• Clinical and Experimental Pediatrics
• /
• v.48 no.9
• /
• pp.929-934
• /
• 2005

Purpose : This study describes how often complementary and alternative medical(CAM) therapies, what patterns of CAM therapies utilization, what types of CAM therapies and why CAM therapies are used in children and adolescent with chronic disease. Methods : We interviewed and filled out questionnaires with parents of patients suffering from asthma, atopic dermatitis, congenital myopathy, epilepsy and so on from Mar 2004 to Aug 2004. Results : Two hundred fifty two parents answered questionnaires; 160 cases(63.5 percent) had used CAM therapies. Utilization of CAM therapies according to each chronic disease was as follows : congenital myopathy(100 percent), atopic dermatitis(91.1 percent), asthma(72.5 percent), chronic diarrhea (50.0 percent), epilepsy(17.1 percent) etc. Types of CAM therapy were as follows : dietary supplement (31.1 percent), herb medicine(23.4 percent), massage(14.2 percent), acupuncture(4.6 percent) etc. Sixty four(40.0 percent) case underwent more than two types of CAM therapies simultaneously. One hundred thirty three(83.1 percent) case were asked through non-medical prescription. Ninety nine(61.9 percent) case were recognized positive effect of CAM therapies. Parents' and childrens' ages were influential factors in CAM therapies utilization : the older the parents and the younger the children, the higher the utilization. Conclusion : Although patients receive treatment with western medicine, many of them not only undergo CAM therapies, especially more than two types, but also recognize the positive effects of CAM therapies. As a result, we suggest that it is easy to use of CAM therapies, and the positive effects of CAM therapies are prominent, domestically. Therefore, medical approach and study about the effectiveness and side effects of CAM therapies is necessary to avoid the imprudent use of such therapies.

• Economic and Environmental Geology
• /
• v.48 no.3
• /
• pp.231-240
• /
• 2015

A total of 93 mineral medicines are mentioned in the Chinese Bonchodogam(本草圖鑑). In Donguibogam(東醫寶鑑), 77 mineral medicines are listed, where 18 are from soil origin, 4 from gem origin, and 55 mineral medicines were originated from stone. In the Herblogy(本草學), which is the textbook used in most oriental medicine colleges in Korea, a total of 23 mineral medicines are listed. Of those, Cinnabaris, Alumen, Melanteritum, Realgar, Orpimentum, Sulfur, Lime from Donguibogam, additional eight which are Talcum, Calomelas, Minium, Calamina, Stannum, Hydrargyrum, Lithargyrum, Hydrargyrum Chloratum from Bonchodogam and Gypsum, Natrii Sulfas, Talcum, Cinnabaris, Sulfur, Arsenicum Sublimatum, Realgar, Calomelas, Minium, Calamina, Borax, Aurum, Glauberitum from Herblogy were selected as the mineral medicine applicable as external atopic dermatitis treatment. Most of the mineral medicines were generally regarded as toxic materials, and therefore, they were elaborately processed to remove toxicity before use. In accordance, it is necessary to discuss how to effectively remove toxicity from toxic mineral medicines. In addition, detoxification can be applied to those mineral medicines classified based on the index material or high content compounds, and if efficacy can be evaluated through various analytical methods, this can be applied to diverse inflammatory diseases as well as atopic dermatitis.

• Clinical and Experimental Pediatrics
• /
• v.49 no.10
• /
• pp.1061-1066
• /
• 2006

Purpose : The purpose of this study was to research whether measurement of cow's milk specific IgE on the newborn would be helpful in the diagnosis of cow's milk allergy. We tried to find out the relation between cow's milk specific IgE and other allergy diseases by following up cases. Methods : We reviewed clinical features of 87 episodes in infants less than 4 weeks old who were positive in cow's milk specific IgE test. For the study group, history taking, physical examinations, elimination and cow's milk specific IgE tests were carried out. We investigated the connection among cow' milk specific IgE, allergic disease and family history in 40 of 87 patients we could follow up on. Results : The mean age of the study group was $17.2{\pm}5.4days$. The subjects were classified in four groups according into allergens : 87 milk allergy positive patients, 24 casein positive, 38 ${\alpha}$-lactoalbumin positive, and 75 ${\beta}$-lactoglobulin positive. The number of patients who had follow-ups for more than 6 months to was 40(45.9 percent). The patients whose parents had allergic disease numberred 10(25 percent). Fiften patients had allergic diseases, 4 had asthma and 11 atopic dermatitis. According to the follow-up study, there is a significant relation between casein positive patients and allergic disease. But there is no statistical and significant relation between cow's milk specific IgE and a family history of allergic disease. Conclusion : For the newborn babies, elimination tests and cow's milk specific IgE tests can be useful in the diagnosis of IgE-mediated or mixed milk allergies.

• Pediatric Infection and Vaccine
• /
• v.18 no.2
• /
• pp.182-192
• /
• 2011

Purpose : Atopic findings may be associated with severity of pneumonia in 2009 pandemic influenza A (H1N1) infection, which could suggest a possible association between atopic findings and the severity of viral infections. Thus, we studied association between atopic findings and severity of disease in children with H1N1 influenza infection. Methods : A retrospective study was performed in 74 children admitted in a single tertiary institute and confirmed as H1N1 patients by reverse transcriptase (RT) - polymerase chain reaction (PCR). They were divided into 2 groups according to the severity of pneumonia. We evaluated whether the atopic finding is risk factor between the two groups. Results : Children with severe pneumonia had higher percentages of serum eosinophilia (88% vs 40%, P <0.001), asthma (65% vs 35%, P =0.011), allergic rhinitis (71% vs 40%, P =0.009), and IgE level (P =0.007). We found positive correlations between aeroallergen sensitizations and severity of pneumonia (82% vs 53%, P =0.007). Conclusion : Among patients with H1N1 pneumonia, asthma and atopic findings are risk factors for severity of pneumonia.

• The Journal of Pediatrics of Korean Medicine
• /
• v.28 no.1
• /
• pp.32-42
• /
• 2014

Objectives The purpose of this study is to establish relationship between allergic diseases and functional gastrointestinal disorders in children and adolescents using objective criteria and questionnaires. Methods This study surveyed 237 children and adolescents who visited the department of Pediatrics of ${\bigcirc}{\bigcirc}$ Korean Medicine Hospital from September 23rd, 2013 to December 26th, 2013. The Korean version of International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and the Korean-translated Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III (QPGS-Rome III) were used. We analyzed the data by using PASW Statistics 18.0 with Chi-square test, Fisher's exact test and Linear by linear association. Results There was no significant difference between prevalence of allergic diseases and functional gastrointestinal disorders. Also, there was no strong relationship between the number of allergic diseases and the functional gastrointestinal disorders. However, some parts showed significant relationships - such as asthma symptoms ever and belch; asthma symptoms last 12 months and belch; allergic rhinitis diagnosis ever and belly aches and abdominal pain around and below the belly button; allergic rhinitis treatment last 12 months and belly aches and abdominal pain around and below the belly button; and atopic dermatitis diagnosis ever and irritable bowel syndrome (respectively; p=0.046, p=0.008, p=0.004, p=0.029, p=0.035). And as the number of allergic diseases increases, the prevalence of functional gastrointestinal disorders are 19.4%, 31.3%, 41.7%, 31.0% respectively. Conclusions Although there was no significant relationship between allergic diseases and functional gastrointestinal disorders, some gastrointestinal symptoms were related to allergic diseases.

• Journal of Science and Technology Studies
• /
• v.9 no.1
• /
• pp.1-31
• /
• 2009

The need and rationale for public participation in science and technology is widely acknowledged in academic communities and policy circles. In addition to institutionalized forms of participation, some STS researchers have paid attention to spontaneous forms of public participation, particularly with regard to social movement. This paper aims to explore a new form of public participation, which had been relatively neglected in STS studies. For this purpose, in this paper we examine environmental health issues and cumulative trauma disorders (CTDs) debates as examples of doing "undone science" in Korea. Our focus will be specifically on how environmental organizations and trade unions have both succeeded in making those issues as research and policy agenda for both scientific community and policy makers. In a concluding section, a couple of suggestions for further research are proposed.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.43 no.4
• /
• pp.329-335
• /
• 2017

We have studied on the keratinocytes differentiation and skin barrier function using Adenophorae radix (A. radix) root extract, which was known to contain triterpenoid, saponin and starch. A. radix root extracts showed the $PPAR{\alpha}$ expression level of Wy-14,643 $0.5-1.0{\mu}M$ in CV-1 cells. The cornified envelop formation (CE) of human keratinocyte cell line (HaCaT) and normal human keratinocyte (NHK) showed a statistically significant increased compared to the control. When HaCaT cells were treated with A. radix root extract, transglutaminase (TGase-1) was significantly increased. As a result of clinical study of the simple cosmetic formulation containing A. radix root extract for about 2 weeks, TEWL values were significantly decreased and water contents were increased. The ceramides, which were obtained from the inner forearm, were also significantly increased statistically. We suggest that the A. radix root extract can be used as a preventive and therapeutic agent for skin diseases such as dry skin and atopy.

• Journal of Yeungnam Medical Science
• /
• v.4 no.2
• /
• pp.205-210
• /
• 1987

Kaposi's varicelliform eruption is a more or less generalized infection of the skin, and sometimes of internal organs, with herpes simplex, vaccinia or Coxsackie virus A 16 ; it appears in people who have atopic dermatitis or some other skin diseases. There is a predilection for infants and children, but no age-group is exempt. We reported 3 cases of Kaposi's varicelliform eruption with atopic dermatitis. They had characteristic multiple umbilicated vesicles on the sites that atopic dermatitis had been involved. A 14-year-old boy and a 2-month-old infant had fever. A 17-year-old boy had wide-spread vesicles. All three patients showed multinucleated giant cells on Tzanck test, that suggests herpes simplex virus origin. They were treated with acyclovir. Within 1 to 2 days after the initiation of the therapy, new lesions had ceased to develop. Most of the lesions were cleared in 7 days without complication.

• Journal of Life Science
• /
• v.18 no.10
• /
• pp.1336-1341
• /
• 2008

Inflammation through the respiratory tract is a crucial event in immune disorders, including asthma, and atopic rhinitis. To investigate whether an aqueous extract of Angelica archangelica L. (AaL) has a beneficial influence in terms of anti-asthmatic activity, its effects on an ovalbumin-induced asthmatic model were examined. Mice sensitized to ovalbumin were orally administered the AaL extract, and their lungs examined by Haematoxylin-Eosin staining to determine IL-4/13 cytokine expression. The AaL extract exerted strong anti-asthmatic effects by regulating each level in the $CD4^+$ cell number, IL-4/13, and other target markers in the lungs. Together, these results collectively indicate that the aqueous AaL extract ameliorates asthmatic symptoms effectively in a mouse ovalbumin-challenge model.

• Journal of Dairy Science and Biotechnology
• /
• v.28 no.1
• /
• pp.35-41
• /
• 2010

Food allergy is defined as adverse reactions toward food mediated by aberrant immune mechanisms. Therefore, an allergic response to a food antigen can be thought of as an aberrant mucosal immune response. Food allergy most often begins in the first 1~2 years of life with the process of sensitization by which the immune system responds to specific food proteins, most often with the development of allergen-specific immunoglobulin E (IgE). Over time, most food allergeies are lost, although allergy to some foods is often long lived. The most important allergen sources involved in early food allergy are milk, eggs, peanut, soybean, meat, fish and cereals. Milk allergy seem to be associated with casein and whey protein. Important features of proteins as allergenicity are size, abundance and stability. Strategies for the prevention of milk allergy is breast-feeding, partially hydrolysised infant formula, using of probiotics, immune components in milk, preparation of low allergenicity milk protein and allergy therapy (immune therapy).