• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.188.2-188.2
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• 2003

Large-conductance $Ca^{2+}$ activated potassium channels $(BK_{ca})$ are widely distributed and play key roles in various cell functions. In nerve cells, B $K_{ca}$ channels shorten the duration of action potentials and block $Ca^{2+}$ entry thereby repolarizing excitable cells after excitation. $(BK_{ca})$ channel opening has been postulated to confer neuroprotection during stroke and has attracted attention as a means for therapeutic intervention in asthma, hypertension, convulsion, and traumatic brain injury. (omitted)

• 한국지반공학회논문집
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• 제24권6호
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• pp.77-84
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• 2008

실내시험에서 측정된 배수재의 통수능과 실제 현장에서 나타나는 배수거동은 근본적으로 다름에도 불구하고 기존의 많은 연구들은 실내시험을 통해 획득한 통수능 값을 이용하여 압밀 곡선을 예측하고 있다. 또한 기존의 압밀해는 압밀 진행에 따른 교란효과와 배수저항의 변화를 고려할 수 없어 실제 압밀거동과 잘 일치하지 않는 문제점이 있다. 본 연구에서는 현장에서 채취한 대형 블록시료에 연직배수재를 설치하고 압밀을 진행하면서 시간에 따른 침하량을 측정하였다. 이를 이용하여 시간에 따라 증가되는 배수 저항계수를 시간 의존적 함수로 정의하고 기존의 방사방향 압밀 해에 도입하여 수정된 방사방향 압밀 예측 방법을 제안하였다. 제안된 방법으로 예측한 결과를 실측 데이터 및 기존 제안식과 비교한 결과, 제안된 방법이 실측치에 가장 근접한 방사방향 압밀 곡선을 예측하는 것으로 관찰되었다.

• 한국가축번식학회지
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• 제16권3호
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• pp.209-215
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• 1992

These studies were carried out to overcome 2-cell block and in vitro development to blastocysts in vitro fertilization of mouse embryos. The unfertilized ova were obtained by superovulation in ICR mice of 4 to 6 weeks old. Tyrode's 280 solution was used as basal media, and the pH range of media examined was designed from 6.5 to 7.5 with 0.2 interval and the range of osmolality from 250 to 370 mOsm with 20 interval, and the period of sperm preincubation examined was 30, 60, 120, and 180 minutes. The ova developed to 2-cell embryos after 26hrs of incubation with preincubated sperm were evaluatated as in vitro fertilized ones. The results obtained were summarized as follows: 1. The optimal ranges of pH and osmolality of culture media and of sperm preincubation time for in vitro development of in vitro fertilized ova to blastocyst were pH 7.1 to 7.3, 250 to 350 mosmol and 60 to 180 min, respectively. 2. With the media of pH 7.1, 310 mOsm and sperm preincubation period of 120min in another experiment of large sample size, the in vitro fertilized ova was found 66.5% and the in vitro development of in vitro fertilized ova to blastocyst was found 35.8%. From the above results it was concluded that the optimal conditions of pH and osmolality of the media for mouse IVF and embryo culture, and the period of sperm preincubation might be 7.1, 310 mOam and 120min, respectively.

• 한국정보통신학회논문지
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• 제20권7호
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• pp.1296-1302
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• 2016

경량 암호기술 표준인 ISO/IEC 29192-2에서 블록암호 표준으로 지정된 초경량 블록암호 알고리듬 PRESENT의 하드웨어 구현에 대해 기술한다. 암호 전용 코어와 암호/복호 기능을 갖는 두 종류의 PR80 크립토 코어를 80 비트의 마스터키를 지원하도록 설계하였다. 설계된 PR80 크립토 코어는 블록암호의 기본 ECB (electronic code book) 운영모드를 수행하며, 마스터키 재입력 없이 평문/암호문 블록들을 연속적으로 처리할 수 있도록 설계되었다. PR80 크립토 코어는 Verilog HDL을 사용하여 소프트 IP로 설계되었으며, Virtex5 FPGA에 구현하여 정상 동작함을 확인하였다. 설계된 코어를 $0.18{\mu}m$ 공정의 CMOS 셀 라이브러리로 합성한 결과, 암호 전용 코어와 암호/복호 코어는 각각 2,990 GE와 3,687 GE로 구현되어 적은 게이트를 필요로 하는 IoT 보안 응용분야에 적합하다. 암호 전용 코어와 암호/복호 코어의 최대 동작 주파수는 각각 500 MHz와 444 MHz로 평가되었다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 ITC-CSCC -2
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• pp.1121-1124
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• 2002

In this paper, an IC realization of a cell-network type SC DC-DC converter is reported. To achieve small and low-cost realization, the converter is designed by using a 1.2 $\mu\textrm{m}$ CMOS technology. The CMOS implemented converter will be useful as a building block of various mobile equipments since step-up and step-down voltages can be provided at one time. Concerning the proposed DC-DC converter, SPICE simulatiorls are performed to investigate the characteristics of the circuit. The SPICE simulations show that, the efficiency of the simulated circuit is more than 95 %. From the layout design using a CAD tool, MAGIC, the VLSI chip is fabricated in the chip fabrication program of VLSI Design and Education Center(VDEC), the University of Tokyo with the collaboration by On-Semiconductor. The proposed circuit is integrable by a standard 1.2 $\mu\textrm{m}$ CMOS technology.

• 대한전자공학회논문지SD
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• 제39권12호
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• pp.1022-1032
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• 2002

테스트와 동시에 오류 비트의 수와 위치를 파악하도록 하여 redundancy 프로그래밍이 용이한 다수 비트 출력 DRAM을 위한 BIST 구조가 소개되었다. 일반적으로, DRAM 셀이 n개의 블록으로 구성된 경우에, 단지 n개의 비교기와 한 개의 3가지 상태 엔코더를 사용하여, 무오류 상태, 한 개의 오류가 있을 경우, 오류상태 및 오류비트가 존재하는 블록의 위치, 두개의 블록에 오류가 있을 경우 오류 상태 등 총 n ＋ 2개의 상태를 나타낼 수 있다. 제안된 방법을 통하여, 두개 이상의 블록에 오류가 있을 경우, 오류 비트의 위치와 수를 파악하는 방법으로 용이하게 확장 구현가능하다. 8블록으로 구성된 64MEG DRAM 경우의 성능 비교 결과 단지 0.115%의 칩 면적 증가로, 테스트 및 redundancy 프로그래밍 시간이 1/750로 감소하였다.

• 한국해양바이오학회지
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• 제10권2호
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• pp.53-61
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• 2018

Sargassum fulvellum (gulfweed) is a widespread seaweed in the coastal areas of northeast Asia. In the present study, we identified the phenolic compounds present in aqueous and ethanolic extracts of S. fulvellum and evaluated their antioxidative properties and their abilities to block cell proliferation using in vitro assays: antioxidant activity was assessed by using a DPPH assay and superoxide anion scavenging activity, anti-tyrosinase activity, and anti-proliferative activity were assessed using MTT and lactate dehydrogenase [LDH] assays in vascular smooth muscle cells. The hot-water ($65^{\circ}C$) extract had a higher phenol content than the ethanolic extract. The hot-water extract showed a statistically significant increase in free radical scavenging activity and a greater ability to reduce proliferation of vascular smooth muscle cells stimulated with platelet-derived growth factor-BB. Taken together, hot-water extracts of S. fulvellum may be an important source of antioxidative and antiproliferative agents.

• 한국수소및신에너지학회논문집
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• 제35권2호
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• pp.185-194
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• 2024

Fe-Ni nanocatalysts loaded on carbon black were prepared via spontaneous reduction reaction of iron (II) acetylacetonate and nickel (II) acetylacetonate in dry process. Their morphology and elemental analysis were characterized by scanning electron microscopy, transmission electron microscopy (TEM), and energy dispersive X-ray analyzer. The loading weight of the nanocatalysts was measured by thermogravimetric analyze and the surface area was measured by BET analysis. TEM observation showed that Fe and Ni nanoparticles was well dispersed on the carbon black and their average particle size was 4.82 nm. The loading weight of Fe-Ni nanocatalysts on the carbon black was 6.83-7.32 wt%, and the value increased with increasing iron (II) acetylacetonate content. As the Fe-Ni loading weight increased, the specific surface area decreased significantly by more than 50%, because Fe-Ni nanoparticles block the micropores of carbon black. I-V characteristics showed that water electrolysis performance increased with increasing Ni nanocatalyst content.

• Journal of Korean Dental Science
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• 제11권2호
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• pp.43-56
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• 2018

Purpose: The purpose of this study was to assess the adhesiveness and cytotoxicity of 3, 4-dihydroxyphenylalanine (DOPA), and to evaluate the role of collagen membrane with DOPA in the guided bone regeneration. Materials and Methods: Peel resistance and cell cytotoxicity test were performed. Four defect types in nine rabbit calvaria were randomly allocated: i) control, ii) membrane, iii) deproteinized porcine bone mineral (DPBM) covered by membrane with DOPA, and iv) DPBM covered by membrane with cyanoacrylate. Animals were sacrificed at 2 (n=4) and 8 weeks (n=5) for microcomputed tomography and histomorphometric analysis. DOPA showed low peel resistance but high cell viability. Result: Cyanoacrylate and DOPA groups showed significantly higher mineralized tissue volume (MTV) compared to control and membrane groups at 2 weeks (P<0.05). At 8 weeks, DOPA group showed the highest MTV. Significantly higher new bone area was found in DOPA group at 8 weeks (P<0.05). Bone formation increased from 2 to 8 weeks in DOPA group (P<0.05). Conclusion: DOPA showed high cell viability and in vivo study revealed predictable performance in bone regeneration.

• 농업과학연구
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• 제43권1호
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• pp.52-60
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• 2016

In animal reproduction, the quality of oocytes and embryos has been evaluated by the expression of specific molecules. Follistatin (FST), which was isolated from follicular fluid, binds and bio-neutralizes the TGF-${\beta}$ superfamily members. Previous studies using the bovine model showed FST could be an important molecular determinant of embryo developmental competence. However, the effect of FST treatment on porcine embryo developmental competence has not been established. In this study, the effect of exogenous FST on porcine embryo developmental competence was investigated during in vitro culture. FST (10 ng/ml) treatment induced a significant decrease in the rate of cell arrest at the 4-cell stage. The expression levels of DNA-methyltransferase 1 (DNMT1), histone deacetylase 1 (HDAC1), and histone deacetylase 2 (HDAC2) were decreased in 4-cell stage embryos. FST treatment also resulted in significant improvements in developmental competence of embryos in terms of blastocyst formation rate and OCT-4 mRNA levels, the latter being related to pluripotency. In conclusion, during in vitro culture, FST treatment significantly ameliorated 4-cell block during embryonic development and improved embryo developmental competence. Therefore, FST treatment may potentially have a functional role in porcine embryogenesis that is broadly applicable to enhance in vitro embryo development.