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http://dx.doi.org/10.5392/JKCA.2016.16.10.435

Personalized Dietary SikdanOme Recommendation based on Obesity Related SNP Genotype and Phenotype  

Shin, Ga-Hee ((주)인실리코젠)
Lee, Sang-Min ((주)인실리코젠)
Kang, Byeong-Chul ((주)인실리코젠)
Jang, Dai-Ja (한국식품연구원)
Kwon, Dae Young (한국식품연구원)
Kim, Min-Jung (한국식품연구원)
Kim, Ri-Rang (한국식품연구원)
Kim, Jin-Hee (한국식품연구원)
Yang, Hye Jeong (한국식품연구원)
Publication Information
Abstract
Obesity extends the global economic burden and it causes that the failure of a reduction of physical activity, and diet management. In this work, nutritional information and personalized diet based on calorie supply system and is discriminatory utilized the obesity-related SNP information in order to recommend a personalized functional foods. This study performed a GWAS analysis for the excavation of a Korean-specific and obesity-related SNP, which utilizes genetic information were recommended by entering a personalized diet in accordance with the SNP genotype-phenotype information. In addition, we integrated Database with relation of nutrient for utilizing the USDA Food information and it was applied to recommend with Sickdanome. As a result, the obesity-related SNP information was confirmed in the sample which has the normal value BMI. In this study, we have recognized that the phenotype information related obesity, BMI is inconsistent with the SNP genotype information. This result is shown that it is necessary to provide the personalized dietary SickdanOme recommendation based on the both pheotype-genotype information.
Keywords
Korea Traditional Food Standard Reference; Semantics; Sickdanome; Integrated Database;
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1 C. T. Verrips, M. M. C. G. Warmoeskerken, and J. A. Post, "General introduction to the importance of genomics in food biotechnology and nutrition," Current Opinion in Biotechnology, Vol.12, No.5, pp.483-487, 2001.   DOI
2 Sonja I. Berndt, Stefan Gustafsson, Reedik Magi, Andrea Ganna, Eleanor Wheeler, Mary F. Feitosa, Anne E. Justice, Keri L. Monda, Damien C Croteau-Chonka, Felix R Day, Tonu Esko, Tove Fall, Teresa Ferreira, Davide Gentilini, Anne U Jackson, Jian'an Luan, Joshua C Randall, Sailaja Vedantam, Cristen J Willer, Thomas W Winkler, Andrew R Wood, Tsegaselassie Workalemahu, Yi-Juan Hu, Sang Hong Lee, and Liming Liang, "Genome-wide meta-analysis identifies 11 new loci for anthropocentric traits and provides insights into genetic architecture," Nat Genet, Vol.45, No.5, pp.501-512, 2013.   DOI
3 E. Wheeler, N. Huang, E. Bochukova, J. M. Keogh, S. Lindsay, S. Garg, E. Henning, H. Blackburn, R. J. F. Loos, N. J. Wareham, S. O'Rahilly, M. E. Hurles, I. Barroso, and I. Sadaf Farooqi, "Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity," Nat Genet, Vol.45, No.5, pp.513-517, 2013.   DOI
4 Z. David, K. Tal, Z. Niv, I. David, R. Daphna, W. Adina, B.-Y. Orly, L. Dar, A.-S. Tali, L.-P. Maya, S. Jotham, A. M. Jemal, M. Elad, M. Gal Malka, K. Noa, R. Michal, Z.-S. Gili, D. Lenka, P.-F. Meirav, B. Rony, H. Zamir, E. Eran, and S. Eran, "Personalized Nutrition by Prediction of Glycemic Response," Cell, Vol.163, No.5, pp.1079-1094, 2015.   DOI
5 R. J. Kuczmarski, K. M. Flegal, S. M. Campbell, and C. L. Johnson, "Increasing prevalence of overweight among US adults : The National Health and Nutrition Examination Surveys, 1960 to 1991," JAMA, Vol.272, No.3, pp.205-211, 1994.   DOI
6 N. E. A. Gaboon, "Nutritional genomics and personalized diet," The Egyptian Journal of Medical Human Genetics, Vol.12, No.1, pp.1-7, 2001.   DOI
7 P. G. Kopelman, "Obesity as a medical problem," Nature, Vol.404, pp.635-643, 2000.   DOI
8 J. S. Lee, K. Kawakubo, C. M. Park, and A. Akabayashi, "Rapidly increasing prevalence of obesity and their confident determinants in Korea," Korean J Health Educ Promot, Vol.23, No.5, pp.1-11, 2006.
9 Korean National Statistical Office, The statistics of life table, 2010.
10 B. H. Choi, J. B. Kim, and M. S. Do, "Current Trends in Nutrigenomics," J Korean Soc Food Sci Nutr, Vol.34, No.10, pp.1642-1654, 2005.   DOI
11 L. AFMAN and M. MULLER, "Nutrigenomics: From Molecular Nutrition to Prevention of Disease," Journal of the Academy of Nutrition and Dietetics, Vol.106, No.4, pp.569-576, 2006.
12 B. Padhukasahasram, E. Halperin, J. Wessel, D. J. Thomas, E. Silver, H. Trumbower, M. Cargill, and D. A. Stephan, "Presymptomatic Risk Assessment for Chronic Non-Communicable Diseases," PlosOne, Vol.5, No.12, p.e14338, 2010.   DOI
13 김경훈, 송영재, "A Design of Prescription management System using Network Analysis Technique," 한국콘텐츠학회논문지, 제11권, 제12 호, pp.112-121, 2011.   DOI
14 M. S. Lee, D. Y. Kwon, M. S. Kim, C. R. Choi, M. Y. Park, and A. J. Kim, "Genome-wide association study for the interaction between BMR and BMI in obese Korean women including overweight," Nutr Res Pract., Vol.10, No.1, pp.115-124, 2016.   DOI
15 J. R. Choi, I. S. Kwon, D. Y. Kwon, M. S. Kim, and M. S Lee, "TT Mutant Homozygote of Kruppel-like Factor 5 Is a Key Factor for Increasing Basal Metabolic Rate and Resting Metabolic Rate in Korean Elementary School Children," Genomics Inform., Vol.11, No.4, pp.263-271, 2013.   DOI
16 김규아, 박만곤, "A Study on the U-Healthcare Service System for Obesity Patients," 2010년도 추계학술발표논문집, pp.720-722, 2010.
17 J. B. German, A. M. Zivkovic, D. C. Dallas, and J. T. Smilowitz, "Nutrigenomics and Personalized Diets: What Will They Mean for Food?," Annu Rev Food Sci Technol., Vol.2, pp.97-123, 2011.   DOI
18 E. J. Schiffrin and S. Blum, "Food Processing: probiotic microorganisms for beneficial foods," Current Opinion in Biotechnology, Vol.12, No.5, pp.499-502, 2001.   DOI
19 M. Barnett, W. Young, J. Cooney, and N. Roy, "Metabolomics and Proteomics, and What to Do with All These 'Omes': Insights from Nutrigenomic Investigations in New Zealand," J Nutrient Nutrigenomics, Vol.7, pp.274-282, 2014.
20 M. A. Roberts, D. M. Mutch, and J. B. German, "Genomics: food and nutrition," Current Opinion in Biotechnology, Vol.12, No.5, pp.516-522, 2001.   DOI