• Title/Summary/Keyword: 인공촉진시험

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The Influence of Skin surface temperature on Transdermal Absorption of Active Substances and Changes in Skin Condition (피부표면온도가 유효물질 경피 흡수 및 피부 상태변화에 미치는 영향)

  • Kwon, Hye-Jin;Han, Sa-Ra;Jung, Na-Seul
    • Journal of the Korean Applied Science and Technology
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    • v.36 no.1
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    • pp.299-304
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    • 2019
  • This study was conducted to investigate the effects of skin surface temperature on transdermal absorption of active substances and changes in skin condition. A transdermal absorption test was conducted using an emulsion containing 10% heat-resistant niacinamide, and the same emulsion was used in a clinical trial to test the thermal effects. As a result, absorption was found to be 2 times greater at 10 minutes and 3 times greater at 15 minutes after application at $42^{\circ}C$ than that of compared to normal skin temperature. During the clinical evaluation on skin, no clinical subjects showed any specific adverse reactions, while moisture and oiliness showed statistically significant effects at higher temperatures. Based on these results, it was confirmed that thermal warmer improves the absorption of active substances and had a positive effect on skin condition. It is deemed that this study will provide a preliminary data to support the development of various beauty devices using heat.

Identification of Feeding Stimulants for Juvenile Pacific Bluefin Tuna, Thunnus orientalis in Muscle Extract of Horse Mackerel, Trachurus japonicus (참다랑어(Thunnus orientalis) 치어에 있어서 전갱이(Trachrus japonicus) 근육 엑기스 중의 섭이촉진물질 검색)

  • Ji, Seung-Cheol;Takaoka, Osamu;Seoka, Manabu;Kohbara, Jun;Hosokawa, Hidetuyo;Shimeno, Sadao;Jeong, Gwan-Sik;Lee, Si-Woo;Takii, Kenji
    • Journal of Aquaculture
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    • v.20 no.1
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    • pp.19-25
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    • 2007
  • For establishing a basal diet for the Pacific bluefin tuna Thunnus orientalis (PBT), feeding stimulants were initially identified by omission test using the synthetic extract of horse mackerel, Trachurus japonicus. Four feeding trials were conducted using juvenile PBT weighing $9.0{\pm}0.91\;g$ (trial 1, 2 and 3) and $1.6{\pm}0.23\;g$ (trial 4), which were originated from an artificial seedling production. The fish fed the casein diet with each test solution were added at the ratio of 100 g casein diet to 100 g jack mackerel muscle. A complete synthetic extract of jack mackerel containing all 3 fractions, amino acid, nucleotide and organic nitrogenous base, exhibited a comparable feeding stimulant activity compared to that of natural extract. The omission of nucleotide or amino acid fraction showed lower feeding activity, but the omission of other nitrogenous fraction maintained a similar feeding stimulant activity compared to that of the synthetic extract (trial 1). Inosine-5' monophosphate $Na_2$ (IMP) was identified as a major constituent for maintaining feeding activity. The mixture of L-alanine, L-glutamic acid, L-histidine, L-lysine, taurine and IMP induced a similar feeding activity compared to that of the synthetic extract (trial 2 and 3). In trial 4, the highest feeding activity was finally obtained in the mixture of L-histidine, L-glutamine and IMP, followed by the synthetic extract, the mixture of L-lysine, L-alanine and IMP, IMP and the mixture of L-histidine, L-glutamic acid, L-lysine and L-alanine. These results revealed that the mixture of L-histidine, L-glutamic acid and IMP for the proper feeding stimulant of PBT in this study.

Web Cogmulator : The Web Design Simulator Using Fuzzy Cognitive Map (Web Cogmulator : 퍼지 인식도를 이용한 웹 디자인 시뮬레이터에 관한 연구)

  • 이건창;정남호;조형래
    • Proceedings of the Korea Inteligent Information System Society Conference
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    • 2000.04a
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    • pp.357-364
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    • 2000
  • 기존의 웹 디자인은 웹이라는 매체의 특성 상 디자인적인 요소가 매우 중요함에도 불구하고 디자인은 위한 구체적인 방법론이 미약하다. 특히, 많은 소비자들을 유인하고 구매를 촉발시켜야 하는 인터넷 쇼핑몰의 경우에는 더욱 더 그럼하에도 불구하고 이를 위한 전략적인 방법론이 부족하다. 즉, 기존 연구들은 제품의 다양성, 서비스, 촉진, 항해량, 편리성, 사용자 인터페이스 등이 중요하다고 하였지만 실제 인터넷 쇼핑몰을 디자인하는 입장에서는 활용하기가 상당히 애매하다. 그 이유는 이들 요인들은 서로 영향관계를 가지고 있어서 사용자 인터페이스가 복잡하면 항해량이 늘어나 편리성이 감소하고, 제품이 늘어나더라도 검색엔진을 사용하면 상대적으로 항해량이 감소하게 되어 편리성이 증가한다. 따라서, 이들 요인을 활용하여 인터넷 쇼핑몰을 구축하려면 요인간의 영향관계를 면밀히 파악하고 이 영향요인이 소비자의 구매행동에 어떠한 영향을 주는지가 충분히 검토되어야 한다.이에 본 연구에서는 퍼지인식도를 이용하여 인터넷 쇼핑몰 상에서 소비자의 구매행동에 영향을 주는 요인을 추출하고 이들 요인간의 인과관계를 도출하여 보다 구체적이고 전략적으로 인터넷 쇼핑몰을 디자인할 수 있는 방법으로 web-Cogmulator를 제시한다. Web-Cogmulator는 소비자의 쇼핑몰에 대한 암묵지식 형태의 구매행동을 형태지식화하여 지식베이스 형태로 가지고 있기 때문에 인터넷 쇼핑몰의 다양한 요인의 변화에 따른 소비자의 구매행동을 추론 시뮬레이션하는 것이 가능하다. 이에 본 연구에서는 기본적인 인터넷 쇼핑몰 시나리오를 바탕으로 추론 시뮬레이션을 실시하여 Web-Cogmulator의 유용성을 검증하였다.를, 지지도(support), 신뢰도(confidence), 리프트(lift), 컨빅션(conviction)등의 관계를 통해 다양한 방법으로 모색해본다. 이 연구에서 제안하는 이러한 개념계층상의 흥미로운 부분의 탐색은, 전자 상거래에서의 CRM(Customer Relationship Management)나 틈새시장(niche market) 마케팅 등에 적용가능하리라 여겨진다.선의 효과가 나타났다. 표본기업들을 훈련과 시험용으로 구분하여 분석한 결과는 전체적으로 재무/비재무적 지표를 고려한 인공신경망기법의 예측적중률이 높은 것으로 나타났다. 즉, 로지스틱회귀 분석의 재무적 지표모형은 훈련, 시험용이 84.45%, 85.10%인 반면, 재무/비재무적 지표모형은 84.45%, 85.08%로서 거의 동일한 예측적중률을 가졌으나 인공신경망기법 분석에서는 재무적 지표모형이 92.23%, 85.10%인 반면, 재무/비재무적 지표모형에서는 91.12%, 88.06%로서 향상된 예측적중률을 나타내었다.ting LMS according to increasing the step-size parameter $\mu$ in the experimentally computed. learning curve. Also we find that convergence speed of proposed algorithm is increased by (B+1) time proportional to B which B is the number of recycled data buffer without complexity of computati

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Wear Resistance of Crosslinked Ultra-high Molecular Weight Polyethylene (가교된 초고분자량 폴리에틸렌의 내마모성)

  • Im, Chae-Ik;Lee, Gwi-Jong;Jo, Jae-Yeong;Choe, Jae-Bong;Choe, Gwi-Won
    • Journal of Biomedical Engineering Research
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    • v.20 no.1
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    • pp.99-106
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    • 1999
  • Ultra-high molecular weight polyethylene (UHMWPE) was crosslinked in the melt state to enhance wear resistance, Dicumyl peroxide (DCP) and triallyl cyanurate (TAC) was used as a crosslinking agent and a promoter, respectively. With increasing amount of DCP and TAC used, gel content of crosslinked UHMWPE (XUMPE) increased, while the melting temperature, crystallizaiton temperature, crystallinity, and tensile properties decreased. The results of pin-on-disk wear test and ball-on-disk test with small applied load showed reduced wear volumes of XUMPE from that of the unmodified UHMWPE. As the wear mechanism effected in the experimental condition of this study was thought to be deformation rather than adhesion or fatigue, a new parameter, the ratio of maximum contact stress to yield stress, was proposed to correlate well with observed wear resistance. In ball-on-disk wear test with larger applied load, XUMPE showed higher wear volumes than that of the unmodified UHMWPE which were accompanied with increased friction coefficients and surface roughness of the wear tracks. When contact stress was well above yield stress, the failure of XUMPE, as well as deformation, was thought to be much accelerated.

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Studies on the Browning of Red Ginseng (홍삼(紅蔘)의 갈변(褐變)에 관(關)한 연구(硏究))

  • Kim, Dong-Youn
    • Applied Biological Chemistry
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    • v.16 no.2
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    • pp.60-77
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    • 1973
  • The non-enzymatic browning phenomenons of red ginseng were studied to identify these compounds which function as the factors for browning. The samples were classified into five divisions; Fresh ginseng, blanched ginseng, sun dried red ginseng, dehydrated red ginseng, and browning accelerated red ginseng respectively, and the various compounds in each of them were analyzed quantitatively and investigated the compounds which were thought to function for browning during the drying and the dehydration processes; the results were as follows. 1. The chemical compositions among five divisions did not show any difference except a) total and reducing sugars, b) total acids, c) water soluble extracts; a) and b) were decreased during the drying process, c) was decreased about 6-7% in red ginseng divisions. 2. Sixteen free amino acids; asp., thr., ser., glu., gly., ala., val., cys., met., ileu., leu., tyr., phe., lys., his., and arg, were identified in each division. Among them the arg, was extremly high. All of the essential amino acids were contained, while generally these amino acids were decreased in drying period and their rates were smaller in dehydrated red ginseng than in sun dried red ginseng. 3. Three kinds of sugars; fructose, glucose and sucrose were identified and other four kinds of unidentified sugars were seperated. The content of sucrose was 80% and all kind of sugars were generally less in red ginseng divisions than in the other two divisions. The decreasing rate of sngars was higher in the sun dried red ginseng than in the dehydrated red ginseng. Especially the decreasing rate of the reducing sugars was high as compared with that of sucrose. 4. Almost all the ascorbic acid was decomposed during the blanching whereas there could'nt be shown any change of the ascorbic acid content during the period of drying. 5. Eleven kinds of volatile acids; acetic acid, propionic acid, acrylic acid, iso-butyric acid, n-butyric acid, isovaleric acid, n-valeric acid, isoheptylic acid, n-heptylic acid, and an unknown volatile acid were identified. They showed a little decrease during the period of blanching perhaps on account of their volatility whereas they were increased in drying period. 6. Six kinds of non-volatile acids; citric acid, malic acid, ${\alpha}-ketoglutaric$ acid, succinic acid, pyruvic acid and glutaric acid were identified. The content of them were decreased during the drying procedures in red ginseng but only that of succinic acid was increased. 7. Three kinds of polyphenols; 3-caffeyl quinic acid, 4-caffeyl quinic acid, 5-caffeyl quinic acid and an unknown polyphenol were identified. The content of them showed considerable decrease during the drying procedures, especially in sun drying. 8. The intensity of the browning in each divisior was as follows; browning accelerated red ginseng> sun dried red ginseng> dehydrated red ginseng. 9. In the process of red ginseng preparation, a. certain relationship could be found between the decreasing rates of amino acids, reducing sugars, polyphenols and the intensity of browning. Therefore the browning phenomenon may be concluded that nonenzymatic browning reactions of the amino-carbonyl reaction and autoxidation of polyphenols are the most important processes, furthermore, as their reactions could be controlled it is thought to be possible to accelerate effectively browning within a relatively short period.

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Properties of Temperature Reduction of Cooling Asphalt Pavements Using High-Reflectivity Paints (고반사 도료를 사용한 차열성 아스팔트 도로포장의 온도저감특성)

  • Hong, Chang Woo
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.33 no.1
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    • pp.317-327
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    • 2013
  • Air pollution and artificial heat of urban areas have caused the urban heat island in which asphalt pavements absorb solar heat during the daytime and release the heat at night. Hence, in order to improve the environment of urban areas, it is necessary to examine cooling pavements that can reduce heat on road pavements in urban areas. The application of temperature insulation paints on road pavements require to reduce black brightness for visibility, to increase the reflection rate of infrared light and minimize the reflection rate of visible light. In the study, one part of Acrylic-emulsion was used as a main binder, and the changes in black brightness and the changes of addition ratio (0%, 15%, 30%) of hollow ceramics, as well as kinds of paints (carbon black pigment, mixed mineral pigment) were selected as the main experimental factors. The performance of temperature reduction of cooling pavements was analyzed through the reflection rate of spectrum, the reflection rate of solar heat, and the lamp test. Abrasion resistance, UV accelerated weather resistance, and sliding resistance were tested in real situations. In addition, the performance of heat reduction of testing pavements covered with high-reflection paints was analyzed by using an infrared camera. As the test results, when using mixed mineral paints and hollow ceramic of 30%, the reflection rate of spectrum was 43% in the area of near-infrared ray and 17% in the area of visible light at black brightness of $L^*$=42.89 and the reflection rate of solar heat was 27.5%. Total color difference was ${\Delta}E$=0.27 in the test of UV Accelerated Weather Resistance, indicating almost no changes in color. BPN was more than 53 when scattering #2 and #4 silica sand of more than $0.12kg/m^2$. In Taber's abrasion resistance test, abrasion loss was up to 86.4mg at 500 rotations. The performance of heat reduction was evaluated using an infrared camera at the test section applying high-reflection paints to asphalt pavements, in which the results showed that the temperature was reduced by $12.7^{\circ}C$ on CI-30-40 cooling pavements ($L^*$=38.76) and by $14.2^{\circ}C$ on CI-30-60 cooling pavements ($L^*$=57.12).

A Study on the Strength, Drying Shrinkage and Carbonation Properties of Lightweight Aggregate Mortar with Recycling Water (회수수를 사용한 경량골재 모르타르의 강도, 건조수축 및 중성화 특성에 관한 연구)

  • Oh, Tae-Gue;Kim, Ji-Hwan;Bae, Sung-Ho;Choi, Se-Jin
    • Journal of the Korea Institute of Building Construction
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    • v.20 no.5
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    • pp.391-397
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    • 2020
  • This study is to compare and analyze the strength, drying shrinkage and carbonation properties of lightweight aggregate mortar using recycling water as prewetting water and mixing water. The flow, compressive strength, split tensile strength, drying shrinkage and carbonation depth of lightweight aggregate mortar with recycling water were measured. As test results, the mortar flow was similar in all mixes regardless of the recycling water content. The compresseive strength of the RW5 mix with 5% recycling water as prewetting water and mixing water was the highest value, about 53.9 MPa after 28 days. In addition, the tensile strength of lightweight mortar was about 3.4 to 3.8 MPa, indicating 7 to 9% of the compressive strength value regardless of recycling water content. In the case of drying shrinkage, the RW2.5 mix using 2.5% recycling water showed the lowest shrinkage rate as about 0.107% at 56 days. The drying shrinkage of the plain mix without recycling water was relatively higher than the RW2.5 and RW5 mix. The RW5 mix showed lowest carbonation depth compared to other mixes. In this study, the RW5 lightweight aggregate mortar with 5% recycling water exhibits excellent compressive strength and carbonation resistance. Therefore, it is considered that if the recycling water, a by-product of the concrete industry, is properly used as prewetting water and mixing water of lightweight mortar and concrete, it will be possible to increase the recycling rate of the by-product and contribute to improve the property of lightweitht aggregate mortar and concrete.

A Study on the Characteristics of Verdigris Manufactured by Acid Corrosion Method (산부식법으로 제조한 동록안료의 특성에 관한 연구)

  • Kang, Yeong Seok;Mun, Seong Woo;Lee, Sun Myung;Jeong, Hye Young
    • Journal of Conservation Science
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    • v.36 no.3
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    • pp.178-186
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    • 2020
  • Verdigris is a traditional artificial pigment reported on old research papers and according to the methods mentioned in the literature, it is manufactured by the corrosion of copper or copper alloys using vinegar and by further scraping the generated rust. Since the Three Kingdoms Period, various household products with copper alloys, such as bronze and brass, have been used, and pigment analysis of these cultural heritage items has revealed the presence of tin, zinc, lead, and copper in green pigments. Based on these data, five types of verdigris were prepared from copper and copper alloys, and analyzed. the analysis results revealed a bluish green pigmentation, and the chromaticity, particle shape, and oil absorption quantity of each verdigris differed based on the type of copper alloy used in its preparation. The main components of verdigris are Cu, Sn, Zn and Pb, and their proportions depended on the type of copper alloy used during manufacturing. However, the main constituent mineral of the pigments is the same as 'hoganite[Cu(CH3COO)2·H2O]', regardless of the copper alloy used. The result of accelerated weathering test for stability evaluation revealed that verdigris was discolored rapidly, thereby indicating that its stability was low, in particular, the pigments comprising lead presented relatively lower stability.

Studies on the Stability of Multivitamin Solutions (종합비타민 액제의 안정성에 대한 연구)

  • Park, Hong-Koo
    • Applied Biological Chemistry
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    • v.43 no.1
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    • pp.39-45
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    • 2000
  • The stability of vitamin A, $B_1,\;B_2,\;B_6$, C in aqueous multivitamin solutions was carried out by means of estimation of reaction velocity and the results are described in this paper. The stability of vitamin A, $B_1$ and C due to thermal degradation method in aqueous multivitamin solutions was evaluated at 40, 50, 60 and $70^{\circ}C$ up to 40 days. The shelf-lives of vitamin A, B₁ and C in this preparation, calculated using the Arrhenius equation, were 1493, 449 and 639 days at $25^{\circ}C$ respectively. Examination was made on the effect of initial concentration of vitamin $B_2$$(C_0)$ on light fading of vitamin $B_2$ in aqueous multivitamin solutions and it was found that the fading progressed according to the following formula : $-{\frac {dc}{dt}}=K_c\;{\frac C{C_0}}$ where Kc is apparent light-fading rate constant relate to $C_0$. Photodecomposition of vitamin $B_6$ in aqueous multivitamin solutions was apparently first order kinetics and was stable in polyethylene>brown color>glass container to sunlight. Photodecomposition of vitamin $B_6$ in four seasons also investigated.

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A Study on Improvement on National Legislation for Sustainable Progress of Space Development Project (우주개발사업의 지속발전을 위한 국내입법의 개선방향에 관한 연구)

  • Lee, Kang-Bin
    • The Korean Journal of Air & Space Law and Policy
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    • v.25 no.1
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    • pp.97-158
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    • 2010
  • The purpose of this paper is to research on the contents and improvement of national legislations relating to space development in Korea to make the sustainable progress of space development project in Korea. Korea has launched its first satellite KITST-1 in 1992. The National Space Committee has established "The Space Development Promotion Basic Plan" in 2007. The plan addressed the development of total 13 satellites by 2010 and the space launch vehicle by 2020, and the launch of moon exploration spaceship by 2021. Korea has built the space center at Oinarodo, Goheng Province in June 2009. In Korea the first small launch vehicle KSLV-1 was launched at the Naro Space Center in August 2009, and its second launch was made in June 2010. The United Nations has adopted five treaties relating to the development of outer space as follows : The Outer Space Treaty of 1967, the Rescue and Return Agreement of 1968, the Liability Convention of 1972, the Registration Convention of 1974, and the Moon Treaty of 1979. All five treaties has come into force. Korea has ratified the Outer Space Treaty, the Rescue and Return Agreement, the Liability Convention and the Registration Convention excepting the Moon Treaty. Most of development countries have enacted the national legislation relating to the development of our space as follows : The National Aeronautic and Space Act of 1958 and the Commercial Space Act of 1998 in the United States, Outer Space Act of 1986 in England, Establishment Act of National Space Center of 1961 in France, Canadian Space Agency Act of 1990 in Canada, Space Basic Act of 2008 in Japan, and Law on Space Activity of 1993 in Russia. There are currently three national legislations relating to space development in Korea as follows : Aerospace Industry Development Promotion Act of 1987, Outer Space Development Promotion Act of 2005, Outer Space Damage Compensation Act of 2008. The Ministry of Knowledge Economy of Korea has announced the Full Amendment Draft of Aerospace Industry Development Promotion Act in December 2009, and it's main contents are as follows : (1) Changing the title of Act into Aerospace Industry Promotion Act, (2) Newly regulating the definition of air flight test place, etc., (3) Establishment of aerospace industry basic plan, establishment of aerospace industry committee, (4) Project for promoting aerospace industry, (5) Exploration development, international joint development, (6) Cooperative research development, (7) Mutual benefit project, (8) Project for furthering basis of aerospace industry, (9) Activating cluster of aerospace industry, (10) Designation of air flight test place, etc., (11) Abolishing the designation and assistance of specific enterprise, (12) Abolishing the inspection of performance and quality. The Outer Space Development Promotion Act should be revised with regard to the following matters : (1) Overlapping problem in legal system between the Outer Space Development Promotion Act and the Aerospace industry Development promotion Act, (2) Distribution and adjustment problem of the national research development budget for space development between National Space Committee and National Science Technology Committee, (3) Consideration and preservation of environment in space development, (4) Taking the legal action and maintaining the legal system for policy and regulation relating to space development. The Outer Space Damage Compensation Act should be revised with regard to the following matters : (1) Definition of space damage and indirect damage, (2) Currency unit of limit of compensation liability, (3) Joint liability and compensation claim right of launching person of space object, (4) Establishment of Space Damage Compensation Council. In Korea, it will be possible to make a space tourism in 2013, and it is planned to introduce and operate a manned spaceship in 2013. Therefore, it is necessary to develop the policy relating to the promotion of commercial space transportation industry. Also it is necessary to make the proper maintenance of the current Aviation Law and space development-related laws and regulations for the promotion of space transportation industry in Korea.

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