• Journal of Life Science
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• v.27 no.8
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• pp.879-887
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• 2017

It is well established that brain-derived neurotrophic factor (BDNF) is expressed not only in the brain but also in skeletal muscle, and is required for normal neuromuscular system function. Histone deacetylases (HDACs) and insulin-like growth factor-I (IGF-I) are potent regulators of skeletal muscle myogenesis and muscle gene expression, but the mechanisms of HDAC and IGF-I in skeletal muscle-derived BDNF expression have not been examined. In this study, we examined the effect of IGF-I and suberoylanilide hydroxamic acid (SAHA), a pan-HDAC inhibitor, on BDNF induction. Proliferating or differentiating C2C12 skeletal muscle cells were treated with increasing concentrations (0-50 ng/ml) of IGF-I in the absence or presence of $5{\mu}M$ SAHA for various time periods (3-24 hr). Treatment of C2C12 cells with IGF-I resulted in a dose- and time-dependent decrease in BDNF mRNA expression. However, inhibition of HDAC led to a significant increase in the expression of BDNF mRNA levels. In addition, immunocytochemistry revealed high BDNF protein levels in undifferentiated C2C12 skeletal muscle cells, whether untreated, IGF-I-treated, or exposed to SAHA. These results represent the first evidence that IGF-I can suppress the mRNA and protein expression of BDNF; conversely, SAHA attenuates the effects of IGF-I. Consequently, SAHA upregulates BDNF expression in C2C12 skeletal muscle cells.

• Archives of design research
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• v.17 no.3
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• pp.343-352
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• 2004

Under the production system of a free market economy, the modern consumers'goods that feature current trends reveal diverse aspects of the whole society and culture. This phenomenon is progressing at such a rapid speed that theories can barely keep up to explain it dearly. It is believed that the reason for the lag in academic theories is the formation of pluralistic values in human lifestyles due to the development of science and information communication. The pluralism of values in contemporary society is being studied in many academic fields, and the design among these fields often sees such a phenomenon as one of the post-modernism concepts, where post-modernism suggests a diversification and dismantling of modernism. In other words, the current design is closely watching products that are totally different from existing products, from complex and conceptual outcomes in the field of design to products that reflect various trends. Thus, it is true that package design, which proactively reflects current trends, freely traverses among specific domains of various fields that have been determined tacitly. It is also believed that other fields are also reflecting the same developments. Such a phenomenon is strikingly revealed with so-called 'fancy products', while other products 'parody' package design. This study sees the phenomenon as dismantling the border between product design and package design. The examined package design reflects the broader characteristics of the times, based on current concepts and meanings, after reviewing design examples.

• Korean Journal of Social Welfare Studies
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• v.44 no.1
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• pp.267-302
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• 2013

In recent years, partnership has become a central strategy for welfare provision worldwide. Particularly, civil society organisations have obtained considerable attention as the most accountable and democratic partner for public welfare delivery. Yet the mainstreaming of civil society into welfare policies challenges the conventional nature of civil society as an independent sector, and brings into critical question, how the political position of the civil society sector could be redefined in the new era of multi-sectoral partnership. The purpose of this study is to explore the current debates of state-civil society partnership and to propose three theoretical viewpoints (i.e. the mainstream, critical and alternative perspectives) regarding the role of the civil society sector in partnership. In doing so, this article introduces the key literature and scholars in partnership debates and provides analytical frameworks that researchers can use in examining state-civil society partnership cases.

• Trans-
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• v.11
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• pp.65-95
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• 2021

Grotesque, which has often emerged as a breakthrough in Western art to protest rational and classical pure beauty, is often seen in modern art. Grotesque, along with the concept of pendulum, appears in infinitely expanded forms across cultures, arts, and society. In particular, transformed body images through deformatization and deformatization of the body are interpreted as strong rejections that seek to break away from formalized beauty. The main purpose of this study is how the body reproduced through body deformation, distortion, and bonding in Dimitris Papaioannou's work can be interpreted within the grotesque category. To this end, he examines the Grotesque discourse and modern meaning underlying the interpretation of the work and identifies how the fragmented and expanding body, which is currently actively discussed in the dance world, has an interaction with Grotesque. It selects , , , and , which are the main attributes of the grotesque, focus on conflicting familiarity, life, hatred, and beauty. Based on this, we would like to confirm that in contemporary dance, the reconstructed body reveals concealed things rather than expressing an unrealistic fictional world, and seeks new possibilities beyond boundaries as well as reconsider existing aesthetic views.

• The Korean Journal of Pesticide Science
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• v.4 no.2
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• pp.29-31
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• 2000

New convenient and economical synthesis of 5,6-dihydro-2-methyl-1,4-oxathiin-3-carboxanilide 1 and the plausible reaction mechanism were described. Reaction of ${\alpha}$-chloroacetoacetanilide 4 (1 molar equivalent) with 2-mercaptoethanol (1.2 molar equivalent) in the presence of p-toluenesulfonic acid monohydrate (0.05 molar equivalent) as a catalyst in refluxing toluene with water trap yielded carboxin 1. The proposed mechanism is that ${\alpha}$-chloro 1,3-oxathiolane 8 which is a heuithioketal of 4 was converted to unisolable sulfonium ion 9 through neighboring group participation of sulfur followed by rearrangement to more stable oxonium ion 12 and then release acidic proton to produce the carboxin 1.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.1
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• pp.69-77
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• 2005

To optimize and limit the axial length of the baffle of the KSR-III engine, stability rating tests using pulse gun as one of artificial disturbance devices have been done. Generally a rocket engine can be considered to be dynamically stable if a certain imposed external perturbation or pressure oscillation in rocket combustion chamber could be suppressed within a short time period. Decay time and other parameters for the evaluation of stabilization ability of an engine to external perturbation have been analyzed to quantify stabilization capacity of engine, in other words, dynamic stability margin. Baffle not covering flame zone enough which can be considered as collision region of injector wasn't be able to suppress external perturbation sufficiently. The limit of combustion stability margin of engine is assumed to be 50 mm length baffle of the KSR-III engine.

• Korean Journal of Social Welfare
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• v.63 no.1
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• pp.85-111
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• 2011

This study has the purpose to measure the multidimensional poverty in Korea by the counting approach which was theorized by Alkire and Foster to overcome problems of unidimensional approach, union method and intersection method for the identification of the multidimensional poor. By the counting approach applying to Welfare Panel in Korea during 2006-2008, the head-count ratio of the multidimensional poverty was measured. When 3 dimensions are applied as a dimension poverty line, the multidimensional poverty rate was 20% in 2008. It was due to broad deprivations in assets, social securities, income and health. Vulnerable classes such as single parent families, low-education level group, the aged, economically non-active population were among the severe poverty rates, which were reaching around 50%. The analysis reveals the possible alternative to change the present public assistance program to the robust approach of multidimensional poverty measurement, the counting approach. Social policies to reduce poverty in Korea would gain expected positive outcome with the various approaches based on the concepts of multidimensional poverty.

• Journal of the Korean association of regional geographers
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• v.22 no.2
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• pp.331-352
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• 2016

This paper pays attention to the fact that not only Gangnam but also cities outside Seoul that attempt to follow the Gangnam model are deeply involved in Korean developmental urbanism. It examines discursive materials such as newspaper articles, newspaper advertisements and online debates as significant sources of information showing how certain districts are materially and discursively constructed by diverse actors in the national capital and in other cities. The result of in-depth interviews lasting up to two hours reveals local residents' imagined geographies. The article emphasizes that the so-called "Gangnam problem" should be understood as existing beyond the physical, symbolic and administrative boundaries of Gangnam, in cities that follow the Gangnam model. This study helps to provide an epistemological foundation for more equitable, sustainable and de-developmental urbanism.

• The Research Journal of the Costume Culture
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• v.27 no.4
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• pp.310-322
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• 2019

Since the late 2000s, fashion exhibitions have expanded to encompass a variety of concepts and sizes, and the need for research on exhibition planning, installation, and direction, including curating, is emerging. In this context, basic research is deemed necessary to encourage more experimental and in-depth research into the planning and orientation of domestic fashion exhibitions. Accordingly, by analyzing the exhibitions of Judith Clark, a pioneering fashion curator, and fashion exhibition planner, the aim of this study is to examine the characteristics and directing points of her curation. This study proceeds as follows: first, the concept and type of fashion exhibition and curation are investigated. Second, the exhibition cases curated or produced and installed by Judith Clark are examined and analyzed. Finally, based on this analysis, the characteristics and directing points of her curation are identified. In exhibitions, Clark's directing style features use of a variety of objects, the diversification of the flow-path through space division, and collaborations with various fields or experts. Clark's curation points, based on such characteristics, are as follows: reproduction-oriented curation to capture the age of the time based on historical research; storytelling-based curation; and transboundary curation with multiple methods and open processes. This study is expected to serve as a foundation and precedent that will lead to further research on fashion exhibitions and implementation.

• Journal of the Korea Convergence Society
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• v.13 no.4
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• pp.227-232
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• 2022

This thesis studies and analyzes the performative expression and meaning of ceramic performance art in the diversifying contemporary ceramic art. Therefore, after analyzing the ceramic performance works of Miquel Barcelό, Josef Nadj, Kang-hyo Lee, Teri Frame, and J. J. McCracken, I tried to find out the performativity and effectiveness of the performance. As a result of the study, the ceramic performance shows the expandability beyond the expression form and production process shown in general ceramic artworks through physical actions using clay. In addition, the real-time performance of the actor is a process embodiment of creating an event, and the open structure in which the artist and the audience relate to each other enables interpretation and understanding in a different way than before. Convergence attempts with other media imply borderlessness in contemporary ceramics and show the possibility of expanding into new field. This is expected to have a positive impact that breaks the ideological frame of the ceramic arts field, which has strong craft characteristics.