• Journal of agriculture & life science
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• v.53 no.4
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• pp.55-59
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• 2019

Hanwoo has improved the quality of carcass traits. Especially, the higher the grade, the better the texture and taste of Hanwoo. One of the many factors that determine consumer preferences in food is the flavor. The flavor of food is expressed through heat treatment, and fat, carbohydrate and water-soluble compound are important ingredients for flavor. Therefore, The purpose of this study was to investigate the characteristics of fatty acids and carcass traits of 373 Hanwoos. The oleic acid (C18:1) and linolenic acid (C18:3) contents were 48.08% and 0.11%, respectively, while the carcass weight, Eye muscle area, back fat thickness and marbling score of the carcass trait were 383.73 kg, 83.88 ㎠, 10.91 mm, 3.89, respectively. The heritability of oleic acid was estimated to be 0.726, and the phenotypic correlation between eye muscle area and marbling score was estimated to be 0.105 and 0.141, respectively. The phenotype of the marbling score and eye muscle area were positively correlated with Oleic acid. Therefore, the improvement of these two traits seems to affect the increase of unsaturated fatty acid content.

• Journal of Life Science
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• v.34 no.3
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• pp.170-178
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• 2024

Adipose-derived stem cells (ADSCs) are capable of differentiation into multiple lineages of cells, which has attracted attention for clinical therapy. However, ADSCs have poor proliferation capacity and a short life span in culture, which is an impediment in the application to clinical use. Previously, to overcome growth disadvantages, we had established an immortalized ADSC line (ADSC-T) by introducing the SV40 T antigen coding gene into primary human ADSC. In the present study, we evaluated the differentiation potential of this cell line and assessed the anti-inflammatory effect of its conditioned medium (CM). ADSC-T appeared to maintain the differentiation potential into adipocyte and chondrocyte. The CM of ADSC-T suppressed the NF-κB activity and its target gene expression of COX-2 and iNOS. Furthermore, the phosphorylations of MAPKs, including ERK, JNK and p38, were suppressed by the ADSC-T CM. The expressions of pro-inflammatory cytokines such as TGF-β, TNF-α, IL-6, and IL-13 were also suppressed by the CM of ADSC-T. In the Nc/Nga atopic model mice, the CM showed therapeutic effect on DNCB-induced atopic dermatitis. These results indicate that the immortalized ADSC-T maintains the beneficial properties of primary ADSC and could be a versatile cell source for not only research into ADSC but also for production of CM suitable for clinical application.

• Journal of Industrial Convergence
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• v.19 no.1
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• pp.137-146
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• 2021

In This study investigated the effects of various intensity cycling exercise on body composition, blood lipids and fat metabolism in obese middle-aged women. 17 people obesity middle - aged women aged 35 to 55 years were divided into 3 groups: 5 people in the low intensity group, 6 people in the medium intensity group, and 6 people in the high intensity group. The object of this study was to compare the effect of cycle exercise performed between 20 ~ 50 minutes per a day,1 3 day times per week on the body composition, lipid profile and lipid metabolism of obesity middle - aged women. There was not substantial difference in body construction between groups. in blood lipid changes, there was a substantial difference in glucose between groups, There was not substantial difference between groups in the change of fat metabolism. In addition, there was not substantial difference in the interaction effect between time and time × group. It is expected that the results of this study will be used as basic data for related field.

• Journal of Life Science
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• v.32 no.12
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• pp.979-988
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• 2022

Halophytes have been reported to possess a variety of physiological activities, such as anti-cancer, anti-oxidant, anti-diabetes, anti-inflammatory, and anti-obesity. Studies on the roots of the halophyte Rosa rugosa, in particular, have shown a variety of physiological activities and are known to be effective for nursing diabetic complications in traditional Korean medicine. In this study, the effect of R. rugosa on adipogenesis was investigated in 3T3-L1 pre-adipocytes treated with crude extract and solvent fractions (H₂O, n-BuOH, 85% aq. MeOH, and n-Hex) obtained from R. rugosa roots. Treatment with extract and the solvent fractions inhibited the formation of intracellular lipid droplets in differentiated 3T3-L1 adipocytes compared to the untreated group. In particular, n-BuOH and 85% aq. MeOH fractions effectively decreased the expression of adipogenic transcription factors: peroxisome proliferator activated receptor-γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), and sterol regulatory element-binding protein 1c (SREBP1c) in both mRNA and protein levels. In conclusion, these results suggest that R. rugosa contains anti-adipogenic molecules that can be utilized as a nutraceutical against obesity. Further refining of n-BuOH and 85% aq. MeOH fractions and analysis of their action mechanisms could yield potential therapeutic agents with anti-adipogenic effects.

• Journal of the Korea Convergence Society
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• v.9 no.11
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• pp.345-351
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• 2018

This study was conducted to explain the capacity building policy of local public officials. Especially, it is to derive the policy task that can increase the efficiency within the limit of limited resources. The results of the study are as follows. First, local government officials' job management was the most important policy task in the largest framework to strengthen the capacity of local public officials. Next, the evaluation was in the order of recruitment management of local public officials and personnel management of local public officials. Second, the results of the evaluation of detailed policies. Among the local government officials 'job management, the introduction of the local government officials' rest period was evaluated as the most important. Regarding recruitment management of local public officials, reform of the public official exam courses was evaluated as the most important. In the personnel management of the local public officials, the job training of the elected officials was the most important. The results of this study will help to explain the policy development for strengthening the capacity of local public officials in realistic aspect. In order to strengthen the capacity of local public servants in future, it is necessary to analyze the measurement variables more.

• Journal of the Korean Regional Science Association
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• v.40 no.1
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• pp.37-51
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• 2024

To respond to local extinction, South Korea, under the leadership of the Ministry of the Interior and Safety, identified depopulated areas in 2021 and launched the Local Extinction Response Fund in 2022. However, due to its early stage of implementation, analyzing the characteristics and changes of policy response to local extinction at the central government level remains a challenge. In contrast, Japan, facing similar issues of local extinction as South Korea, has established a robust central government-led response system based on the Regional Revitalization Act and the Comprehensive Strategy and Basic Policy on Community-Population-Job Creation. Hence, this study examines Japan's policy responses to local extinction by analyzing the first and second periods of the Comprehensive Strategy and Basic Policy on Community-Population-Job Creation. For the analysis, topic modeling was employed to enhance text analysis efficiency and accuracy, complemented by expert interviews for validation. The results revealed that the first-period strategy's topics encompassed economy and society, start-up, local government, living condition, service, and industry. Meanwhile, the second-period strategy's topics included resource, the New Normal, woman, digital transformation, industry, region, public-private partnership, and population. The analysis highlights that the policy target, policy direction, and environmental change significantly influenced these policy shifts.

• Journal of Life Science
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• v.29 no.3
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• pp.332-336
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• 2019

Obesity is associated with an increased risk of many diseases including type 2 diabetes mellitus, hypertension, and hyperlipidemia. The flowers of Chrysanthemum boreale have been used as traditional medicines for the treatment of diseases such as obesity and type 2 diabetes mellitus. This study aimed to evaluate the effect of C. boreale Makino flower essential oil (CFEO) on adipocyte differentiation using preadipocyte cell line 3T3-L1. CFEO at concentrations between 0.1 and $5{\mu}g/ml$ did not affect 3T3-L1 cell viability. A CFEO concentration of between 0.1 and $1{\mu}g/ml$ significantly inhibited lipid accumulation during MDI-induced differentiation in 3T3-L1 cells in a dose-dependent manner, reaching a maximal level at $1{\mu}g/ml$ ($28.94{\pm}2.01%$; approximately 30% of control treated with MDI alone). Western blot analysis revealed that CFEO concentrations between 0.1 and $1{\mu}g/ml$ suppressed the activations of three adipogenic transcription factors in the MDI-stimulated 3T3-L1 cells: peroxisome proliferator-activated receptor ${\gamma}$; CCATT/enhancer binding protein ${\alpha}$; and sterol regulatory element binding protein-1. Moreover, the expressions of lipogenic enzymes, acetyl-CoA carboxylase, and fatty acid synthase were also inhibited by treatment with CFEO between 0.1 and $1{\mu}g/ml$. CFEO may therefore be a promising functional material for obesity prevention.

• Proceedings of the Korea Information Processing Society Conference
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• 2012.04a
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• pp.1125-1127
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• 2012

오늘날의 지역축제는 역사적, 문화적, 지역적 특징을 기반으로 하여 기획된 다양한 축제가 지방 곳곳에서 개최되고 있다. 이에 따라 각 지방자치단체들은 지역경쟁력을 강화하고 활성화하기 위한 방안으로 지역축제를 적극 활용하고 있다. 우리나라의 지역축제 중에도 그 지역의 문화컨텐츠와 상관없이 획일화된 축제내용과 진행, 홍보 노력의 부족 등으로 축제의 가치를 발휘하지 못하고 있는 실정이다. 본 논문에서는 오늘날 대부분의 축제 예매 관리시스템이 현장예매와 인터넷으로만 이루어지고 있는 단점을 보완하여 지방자치단체나 백화점, 대형마트 등에서도 홍보 및 예매를 할 수 있도록 지능형 예매 시스템을 구현하기 위한 요구분석 내용을 기술한다.

• Journal of Clinical Otolaryngology Head and Neck Surgery
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• v.29 no.2
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• pp.295-300
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• 2018

Pleomorphic liposarcoma is extremely rare in the head and neck region. It can be diagnosed by identifying multivacuolated lipoblast with pleomorphism. Most studies have reported that pleomorphic liposarcoma shows an aggressive behavior with poor prognosis. The treatment of choice is wide resection to ensure negative margin. The authors report a case of pleomorphic liposarcoma in a 67-year-old female, who was treated with primary resection of tumor and postoperative radiation therapy. The patient is well without any recurrence or metastasis after 1 year of follow-up.

• 한국벤처창업학회:학술대회논문집
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• 2019.04a
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• pp.91-96
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• 2019

창업지원시설은 창업의 성공가능성을 높이기 위해 지방자치단체에서 시설과 공간, 교육프로그램 등을 제공하는 것으로 경영, 기술분야 등에 대한 지원을 목적으로 하는 사업장을 의미한다. 많은 지방자치단체에서 이러한 시설을 관련 법령에 따라 꾸준히 개설중이며, A시도 또한 2005년부터 관련 시설을 개설하였다. 본 연구는 국내 A시의 창업지원시설의 문제점을 구조적 문제와 관리상의 문제로 구분하여 조사하고, 그에 대한 해결방안을 각각 제시하였다. 구조적 문제로는 시설의 기능 중복 등이 부족하였으며 관리상 문제로는 외부 민간의 투자 연계와 담당 매니저들의 전문성 등이 한계로 나타났다. 이에 대한 해결을 위하여 A시 창업지원시설의 구조적인 재구조화와 관리상 문제에 대한 해결을 제시하였다.