• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.2
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• pp.649-656
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• 2016

This study was a retrospective examination to identify the association of postoperative delirium of the prognosis on following femur fracture surgery in elderly patients. Data was collected from the medical records of elderly patients (aged 65 years or older), who underwent femur fracture surgery from July 2010 to January 2014, following on 3-years in one university hospital. A total of 68 patients were involved. There were 31 cases (45.6%) with delirium and 37 cases (54.4%) without delirium. The participant's average age was 80.8 (patients with delirium), and 81.8 (delirium without patients) years of age, respectively, and most of them were female. There was no significant difference between the two groups. Taking five or more medications, serum creatinine level, and the total medical costs were significantly different in the delirium group and non-delirium group. In addition, the proportional hazard model of Cox to determine the predictors for the major clinical outcome occurring after surgery revealed delirium, five or more multi-drug use, and an experience of transfusion to be significant predictors. In conclusion, postoperative delirium in the elderly undergoing femur fracture surgery can have a negative clinical outcome in patients and caregivers. Therefore, a preoperative evaluation and management of the risk factors will be necessary.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.48 no.4
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• pp.1-9
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• 2011

Hemorrhagic shock is a clinically widespread syndrome characterized by inadequate oxygenation and supply. It is important to diagnose hemorrhagic shock in its early stage for improving treatment effects and survival rate. However, an accurate diagnosis and treatment could be delayed in the early stage of hemorrhagic shock by evaluating only vital signs such as heart rate and blood pressure. There have been many studies for the early diagnosis of hemorrhagic shock, reporting that lactate concentration and perfusion were useful variables for tissue hypoxia and metabolic acidosis. In this study, we measured both perfusion using a laser Doppler flowmeter and lactate concentration from the volume controlled hemorrhagic shock using rats. We also proposed a new shock index which was calculated by dividing lactate concentration by perfusion for early diagnosis. As a result of the survival prediction by the proposed index with the receiver operating characteristic curve method, the sensitivity, specificity, and accuracy of survival were 90.0, 96.7 and 94.0%, respectively. The proposed index showed the fastest significant difference among the other parameters such as blood pressure and heart rate. It could offer early diagnosis and effective treatment for human hemorrhagic shock if it is applicable to humans.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.3
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• pp.277-285
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• 2019

An inverse correlation between obesity and arterial stiffness has been reported, but there are no consistent results in elderly subjects. This study examined the relationship between the arterial stiffness measured by the CAVI (cardio-ankle vascular index) and BMI (body mass index) in healthy elderly people. This study included 629 healthy elderly people aged 65 and over who underwent health examinations at a general hospital in Gyeonggi from July 2018 to June 2019. Metabolic syndrome was diagnosed using the criteria of the Adult Treatment Panel (ATP) III of the US National Cholesterol Education Program (NCEP). Among the criteria of NCEP-ATP III, the waist circumference and obesity criteria were based on the WHO criteria. All subjects underwent a biochemical blood test and an assessment of the CAVI. In both men and women, the CAVI was lower in the obese group than in the normal weight group. Gender (P=0.047), age (P<0.001), BMI (P<0.001), and waist circumference (P=0.008) were factors affecting the CAVI. Gender, high blood pressure, and hyperglycemia were independent positive predictors of the CAVI levels, while obesity was a negative predictor. Therefore, the CAVI and BMI showed an inverse correlation. In conclusion, there was an inverse correlation between the CAVI and BMI in the elderly, and obesity was a negative predictor of the CAVI.

• Journal of the Korean Academy of Esthetic Dentistry
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• v.10 no.1
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• pp.48-54
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• 2001

아름다움이라는 것은 완전히 객관적이기도 하지만 극히 주관적인 표현의 결과일 수 있다. 심미치의학은 얼굴에서 표현되는 이러한 주관적인 면과 객관적인 면을 조화시킬 수 있는 학문이기에 21세기에도 여전히 치과 치료에 있어서 중요한 화두 중의 하나임에 틀림이 없다. 과거 심미적인 치료로 행하였던 많은 치료 술식들(open faced crown, resin faced crown,3/4 crown,7/8crown등)이 치과 치료 술식의 발달과 함께 재료와 치아 보철물 제작술 등의 발달로 인해 점차 사라지거나 변화하고 있는 것이 사실이다. 지금 소개하는 증례들은 현재 치과계에서 심미적인 치료 술식으로 인정하고 있기에 이러한 치료 술식에 대한 이해가 필요할 것이다. 우리 임상가들의 최종목표는 환자들에게 자연스러운 얼굴과 웃음을 회복시켜주는 것이다. 각 증례에 대한 한계에 대해 미리 알 수 있는 방법을 모색해 보고, 예측 가능한 치료를 시행하기위한 과정들을 살펴보고자 한다.

• Journal of Life Science
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• v.20 no.10
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• pp.1458-1467
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• 2010

The present study was retrospectively designed to define whether preoperative levels of leukocytes and D-dimer are potentially useful factors in predicting perioperative outcomes of coronary heart disease (CHD). There was no relationship between preoperative leukocyte counts (Pre-OP leukocyte) and preoperative D-dimer levels (Pre-OP D-dimer). Pre-OP leukocyte counts each had positive correlation with cardiac troponin-I, creatine kinase-MB or C-reactive protein (cardiac markers) levels at preoperative and postoperative periods. Pre-OP D-dimer levels were positively associated with each cardiac marker at the same periods. Pre-OP leukocyte counts positively related with aspartate aminotransferase and alanine aminotransferase (liver markers), whereas Pre-OP D-dimer level positively or negatively correlated with bilirubin (liver marker), creatinine (renal marker) or glucose levels at preoperative and/or postoperative periods. Pre-OP leukocyte and Pre-OP D-dimer were inversely associated with Pre-OP high density lipoprotein cholesterol levels or left ventricular ejection fraction. Pre-OP leukocyte counts each had positive correlation operation duration and postoperative mechanical ventilation-time (PMVT), whereas Pre-OP D-dimer levels had positive relationship with PMVT, intensive care unit-staying period and hospitalization. The retrospective data suggest that Pre-OP leukocyte and Pre-OP D-dimer levels may be clinically useful factors for predicting perioperative outcomes in patients with CHD.

• Korean Journal of Head & Neck Oncology
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• v.28 no.2
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• pp.107-113
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• 2012

배 경 편평상피암은 두경부의 악성종양 중 가장 흔하며, 임상적인 경과가 불량하다. 따라서 나쁜 예후를 가지는 환자군을 조기에 선별하여 더 적극적인 치료의 시행을 결정짓는 표지자의 필요성이 대두된다. 우리는 일련의 두경부 편평세포암 검체에서 몇몇 분자 표지자의 예후적 유용성을 평가하고자 하였다. 방 법 23예의 두경부 편평세포암 검체를 대상으로 VEGF, p53, Apaf-1, caspase-9의 발현과 몇몇 임상병리학적 지표들간의 연관성을 면역조직화학염색을 통해 조사하였다. 결 과 환자군은 남성이 더 많았으며 평균연령은 63.7세였다. 1기가 5예, 2기가 2예, 3기가 8예, 4기가 8예였다. 평균생존기간은 37.3개월이었다. VEGF단백 발현은 종양의 크기와 통계적으로 유의한 연관성을 보였다. 이와 더불어 VEGF단백 발현은 병기, 그리고 림프관 침습과 연관적인 경향성을 보였다. 그러나 VEGF단백 발현과 생존기간과는 관련성이 없었다. 또한, Apaf-1과 caspase-9의 단백발현은 다른 임상지표, 환자의 생존기간과는 관련이 없었다. 결 론 VEGF단백 발현은 두경부 편평세포암 환자에서 나쁜 임상경과를 예측할 수 있게 하는 표지자로서의 역할을 할 수 있다. 또한 본 연구는 두경부 편평세포암에서 별로 연구되지 않은 Apaf-1과 caspase-9의 발현상태를 밝힌 점에서 의의가 있다.

• Journal of Life Science
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• v.26 no.6
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• pp.705-710
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• 2016

Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related death worldwide. Although several diagnostic and therapeutic tools have been available, CRC remains difficult to complete cure because of insufficient understanding of the molecular mechanisms underlying this disease progression. MicroRNAs (miRNAs) are small non-coding RNA molecules that strongly regulate gene expression via transcriptional and translational control mechanisms. Many crucial cellular pathways are frequently disrupted in cancer development process due to dysregulation of several miRNAs. Mir-31 functions as an oncogene that modulate expression of multiple cancer related genes. Thus, we aimed to demonstrate clinical relevance of miR-31 in human CRC. Quantitative RT-PCR analysis of miR-31 expression was performed in 175 CRC tissues and 16 normal colonic mucosa (NM). Next, we investigated clinical significances of miR-31 expression in various clinicopathologic features in CRC patients cohort. Mir-31 was significantly up-regulated in CRC tissues compared to NM. In CRC tissues, miR-31 expression level was significantly elevated in a stage-dependent manner, which was associated with poor survival in patients with CRC. High miR-31 levels in CRC tissues significantly correlated with poor prognosis (hazard ratio [HR]=2.4) as well as distant metastasis (odds ratio [OR]=2.3). In conclusion, we identified clinical significance of miR-31 expression in CRC. High miR-31 expression may be clinically able to use as a biomarker for CRC prognosis and predicting metastasis.

• The Journal of the Acoustical Society of Korea
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• v.19 no.5
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• pp.65-70
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• 2000

It is blown that the loudness is one of the most important metrics in assessing the sound quality and a calculation method for loudness has been standardized for steady sounds. In this study, a new loudness model is suggested for dealing with the transient sound for a unified analysis of various practical sounds. A signal processing technique is introduced for this purpose, which is required for the band subdivision and the prediction of band-level change of transient sounds. In addition, models for the post-masking and the temporal integration are adopted in the analysis of the loudness of transient sounds. In order to solve the problem of the conventional loudness model in the pure-tone signal processing, a critical band filter is employed in the analysis, which consists of 47 critical filters having a filter spacing of a half of the critical bandwidth. For testing the effectiveness of the present model, the predicted responses are compared with the experimental data and it is observed that they are in good agreements.

• The Journal of the Korea Contents Association
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• v.16 no.12
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• pp.360-372
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• 2016

South Korea has become richer economically than the past, but still level of happiness is low. This research was conducted to verify the relationships among mental health, self-forgiveness, and psychological well-being. Participants were 232 college students in an university in Seoul. Methods of data analysis were ANOVA, regression analysis, and path analysis. As a result of analyses, first, MMPI-2 clinical scales which showed significant correlation with psychological well-being were as follows: Hs, D, Pd, Pa, Pt, Sc, Si. Second, PSY-5 scales which showed significant correlation with psychological well-being were as follows: PSYC, NEGE, INTR. Third, stepwise regression analysis revealed that Sc, Si and Pd among clinical scales of MMPI-2 were associated with psychological well-being. Fourth, PSYC, NEGE and INTR among clinical scales of PSY-5 scales were associated with psychological well-being. Fifth, self-forgiveness had a significant mediating effect in the relationship between mental health and psychological well-being. Based on the results, implications related to importances of mental health and self-forgiveness were discussed for increasing psychological well-being of college students.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.36 no.6
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• pp.507-514
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• 2018

TSI (TPI-Slope Index) which is the combination of TPI (Topographic Position Index) and slope was newly proposed for landslide and applied to a landslide susceptibility model. To do this, we first compared the TPIs with various scale factors and found that TPI350 was the best fit for the study area. TPI350 was combined with slope to create TSI. TSI was evaluated using logistic regression. The evaluation showed that TSI can be used as a landslide factor. Then a logistic regression model was developed to assess the landslide susceptibility by adding other topographic factors, geological factors, and forestial factors. For this, landslide-related factors that can be extracted from DEM (Digital Elevation Model), soil map, and forest type map were collected. We checked these factors and excluded those that were highly correlated with other factors or not significant. After these processes, 8 factors of TSI, elevation, slope length, slope aspect, effective soil depth, tree age, tree density, and tree type were selected to be entered into the regression analysis as independent variables. Three models through three variable selection methods of forward selection, backward elimination, and enter method were built and evaluated. Selected variables in the three models were slightly different, but in common, effective soil depth, tree density, and TSI was most significant.