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Anti-oxidative and Anti-inflammatory Effect of Fractionated Extracts of Smilacis Glabrae Rhizoma in Human Umbilical Vein Endothelial Cell (혈관내피세포에서 토복령(土茯苓)의 항산화 및 항염증 효과)

  • Lee, Chang-Hyun;Yi, Hyo-Seung;Kim, Jae-Eun;Heo, Sook-Kyoung;Cha, Chang-Min;Won, Chan-Wook;Park, Sun-Dong
    • The Korea Journal of Herbology
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    • v.24 no.3
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    • pp.39-50
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    • 2009
  • Objectives : Smilacis glabrae rhizoma (SG) has been traditionally used as a herbal medication of musculoskeletal disorders like arthritis, pain, convulsions, and syphilis in traditional Korean medicine. This study was investigated anti-oxidative and anti-inflammatory effect of fractionated extracts of Smilacis Glabrae Rhizoma in Human Umbilical Vein Endothelial Cell (HUVEC). Methods : SG extract prepared with methanol, and then fractionated with hexane, dichloromethane, ethylacetate, n-butanol and water. Inhibitory effect of SG onto free radical generation was determined by measuring DPPH, superoxide anions and nitric oxide scavenging activities in vitro. Cytotoxic activity of extracts on RAW 264.7 cells was measured using 5-(3-caroboxymethoxyphenyl)-2H-tetra-zolium inner salt (MTS) assay. Intracelluar oxidation was analysed by DCF-DA assay. The nitric oxide (NO) production was measured by Griess reagent system. The levels of ICAM-1 and VCAM-1 expression were confirmed by western blot. And proinflammatory cytokines were measured by ELISA kit. Results : Our results indicated that fractionated extracts, especially ethyl acetate (EA) extract, significantly inhibited free radical generation, the TNF-$\alpha$-induced intracellular oxidation. Furthermore, the EA extract protected TNF-$\alpha$-induced adhesion to THP-1, expression of adhesion molecules accompanied by an attenuation of IL-6 and IL-8 formation in HUVEC. Conclusions : These results indicate that EA extract of SG have potential as an agent of atherosclerosis and other chronic inflammatory diseases including diabetes, hypertension, and arthritis.

Heating Characteristics of Carbon Fiber Polyimide-Coated by Electrophoretic Deposition (전기영동증착법으로 폴리이미드를 코팅한 탄소섬유의 발열 특성 연구)

  • Geon-Joo Jeong;Tae-Yoo Kim;Seung-Boo Jung;Kwang-Seok Kim
    • Journal of the Microelectronics and Packaging Society
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    • v.30 no.1
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    • pp.90-94
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    • 2023
  • Carbon fiber(CF) with excellent thermal conductivity and electrical conductivity is attracting attention as an alternative material because metal heating elements have problems such as high heat loss and fire risk. However, since CF is oxidized and disconnected at about 200℃ or higher, the application of heating elements is limited, and CF heating elements in the form of vacuum tubes are currently used in some commercial heaters. In this work, polyimide(PI) with high heat resistance was coated on the surface of carbon fiber by electrophoretic deposition to prevent oxidation of CF in the atmosphere without using a vacuum tube, and the coating thickness and heat resistance were investigated according to the applied voltage. The heater made by connecting the PI-coated CF heating elements in series showed stable heating characteristics up to 292℃, which was similar to the heating temperature result of the heat transfer simulation. The PI layer coated by the electrophoretic deposition method is effective in preventing oxidation of CF at 200℃ or higher and is expected to be applicable to various heating components such as secondary batteries, aerospace, and electric vehicles that require heat stability.

Feed Evaluation, Germination and Early Growth of Puccinellia coreensis Honda and P. nipponica Ohwi as affected by Salt Concentration (갯겨이삭, 갯꾸러미풀의 조사료 평가와 발아 생리 및 염농도별 초기생육)

  • Kim, Young-Doo;Park, Tae-Ill;Chae, Jae-Suk;Chang, Young-Sun;Park, Keun-Yong
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.40 no.3
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    • pp.269-277
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    • 1995
  • This experiment was conducted to study on forage utility of native grasses in polderland for salt tolerance plant selection and good feed with collection and evaluation. As the result of investgate, it was carried out feed evaluation, germination physiology and early growth at the different salt content of Puccinellia coreesis Honda and P. nipponica Ohwi from May 1993 to June 1994. Germination physiology of the grasses was light and low temperature favored optimum germination temperature was 1$0^{\circ}C$, germination period was 30 days. Dormancy awakening was needed wet and high temperature condition with 1~3 days storage. Germination rate increased 18.0% of P. coreensis and 39.0% of P. nipponica than those of non treatments. Early growth condition of different salt content was good also at in 1.00% and 0.50% levels of P. coreensis and P. nipponica. Crude protein content was 8.4% at P. coreensis, 7.1% at P. nipponica and 10.3% of Italian ryegrass, and NFE content was arrangement in order of P. coreensis, Italian ryegrass and P. nipponica. TDN content was not different between P. coreensis, P. nipponica and Italian ryegrass. Also P. coreensis and P. nipponica have a good taste for cattle as same as other crops.

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Evaluation of the Geological Heritages in Ulsan Area, Korea (울산 지역 지질유산의 가치평가)

  • Sujin Ha;Yong-Un Chae;Hee-Cheol Kang;Hyoun Soo Lim
    • Journal of the Korean earth science society
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    • v.43 no.6
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    • pp.749-761
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    • 2022
  • As the number of National and UNESCO Global Geoparks has increased, awareness of geological heritage and local government interests have also increased. In this study, data from the geological heritage sites in the Ulsan area were summarized, a practical use plan for geological heritage was prepared based on the assessment results, and the expected effects were also presented. The value for 33 of 112 geological heritage sites identified through literature surveys was evaluated. In terms of the geological heritage types in Ulsan, there were two geological, one geomorphological, and thirty mixed-heritage sites. In the context of the geological heritage of Ulsan, rivers and coastal topography were found to be dominant, and various geomorphological and geological features, such as fossils, folds, faults, shear zones, minerals, and ore deposits are included. Based on the assessment results, there were three, eighteen, nine, and three sites in Classes I, II, III, and IV, respectively. Considering the intrinsic and subsidiary values of geological heritage, the Gangdong Coast, Jujeon Coast, Taehwagang area, Daewangam area, the Daegokri-Cheonjeonri track sites, and Mujechineup are likely to be listed as potential geosites. When the endorsement of the geopark has been promoted alongside these geosites, it can contribute to the sustainable preservation and maintenance of the geosites, satisfy the demand for science education through geo-education, and support the sustainable development of the local economy following the detailed standards for geopark certification in the Natural Parks Act. This is expected to increase the brand value of Ulsan Metropolitan City.

Clinical Effect of Transverse Process Hook with K-Means Clustering-Based Stratification of Computed Tomography Hounsfield Unit at Upper Instrumented Vertebra Level in Adult Spinal Deformity Patients

  • Jongwon, Cho;Seungjun, Ryu;Hyun-Jun, Jang;Jeong-Yoon, Park;Yoon, Ha;Sung-Uk, Kuh;Dong-Kyu, Chin;Keun-Su, Kim;Yong-Eun, Cho;Kyung-Hyun, Kim
    • Journal of Korean Neurosurgical Society
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    • v.66 no.1
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    • pp.44-52
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    • 2023
  • Objective : This study aimed to investigate the efficacy of transverse process (TP) hook system at the upper instrumented vertebra (UIV) for preventing screw pullout in adult spinal deformity surgery using the pedicle Hounsfield unit (HU) stratification based on K-means clustering. Methods : We retrospectively reviewed 74 patients who underwent deformity correction surgery between 2011 and 2020 and were followed up for >12 months. Pre- and post-operative data were used to determine the incidence of screw pullout, UIV TP hook implementation, vertebral body HU, pedicle HU, and patient outcomes. Data was then statistically analyzed for assessment of efficacy and risk prediction using stratified HU at UIV level alongside the effect of the TP hook system. Results : The screw pullout rate was 36.4% (27/74). Perioperative radiographic parameters were not significantly different between the pullout and non-pullout groups. The vertebral body HU and pedicle HU were significantly lower in the pullout group. K-means clustering stratified the vertebral body HU ≥205.3, <137.2, and pedicle HU ≥243.43, <156.03. The pullout rate significantly decreases in patients receiving the hook system when the pedicle HU was from ≥156.03 to < 243.43 (p<0.05), but the difference was not statistically significant in the vertebra HU stratified groups and when pedicle HU was ≥243.43 or <156.03. The postoperative clinical outcomes improved significantly with the implementation of the hook system. Conclusion : The UIV hook provides better clinical outcomes and can be considered a preventative strategy for screw-pullout in the certain pedicle HU range.

Pre-service English Teachers' Peer Feedback on Microteaching (초등예비교사의 영어수업시연에 나타난 동료피드백 연구)

  • Jaeseok Yang
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.1
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    • pp.339-345
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    • 2023
  • Pre-service teachers have established and developed their own teaching strategies and professional language teaching skills based on their pedagogical and learning experiences. In this regard, it is conceivable that pre-service teachers' feedback may have distinct viewpoints and focuses. Therefore, the purpose of this study is to analyze pre-service teachers' feedback to microteaching demonstrations. Participants in the study were 40 prospective elementary school teachers. They were invited to offer feedback on microteachings video-recorded by their peers. According to the findings, we identified a total of 708 comments. The majority of feedback was categorized as teacher talk(40.1%) , followed by teaching and learning activity (20.9%), interaction (12.6%), teaching materials (11.4%), classroom atmosphere and learning environment (8.9%), lesson flow (3.7%), review and evaluation (1.3%), and introduction and objectives (1.1%). The most frequent types of feedback were the teacher's use of appropriate speaking rate, tone, and intonation. This finding reflects the fact that English teachers realize the importance of the teacher's English proficiency, therefore we suggest that teacher education institutions need raise awareness not just of teachers' English skills but also of their diverse perspectives.

Concentration of heavy metals in shellfishes and health risk assessment from Korean coastal areas

  • Ka Jeong Lee;Eun Hye Kang;Minchul Yoon;Mi Ra Jo;Hong Sik Yu;Kwang Tae Son
    • Fisheries and Aquatic Sciences
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    • v.25 no.12
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    • pp.626-636
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    • 2022
  • Shellfish are exoskeleton-bearing aquatic invertebrates that consume various organic and inorganic substances floating in seawater through filter feeding. Heavy metals are known as absorbed and accumulated in seawater. Some of the toxic heavy metals are highly accumulated in seawater, and exposure to them can cause a variety of risks to the human body. Since Koreans like to eat seafood, they are more likely to be exposed to contaminated seafood with heavy metals. In this study, nine types of heavy metals were analyzed on ten different shellfish species in the coastal area of South Korea. The risk assessment was also done on shellfish in which heavy metals were detected. Zinc (Zn) and copper (Cu) were identified at an average of 56.7 mg/kg (6.70 to 466 mg/kg) and 13.2 mg/kg (0.064 to 143 mg/kg), respectively. Lead (Pb) average of 0.208 mg/kg (0.000750 to 1.02 mg/kg), cadmium (Cd) average of 0.454 mg/kg (0.0388 to 1.56 mg/kg) and mercury (Hg) average of 0.0266 mg/kg (0.00548 to 0.174 mg/kg) were identified. Additionally, arsenic (As), chromium (Cr), nickel (Ni), and silver (Ag) were also identified as average concentrations of 4.02 (0.460 to 15.0 mg/kg), 0.167 (< limit of quantification [LOQ] to 0.820 mg/kg), 0.281 (< LOQ to 1.46 mg/kg), and 0.158 mg/kg (< LOQ to 1.15 mg/kg). The result indicates that the monitoring results of heavy metals in most shellfish satisfied the Korean standard. However, Pb and Cd have exceeded some foreign standards, such as the United States and the EU. The permissible human exposure calculated using the heavy metal intake and detection amount was lower than the Joint FAO/WHO Expert Committee on Food Additives human safety standard, and the risk of heavy metals from shellfish consumption was at an acceptable level.

Comparative Study on the Committed Dose Equivalent for Adults and Infants (예탁선양치(預託線量値)에서 본 성인(成人)과 유아(幼兒)와의 비교연구(比較硏究))

  • Sung, Kye-Yong;Yook, Chong-Chul;Ha, Chung-Woo
    • Journal of Radiation Protection and Research
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    • v.9 no.2
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    • pp.76-89
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    • 1984
  • Weighted committed dose equivalents($W_T\;H_{50}$) per intake of unit activity of four nuclides-I-131, I-133, Cs-134 and Cs-137-, which was based on the concepts of ICRP Pub. 30, are calculated for adult who is 70 kg and 25 years old and, for infant who is 10 kg and 1 year old. Metabolism of iodine taken through oral or inhalation pathway is described by using the three-compartment model which consists of inorganic, thyroid and organic compartment. After intake, the amount of iodine in every compartment is calculated by solving the transfer equations among the these compartments. As soon as caesium is taken into the body, it is distributed uniformly in the body through the transfer compartment. In this case, the amount of caesium in total body is calculated by using the total body compartment model which is divided into two tissue compartments because of their different biological half-lifes of caesium in body. As a result of calculations, whether oral or inhalation pathway, the values of ($W_T\;H_{50}$) per intake of unit activity of I-131 for infants are about ten times as much as those of adults. On the other hand, for Cs-134 and Cs-137, the values of $W_T\;H_{50}$ per intake of unit activity show that, whether adults of infants, they have almost the same values.

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R&D Service Industry Innovation Plan to Improve R&D Productivity and Vitalize Technology Innovation Ecosystem (R&D 생산성 제고와 기술 혁신 생태계 활성화를 위한 연구 서비스산업 혁신 방안)

  • Pyoung Yol Jang
    • Journal of Service Research and Studies
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    • v.13 no.1
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    • pp.144-158
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    • 2023
  • R&D (Research and Development) investment by companies and the government continues to increase, and the total R&D expenditure of public and private sectors in 2021 reached KRW 102 trillion, and the ratio of R&D investment to GDP was 4.96%. It ranks second in the world after Israel. This study analyzes the current status of the domestic R&D service industry and the research and development (R&D) innovation ecosystem based on the business activity survey data of the National Statistical Office in terms of improving R&D productivity of domestic R&D investment that has exceeded 100 trillion won, and analyzes the global R&D service industry and analyzes the global research service industry and R&D service Industry support government policy As a result of the analysis, in the domestic R&D ecosystem, the R&D outsourcing demand of service companies is rapidly increasing, compared to the stagnant R&D outsourcing demand of traditional manufacturing companies. In order to respond to these changing demands for technological innovation, this study suggests balanced support for R&D outsourcing for manufacturing and service companies, expansion of domestic R&D outsourcing, establishment of R&D outsourcing strategies specialized for the service industry, establishment of an open R&D ecosystem, and innovation in connection with materials/parts/equipment strategies.

Types and Roles of Visualization Materials in National Compared with Authorized Textbooks for Third- and Fourth-Grade Science under the 2015 Revised Curriculum (2015 개정 교육과정 초등 3~4학년 과학 국정교과서와 검정교과서 시각화 자료의 유형과 역할 비교 분석)

  • Ko, Mi-Jeong;Shin, Dong-Hoon
    • Journal of Korean Elementary Science Education
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    • v.42 no.1
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    • pp.93-108
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    • 2023
  • This study aims to analyze the types and roles of visualization materials presented in the third- and fourth-grade national and authorized science textbooks based on the 2015 revised curriculum. Using the type and role framework, 17 chapters were analyzed. The analysis revealed, first, that the national and authorized textbooks had different total amounts of visualization data and total amounts of simple illustrations. However, no difference in the amounts of simple illustrations and infographics used in the units was evident. The units that used the most infographics were Life, Earth and Universe, in that order, in both the national and the authorized textbooks. Second, simple illustrations were observed to have role differences according to the type of visualization data, but infographics had no such differences. Specifically, the motivational role in a simple illustration increased in all the authorized textbooks. Third, looking at the frequencies of the infographic subtypes, the Process, Structure, Comparative Analysis, and Timeline types accounted for 86% of the total, but the proportions of those subtypes varied in the national and authorized textbooks. Based on the results of this study, I suggest that to achieve differentiation in the types or roles of visualization materials, changes in the types, processes, and skills of inquiry must first occur, as must changes in the structure of chapters or lessons. Continuous research and discussion on the standards and methods for authorized textbooks are also needed.