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A Case of Amiodarone-Induced Pulmonary Toxicity After a Long Course of a Low Dose Therapy  

Ryu, Jung-Il (Department of Internal Medicine, College of Medicine, Catholic University of Daegu)
Lee, Wan-Suk (Department of Internal Medicine, College of Medicine, Catholic University of Daegu)
Hyun, Dae-Sung (Department of Internal Medicine, College of Medicine, Catholic University of Daegu)
Lee, Sang-Chae (Department of Internal Medicine, College of Medicine, Catholic University of Daegu)
Shin, Tae-Rim (Department of Internal Medicine, College of Medicine, Catholic University of Daegu)
Publication Information
Tuberculosis and Respiratory Diseases / v.53, no.6, 2002 , pp. 656-661 More about this Journal
Abstract
Amidarone is one of the most commonly prescribed anti-arrythmic agents for almost all arrythmias, whether atrial or ventricular in origin. There are several side effects associated with amiodarone therapy. These include corneal deposits, abnormal liver function tests, hyper and hypothyroidism, bluish discolorations of the skin, bone marrow suppression, coagulopathies, peripheral neuropathies, and pulmonary toxicity. Amiodarone-induced pulmonary toxicity(APT), which was first described in 1980, is potentially serious side effects that are believed to develop in 5% of patients. Doctors often assume that APT occurs only when high amiodarone doses are used for a long time, but in practice a low maintenance dose of amiodarone may also be toxic. In this report, a case of amiodarone-induced pulmonary toxicity after a long course of a low dose therapy for refractory supraventricular arrythmia is described.
Keywords
Amiodarone; Pulmonary toxicity;
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