hanwoo vagina and feces, as well as to confirm the difference and correlation between vaginal and fecal microorganisms. As a result, the goal is to investigate if fecal microbiome can be used to predict vaginal microbiome. Methods: A total of 31 clinically healthy Hanwoo that delivered healthy calves more than once in Cheongju, South Korea were enrolled in this study. During the breeding season, we collected vaginal and fecal samples and sequenced the microbial 16S rRNA genes V3-V4 hypervariable regions from microbial DNA of samples. Results: The results revealed that the phylum-level microorganisms with the largest relative distribution were Firmicutes, Actinobacteria, Bacteroidetes, and Proteobacteria in the vagina, and Firmicutes, Bacteroidetes, and Spirochaetes in the feces, respectively. In the analysis of alpha, beta diversity, and effect size measurements (LefSe), the results showed significant differences between the vaginal and fecal samples. We also identified the function of these differentially abundant microorganisms by functional annotation analyses. But there is no significant correlation between vaginal and fecal microbiome. Conclusion: There is a significant difference between vaginal and fecal microbiome, but no significant correlation. Therefore, it is difficult to interrelate vaginal microbiome as fecal microbiome in Hanwoo. In a further study, it will be necessary to identify the genetic relationship of the entire microorganism between vagina and feces through the whole metagenome sequencing analysis and meta-transcriptome analysis to figure out their relationship.

• 한방재활의학과학회지
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• 제32권1호
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• pp.89-106
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• 2022

Objectives In this study, a scoping review was conducted to inform decision-making related to traditional Korean medicine for people with disabilities in the future. Methods Seven databases were searched to find previous studies on traditional Korean medicine for people with disabilities. Studies published until August 2021 were considered. Using the methodology of scoping review, research on traditional Korean medicine for people with disabilities was reviewed with the following steps: 1) drawing research questions, 2) searching for related studies, 3) selecting studies, 4) extracting data, and 5) analyzing and reporting results. Results Out of 2,072 studies, 7 research papers and 10 reports were finally selected. The research papers included 5 cases studies, 1 survey study, and 1 chart review. Most studies used herbal medicine and acupuncture treatment, but the reports on the interventions were not detailed. The reports included policy studies, project performance guidelines, and project results reports, and most of the evaluation indicators tended to be standardized. Conclusions This study reviewed the literature on traditional Korean medicine for people with disabilities. It presents future directions for clinical research on traditional Korean medicine for people with disabilities and can be used to inform healthcare policies and clinical practice. In the future, quantitative research such as clinical trials, meta-analysis, and health insurance big data analysis is needed to understand the current status and effects of traditional Korean medicine for people with disabilities. In addition, qualitative research is necessary to identify unmet demands of traditional Korean medicine for people with disabilities.