• Venture DIGEST
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• no.1 s.126
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• pp.24-25
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• 2009

다리미 크림을 아시나요?' 주름이 다리미처럼 펴진다고 해서 붙여진 주름 개선 기능성 화장품의 별칭. 요즘 이 화장 품이 모 인터넷 쇼핑몰에서 폭발적인 인기를 얻고 있다. 보톡스를 능가하는 주름개선 효과와 저렴한 가격이 인기몰이의 비결이다. 세계 어떤 주름 제품과 비교해도 자신있다는, 화장품 업계의 글로벌 리더를 꿈꾸는 충남테크노파크 천안밸리 입주기업 (주)콧데를 소개한다.

• Journal of the Korean Society of Costume
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• v.52 no.5
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• pp.155-172
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• 2002

The research has the aim of defining the special characteristics of the functionalist fashion design in the 1900s by understanding the essence of functionalism in the sociocultural contexts. Giving careful consideration to functionalist fashion design in the 1990s makes it possible to foresee the way of fashion design to meet the needs of the modems and men of the future world. To obtain the purposes, documentary study and demonstrative study with fashion photographs have been executed. Main results are as follows. Functionalism in the 1990s has been developed in different ways from the analogies in the beginning of the 20th century. It doesn't belong to an analogy but has the fused characteristics. It can be classified into techno functionalism influenced by new technology Pure functionalism related to minimalism. casual functionalism for those who are crazy about the speed and sports and enjoy the freedom and comfort and symbolic functionalism. Mechanical analogy has been developed into techno functionalism. Pure functionalism has come from the blend of mechanical and moral analogy, casual functionalism from mechanical. organic and moral analogy. and symbolic functionalism from organic and moral analogy. Since fashion design has much closer relation to human body and movements. it has been expressed considering a division of men and women and the places and times for the designs more than other designs. More casual manners of formal wear are distinct elements in functionalist fashion design in the 1990s. The 20th century general cultural phenomena including post modernism can be explained by eclectic functionalism. Functionalism considering Practical and conceptional functions ill continue and techno functionalism and casual functionalism in future fashion design will be expressed more strongly with new technology and casual trends of life style.

• Journal of the Korean Society of Clothing and Textiles
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• v.26 no.10
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• pp.1455-1466
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• 2002

This research focuses on functionalism in American fashion designs which have become the center of public attention in recent. First, documentary studies about how functionalism, which originated in Europe in the beginning of the 20th century, has been developed throughout the 20th century were preceded Second, content analysis was done for the articles, including the word ‘unction’,‘utility’ and ‘practical’in the New York Times and American Vogue from January 1990 to January 2001. As a result, functionalism in 1990s has been developed in different ways from the mechanical, organic, and mea analogies of functionalism in the beginning of 20th century. It doesn't belong to an analogy but has the fused characteristics of those three analogies. It can be classified into techno functionalism influenced by new technology, pure functionalism related to minimalism, sports casual functionalism for those who are crazy about the speed and sports and enjoy the freedom and comfort, and symbolic functionalism which stresses Zen style. More casual manners of formal wear are distinct elements in functionalist fashion design in 1990s. It leads to strong expressions of sports casual functionalism, which plays a great role in sportswear industry of American fashion design. The American fashion designers who were mentioned often in the articles were Donna Karan, Calvin Klein, Ralph lauren and Tommy Hilfiger. As well as their works have common formative features based on functionalism, each of them shows his/her own strung color. A]1 of these designers make American fashion design, which can be defined as casual wear or sportswear, very popular worldwide based on the developed American functionalism. Functionalism considering practical and conceptional functions will continue in coming century and techno functionalism and sports casual functionalism in future fashion designs wilt be expressed more strongly with new technology and casual trends of life style.

• Korean Journal of Plant Resources
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• v.35 no.4
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• pp.435-444
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• 2022

Hibiscus hamabo Sieb. et Zucc. (yellow hibiscus) is a deciduous semi-shrub plant and mainly growing in Jeju Island. This is known the unique wild hibiscus genus and classified as an 2nd grade of endangered plant for Korean Red List. In previous studies, properties of germination, ecological, genetical and salt resistance have been reported. In this study, we investigated mass-proliferated adventitious root using bioreactor, antioxidant and whitening effects to conduct functional ingredients. Yellow hibiscus were collected from Gujwa, Jeju by prior permission and they were introduced by explant type and various medium composition after surface sterilization. As a result, seed response rates were evaluated at range of 51.17~51.83%, in terms of comprehensive efficiency of shoot and root formation. In the case of adventitious root propagation condition was confirmed in half strength Murashige and Skoog medium salts, 30 mg/L sucrose, and 2 mg/L indole-3-butyric acid for 8 weeks in 5,000 mL bioreactor. We also compared between relationship with biomass and secondary metabolites accumulation by total phenolics content, the flavonoid content, DPPH free radical scavenging activity and melanin content. The results indicated that adventitious root mass proliferation, antioxidant and whitening effect could develop value of the high-quality cosmeceutical ingredient and further metabolite studies.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2022.09a
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• pp.25-25
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• 2022

피부 노화는 피부와 피부 지지층 등의 광범위한 퇴행 과정을 말한다. 피부 노화의 원인은 흡연, 공해, 스트레스 등이 있지만, 그 중에서도 자외선(ultra violet, UV) 조사가 가장 큰 요인으로 꼽힌다. 반복적인 자외선 조사에 의해 진행되는 피부노화를 광노화라고 하며 그 가장 큰 특징으로는 콜라겐 섬유와 엘라스틴의 감소로 야기되는 주름을 들 수 있다. 본 연구에서는 제주에서 채집한 바위수국의 추출물 및 분획물의 항산화 및 자외선으로 인한 피부노화 예방(anti-photoaging) 효능을 확인하고, 활성물질을 분리하여 광노화 예방 효능과 그 메커니즘을 확인하였다. 실험에 사용된 바위수국은 범의귀과의 덩굴성 식물로 바위면이나 나무줄기 등에 붙어서 자라며, 한국(제주, 울릉도)과 일본에 분포한다. 바위수국 추출물과 분획물에서 총 페놀 함량. 총 플라보이드 함량, DPPH 및 ABTS 라디칼소거 활성의 항산화 실험 결과, 부탄올과 에틸아세테이트 분획층에서 강력한 항산화 활성이 관찰되었다. 또한 UVA를 조사한 인간 진피 섬유아세포 (human dermal fibroblast, HDF)데 대한 콜라겐 분해효소인 matrix metalloproteinase-1(MMP-1) 생성 억제 활성을 확인한 결과, 부탄올 분획층이 세포 생장 저해 없이 가장 우수한 효능이 확인되었다. 따라서 부탄올 분획층에서 주요 성분 분리 실험을 수행하여 총 4개의 화합물을 분리하였다; Chlorogenic acid (1), Quercetin-3-O-glucosyl-(1-2)-rhamnoside (2), Quercetin-3-O-xylosyl-(1-2)-rhamnoside (3), Quercitrin (4). 분리한 4개의 물질의 MMP-1 생성 억제 활성을 비교한 결과 화합물 2가 세포독성 없이 MMP-1 생성 억제 효능이 우수하였고, 이후 화합물 2의 광노화 예방 효능과 그 메커니즘을 확인하였다. 화합물 2는 MMP-1의 생성을 억제할 뿐만 아니라 procollagen type I의 생성을 증가시켰으며, MMP-1 생성에 관여하는 mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) 신호전달경로를 하향 조절하며, 콜라겐 생성과 관련된 Transforming growth factor-β (TGF-β)/Smad 신호전달경로를 상향 조절하여 UVA에 의한 광노화 예방에 효능을 나타내었다. 이러한 결과들을 바탕으로, 바위수국은 항노화(anti-aging) 기능성 화장품 및 이너뷰티 기능성 식품 소재로 개발이 가능할 것으로 기대된다.

• Journal of the Economic Geographical Society of Korea
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• v.25 no.4
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• pp.531-546
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• 2022

This study analyzes the performance and characteristics of the fostering policies for the focusing on growth path and type occupied in the Technoparks. First, the companies occupied in the Technoparks have shown the characteristics of landing on an actual growth phase beyond the start-up and fostering phases, and when considering the possession of a dedicated R&D organization and the portion of highly educated technical personnel having masters and doctorate degrees, these companies have also entailed the characteristics of being a technological innovation company. Second, about 30% of the companies that left the Technoparks secured their own factories and offices after standing alone, indicating that the fostering function after startup in the Technoparks has been performing a significant role on the growth path of start-up companies from a temporal perspective. Third, a majority of the companies occupied in the Technoparks were composed of scale-up companies or preliminary scale-up companies that contained promising innovative growth potential. However, it seems to urgently require the acceleration of innovation because many companies are categorized into a stagnated growth type that demonstrates a high R&D investment but low sales revenue growth.

• Korean Journal of Plant Resources
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• v.32 no.5
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• pp.433-441
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• 2019

This study describes a preliminary evaluation of the anti-inflammatory activity and anti-atopic activity of Phormium tenax leaf extracts. P. tenax leaf was extracted using 70% ethanol and then fractionated sequentially with n-hexane, methylene chloride, ethyl acetate, n-butanol. In order to effectively screen for anti-inflammatory agents, we first investigated the inhibitory effects of P. tenax leaf crude extracts and solvent fractions on production of pro-inflammatory factors[nitric oxide(NO), prostaglandin $E_2(PGE_2)$, inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2)] and pro-inflammatory cytokines [tumor necrosis $factor-{\alpha}(TNF-{\alpha})$, interleukin-6(IL-6) and $interleukin-1{\beta}(IL-1{\beta})$] in lipopolysaccharide(LPS)-stimulated RAW 264.7 cells. In addition, we also evaluated of their inhibitory effect on the atopic dermatitis-like inflammatory markers such as macrophage-derived chemokine(MDC) and thymus and activation-regulated chemokine(TARC) in HaCaT cells. Among the five solvent fractions of P. tenax, methylene chloride and ethyl acetate fractions inhibited production of pro-inflammatory factors and pro-inflammatory cytokines in a dose dependent manner, respectively. These fractions were also showed inhibitory activity for MDC and TARC expression levels in $IFN-{\gamma}-stimulated$ HaCaT cells, respectively. These results suggest that P. tenax have significantly effects of anti-inflammatory activity and anti-atopic activity that might be beneficial for the topical treatment of inflammatory skin disorders.

• Journal of Korea Technology Innovation Society
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• v.19 no.4
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• pp.848-872
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• 2016

This study is an empirical analysis that makes a survey on the evaluation of innovation cluster. For this purpose, we explore a case of innovation cluster, the Pangyo Techno Valley. This survey applies a research frame and evaluation contents that the innovation performance which is the institutional, physical, and social configurations of innovation clusters. In particular, this empirical analysis identifies the configuration factors which are the rational influence factors of individual subjects, in order to foster innovation clusters from the case study of the Pangyo Techno Valley. We can suggest that innovation policy from the results of innovation performance by applied configuration factors for evaluation of innovation cluster in order to enhance and facilitate for innovation cluster. Also, this study can provide lessons for regional policy implementation and new cluster policy agenda in Korea.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.34-34
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• 2018

천연물 산업은 과학적 기술력이 요구되는 고부가가치 산업으로 건강기능식품 등의 원료 산업으로 각광받고 있다. 최근 친환경, 지속가능성에 대한 관심 증가로 천연물 제품에 대한 수요가 증가되고 있으며 고령화 사회 진입과 건강에 대한 의식 수준 상승으로 전세계 건강기능 식품 시장 확대 추세에 있다. 생물자원의 70%이상을 수입에 의존하고 있는 우리나라는 천연물 산업의 경쟁력 확보와 고부가가치화 실현을 위해 천연물 산업 육성 촉진이 필요하다. 또한 지역 균형발전 측면에서 신성장동력 마련 및 국가 차원의 형평성을 고려한 전략적 투자가 필요한 시점에서 천연물 관련 산업의 신성장동력화를 통해 지역의 한계점 등을 개선하고, 새로운 먹거리 발굴과 함께 지역 전략산업으로 육성이 필요하다. 제천의 특화산업업인 한방천연물산업의 고도화와 활성화를 위해 영세한 스타트업 및 중소기업의 연구 및 제품개발을 지원하기 위한 인프라와 산업 클러스터 조성이 요구되고 있다. 제천은 풍부한 한약재 생산지를 보유하고 있어 전체 면적의 50% 이상이 석회암 지대로 알칼리성 토양이 넓게 분포되어 있고, 토양의 양분이 풍부하며 해발고도 250m 이상의 준산간 지역에서 주로 재배가 이루어지고 있어, 배수가 양호하고 병충해가 적어 한약재의 친환경 재배 및 다년생 한약재 재배가 가능한 지역이다. 이러한 천연물 산업을 육성하기 위하여 산업통상자원부, 충청북도, 제천시, (재)충북테크노파크는 180억원의 사업비로 '글로벌 천연물 원료제조거점시설'을 구축하여 규격화된 천연물 원료공급 시스템을 갖추었으며 150억원을 투자하여 '천연물 조직배양 상용화 시설'을 건립 중에 있다. 또한 향후에는 천연물 클러스터 가치 사슬의 완성형으로 160억 상당의 '천연물 제제개발 생산시설' 사업을 기획하고 있어 장차 대한민국의 천연물 산업을 앞장서 견인할 것으로 예상 된다.

• Journal of Life Science
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• v.31 no.6
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• pp.550-558
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• 2021

Fructus Corni, the fruit of Cornus officinalis, has long been used for the prevention and treatment of various diseases. We recently suggested that it was effective against benign prostatic hyperplasia (BPH). In this study, we investigated the inhibitory effect of Corni Fructus (CF) water extract on BPH induced by testosterone propionate (TP) in noncastrated and castrated animal models. BPH was induced in Sprague Dawley rats by an intramuscular injection of TP in castrated or noncastrated rats. Finasteride (FINA) treatment was used as a positive control for inhibition of BPH. According to our results, CF administration inhibited excessive enlargement of development of the prostate in both the noncastrated and castrated groups compared to the control and FINA-treated groups. The inhibitory effect of CF on BPH was associated with inhibition of expression of hypoxia-inducible factor-1α, 5α-reductase type 2, steroid receptor coactivator-1, androgen receptor (AR), and prostate-specific antigen. Serum levels of the stress hormone cortisol increased during BPH induction by TP in both the noncastrated and castrated groups, but they were attenuated significantly by CF administration. However, insulin and IGF-1 levels were not increased in the BPH-induced groups and CF, and no effective results were found by CF administration. These results point to a beneficial effect of CF on BPH through inhibition of AR signaling pathway activity and imply that CF shows excellent potential as a therapeutic agent for the prevention and treatment of BPH.