Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Expression of VEGF, p53, Apaf-1 and Caspase-9 in Head and Neck Squamous Cell Carcinoma

두경부 편평세포암에서 VEGF, p53, Apaf-1 and Caspase-9의 발현

  • Lee, Sung Hak (Department of pathology, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine) ;
  • Kang, Yeo Ju (Department of pathology, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine) ;
  • Jo, Ui Ju (Department of pathology, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine) ;
  • Lee, Youn Soo (Department of pathology, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine) ;
  • Kang, Chang Suk (Department of pathology, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine)
  • 이성학 (가톨릭대학교 의과대학 서울성모병원 병리과학교실) ;
  • 강여주 (가톨릭대학교 의과대학 서울성모병원 병리과학교실) ;
  • 조의주 (가톨릭대학교 의과대학 서울성모병원 병리과학교실) ;
  • 이연수 (가톨릭대학교 의과대학 서울성모병원 병리과학교실) ;
  • 강창석 (가톨릭대학교 의과대학 서울성모병원 병리과학교실)
  • Received : 2012.09.25
  • Accepted : 2012.10.29
  • Published : 2012.11.30
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Abstract

배 경 편평상피암은 두경부의 악성종양 중 가장 흔하며, 임상적인 경과가 불량하다. 따라서 나쁜 예후를 가지는 환자군을 조기에 선별하여 더 적극적인 치료의 시행을 결정짓는 표지자의 필요성이 대두된다. 우리는 일련의 두경부 편평세포암 검체에서 몇몇 분자 표지자의 예후적 유용성을 평가하고자 하였다. 방 법 23예의 두경부 편평세포암 검체를 대상으로 VEGF, p53, Apaf-1, caspase-9의 발현과 몇몇 임상병리학적 지표들간의 연관성을 면역조직화학염색을 통해 조사하였다. 결 과 환자군은 남성이 더 많았으며 평균연령은 63.7세였다. 1기가 5예, 2기가 2예, 3기가 8예, 4기가 8예였다. 평균생존기간은 37.3개월이었다. VEGF단백 발현은 종양의 크기와 통계적으로 유의한 연관성을 보였다. 이와 더불어 VEGF단백 발현은 병기, 그리고 림프관 침습과 연관적인 경향성을 보였다. 그러나 VEGF단백 발현과 생존기간과는 관련성이 없었다. 또한, Apaf-1과 caspase-9의 단백발현은 다른 임상지표, 환자의 생존기간과는 관련이 없었다. 결 론 VEGF단백 발현은 두경부 편평세포암 환자에서 나쁜 임상경과를 예측할 수 있게 하는 표지자로서의 역할을 할 수 있다. 또한 본 연구는 두경부 편평세포암에서 별로 연구되지 않은 Apaf-1과 caspase-9의 발현상태를 밝힌 점에서 의의가 있다.

Keywords

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