• Journal of Preventive Medicine and Public Health
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• v.26 no.2 s.42
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• pp.202-209
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• 1993

A accidental spills of phenol(100%) to the river Nakdong with subsequent contamination of the tap water fer about two million consumers in Taegu city of Korea were occurred in March 1991. A historical cohort study of 6,913 individuals was undertaken to determine the associated with illness. Population subjects were divided into two groups of exposed and unexposed. Exposed subjects were reported to be phenol associated symptoms significantly higher than those in a nearby unexposed area(39.6% vs 9.4%, p<0.01). Especially, in the related symptoms, highly significant differences were noted in the number of subjects reporting gastrointestinal illness such as nausea, vomiting, diarrhea, or abdominal pain. During the accident, study subjects who experienced peculiar taste or odor in the tap water were significantly higher in the exposed areas(92% vs 34.3%). Chlorophenols formed from chlorination of water may have aggravated the problem.

• Journal of Hospice and Palliative Care
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• v.18 no.3
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• pp.188-195
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• 2015

Purpose: We examined the effects of a well-dying program on nursing students in terms of death preparation, death recognition and perception of well-dying perception. Methods: The design of this study was quasi-experimental and non-synchronized with a non-equivalent control group. The study was conducted with nursing students: 32 in the experimental group and 36 in the control group. The well-dying program was consisted of five sessions: introduction, thinking about meaning of death, organizing things to do before dying, looking back on my life, and leaving a trail of my life. Descriptive analysis, t-test, ${\chi}^2$ test and ANCOVA were used with SPSS 18.0 program to analyze the data. Results: After attending the program, a difference was observed in death preparation of the experimental group (t=2.61, P=0.014). The death recognition (F=154.15, P<0.001) score of the experimental group was significantly higher than the control group. There was no significant difference between the groups in perception of well-dying (F=0.11, P=0.747). Conclusions: The well-dying program helped nursing students build positive death recognition. Therefore, this study is expected to contribute to development of a death education program for nursing students.

• Journal of the Korean Association of Geographic Information Studies
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• v.21 no.4
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• pp.132-144
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• 2018

3D Geo-spatial information models have been widely used in the field of Civil Engineering, Medical, Computer Graphics, Urban Management and many other. Especially, in surveying and geo-spatial field, the demand for high quality 3D geospatial information and indoor spatial information is so highly increasing. However, it is so difficult to provide a low-cost and high efficiency service to the field which demand the highest quality of 3D model, because pre-constructed spatial data are composed of different formats and storage structures according to the application purpose of each institutes. In fact, the techniques to construct a high applicable 3D geo-spatial model is very expensive to collect and analyze geo-spatial data, but most demanders of 3D geo-spatial model never want to pay the high-cost to that. This study, therefore, suggest the effective way to construct 3D geo-spatial model with low-cost of construction. In general, the effective way to reduce the cost of constructing 3D geo-spatial model as presented in previous studies is to combine the raw data obtained from point cloud observatory and UAV imagery, however this method has some limitation of usage from difficulties to approve the use of raw data because of those have been managed separately by various institutes. To solve this problem, we developed the linking & management system for unifying a high-Resolution raw geo-spatial data based on the point cloud DB and apply this system to extract the basic database from 3D geo-spatial mode for the road database registration. As a result of this study, it can be provided six contents of main entries for road registration by applying the developed system based on the point cloud DB.

• The Journal of Korean Institute of Next Generation Computing
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• v.15 no.5
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• pp.64-74
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• 2019

Although a non-rigid registration has high demands in clinical practice, it has a high computational complexity and it is very difficult for ensuring the accuracy and robustness of registration. This study proposes a method of applying a non-rigid registration to 3D magnetic resonance images of brain in an unsupervised learning environment by using a deep-learning network. A feature vector between two images is produced through the network by receiving both images from two different patients as inputs and it transforms the target image to match the source image by creating a displacement vector field. The network is designed based on a U-Net shape so that feature vectors that consider all global and local differences between two images can be constructed when performing the registration. As a regularization term is added to a loss function, a transformation result similar to that of a real brain movement can be obtained after the application of trilinear interpolation. This method enables a non-rigid registration with a single-pass deformation by only receiving two arbitrary images as inputs through an unsupervised learning. Therefore, it can perform faster than other non-learning-based registration methods that require iterative optimization processes. Our experiment was performed with 3D magnetic resonance images of 50 human brains, and the measurement result of the dice similarity coefficient confirmed an approximately 16% similarity improvement by using our method after the registration. It also showed a similar performance compared with the non-learning-based method, with about 10,000 times speed increase. The proposed method can be used for non-rigid registration of various kinds of medical image data.

• Journal of Life Science
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• v.31 no.1
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• pp.28-36
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• 2021

Edwardsiella piscicida is a significant cause of hemorrhagic septicemia in fish and gastrointestinal infections in humans. Survival bacteria require specialized mechanisms to adapt to environmental fluctuations. Hence, to understand the mechanism through which E. piscicida senses and responds to environmental osmolarity changes, we determined the protein expression profile and physiological properties under various salinity conditions in this study. The OmpR protein is a part of the Env-ZOmpR two-component system that has been implicated in sensing salt stress in bacteria. However, the physiological role played by this protein in E. piscicida remains to be elucidated. Therefore, in this work, the function of the OmpR protein in response to salt stress was investigated. Phenotypic analysis revealed that, in the mutant, three of the biochemical phenotypes were different from the wild type, including, citrate utilization, hydrogen sulfide, and indole production. Introduction of the plasmid containing the entire ompR gene to the mutant strain returned it to its parental phenotype. The retarded growth rate also partially recovered. Furthermore, in our studies, OmpR was not found to be related to cell motility. Taken together, our results from the mutational analysis, the growth assay, MALDI-TOF MS, qRT-PCR, and the phenotype studies suggest that the OmpR of E. piscicida is implicated in osmoregulation, growth, expression of porins (ETAE_1826), virulence-related genes (EseC, EseD and EvpC), and certain genes of unknown function (ETAE_1540 and ETAE_2706).

• Health Policy and Management
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• v.32 no.2
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• pp.190-204
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• 2022

Background: In Korea, the population is rapidly aging, and the types of households for the elderly are also diversifying. The self-rated health of the elderly is a valuable health indicator that can comprehensively represent the overall quality of life along with physical, mental, and functional health. On the other hand, studies on the association between household type and self-rated health of the elderly are still insufficient. Thus, this study analyzed the association between household type and self-rated health by gender in Korean older adults. Methods: Using data from the analysis of the National Survey of Older Koreans 2017, 10,299 elderly people aged 65 and over were targeted. For the accuracy of the analysis data, 9,910 people were selected as the study sample by excluding proxy responses, those diagnosed with dementia, and non-response. And technical analysis, univariate analysis using the Rao-Scott chi-square test, and logical regression analysis involving survey characteristics were conducted by gender. Results: According to the adjusted model with all variables, in both men and women, the odds ratio of self-rated health 'bad' in 'couple (with ill spouse)' was significantly higher than 'couple (with spouse)'. It was 2.54 (95% confidence interval [CI], 2.05-3.15) for men and 2.11 (95% CI, 1.70-2.62) for women. In addition, the odds ratio of self-rated health 'bad' in 'living with adult children' was 1.43 (95% CI, 1.09-1.87) for men and 1.42 (95% CI, 1.15-1.75) for women, which was more significant in women than men. Conclusion: This study states that there is an association between gender, household type, and self-rated health of the elderly, and the health of a spouse and cohabitation with children have a significant effect on self-rated health. As a result, in order to improve the health status of the elderly, health promotion and health care policies involving the characteristics of the elderly's gender and household type are needed.

• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.791-802
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• 2021

In Korea, the cities continue to deteriorate, while the vacant houses in the small local towns emerge as a serious social problem. Despite the vacant houses emerge as a serious social problem in the small local towns as well as in the large cities, the basic researches into them are yet to be conducted on a full scale. Thus, in order to know about the spatial distribution of the vacant houses, this study conducted the square analysis and the kernel density analysis. As a result, it was confirmed that the vacant houses in Okcheon-gun had certain crowding forms and characteristics at the level of statistical significance. Next, in order to examine the distribution of the vacant houses in terms of the accessibility to the living SOC facilities, the GIS network analysis was performed, focusing on the major facilities and road networks. As a result, it was found that the better the accessibility to the living SOC facilities such as medical and well-being was, the ratio of the vacant houses was lower. In contrast, it was found that the accessibility to the obligatory facilities such as public administration and educational facilities did not have any important effects on the distribution of the vacant houses. All in all, through this study, the spatial distribution of the vacant houses in the small local town and their accessibility to the major SOC facilities could be analyzed.

• Information Systems Review
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• v.25 no.1
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• pp.93-110
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• 2023

Recently, attempts have been made to convert unstructured text into vectors and to analyze vast amounts of natural language for various purposes. In particular, the demand for analyzing texts in specialized domains is rapidly increasing. Therefore, studies are being conducted to analyze specialized and general-purpose documents simultaneously. To analyze specific terms with general terms, it is necessary to align the embedding space of the specific terms with the embedding space of the general terms. So far, attempts have been made to align the embedding of specific terms into the embedding space of general terms through a transformation matrix or mapping function. However, the linear transformation based on the transformation matrix showed a limitation in that it only works well in a local range. To overcome this limitation, various types of nonlinear vector alignment methods have been recently proposed. We propose a vector alignment model that matches the embedding space of specific terms to the embedding space of general terms through end-to-end learning that simultaneously learns the autoencoder and regression model. As a result of experiments with R&D documents in the "Healthcare" field, we confirmed the proposed methodology showed superior performance in terms of accuracy compared to the traditional model.

• KSBB Journal
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• v.24 no.1
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• pp.1-8
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• 2009

In the past decade, we have observed rapid advances in the development of biochips in many fields including medical and environmental monitoring. Biochip experiments involve immobilizing a ligand on a solid substrate surface, and monitoring its interaction with an analyte in a sample solution. Metal nanoparticles can display extinction bands on their surfaces. These charge density oscillations are simply known as the localized surface plasmon resonance (LSPR). The high sensitivity of LSPR has been utilized to design biochips for the label-free detection of biomolecular interactions with various ligands. LSPR-based optical biochips and biosensors are easy to fabricate, and the apparatus cost for the evaluation of optical characteristics is lower than that for the conventional surface plasmon resonance apparatus. Furthermore, the operation procedure has become more convenient as it does not require labeling procedure. In this paper, we review the recent advances in LSPR research and also describe the LSPR-based optical biosensor constructed with a core-shell dielectric nanoparticle biochip for its application to label-free biomolecular detections such as antigen-antibody interaction.

• Progress in Medical Physics
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• v.16 no.2
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• pp.62-69
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• 2005

The purpose of this study has been performed to investigate the possibility of external audit program using thermoluminescence dosimetry for electron beam in korea. The TLD system consists of LiF powder, type TLD-700 read with a PCL 3 reader. In order to determine a calibration coefficient of the TLD system, the reference dosimeters are irradiated to 2 Gy in a $^{60}CO$ beam at the KFDA The irradiation is performed under reference conditions is water phantom using the IAEA standard holder for TLD of electron beam. The energy correction factor is determined for LiF powder irradiated of dose to water 2 Gy in electron beams of 6, 9, 12, 16 and 20 MeV (Varian CL 2100C). The dose is determined according to the IAEA TRS-398 and by measurement with a PTW Roos type plane-parallel chamber. The TLD for each electron energy are positioned in water at reference depth. In this study, to verify of the accuracy of dose determination by the TLD system are performed through a 'blind' TLD irradiation. The results of blind test are $2.98\%,\;3.39\%\;and\;0.01\%(1\sigma)$ at 9, 16, 20 MeV, respectively. The value generally agrees within the acceptance level of $5\%$ for electron beam. The results of this study prove the possibility of the TLD quality assurance program for electron beams. It has contributed to the improvement of clinical electron dosimetry in radiotherapy centers.