Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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The Influence of Skin surface temperature on Transdermal Absorption of Active Substances and Changes in Skin Condition

피부표면온도가 유효물질 경피 흡수 및 피부 상태변화에 미치는 영향

  • Kwon, Hye-Jin (Department of Chemical Engineering, Soongsil University) ;
  • Han, Sa-Ra (Department of Chemical Engineering, Soongsil University) ;
  • Jung, Na-Seul (Department of Chemical Engineering, Soongsil University)
  • Received : 2019.03.04
  • Accepted : 2019.03.28
  • Published : 2019.03.31
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Abstract

This study was conducted to investigate the effects of skin surface temperature on transdermal absorption of active substances and changes in skin condition. A transdermal absorption test was conducted using an emulsion containing 10% heat-resistant niacinamide, and the same emulsion was used in a clinical trial to test the thermal effects. As a result, absorption was found to be 2 times greater at 10 minutes and 3 times greater at 15 minutes after application at $42^{\circ}C$ than that of compared to normal skin temperature. During the clinical evaluation on skin, no clinical subjects showed any specific adverse reactions, while moisture and oiliness showed statistically significant effects at higher temperatures. Based on these results, it was confirmed that thermal warmer improves the absorption of active substances and had a positive effect on skin condition. It is deemed that this study will provide a preliminary data to support the development of various beauty devices using heat.

본 연구는 피부표면온도가 유효물질 경피 흡수와 피부 상태변화에 미치는 영향을 실험하였다. 열에 강한 나이아신아마이드 10% 에멀젼을 인공피부에 도포하여 경피 흡수 시험을 진행하였고 동일한 에멀젼으로 피부임상시험을 시행하여 온열효과를 확인하였다. 그 결과 피부표면 온도 $42^{\circ}C$에서 정상 피부 온도보다 도포 10분 경과 후 2배, 15분 경과 후 3배의 경피 흡수 효과를 보였다. 피부임상평가에서는 임상대상자 모두 특이한 이상반응을 보이지 않았으며 수분, 유분 항목에서 통계적으로 유의한 효과를 나타냈다. 이상의 결과로 온열은 유효물질 경피 흡수 촉진과 피부상태 개선에 긍정적인 영향을 미치는 것을 확인하였고 이는 온열을 이용한 다양한 뷰티디바이스 개발에 기초자료가 될 것으로 판단된다.

Keywords

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Fig. 1. Result of permeation test of Niacinamide10% (15min).

Table 1. Result of permeation test of Niacinamide 10% (60min)

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Table 2. Change of skin condition before and after heating

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