• Tuberculosis and Respiratory Diseases
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• v.53 no.6
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• pp.656-661
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• 2002

Amidarone is one of the most commonly prescribed anti-arrythmic agents for almost all arrythmias, whether atrial or ventricular in origin. There are several side effects associated with amiodarone therapy. These include corneal deposits, abnormal liver function tests, hyper and hypothyroidism, bluish discolorations of the skin, bone marrow suppression, coagulopathies, peripheral neuropathies, and pulmonary toxicity. Amiodarone-induced pulmonary toxicity(APT), which was first described in 1980, is potentially serious side effects that are believed to develop in 5% of patients. Doctors often assume that APT occurs only when high amiodarone doses are used for a long time, but in practice a low maintenance dose of amiodarone may also be toxic. In this report, a case of amiodarone-induced pulmonary toxicity after a long course of a low dose therapy for refractory supraventricular arrythmia is described.

• Polymer(Korea)
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• v.37 no.4
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• pp.478-485
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• 2013

In this study, hydrogels with fast swelling and high absorbent properties were prepared using biopolymers approved as a food additive and their swelling properties were characterized. To improve the swelling properties of conventional hydrogels, we formed gas bubbles using a foaming agent in the process of preparing hydrogels and characterized in terms of equilibrium swelling ratio, swelling kinetics and cytotoxicity. In particular, alginate hydrogels observed by a digital microscope have an open-pore channels structure with the sizes of hundreds micrometers. Also, the cell viability of all hydrogels were found to be much higher than that of poly(acrylic acid).

• Journal of the Korean Society of Propulsion Engineers
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• v.24 no.4
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• pp.79-88
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• 2020

Hypergolic propellants have been widely used for space propulsion systems based their long-term storability and high ignition reliability. Since conventional hypergolic propellants are highly toxic and carcinogenic, handling and operating costs are significant. To overcome the drawbacks, numerous studies have been actively performed to develope new hypergolic propellants, ensuring that the combinations are high performance, low toxicity and low environmental impact. In the present study, a comprehensive survey was conducted to summarize the research and development of green hypergolic propellants involving hydrogen peroxide, nitric acid, and ionic liquids.

• Clinical and Experimental Pediatrics
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• v.45 no.8
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• pp.1048-1051
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• 2002

Toxic shock syndrome(TSS) is clinically similar to Kawasaki disease(KD) in that both of them are characterized by fever, desquamating rash and mucous membrane erythema. In contrast the main feature of TSS is hypotension, whereas the complication of KD is coronary vasculitis. We report an 8-year-old boy who fulfilled the crireria for TSS and KD. Initially he showed clinical features of TSS, so he was treated with intravenous antibiotics and supportive management. But the fever sustained, and the coronary aneurysm that is the main complication of Kawasaki disease was shown by echocardiogram on Day 14. He was treated with intravenous immunoglobulin twice and the fever subsided and general condition was improved.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.31 no.6
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• pp.817-822
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• 1998

The biweekly monitoring of paralytic shellfish toxin on wild mussels (Mytilus corsucus) was carried out at Jangmok Bay, near Koje Island from Feb, 1996 to Feb. 1997. Toxicity and toxin composition were monitored by means of the mouse bioassay and HPLC. Paralytic shellfish toxin was detected from 27 March to 27 May and 28 November. This is the first record of paralytic shellfish toxin during autumn in Korean waters. Toxin composition between the two different season was similar and was composed of 5$\~$8 toxin fractions as GTXs STXs and PXs. The major toxin component in affected musssels shifted from GTXs in spring to PXs in autumn.

• Polymer(Korea)
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• v.31 no.5
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• pp.454-459
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• 2007

Gene therapy using low molecular weight water soluble chitosan (LMWSC) as polycationic polymer shows good biocompatibility, but low transfection efficiency. The mechanism of folic acid (FA) uptake in the cells to promote targeting and internalization could improve transfection rates. The objective of this study was to synthesize and characterize the WSCFA-DNA complex and evaluate their cytotoxicity, in vitro. In $^1H-NMR$ spectra, specific peaks appeared both of FA and LMWSC in $D_2O$. WSCFA nanoparticles have spherical shapes with particle size show below 110 nm. In the cell cytotoxicity test, the WSCFA-DNA complex showed high cell viability, in vitro. Gel electrophoresis showed condensed DNA within the carriers. hi vitro transfection efficiency was assayed by fluorescence spectroscopy WSCFA nanoparticles have less cytotoxicity, good DNA condensation and particle size around 110 nm, which makes them a promising candidate as a non-viral gene vector.

• Journal of the Korean Institute of Gas
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• v.21 no.4
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• pp.6-15
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• 2017

Process safety management(PSM) system was implemented in Korea since 1996. It helps reduce and prevent the occurrence of chemical accidents. There has been no review on the feasibility of the threshold quantities of the existing 21 species and the newly added toxic substances such as hydrogen bromide in the PSM system. The threshold quantities of the target toxic substances(25 species) of PSM were compared with domestic and foreign PSM systems similar to those of Korea. Also, we proposed the toxic harmfulness and hazard equation consisted of inhalation toxicity, NFPA index and others. According to this equation, high risk, medium risk and low risk are classified and reflected in the adjustment of threshold quantities. From the above research, It is expected to help to reduce confusion and burden of the workplaces due to the difference from other PSM system and improve in the threshold quantities.

• Korean Journal of Food Science and Technology
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• v.43 no.5
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• pp.641-647
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• 2011

Polyphenols in green tea are biologically active and may interact with commonly-consumed over-the-counter (OTC) drugs in the body. In this study, modulation of cytotoxicity of polyphenon 60 (PPE, tea polyphenol mixture) with co-treatment of several OTC drugs, including ibuprofen (Ibu), acetaminophen (AAP), and aspirin was investigated in intestinal cells. PPE showed more potent cytotoxic effects on colon cancer HCT 116 cells than on normal intestinal INT 407 cells. Ibu had the strongest cytotoxic effects on both cell types. Cytotoxicity of PPE on HCT 116 and INT 407 cells was not markedly altered by co-treated OTC drugs. Cytotoxicity of the OTC drugs was not affected by PPE. When HCT 116 cells were incubated with AAP before or after PPE treatment, cytotoxicity was slightly enhanced more than their additive effect. The present study may provide basic information of possible toxicity due to interaction of the polyphenols and the OTC drugs.

• Journal of Life Science
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• v.16 no.1
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• pp.108-113
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• 2006

To compensate the problems of chemical assay in detoxification of recalcitrant and a practical approach in selection of bioremediation bacteria, a simple and rapid toxicity evaluation system was constructed based on Lumbricus rubellus. Long term-culture and specific equipment are not necessary, and semi-quantitative analysis of toxicity at sub-lethal concentration is possible by measuring of dose-dependent increased yellowish secreted compounds. When the toxicity of endosulfan, its metabolites and structurally related chemicals were measured for 24 h, the results were coincided with previous reports. Toxicity was found in endosulfan, endosulfan sulfate, aldrin, and dieldrin, respectively. Rapid and economic selection of endosulfan-detoxifying bacteria was possible using our system. Klebsiella pneumoniae KE-1, K. oxytoca KE-8 and Pseudomonas sp. KS-2P, reported endosulfan degrading bacteria, ameliorated the endosulfan toxicity, whereas E. coli, B. subtilis and other bacteria failed to protect the toxicity of endosulfan in L. rubellus. Our results suggest that the constructed system is useful to selection of microorganism as well as toxicity evaluation against toxic recalcitrants.

• The Korean Journal of Pesticide Science
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• v.19 no.4
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• pp.418-423
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• 2015

Effects of 9 acaricides to the predatory mite, Neoseiulus californicus were evaluated. Seven of the acaricides tested, cyenopyrafen. spirodiclofen, spiromesifen, acequinocyl, bifenazate, flufenoxuron and cyflumetofen exhibited low toxicity to adult females and nymphs of N. californicus and had little effect on the reproduction and eclosion of eggs deposited by treated predators. Moreover, hatch percentage of N. californicus eggs was unaffected by exposure to these seven acaricides. Etoxazole did not significantly affect the survival and reproduction of adult female predators but caused very low eclosion in eggs laid by treated females and high egg mortality. Pyraclofos was extremely toxic to adult female predators and caused 100% mortality. Adult female predators survived on a diet of spider mites treated with cyenopyrafen. spirodiclofen, spiromesifen, acequinocyl, bifenazate, flufenoxuron and cyflumetofen and their fecundity was not substantially affected. Based on the results, cyenopyrafen. spirodiclofen, spiromesifen, acequinocyl, bifenazate, flufenoxuron and cyflumetofen are appeared to be promising candidates for use in integrated mite management program where N. californicus is the major natural enemy.