• Journal of Ginseng Research
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• v.39 no.1
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• pp.14-21
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• 2015

Background: Colorectal cancer is a leading cause of cancer-related death, and inflammatory bowel disease is a risk factor for this malignancy. We previously reported colon cancer chemoprevention potential using American ginseng (AG) in a xenograft mice model. However, the nude mouse model is not a gut-specific colon carcinogenesis animal model. Methods: In this study, an experimental colitis and colitis-associated colorectal carcinogenesis mouse model, chemically induced by azoxymethane/dextran sodium sulfate (DSS) was established and the effects of oral AG were evaluated. The contents of representative ginseng saponins in the extract were determined. Results: AG significantly reduced experimental colitis measured by the disease activity index scores. This suppression of the experimental colitis was not only evident during DSS treatment, but also very obvious after the cessation of DSS, suggesting that the ginseng significantly promoted recovery from the colitis. Consistent with the anti-inflammation data, we showed that ginseng very significantly attenuated azoxymethane/DSS-induced colon carcinogenesis by reducing the colon tumor number and tumor load. The ginseng also effectively suppressed DSS-induced proinflammatory cytokines activation using an enzyme-linked immunosorbent assay array, in which 12 proinflammatory cytokine levels were assessed, and this effect was supported subsequently by real-time polymerase chain reaction data. Conclusion: AG, as a candidate of botanical-based colon cancer chemoprevention, should be further investigated for its potential clinical utility.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.10
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• pp.1437-1449
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• 2006

Thirty six pre-weaned Barbari kids at 4 months age were reared on four rations computed using coarse cereal grains and by-products of pulses and oil seeds with Crude Protein (CP) and Total Digestible Nutrients (TDN) of 12 and 55% (Low protein Low energy); 12 and 60% (Low protein High energy); 14 and 55% (High protein Low energy); and 14 and 60% (High protein High energy), respectively. After 180 days on feed, male animals ($4{\times}5=20$) were slaughtered to study the effect of diet on carcass characteristics and meat quality. To asses the effect, if any, of such diet on product quality, meat balls were prepared and evaluated for quality changes when fresh as well as during storage ($-20{\pm}1^{\circ}C$). Feeding a ration with CP12 and TDN 60% (LH) to kids produced animals with highest slaughter weight (20.3 kg) yielding higher carcass weight and dressing percentage, lean (65.6%) and fat (6.6%) contents with low bone and trim losses. Although total variety meat yield was markedly higher in HL, the non-carcass fat deposition was relatively higher in LH carcasses. The water activity ($a_w$) of fresh goat meat ranged from 0.994-0.995 and total cholesterol 72.8-90.5 mg/100 g meat. The pH was high in HL and HH meat resulting in decreased ($p{\leq}0.05$) extract release volume (ERV). Meat balls were prepared using meat obtained from goats fed different rations (treatments) and stored at $-20{\pm}1^{\circ}C$. They were evaluated on day 0 and months 1, 2, 3, 4 for physicochemical, microbiological and organoleptic changes. Overall moisture (%), $a_w$, TBA number and pH value were 67.9, 0.987, 0.17, 6.6 respectively and were not affected by treatments except pH that was significantly ($p{\leq}0.01$) lower on LH. As the storage period advanced moisture, pH, $a_w$ and TBA number increased irrespective of treatments. Feeding various diets had no marked effect on microbial load of meat balls but with increasing storage period Standard Plate Count (SPC) and psychrotrophs declined ($p{\leq}0.01$). Treatment LL and LH produced meat balls with better flavour.

• Journal of Environmental Health Sciences
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• v.27 no.2
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• pp.127-137
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• 2001

Polychlorinated biphenyls(PCBs) are halogenated aromatic compounds with the empirical formula $C_{12}$ $H_{10-n}$C $l_{n}$(n=1~10), and are a mixture of possible 209 different chlorinated congeners. PCBs were widely used as dielectric fluids for capacitors and transformers, plasticizers, lubricant inks and paint addirives. Once released into the environment, PCBs persist for years because they are so resistant to degradation. In addition to their persistence in the environment, PCBs in ecological food chains undergo biomagnification because of their high degree of lipophilicity. In 1970s, the worldwide production of PCBs was ceased and the import of PCBs was prohibited since 1983 in Korea. In spite of these actions, many PCBs seems to be still in use. The environmental load of PCBs will continue to be recycled through air, land, water, and the biosphere for decades to come. This study was conducted to measure the concentrations of PCBs in the serum samples of 112 women by GC/MSD and GC/ECD. The main results of this study were as follows. 1. PCBs were detected in all samples. The mean $\pm$SD levels of PCBs in the serum were 3.613$\pm$0.759 ppb, and median were 3.828 ppb. 2. The correlation coefficients of the concentrations of 13 PCB congeners were from minimum, 0.7913 to maximum, 0.9985, and all was significant(p=0.0001). The correlation coefficient between the concentrations of PCBs and p,p'-DDE was 0.9641(p=0.0001). 3. There was a positive association between age and PCBs' concentrations (simple linear regression ; $R^2$=0.86, $\beta$=0.08023, p<0.001). 4. There was a positive association between total lipids in the serum and PCBs' concentrations (simple linear regression ; $R^2$=0.7058, $\beta$=0.00486, p<0.001). 5. For possible predictors of PCBs and p,p' -DDE levels in the serum, age adjusted model (Y=$\beta$$_{0}$+$\beta$$_1$age+ $B_2$X) was applied. For BMI, major residential area, wether to eat caught fish by angling, where to eat caught fish by angling(by parents in the past), fish consumption, meat consumption, meat consumption, and dairy consumption, there was no association. For total conception frequency and lactation frequency and lactation period, there was negative association.ion.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.12
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• pp.1553-1559
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• 2007

The purposes of this study were to investigate the effect of Saengshik on blood glucose level of normal subject and to explore the marketing possibility of four kinds of Saengshik (ES, HS, BS, SS) as alternative diabetic meals. Blood glucose levels of healthy volunteers was measured at 15, 30, 45, 60, 75, 90, 105 and 120 minutes after taking Saengshik and 50 g glucose. Blood glucose response areas, glycemic index (GI) and glycemic load (GL) were calculated from the glucose response. The Saengshik showed a significantly lower glucose level than the glucose. The glycemic index (GI) of ES showed $43.1{\pm}12.6$, which belonged to low GI foods (GI of 55 or less). Other samples (HS, BS, SS) could be classified as intermediate GI foods ranging $56{\sim}69$ of GI. Saengshik showed a gentle rising and falling pattern showing moderate left area ratio and right area ratio on blood glucose curve. The GL of ES showed 14.1 while HS, BS and SS did $19.2{\sim}19.5$. The results indicated that Saengshik may have a beneficial effect on a diabetic.

• Journal of Life Science
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• v.17 no.3 s.83
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• pp.368-374
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• 2007

The purpose of this study was to investigate the effects of different type of triglycerides (MCT & LCT) on weight, survival time, energy substrate (FFA, TG, pyruvate, lactate), insulin and lipase in the trained rats. Fifty-four Sprague-Dawley rats were divided into 3 groups: control group (CG, n=18), MCT supplement group (MG, n=18), and LCT supplement group (LG, n=18). They also were divided into 3 periods: trained resting (R, n=6) and trained & exercise load (E, n=6), and survival time test was performed to know the supplemented effects. Body weight of all animals was checked every week, MCT group and LCT group received supplementary MCT and LCT orally and preliminary swimming training for 6 days before the start of main experiment. All animals received 15-minute swimming training 5 times during first week of experiment, and swimming training time was increased 15 minutes every week until it reached 90 minutes at last 9th week. After last swimming training, animals were fasted for 12 hours and blood samples were taken from abdominal aorta in the Department of Animal Medicine at the D university Animal Center. Among the CGE, MGE, and LGE groups, the MGE had the greatest increase in physical performance time. In the FFA levels, there was significant differences(p<.05) in CG, MG and LG groups, and also there was major difference of FFA levels in the MG and LG. In the lipase levels, there was signifi.ant differences (p<.05) in CG, MG and LG groups. MG was the greatest than the other groups. In the insulin hormone levels, there was the great differences (p<.05) in LG compare to CG groups, whereas there was no significant difference in the CG and MG. In conclusion, these results suggest that regular prolonged physical training with MCT supplementation, improves exercise performance time through the increase of energy substrate utilization, lipase activity and FFA levels, irrespective of insulin hormone responses.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.12
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• pp.242-252
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• 2016

This study seeks to verify the effect size of the variables relating to job satisfaction through a meta-analysis focusing on previous papers over the last 20 years that have examined the job satisfaction of kindergarten teachers and verified the trend by publication year through a meta-regression analysis. The study results are as follows. First, the results demonstrated that the total effect size of the variables relating to kindergarten teachers was large. Second, the organization's internal variable and organization's external variable groups, except for the individual characteristics variable group, showed a large effect size at similar levels. Third, the status of teachers in the individual characteristics variable group showed a meaningfully large effect size and the interpersonal relationship variable in organization's internal variable group showed a relatively larger effect size than the organizational climate variable did. Finally, the results of the verification of the trend by publication year showed that job satisfaction increased for all variables, except for the individual characteristics variable in more recent publications. This study highlights the imperative of making every effort to improve the organization's internal and external environment. In particular, measures to reduce job stress and work load are required. Furthermore, the atmosphere that is devoted to the teaching profession and teacher efficacy is important.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.21 no.2
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• pp.121-128
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• 2010

This paper presents a design of a 100 W high-efficiency power amplifier, whose operational frequency band expands from 30 to 512 MHz, using negative feedback network, push-pull structure, broadband RF choke, and transmission line transformer for balun configuration. The push-pull amplifier has been tuned for higher output power using a shunt capacitor as a matching component at its load especially for high-frequency region. The implemented power amplifier exhibited a very flat power gain of $18.34{\pm}0.9\;dB$ throughout the operating frequency band and very high power-added efficiency(PAE) of greater than 40% at an output power of 100 W. It also showed second- and third-harmonic distortion levels of below -34 dBc and -12 dBc, respectively, through the entire operating frequency band.

• The Journal of Korean Academy of Prosthodontics
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• v.44 no.3
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• pp.295-313
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• 2006

Statement of problem. Higher fracture rates were reported for Branemark implants placed in the maxilla and for 3.75 mm diameter implants installed in the posterior region. Purpose. The purpose of this study was to investigate the fracture of a fixture by finite element analysis and to compare different diameter of fixtures according to the level of alveolar bone resorption. Material and Methods. The single implant and prosthesis was modeled in accordance with the geometric designs for the 3i implant systems. Models were processed by the software programs HyperMesh and ANSA. Three-dimensional finite element models were developed for; (1) a regular titanium implant 3.75 mm in diameter and 13 mm in length (2) a regular titanium implant 4.0 mm in diameter and 13 mm in length (3) a wide titanium implant 5.0 mm in diameter and 13 mm in length each with a cementation type abutment and titanium alloy screw. The abutment screws were subjected to a tightening torque of 30 Ncm. The amount of preload was hypothesized as 650 N, and round and flat type prostheses were 12 mm in diameter, 9 mm in height were loaded to 600 N. Four loading offset points (0, 2, 4, and 6 mm from the center of the implants) were evaluated. To evaluate fixture fracture by alveolar bone resorption, we investigated the stress distribution of the fixtures according to different alveola. bone loss levels (0, 1.5, 3.5, and 5.0 mm of alveolar bone loss). Using these 12 models (four degrees of bone loss and three implant diameters), the effects of load-ing offset, the effect of alveolar bone resorption and the size of fixtures were evaluated. The PAM-CRASH 2G simulation software was used for analysis of stress. The PAM-VIEW and HyperView programs were used for post processing. Results. The results from our experiment are as follows: 1. Preload maintains implant-abutment joint stability within a limited offset point against occlusal force. 2. Von Mises stress of the implant, abutment screw, abutment, and bone was decreased with in-creasing of the implant diameter. 3. With severe advancing of alveolar bone resorption, fracture of the 3.75 and the 4.0 mm diameter implant was possible. 4. With increasing of bending stress by loading offset, fracture of the abutment screw was possible.

• Journal of the Earthquake Engineering Society of Korea
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• v.14 no.6
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• pp.75-84
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• 2010

In current seismic design provisions, a reduced beam section with bolted web (RBS-B) connections is only permitted for intermediate moment frames (IMF). This study evaluated the seismic performance of steel moment resisting frame systems having RBS-B connections designed according to current seismic design provisions. For this purpose, 12 archetypal IMF systems having two different span lengths (9m, 6m) were designed considering two design load levels (SDC $C_{max}$, SDC $C_{min}$). A nonlinear analytical model that can simulate hysteretic behavior of an RBS-B connection was also developed in this study. The procedures specified in ATC 63 are used to conduct a seismic performance evaluation. Moreover, this study conducts the seismic performance evaluation of IMF systems designed according to a new design method proposed by the authors in the previous study. It was observed that several model frames designed according to current seismic design provisions did not provide satisfactory collapse margin ratios (ACMR). This study also showed that the model frames designed according to the new design procedures had a sufficient ACMR.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.845-856
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• 2020

This study proposes a bridge evaluation system for indivisible permit vehicles such as hydraulic cranes. The permit loads for the bridge evaluation are divided into three categories: routine permit loads, special permit 1 loads, and special permit 2 loads. Routine permit and special permit 1 vehicles are allowed to cross a bridge with normal traffic. For these two permits, the standard lane model in the Korean Highway Bridge Design Code was adopted to consider normal traffic in the same lane. Special permit 2 vehicles are assumed to cross a bridge without other traffic. Structural analyses of two prestressed-beam bridges and two steel box girder bridges were conducted for the proposed permit loads. The rating factors of the four bridges for all permit loads were calculated as sufficiently large values for the moment and shear force so that crossing the bridges can be permitted. A reliability assessment of the bridges was performed to identify the reliability levels for the permit vehicles. It was confirmed that the reliability level of the minimum required strength obtained by the load-resistance factors yields the target reliability index of the design code for the permit vehicles.