• Title/Summary/Keyword: 3b

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Structure studies of Pulmonary Surfactant Protein B(SP-B(3,4)) by NMR Spectroscopy and Molecular Modeling

  • Kim, Yangmee;Dongha Baek;Kang, Joo-Hyun;Shin, Song-Yub;Hahm, Kyung-Soo
    • 한국자기공명학회논문지
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    • 제5권1호
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    • pp.37-45
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    • 2001
  • Synthetic pulmonary surfactants consisting of a mixture of phospholipids with synthetic peptides based on human surfactant-associated protein SP-B were prepared. These surfactants were analyzed f3r their secondary structures by circular dichroism (CD) spectroscopy and NMR spectroscopy. Two synthetic peptides (SP-B(3), SP-B(4)) combined with the phospholipid mixture displayed significant surfactant properties. The CD spectra showed that the u-helical propensities of the peptides in DPC micelles. In the NMR spectroscopy, the tertiary structures of SP-B(3) show that it has $\alpha$-helical structure from Gln5 to Arg13 in DPC micelle and SP-B(4) show that they have $\alpha$-helical structure from Gln5 to Leu12 in DPC micelle. Based on these structures, truncated peptides originated from SP-B protein, can be designed as effective synthetic surfactants for clinical use.

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광대역전력분배기의 설계 및 제작 (Design and Implementation of a Broadband Power Divider)

  • 강상기
    • 한국통신학회논문지
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    • 제39A권9호
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    • pp.560-562
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    • 2014
  • 국내 이동통신 주파수를 모두 수용할 수 있는 광대역분배기를 설계 및 제작하였다. 제작한 20W급 광대역분배기는 810 ~ 2620MHz의 동작주파수에서 삽입손실은 최대 3.49dB, -18.48dB 이하의 입력반사계수, -20.2dB 이하의 출력반사계수, 24.7dB 이상의 격리도 그리고 3차 PIMD(Passive Intermodulation Distortion)는 -141.2dBc의 성능을 갖는다.

Disruption of ATP binding destabilizes NPM/B23 and inhibits anti-apoptotic function

  • Choi, Joung-Woo;Lee, Sang-Bae;Ahn, Jee-Yin;Lee, Kyung-Hoon
    • BMB Reports
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    • 제41권12호
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    • pp.840-845
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    • 2008
  • Nucleophosmin/B23, a major nucleolar phosphoprotein, is overexpressed in actively proliferating cells. In this study, we demonstrate that B23 exclusively localizes in the nucleolus, whereas ATP depletion results in the redistribution of B23 throughout the whole nucleus and destabilizes B23 via caspase-3 mediated cleavage. Interestingly, ATP binding precedes PI(3,4,5)P3 binding at lysine 263 and ATP binding mutants fail to restore the anti-apoptotic functions of B23 in PC12 cells. Thus, the ATP-B23 interaction is required for the stability of the B23 protein and regulates cell survival, confining B23 within the nucleolus in PC12 cells.

Bifidobacterium을 이용한 인삼 요구르트의 개발 (Development of Ginseng yogurt fermented by Bifidobacterium spp)

  • 김나영;한명주
    • 한국식품조리과학회지
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    • 제21권5호
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    • pp.575-584
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    • 2005
  • The objective of this study was to develop bioactive ginseng yogurt, fermented by B. minimum KK-1 and B. cholerium KK-2, which showed transforming activity of ginseng extract to compound K. Among older people, 3% ginseng yogurt fermented by B. minimum KK-1 and mixed with Bifidobacterium KK-1, KK-2 showed the highest overall acceptability(6.80, 6.80) among 1%(3.87, 3.67), 2%(4.40, 4.53) and 3% ginseng yogurt. The pH of ginseng yogurt was lower than that of plain yogurt. During 9 days of storage, the pH of each yogurt slightly decreased and then increased until 15 days of storage. The 3 8.25 log CFU/g and B. cholerium KK-2; 7.78 log CFU/g). Therefore, ginseng might be used as a growth factor during the fermentation of yogurt. The L value of ginseng yogurt decreased, and the a and b values increased, with increasing ginseng concentration.

토양으로부터 항균물질 생성균 및 감수성 균주의 분리 및 동정 (Isolation and Identification of Antimicrobial Agent Producing Microorganisms and Sensitive Strain from Soil)

  • 장해춘;김수인;김인철
    • 한국식품영양과학회지
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    • 제28권3호
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    • pp.526-533
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    • 1999
  • Two species of antimicrobial agent producing bacteria and one sensitive strain were isolated from soil. Those were identified as B. subtilis, B. licheniformis, and Curtobacterium sp. by morphological, biochemical, physiological and chemotaxonomic characteristics. These were designated as B. subtilis cx1, B. licheniformis cy2 and Curtobacterium sp. cf3, respectively. Antimicrobial agent produced by B. subtilis cx1 showed high antibacterial activity against gram positive bacteria including of B. subtilis, Curtobacterium sp., L. mesenteroids, Staphy. aureus, S. faecalis and even gram negative bacteria, P. aeruginosa. Antimicrobial agent from B. licheniformis cy2 showed slightly lower antimi crobial activity than that from B. subtilis cx1. These two strains showed maximum production of antimicrobial agents at 30oC for 9~21hr cultivation. Curtobacterium sp. cf3 showed more sensitive activity than a sensitive strain of B. subtilis ATCC 6633 which was same genus or species with the B. subtilis cx1 and B. subtilis cy2, when the antimicrobial agent producing strains, B. subtilis cx1 and B. subtilis cy2, were directly applied onto these sensitive lawns.

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Single-Balanced Low IF Resistive FET Mixer for the DBF Receiver

  • Ko Jee-Won;Min Kyeong-Sik
    • Journal of electromagnetic engineering and science
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    • 제4권4호
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    • pp.143-149
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    • 2004
  • This paper describes characteristics of the single-balanced low IF resistive FET mixer for the digital beam forming(DBF) receiver. This DBF receiver based on the direct conversion method is designed with Low IF I and Q channel. A radio frequency(RF), a local oscillator(LO) and an intermediate frequency(IF) considered in this research are 1950 MHz, 1940 MHz and 10 MHz, respectively. Super low noise HJ FET of NE3210S01 is considered in design. The measured results of the proposed mixer are observed IF output power of -22.8 dBm without spurious signal at 10 MHz, conversion loss of -12.8 dB, isolation characteristics of -20 dB below, 1 dB gain compression point(PldB) of -3.9 dBm, input third order intercept point(IIP3) of 20 dBm, output third order intercept point(OIP3) of 4 dBm and dynamic range of 30 dBm. The proposed mixer has 1.0 dB higher IIP3 than previously published single-balanced resistive and GaAs FET mixers, and has 3.0 dB higher IIP3 and 4.3 dB higher PldB than CMOS mixers. This mixer was fabricated on 0.7874 mm thick microstrip $substrate(\varepsilon_r=2.5)$ and the total size is $123.1\;mm\times107.6\;mm$.

페이딩 채널에서의 3/4 TC 16QAM의 성능 분석 (Performance Analysis of 3/4 TC 16Qam in Rading Channel)

  • 정구영;문재경;김창주;김영수
    • 한국전자파학회지:전자파기술
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    • 제6권2호
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    • pp.45-53
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    • 1995
  • 이동통신에서 QAM변조방식은 레일리 페이딩채널의 특성으로 인해 채널의 추정 및 보상의 방법을 사용하여 페이딩에 대한 왜곡을 보정하더라도 페이덩이 심하게 타는 부분에 대해서는 연집에러가 생기게 되어 그 성능은 열악하다. 본 논문에서는 이 연집에리를 bit reversal 블럭 인터리버플 이용하여 분산시키고 컴퓨터 탐색의 방법으로 찾아낸 레일리 채널에 적합한 TCM을 이용하여 레일리 페이딩 채널에서의 3/4 16QAM TCM의 성능 을 분석하였다. 분석결과 인터리버의 효과는 $10^{-3}$의 오율에서 약 2dB, 변형된 비터비 복호기의 사용으로는 2 5 5dB 그리고 다이버시티의 사용으로는 약9dB의 이득이 있음을 얄 수 있었다. 이는 16QAM TCM이 디지틀 이 동통신에서 사용될 수 있음을 보인다.

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GSM/CDMA 대역용 LTCC Diplexer 설계 연구 (Study on a LTCC Diplexer Design for GSM/CDMA Applications)

  • 김태완;이영철
    • 한국정보통신학회:학술대회논문집
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    • 한국해양정보통신학회 2008년도 추계종합학술대회 B
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    • pp.632-635
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    • 2008
  • 본 논문에서는 LTCC 다층회로 기술을 이용하여 GSM/CDMA 대역을 분리하는 Diplexer를 설계하였다. Diplexer의 집적도를 높이기 위해 3차원 적층형 인덕터와 커패시터를 이용하여 설계되었다. Diplexer는 유전율 7.2인 총 6층의 LTCC 기판에 설계되었고, 설계 되어진 다이플렉서의 크기는 CB-CPW pad를 포함하여 $3,450{\times}4,000{\times}600{\mu}m^3$이다. GSM 대역의 통과 필터는 -0.23dB 이하의 삽입 손실과 -10dB 이하의 반사 손실, CDMA 대역의 통과 필터는 -0.53dB 이하의 삽입 손실과 -10dB 이하의 반사 손실의 특성을 보였다.

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자전연소 합성법을 이용한 W-B 화합물 합성 및 조건 변수의 영향 (Synthesis of Tungsten Boride using SHS(Self-propagating High-temperature Synthesis) and Effect of Its Parameters)

  • 최상훈;;원창환
    • 한국재료학회지
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    • 제24권5호
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    • pp.249-254
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    • 2014
  • Due to their unique properties, tungsten borides are good candidates for the industrial applications where certain features such as high hardness, chemical inertness, resistance to high temperatures, thermal shock and corrosion. In this study, conditions were investigated for producing tungsten boride powder from tungsten oxide($WO_3$) by self-propagating high-temperature synthesis (SHS) followed by HCl leaching techniques. In the first stage of the study, the exothermicity of the $WO_3$-Mg reaction was investigated by computer simulation. Based on the simulation experimental study was conducted and the SHS products consisting of borides and other compounds were obtained starting with different initial molar ratios of $WO_3$, Mg and $B_2O_3$. It was found that $WO_3$, Mg and $B_2O_3$ reaction system produced high combustion temperature and radical reaction so that diffusion between W and B was not properly occurred. Addition of NaCl and replacement of $B_2O_3$ with B successfully solved the diffusion problem. From the optimum condition tungsten boride($W_2B$ and WB) powders which has 0.1~0.9 um particle size were synthesized.

Steric Hindrance in the Free Radical Polymerization of Aryloxyethyl Vinyl Ethers Containing Electron-Deficient Olefin Groups$^{\dag}$

  • 이주연;진미경
    • Bulletin of the Korean Chemical Society
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    • 제21권6호
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    • pp.613-617
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    • 2000
  • p-(2-Vinyloxyethoxy)benzylidenemalononitrile (4a), methyl p-(2-vinyloxyethoxy)benzylidenecyanoacetate (4b), 3,5-dimethoxy-4-(2'-vinyloxyethoxy)benzylidenemalononitrile (5a), methyl 3,5-dimethoxy-4-(2'-vinyloxy-ethoxy) benzylidenecyanoacetate (5 b), o-(2 -vinyloxyethoxy)benzylidenemalononitrile (6a), methyl o-(2-viny-Ioxyethoxy) benzylidenecyanoacetate (6b), 1,3-di-(2',2'-dicyanovinyl)-5-methyl-2-(2'-vinyloxyetioxy)benzene (7a), l,3-di-(2'-carbomethoxy-2'-cyanovinyl)-5-methyl-2-(2'-vinyloxyethoxy)benzene (7b), 2,3,4-tri-(2'-viny-Ioxyethoxy) benzylidenemalononitrile (8a), methyl 2,3,4-tri-(2'-vinyloxyethoxy)benzylidenecyanoacetate (8b), 2,4,6-tri-(2'-vinyloxyethoxy)benzylidenemalononitrile (9a), and methyl 2,4,6-tri-(2'-vinyloxyethoxy)benzyl-idenecyanoacetate(9b) were prepared by the condensation of the corresponding benzaldehyde 1-3 with malononitrile or methyl cyanoacetate, respectively. Vinyl ether monomers 4, 6, and 8 polymerized readily with radical initiators to yield crosslinked polymers 10, 12, and 14. However, compounds 5, 7, and 9 were inert to radical initiators due to the steric hindrance. The resulting polymers 10, 12, and 14 were not soluble in common solvents showing a thermal stability up to $300^{\circ}C$.