[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.15433/ksmb.2018.10.2.053

Evaluation of the Antioxidant and Antiproliferative Properties of a Hot-water Extract from Gulfweed, Sargassum fulvellum

Kim, So Jung (South Sea Environment Research Department, Korea Institute of Ocean Science and Technology)
Kang, Mingyeong (South Sea Environment Research Department, Korea Institute of Ocean Science and Technology)
Lee, Taek-Kyun (South Sea Environment Research Department, Korea Institute of Ocean Science and Technology)

Publication Information

Journal of Marine Bioscience and Biotechnology / v.10, no.2, 2018 , pp. 53-61 More about this Journal

Abstract

Sargassum fulvellum (gulfweed) is a widespread seaweed in the coastal areas of northeast Asia. In the present study, we identified the phenolic compounds present in aqueous and ethanolic extracts of S. fulvellum and evaluated their antioxidative properties and their abilities to block cell proliferation using in vitro assays: antioxidant activity was assessed by using a DPPH assay and superoxide anion scavenging activity, anti-tyrosinase activity, and anti-proliferative activity were assessed using MTT and lactate dehydrogenase [LDH] assays in vascular smooth muscle cells. The hot-water ( $65^{\circ}C$ ) extract had a higher phenol content than the ethanolic extract. The hot-water extract showed a statistically significant increase in free radical scavenging activity and a greater ability to reduce proliferation of vascular smooth muscle cells stimulated with platelet-derived growth factor-BB. Taken together, hot-water extracts of S. fulvellum may be an important source of antioxidative and antiproliferative agents.

Keywords

S. fulvellum; phenolics; antioxidants; antiproliferation; vascular smooth muscle cell;

Citations & Related Records

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