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http://dx.doi.org/10.15230/SCSK.2017.43.4.329

Study on Keratinocyte Differentiation and Skin Barrier Function of Adeonphorae Radix Root Extracts  

Nam, Gaewon (Department of Cosmetics, Seowon University, Global Skin Research Center)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.43, no.4, 2017 , pp. 329-335 More about this Journal
Abstract
We have studied on the keratinocytes differentiation and skin barrier function using Adenophorae radix (A. radix) root extract, which was known to contain triterpenoid, saponin and starch. A. radix root extracts showed the $PPAR{\alpha}$ expression level of Wy-14,643 $0.5-1.0{\mu}M$ in CV-1 cells. The cornified envelop formation (CE) of human keratinocyte cell line (HaCaT) and normal human keratinocyte (NHK) showed a statistically significant increased compared to the control. When HaCaT cells were treated with A. radix root extract, transglutaminase (TGase-1) was significantly increased. As a result of clinical study of the simple cosmetic formulation containing A. radix root extract for about 2 weeks, TEWL values were significantly decreased and water contents were increased. The ceramides, which were obtained from the inner forearm, were also significantly increased statistically. We suggest that the A. radix root extract can be used as a preventive and therapeutic agent for skin diseases such as dry skin and atopy.
Keywords
Adenophorae Radix root extract; keratinocyte differentiation; skin barrier function; $PPAR{\alpha}$; cornified envelope and ceramide;
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