• The Korean Journal of Nuclear Medicine
• /
• v.22 no.1
• /
• pp.83-92
• /
• 1988

The cocktails of two $^{131}I$ labeled Monoclonal antibody (MCAB) (Anti CA 19-9 F$(ab')_2$ + Anti CEA $F(ab')_2$ fragment), which react specially, with human gastrointestinal cancers, were administered to 10 patients with colorectal (7), stomach(2) and pancreas(1) cancer for scintigraphic detection. All patients were known or postoperatively recurrent cases, and serum tumor markers, CA 19-9 and CEA, were measured with immunoradiometric assay, just before immunoscintigraphy (ISG). The tumor marker's level in serum is not correlated with positive tumor uptake in ISG. The sensitivity and specificity of ISG in detection of 21 tumor sites, based on surgery, CT, ultrasonography and pathology, were 90.5% and 100% One case of colon cancer showed gall bladder metastasis, which was neglected on CT study. Tumor/non tumor uptake ratio of radiolabelled antibody were progressively increased from day 3 to day 7 during study. We summerized as follows 1) The use of cocktails of CEA and CA 19-9 MCAB $F(at')_2$ increased sensitivity and specificity in ISG. 2) Delayed imaging (later than 5 days) increases sensitivitv and specificity due to exclusion of nonspecific iodine accumulation in stomach and lung. 3) Second tracer technique is essential for anatomical landmark by use of a double isotope scan, but subtraction technique, a possible source of artifacts, is no longer necessory when delayed imaging is performed. 4) It may be possible to use two MCAB cocktails of CA 19-9 and CEA in Radioimmunodetection of stomach and pancreas cancer. In conclusion, ISG using MCAB cocktails, $F(ab')_2$ fragment of anti CA 19-9 and Anti CEA, provide additional opportunity for tumor localization and detection of colorectal and other G-I cancer, such as stomach and pancreas.

• Journal of Plant Biotechnology
• /
• v.32 no.4
• /
• pp.251-256
• /
• 2005

Cytokinins are essential plant hormones that play crucial roles in various aspects of plant growth and development. To better understand the molecular mechanisms of cytokinin action, we identified cytokinin related proteins by a proteomic approach. Proteins extracted from control and trans-zeatin treated Arabidopsis seedlings were separated and analyzed by two dimensional gel analysis. Differentially expressed protein spots were identified with peptide mass fingerprinting based on matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry and database searching, We obtained ten up-regulated and one down-regulated proteins upon t-zeatin treatment. The expression of the following proteins was induced; pollen allergen like protein, L-ascorbate peroxidase, tetrapyrrole methylase family protein, SGT1 protein homolog, disease resistance related protein, maternal embryogenesis control protein, paxneb related protein, gluthathione S-transferase and IAA amino acid hydrolase homolog.

• Korean Journal of Pharmacognosy
• /
• v.37 no.2 s.145
• /
• pp.103-109
• /
• 2006

Advanced glycation end products (AGEs) formation plays an important role in the progression of diabetic complications. To develop effective herbal formulations with suppression of diabetic nephropathy, a common complication in diabetic patients, we evaluated inhibitory activities of KIOM-79, a new herbal prescription, on the formation of AGEs using in vitro and in vivo model systems. Effects of KIOM-79 on the expression of AGEs, RAGEs (receptor for Advanced glycation end products), type IV collagen and renal $TGF-{\beta}1$ mRNA was also examined in streptozotocon (STZ)-induced diabetic rats. STZ-induced diabetic rats were treated orally with KIOM-79 (250 and $500\;kg^{-1}$ once a day for 13 weeks). In vitro system KIOM-79 suppressed the formation of AGEs $(18.12\;{\mu}g/ml)$. In STZ-induced diabetic rats showing accumulation of AGE and RAGE, pathological examination revealed that KIOM-79 prevented AGE and RAGE deposition in the kidney. In STZ induced diabetic rats, the expansion of mesangial matrix and the glomerular tufts seemed to be larger than those in normal rats. Howεver, after administration with KIOM-79, mesangial metrix and glomerular volume were decreased, and overexpression of type IV collagen was also decreased. Overexpression of renal $TGF-{\beta}1$ mRNA was inhibited significantly. These results suggest that the KIOM-79 might be an effective herbal prescription to prevent or alleviate the progression of diabetic nephropathy.

• Horticultural Science & Technology
• /
• v.30 no.6
• /
• pp.673-679
• /
• 2012

This study was conducted to examine the effect of artificial light source and photoperiod on the growth of leaf lettuce (Lactuca sativa L.) 'Seonhong Jeokchukmyeon' in a closed-type plant production system. Seedlings were grown under 3 light sources, fluorescent lamp (FL, Philips Co. Ltd., the Netherlands), WL #1 (Hepas Co. Ltd., Korea), and WL #2 (FC Poibe Co., Ltd., Korea), each with 3 photoperiods, 12/12, 18/6, and 24/0 (Light/Dark). An irradiance spectrum analysis showed that FL has various peaks in the 400-700 nm range, while WL #1 and WL #2 have only one monochromatic peak at 450 and 550 nm, respectively. The greatest plant height, fresh and dry weights were obtained in the 24/0 (Light/Dark) photoperiod. The 24/0 (Light/Dark) photoperiod treatment promoted vegetative growth of the leaf area. Length of the longest root, number of leaves, fresh weight, and total anthocyanin contents were greater in FL than in either WL #1 or #2. The greatest chlorophyll fluorescence (Fv/Fm) was found in the 12/12 (Light/Dark) photoperiod with FL treatment. The energy use efficiency of the LED increased by about 35-46% as compared to FL. Results suggest a possibility of LED being used as a substitute light source for fluorescent lamp for lettuce cultivation in a plant factory system.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.45 no.2
• /
• pp.85-95
• /
• 2009

The fishing lamp is a fishing gear that gathers fish at night. But the cost of oil, which is used to light fishing lamp, has been risen significantly up to 30-40% of total fishing costs. Therefore it is very urgent to develop an energy economical fishing lamp in order to solve the business difficulties of fisheries. Under this background, this research aims at developing a fishing lamp for squid jigging and hairtail angling fishery using the LED, which has excellent energy efficiency and durability. The LED fishing lamp developed can be controlled to fix a fit direction of fish shoal deep because a fishing lamp can be adjustable up and down directions. One unit of fishing lamp has about an 80Watt capacity and the frame of fishing lamp is made of aluminium to emit generated heat of LED to outside. The LED lamp developed was highly durable, only 5.7% of emitting efficiency decreased for 18 months. The illuminance of a unit LED lamp was 2,070lux at 1m and 21lux at 10 m distance, and the intensity of LED lamp system emitted 2,580lux and 400lux at the respective distances. After development of this fishing lamp, 100 units are installed on operating fishing vessels. Experimental results show that energy consumption of squid jigging and hairtail angling was reduced by 40% and 87%, respectively. In conclusion, our methods showed elevated fishing power, compared with traditional fishing method: 37.7% for squid jigging and 24.5% for hairtail angling.

• Korean Journal of Cognitive Science
• /
• v.23 no.4
• /
• pp.517-551
• /
• 2012

We are imitating animals. True imitation can be defined as a learning to do an act from seeing it done by others. We have been building culture by imitating others' skills and knowledge with high fidelity. In this regard, it is important to ask how the faculty of imitation has evolved and how imitation behaviors develop ontogenetically. It is also interesting to see whether nonhuman animals can imitate truly or not and how different imitation learning is among human and non-human animals. In this paper, first I review empirical data from imitation studies with human and nonhuman animals. Comparing different species, I highlight their different levels of copying fidelity and explain the reason why they are showing the difference. Then I review recent studies on neurobiological mechanisms underlying imitation. The initial neurobiological studies on imitation in humans suggested a core imitation circuitry composed of mirror neuron system [inferior parietal lobule(IPL) and inferior frontal gyrus(IFG)] and the posterior part of the superior temporal sulcus(pSTS). More recent studies on the neurobiology of imitation, however, has gone beyond the studies on the core mechanisms. Finally, I try to find out implications of psychology and biology of imitation for cultural evolution. I argue for a memetic approach to cultural evolution, along the lines with a recent study on measuring memes by mirror neurons system.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.17 no.3
• /
• pp.243-248
• /
• 2015

Domestic road and railroad construction have been increasingly growing and for reasons of mitigating traffic congestion, urban plan and refurbishment project, deeper and longer tunnels have been built. The event of fire is the most fatal accident in a tunnel, and it can be very disastrous with a high possibility. In this study, QRA (Quantitative Risk Analysis) which is one of quantitative risk analysis approaches was applied to tunnel fire safety design and the evaluation of QRA cases and the cost comparison of QRA methods were carried out. In addition analysis of risk reduction effect of tunnel fire safety system was conducted using AHP (Analytic Hierarchy Process) and the priority of major factors that could mitigate the risk in tunnel fire was presented. As a result, significant cost reduction effect could be obtained by incorporating QRA and it is expected to design fire safety system rationally. The priority of fire safety system based on risk mitigation effect by fire safety system considering the cost is in order of water pipe, emergency lighting, evacuation passage and smoke control system.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.21 no.6
• /
• pp.749-762
• /
• 2019

In recent years, in urban areas, underground of roads are being promoted in order to resolve traffic congestion and to secure green spaces, and due to the low ratio of large vehicles, they are planned or constructed as road tunnels for small cars only. In addition, the tunnels being built in the city is a tendency to be enlarged to play the role of main roads. Accordingly, the capacity of the ventilation system is increasing and various ventilation methods are required, and the importance of maintenance after the completion of the tunnel such as the operating cost of the ventilation system is emphasized. Therefore, the need for optimization of the operation stage for reducing the power consumption of the ventilation system and the study of the ventilation system operation control logic is increasing. In this study, the study on the necessity of the optimization of operation stage and control logic of the ventilation system was carried out to realize the energy-saving operation for the small car only passing through tunnels which is applied of ① jet fan and combination ventilation system (② jet fan + air purifying equipment, ③ jet fan + vertical shaft, ④ jet fan + supply air semi-transverse). As a result of this study, there can be various operating combinations in the case of the combined ventilation system, and even though the amount of ventilation air is the same, the operating power varies greatly according to the operating combinations. It was found that operating the axial fan first rather than the jet fan first operation method has an effect on power saving.

• The Journal of the Korea Contents Association
• /
• v.16 no.10
• /
• pp.435-442
• /
• 2016

Obesity extends the global economic burden and it causes that the failure of a reduction of physical activity, and diet management. In this work, nutritional information and personalized diet based on calorie supply system and is discriminatory utilized the obesity-related SNP information in order to recommend a personalized functional foods. This study performed a GWAS analysis for the excavation of a Korean-specific and obesity-related SNP, which utilizes genetic information were recommended by entering a personalized diet in accordance with the SNP genotype-phenotype information. In addition, we integrated Database with relation of nutrient for utilizing the USDA Food information and it was applied to recommend with Sickdanome. As a result, the obesity-related SNP information was confirmed in the sample which has the normal value BMI. In this study, we have recognized that the phenotype information related obesity, BMI is inconsistent with the SNP genotype information. This result is shown that it is necessary to provide the personalized dietary SickdanOme recommendation based on the both pheotype-genotype information.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.5
• /
• pp.611-617
• /
• 2018

The application of health monitoring, including a fault detection technique, is needed to secure the structural safety of large structures. A 2-step crack identification method for detecting the crack location and size of the beam structure is presented. First, a crack occurrence region was estimated using the modified Laplacian operator for the strain mode shape obtained from the distributed local strain data. The crack location and size were then identified based on the natural frequencies obtained from the acceleration data and the neural network technique for the pre-estimated crack occurrence region. The natural frequencies of a cracked beam were calculated based on an equivalent bending stiffness induced by the energy method, and used to generate the training patterns of the neural network. An experimental study was carried out on an aluminum cantilever beam to verify the present method for crack identification. Cracks were produced on the beam, and free vibration tests were performed. A crack occurrence region was estimated using the modified Laplacian operator for the strain mode shape, and the crack location and size were assessed using the natural frequencies and neural network technique. The identified crack occurrence region agrees well with the exact one, and the accuracy of the estimation results for the crack location and size could be enhanced considerably for 3 damage cases. The presented method could be applied effectively to the structural health monitoring of large structures.