• Journal of Biomedical Engineering Research
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• v.23 no.3
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• pp.189-196
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• 2002

Transdermal drug delivery offers an alternative method to the conventional oral and injection delivery method. Its advantages include its ability to deliver drugs directly into systemic circulation. However, there have been restrictions in its application to deliver drugs because of the skin's barrier function. In this study, we try to combine a Sonophoresis and oxygen Pressure method in order to increase the Permeability of the skin. we used water as the compound and by utilizing the skin impedance method. we measured the hydration Permeability of skin Ultrasound was applied using a sonicator(Solcare-U1000. Solco, Korea) operating at a frequency of 1MHz. oxygen Pressure was applied using a compressor(Oxyjet-Pointer, Nora Bode. Germany) operating at a pressure of 2Bar/cm2. Experiment was performed in vivo for 42 People. We divided the subjects into four smaller groups. A different transdermal drug delivery method was applied for each group on the back of their hand. We measured the skin impedance variations on the hand. during a 20-minute time Period. The control group did not show any significant increase or variation of skin impedance to water. In comparison to the control group(Passive diffusion) the hydration Permeability of the ultrasound group and the oxygen Pressure group was approximately 25 and 30 times higher consecutively. Futhermore, the hydration permeability of the combination of ultrasound and oxygen Pressure group was about 70-fold higher in comparison to the control group(passive diffusion) . The results reveal that a combination of ultrasound and oxygen Pressure will significantly enhance transdermal water transport compared when only one of them is used.

• Journal of IKEEE
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• v.24 no.3
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• pp.713-718
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• 2020

The method of measuring skin active points is a technique for obtaining a lot of biometric information because it is measured with convenience, low cost and non-invasive methods. In this paper, we used in a three electrode measure method that has the advantage of measuring the impedance of the APs under the skin. The impedance measuring method is well illustrated by a simple model of an equivalent electrical circuit that correlates well with experimental results. The characteristic frequencies of APs are about 15-30HZ higher than that of surrounding skin and the values of measured reactance are about 35-77KΩ smaller. This technology analyzed accurately and objectively the reactance and characteristic frequency of APs and the surrounding skin using a non-invasive measuring system.

• Journal of IKEEE
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• v.25 no.3
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• pp.445-450
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• 2021

Bio-impedance measurement is a measurement device that can be used to obtain biometric information and diagnose skin diseases using convenience, low cost, and low cost devices. In this study, the bio-impedance was measured using a direct dry gold electrode and a simulation study through animal bio modeling to obtain biometric information in a biometric form. Impedance was measured by inserting electrodes into subcutaneous areas of animal tissue and applying frequencies of 100 uA, 1-100 kHz using a two-electrode method. As a result of the measurement, the resistance of the electrodes is measured high at 5 mm electrodes compared to 7.5 mm and 10 mm electrodes based on 5 mm electrodes. Based on the 5 mm electrode, an average difference of 1.49% was found for the 7.5 mm electrode in the total frequency range, and the impedance difference was confirmed to be 2.624% for the 10 mm electrode. In the future, the research results are expected to be valuable in designing and manufacturing electrodes for bio-inserted electrocardiogram sensors.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.1194-1197
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• 2004

High temporal-resolution and accurate measurement of skin impedance locus provides useful data for the identification of the physiological/psychological changes and also the identification of acupuncture point. An impedance spectroscopy method using digitally constructed current waveform consisting of many frequency components (multiples of 1Hz) was reported3. The time resolution of the method depends on the lowest frequency used in the waveform construction, and therefore, the measurement would be faster if the lowest frequency is the higher. However, it was not clear that how many and how low frequencies must be used for the estimation of the skin impedance parameters from which the impedance locus can be drawn. This study shows the relationship between the estimation error of the impedance parameters and the frequency coverage of the spectroscopy. The results of this study are expected to serve as the reference of the frequency selection in the impedance spectroscopy.

• Journal of IKEEE
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• v.23 no.4
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• pp.1122-1127
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• 2019

In this study, the bio-impedance of the human body is able to obtain a lot of information by monitoring the pathological and physiological conditions of clinical and biological tissues. The four electrode method system for biometrics measured the potential difference between two electrodes and the other two electrodes were used as electrodes for current flow. The newly developed dry gold electrode measured impedance from 1 Hz to 50 kHz and produced reproducible results. To verify the impedance measurement of the dry electrode, the pitting was performed using an equivalent circuit model of the bioelectrode skin, and the effectiveness was demonstrated through modeling. Fixed electrode types have a constant position of the electrodes attached during the measurement, so that a stable measurement can be obtained, thereby minimizing the error.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.38 no.3
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• pp.47-54
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• 2001

This study is to analyze the impedance response in human body by acoustic stimulation on acupoints and contrast parte; for objectification of the meridian substance. It is to verify meridian pathway and channel theory or bio-energy in body. This paper proposes to make an hypothesis about the underground water theory. The meridian has not tube or pipe line type channel but bio-energy flow along the channel similar to flowing pattern of underground water in body. It was analyzed the current characteristic or impedance response after acoustic stimulation by sound wave of 5 specific tones. The response characteristics of current stimulation are measured by the average current magnitude and variation ratio or meridian. The current variation ratio or Live Meridian(gung) 33.2%, Heart Meridian(sang) 30.7% Kidney Meridian (gak) 33.1%, Spleen Meridian(chi) 33.9%, Lung Meridian (wo) 30.7% are to be compared to contrast parts (non-acupoint and meridian). In experimental results, meridian is discrimination to non-meridian, and 5 vital meridians have a reciprocal relationship with sound wave of 5 specific tones.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.5
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• pp.799-805
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• 2015

In this paper, an inkjet-printed capacitive touch pad is proposed. This touch pad detects contacts of human finger by detecting changes in effective capacitance due to electrical impedance of human finger. A flexible, low-cost and disposable paper is used as a substrate. Inkjet printing technology makes the fabrication fast, simple and environmentally friendly. Measured capacitances of the touched and untouched states are in the range of 163 to 182pF and 218 to 272pF, respectively. The differences in the measured capacitance of each state are sufficiently large to recognize that a finger has made contact with touch pad.

• Journal of the Institute of Convergence Signal Processing
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• v.9 no.4
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• pp.280-287
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• 2008

For the reduction of common-mode noise level in Indirect-contact ECG (IDC-ECG) measurement a driven-right-leg grounding method was a lied to the IDC-ECG. Because the IDC-ECG does not require any direct contact between the electrodes and the human skin. it is adequate for un-constraining long-term ECG measurement at home and its various applications are now under development. However, larger 60 Hz noise induced by power line a ears in IDC-BCG than in conventional ECG, that is a restriction of IDC-ECG a application. In this study, the driven-right-leg ground which has been used in conventional direct-contact ECG, was adapted to the IDC-ECG measurement by feedback of the inversion of amplified common-mode noise to the body through the conductive fertile laid on the chair seat By this study, indirect-contact driven-right-leg ground was developed and it was shown to work stably. It was shown that the level of 60Hz power line noise was reduced to about -40 dB when the driven-right-leg gain was 1000. This study shows that we can extend the upper limit of the frequency band of IDC-ECG to 100Hz from 30Hz which is conventional upper limit in IDC-ECG, and we can raise the ground impedance between the body and conductive textile. So it is expected that the application area of the IDC-ECG will be extended by the results of this study.

• Journal of Biomedical Engineering Research
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• v.18 no.4
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• pp.485-491
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• 1997

This paper describes the relationship between skin impedance signal, behavioral signal, and subjective evaluation depending on arousal level. Nz and reaction time had similar trend with mKSS level, but eyeblink rate was different from these two parameters. eye-blink rate increased slowly from mKSS level 1 to 5, and had high increasing rate at mKSS 7. But it showed steep descent at mKSS level 9. Each subject showed different eye-blink rates, but changing rates of EBR was similar at eachm KSS level. Therefore it suggests that rising rate of EBR can be used arousal level criterion. From the result of reaction time test. human performance was decreased rapidly above the mKSS level 5, and false positive and false negative data was observed above the mKSS level 3. It is desirable to give a subject some stimuli such as sound or aroma to rise arousal level between mKSS level 3 and mKSS level 5.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.7
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• pp.1399-1410
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• 2009

It is a method to treat pain using medication, neurotomy, and surgery. And acupuncture, ultrasound, electric treatment, and magnetic treatment are applied as a alternative physiotherapy. Electronic therapy is useful but it can be affected by impedance of skin or subcutaneous tissue. So, percutaneous stimulation is leading therapy, that is very randomly. We developed the system which can stimulate parts of acupuncture point noninvasively using the focused magnetic field. And we designed the magnetic stimulation electrode which is considered efficiency of the magnetic stimulation. It can make similar stimulation with manual acupuncture. To confirm the availability and reliability we compared Meridian Electronic Potential(MEP) change between manual acupuncture and magnetic stimulation. From this result, we found out the MEP changes of manual acupuncture and magnetic stimulation were similar. And there were various response properties as changes of stimulation method, intensity, and frequency. Also, the MEP change can be induced by electromagnetic stimulation. We confirmed that it is possible to use electromagnetic stimulation as a acupoint stimulation or pain treatment instrument.