• Advances in Computational Design
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• v.5 no.3
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• pp.323-347
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• 2020

The enhancements of bioenergy production effectiveness require the comprehensively experimental study of several parameters affecting these bioprocesses. The interpretation of the obtained experimental results and the estimation of optimum yield are extremely complicated such as misinterpreting the results of an experiment. The use of mathematical modeling and statistical experimental designs can consistently supply the predictions of the potential yield and the identification of defining parameters and also the understanding of key relationships between factors and responses. This paper summarizes several mathematical models used to achieve an adequate overall and maximal production yield and rate, to screen, to optimize, to identify, to describe and to provide useful information for the effect of several factors on bioenergy production processes. The usefulness, the validity and, the feasibility of each strategy for studying and optimizing the bioenergy-producing processes were discussed and confirmed by the good correlation between predicted and measured values.

• International journal of advanced smart convergence
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• v.9 no.1
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• pp.98-108
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• 2020

We consider transmit antenna selection combined with power allocation for quadrature spatial modulation (QSM) systems to improve the error rate performance. The Euclidean distance-based joint optimization criterion is presented for transmit antenna selection and power allocation in QSM. It requires an exhaustive search and thus high computational complexity. Thus its reduced-complexity algorithm is proposed with a strategy of decoupling, which is employed to successively find transmit antennas and power allocation factors. First, transmit antennas are selected without considering power allocation. After selecting transmit antennas, power allocation factors are determined. Simulation results demonstrate considerable performance gains with lower complexity for transmit antenna selected QSM systems with power allocation, which can be achieved with limited rate feedback.

• Natural Product Sciences
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• v.26 no.2
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• pp.109-117
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• 2020

The canonical Wnt/β-catenin signaling pathways play an important role in the embryonic development, cell proliferation, differentiation, and adhesion. Therefore, the abnormal activation and repression have been associated with uncontrolled homeostasis in human tissues. In particular, the activation of Wnt signaling is highly correlated with a diverse of diseases including cancer. On this regard, a strategy for targeting Wnt/β-catenin signaling has been employed in the discovery and development of antitumor agents. Herein, the evolution of Wnt signaling and the Wnt inhibitors derived from natural products were briefly summarized in the drug discovery of anticancer agents.

• Coupled systems mechanics
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• v.9 no.1
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• pp.47-62
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• 2020

In this paper we study the control for nonlinear geometric instability problem of a deep or a shallow truss or yet a frame structure. All the structural models are built with geometrically exact truss and beam finite elements.The proposed models can successfully handle large overall motion under static or dynamic conservative load.The control strategy considers adding a damping from either friction device or viscous damper.This kind of control belong to well-known concept of passivity. Different examples are presented in order to illustrate the proposed theoretical developments.

• Coupled systems mechanics
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• v.9 no.1
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• pp.63-75
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• 2020

Transport is the central ingredient of all numerical schemes for hyperbolic partial differential equations and in particular for hydrodynamics. Transport has thus been extensively studied in many of its features and for numerous specific applications. In more than one dimension, it is most commonly plagued by a major artifact: mesh imprinting. Though mesh imprinting is generally inevitable, its anisotropy can be modulated and is thus amenable to significant reduction. In the present work we introduce a new definition of stencils by taking into account second nearest neighbors (across cell corners) and call the resulting strategy "co-mesh approach". The modified equation is used to study numerical dissipation and tune enlarged stencils in order to minimize transport anisotropy.

• Biomolecules & Therapeutics
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• v.28 no.4
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• pp.293-301
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• 2020

Hypersecretion of pulmonary mucus is a major pathophysiological feature in allergic and inflammatory respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). Overproduction and/or oversecretion of mucus cause the airway obstruction and the colonization of pathogenic microbes. Developing a novel pharmacological agent to regulate the production and/or secretion of pulmonary mucus can be a useful strategy for the effective management of pathologic hypersecretion of mucus observed in COPD and asthma. Thus, in the present review, we tried to give an overview of the conventional pharmacotherapy for mucus-hypersecretory diseases and recent research results on searching for the novel candidate agents for controlling of pulmonary mucus hypersecretion, aiming to shed light on the potential efficacious pharmacotherapy of mucus-hypersecretory diseases.

• Korean Journal of Remote Sensing
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• v.36 no.4
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• pp.637-643
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• 2020

In this study, the information from environmental impact statements was converted into spatial data because environmental data from development sites are collected during the environmental impact assessment (EIA) process. Spatiotemporal big data were built from environmental spatial data for each environmental medium for 2,235 development sites during 2007-2018, available from public data portals. Comparing air-quality monitoring stations, 33,863 measurement points were constructed, which is approximately 75 times more measurement points than that 452 in Air Korea's real-time measurement network. Here, spatiotemporal big data from 2,677,260 EIAs were constructed. In the future, such data might be used not only for EIAs but also for various spatial plans.

• Membrane Journal
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• v.30 no.4
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• pp.205-212
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• 2020

This short review focuses on fouling by proteins and macromolecules in microfiltration/ultrafiltration. First, an experimental system that enables investigation of how the extent of the adsorption of proteins and macromolecules on membrane surfaces contributes to a decrease in filtrate flux in microfiltration/ultrafiltration is described. Using this system, a causal relationship - not a correlation - indicating that adsorption results in a decrease in filtrate flux could be clearly demonstrated in some cases. Second, a hydration structure at the membrane surface that can suppress adsorption is discussed, inspired by biomaterial research. In their hydrated states, polymers with low-fouling properties have water molecules with a particular structure. Finally, some successful examples of the development of low-fouling membranes via surface modification using low-fouling polymers are discussed.

• Journal of Auto-vehicle Safety Association
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• v.12 no.2
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• pp.21-26
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• 2020

This paper presents an anti-lock braking system for commercial vehicles with pneumatic brake system by using slip ratio. By virtue of system reliability, most commercial vehicles adopt pneumatic brake system. However, pneumatic brake systems control is more difficult than hydraulic systems due to a longer time delay and the system nonlinearity. One of the major factors in generating braking forces is the wheel slip ratio. Accordingly, the proposed ABS strategy employs the slip ratio threshold-based valve on/off control. This threshold-based algorithm is simple but effective to control the pneumatic brake systems. The control performance of the proposed algorithm has been validated via simulation studies using MATLAB/Simulink and Trucksim. The results show ABS by using slip ratio reduces the braking distance and improves vehicle control.

• Journal of Information Technology Applications and Management
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• v.27 no.4
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• pp.37-48
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• 2020

This research proposes how to enhance low customer satisfaction with health screening services caused by procedural complexity and limits of health screening. The purpose of this study is to identify sub-components of the service quality provided by general health examination centers. This is a qualitative analysis of in-depth interviews of providers and consumers of medical services. The data were primarily analyzed by affinity diagram, and the data were sorted and analyzed according to the criteria suggested by Donabedian's four components. Four types of quality factors and the health screening service quality components of 39 subordinate items were assessed. Components related to the use of IT facilities comprise a significant amount of the physical factors, and there are high demands for IT facilities among customers.