Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Amiodarone-Induced Pulmonary Toxicity After a Long Course of a Low Dose Therapy

장기간 사용한 저용량 Amiodarone에 의한 폐독성 1예

  • Ryu, Jung-Il (Department of Internal Medicine, College of Medicine, Catholic University of Daegu) ;
  • Lee, Wan-Suk (Department of Internal Medicine, College of Medicine, Catholic University of Daegu) ;
  • Hyun, Dae-Sung (Department of Internal Medicine, College of Medicine, Catholic University of Daegu) ;
  • Lee, Sang-Chae (Department of Internal Medicine, College of Medicine, Catholic University of Daegu) ;
  • Shin, Tae-Rim (Department of Internal Medicine, College of Medicine, Catholic University of Daegu)
  • 류정일 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 이완석 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 현대성 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 이상채 (대구가톨릭대학교 의과대학 내과학교실) ;
  • 신태림 (대구가톨릭대학교 의과대학 내과학교실)
  • Published : 2002.12.30
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Abstract

Amidarone is one of the most commonly prescribed anti-arrythmic agents for almost all arrythmias, whether atrial or ventricular in origin. There are several side effects associated with amiodarone therapy. These include corneal deposits, abnormal liver function tests, hyper and hypothyroidism, bluish discolorations of the skin, bone marrow suppression, coagulopathies, peripheral neuropathies, and pulmonary toxicity. Amiodarone-induced pulmonary toxicity(APT), which was first described in 1980, is potentially serious side effects that are believed to develop in 5% of patients. Doctors often assume that APT occurs only when high amiodarone doses are used for a long time, but in practice a low maintenance dose of amiodarone may also be toxic. In this report, a case of amiodarone-induced pulmonary toxicity after a long course of a low dose therapy for refractory supraventricular arrythmia is described.

저자들은 불응성 상심실성 빈맥으로 저용량 amiodarone을 장기간 사용한 환자에서 발생한 폐독성을 경험하고 적절히 치료하였기에 이를 보고하는 바이다.

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