• Applied Chemistry for Engineering
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• v.10 no.4
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• pp.563-567
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• 1999

Reverse osmosis concentration for cephalosproin C was studied using a polyamide composite membrane, FT-30 in spiral wound type with high solute rejection. The experiments were carried out in the aqueous solution of cephalosporin C for water flux, solute rejection and mass transfer coefficient under applied pressure of $4{\sim}20kg/cm^2$, feed concentration of 100~1000 mg/L and feed velocity of 2.8 and 5.6 L/min at room temperature. The effect of operating pressure on the separation of cephalosporin C showed that permeate flux increased with increasing operation pressure. These results are consistent with those predicted by Kedem-Katchalsky model. Solute rejection was nearly 1. The increase of feed concentration caused the reduction of cephalosporin C rejection, which was higher at low concentration than at high concentration, but degree of reduction was small.

• Proceedings of the Acoustical Society of Korea Conference
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• autumn
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• pp.121-124
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• 2001

음성 합성기의 합성음의 자연감을 높이기 위해 자연음에 내재하는 정확한 운율 법칙을 구하여 음성합성 시스템에서 이를 구현해 주어야 한다 무제한 어휘 음성합성 시스템의 문-음성 합성기에서 필요한 운율 법칙은 언어학적 정보를 이용해 구하거나, 자연음에서 추출하고 있다 그러나 추출한 운율 법칙이 자연음에 내재하는 모든 운율 법칙을 반영하지 못했거나, 잘못 구현되는 경우에는 합성음의 자연성이 떨어지게 된다. 이런 점을 고려하여 본 논문에서는 한국어 자연음을 분석하여 추출한 운율 정보를 인공 신경망이 학습하도록 하고 훈련을 마친 인공 신경망에 문장을 입력하고, 출력으로 나오는 운율 정보와 자연음의 운율 정보를 비교한 결과 제안한 인공 신경망이 자연음에 내재하고 있는 운율을 학습할 수 있음을 알 수 있었다. 운율의 3대 요소는 피치 , 지속시간, 크기의 변화이다. 제안한 인공 신경망이 한국어 문장의 음소 열을 입력으로 받아들이고, 각 음소의 지속시간에 따른 피치변화와 크기 변화를 출력으로 내보내면 자연음을 분석해 구한 각 음소의 운율 정보인 목표 패턴과 출력 패턴 의 오차를 최소화하도록 인공 신경망의 가중치를 조절할 수 있도록 설계하였다. 지속시간에 따른 각 음소의 피치와 크기 변화를 학습시키기 위해 피치 및 크기 인공 신경망을 구성하였다. 이들 인공 신경망을 훈련시키기 위해 먼저 음소 균형 문장 군을 구축하여야 하고, 이들 언어 자료를 특정 화자가 일정 환경에서 읽고 이를 녹음하여 , 분석하여 구한운율 정보를 운율 데이터베이스로 구축하였다. 문장 내의 각 음소에 대해 지속 시간과 피치 변화 그리고 크기 변화를 구하고, 곡선 적응 방법을 이용하여 각 변화 곡선에 대한 다항식 계수와 초기 값을 구해 운율 데이터베이스를 구축한다. 이 운율 데이터베이스의 일부는 인공 신경망을 훈련시키는데 이용하고, 나머지로 인공 신경망의 성능을 평가하여 인공 신경망이 운율 법칙을 학습할 수 있었다. 언어 자료의 문장 수를 늘리고 발음 횟수를 늘려 운율 데이터베이스를 확장하면 인공 신경망의 성능을 높일 수 있고, 문장 내의 음소의 수를 감안하여 인공 신경망의 입력 단자의 수는 계산량과 초분절 요인을 감안하여 결정해야 할 것이다

• The Korean Journal of Pain
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• v.7 no.2
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• pp.287-291
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• 1994

A 49 years old male patient was admitted to our neuro-pain clinic with symptoms of left 11th intercostal neuralgic pain and low back pain that developed 2 months prior to admission. Upon initial physical examination, motor weakness or sensory deficit were absent. Intercostal neuralgic pain improved significantly after we performed thoracic root thermocoagulation. However on the afternoon of the procedure the patient started to experience voiding difficulty, saddle anesthesia and rapidly progressing motor weakness and hypoesthesia that involved the lower back area and the lower extremities for three days. Based on these symptoms spinal cord compression was suspected and subsequently plain T-L spine X-rays and T-L spine MRI were performed. A spinal tumor that appeared metastatic in origin was seen at the T11 and T12 level. Liver ultrasonography demonstrated the presence of a $4{\times}4cm$ sized ill defined mass in the posterior segment of the right lobe. The patient was diagnosed to have hepatocellular carcinoma after needle aspiration biopsy and cytologic studies. Further orthopedic surgery was recommended but as the patient rejected any further treatment and examination, it was not possible to confirm the primary focus of the tumor. However as metastasis of a primary liver tumor to the spine is a rare occurrence, some other primary focus of metastasis or even a malignant primary tumor of the spine is more likely to explain this patient's condition.

• Korean Journal of Metals and Materials
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• v.48 no.8
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• pp.765-774
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• 2010

Oxygen equilibrium and the solubility of MgO have been measured in the $CaO-Fe_tO-MgO-SiO_2({\leq}5mass%)-{\Sigma}M_xO_y$ slag in equilibrium with liquid iron in the temperature range of 1550 to $1700^{\circ}C$. The effect of oxides on the MgO solubility, and a method for calculating the solubility of MgO using slag composition and temperature,were discussed. The solubility of MgO is increased with increasing temperature and $Fe_tO$ content, and with decreasing basicity (C/S). The effect of ${\Sigma}M_xO_y$ on the solubility of MgO is a dilution effect due to the increase in slag volume. The activity and activity coefficient of $Fe_tO$ decreased with increasing basicity (B). The effect of temperature on the activity was negligible. The value of ${\rho}=Fe^{3+}/Fe^{2+}$ increased with the increase of the slag basicity (B") and the decrease of the $Fe_tO$ content in the slag.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.1
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• pp.48-55
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• 2019

Current studies have been reported that fruits such as berries may contain both antioxidant and antitumor polyphenols that may be important in this regard. We investigated the immunostimulatory effect of fermented blueberry (Vaccinium corymbosum L.) on cyclophosphamide-induced immunosuppression in animal model. Rats were administered blueberry yeast fermented powder (BYFP) at doses 30, 100, and 300 mg/kg for 4 weeks after cyclophosphamide (Cy) treatment, respectively. The immunomodulatory effect of BYFP were measured both in vitro and in vivo, and the changes of blood components were also analyzed. We found that BYFP recovered immunosuppression-mediated decreased liver, spleen, and thymus weights as well as up regulation of white blood cell, lymphocyte, and neutrophil in blood. Moreover, BYFP up-regulated IL-2, TNF-${\alpha}$, and IFN-${\gamma}$ pro-inflammatory cytokine production compared to immune suppressed control group, respectively. According to histological studies, BYFP regenerated significantly on Cy-mediated injured spleen at the high doses (BYFP 300) comparison with Cy-treated groups (immunosuppression). Collectively, these findings suggest that BYFP may have the potential as a dietary immunostimulatory agent.

• Korean Journal of Metals and Materials
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• v.47 no.12
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• pp.828-833
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• 2009

As a fundamental study in the development of a distillation process for ferromanganese alloy melts, the evaporation behavior of an electrolytic manganese melt under reduced pressure was investigated. The melt temperature, vacuum degree, surface area of the melt, and reaction time were considered as experimental variables. The amount of vaporized manganese increases linearly as the reaction time increases, and the evaporation of manganese was promoted by increasing the temperature and surface area of the melt. In the pressure range below the equilibrium vapor pressure of manganese, the amount of vaporized manganese per unit surface area of the melt increased sharply with a decrease of the pressure in the reaction chamber. An empirical equation for the evaporation rate of manganese was derived by regression analysis. The evaporation coefficient of manganese was determined to be approximately $3.84{\times}10^{-3}(g{\cdot}K^{1/2})/(Pa{\cdot}cm^2{\cdot}min)$ under the investigated conditions.

• Knowledge Management Research
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• v.22 no.1
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• pp.57-84
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• 2021

In this paper, we explore market and environmental factors which affecting organization's priority claim application which is more powerful and prompt strategic method to protect technology from competitors under uncertain and volatile environments. This study empirically examines why organizations strategically choose the priority claim application which is more strong tactics to protect technology as the source of sustainable competitive advantage. We suggest that market and environmental factors, such as exogenous shock, volatility, and uncertainty, may also affect strategic decision that organization take patent application with claiming priority. The results of our analysis of priority claim application in the Korean high-tech electronics industry from 1994 to 2008 showed that these three strategic factors affected the technology protection decision and organization's status also moderate theses effects, as predicted in our hypotheses.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.2
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• pp.64-70
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• 2021

This study aimed to investigate the anti-inflammatory effects of herbal complex HPL-01 on dextran sodium sulfate(DSS) induced ulcerative colitis in rat. Adult male Sprague-Dawley rats were randomized and divided into six groups. Five groups, excluding the normal group, were orally administered orally HPL-01(50, 100, or 200 mg/kg) for 21 days, and acute colitis was induced during the last 7 days by 4% DSS in the drinking water. The HPL-01 administered DSS-treated rats exhibited significantly reduced colon macroscopic damage index and increased body weight and colonic length 7 days after DSS treatment. Additionally, these rats showed lower serum levels of the pro-inflammatory cytokines TNF-α and IL-6 than those treated only with DSS. HPL-01(100 or 200 mg/kg) also attenuated the DSS-induced increase in the number of white blood cells, granulocytes, and mid cells and improved intestinal damage. Taken together, these results suggest that HPL-01 is a promising anti-inflammatory agent that may be in the treatment of colitis.

• Tuberculosis and Respiratory Diseases
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• v.65 no.1
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• pp.37-40
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• 2008

Nephrotic syndrome is a relatively rare complication of malignancy. A few cases of nephrotic syndrome accompanying Hodgkin's disease, non-Hodgkin lymphoma, leukemia and other malignancies have been reported since the first case of the nephrotic syndrome associated with extrarenal malignancy was reported in 1922. Hodgkin's disease and solid tumors are known to be the most common malignancies accompanying nephrotic syndrome. The pathologic findings of kidney in patients with Hodgkin's disease commonly show minimal change nephropathy. Membranous glomerulonephropathy is the most common pathologic feature in patients with solid tumors. Although membranous glomerulonephropathy related to small cell lung cancer has rarely been reported in Korea, minimal change nephropathy accompanying small cell lung cancer has never been reported. We present here a case of a 70 year-old male with minimal change nephropathy that was related to small cell lung cancer. We detected small cell lung cancer during the diagnosis work-up of nephrotic syndrome. We suggest that nephrotic syndrome can be a manifestation of underlying malignancy.

• Korean Journal of Head & Neck Oncology
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• v.30 no.2
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• pp.53-61
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• 2014

Background and Objectives : Anaplastic thyroid carcinoma(ATC) is a rare but highly aggressive thyroid malignancy that is associated with an extremely poor survival despite the best multidisciplinary care. BRAF(V600E) mutation is detected in about a quarter of ATC, but unlike its high treatment response to selective BRAF inhibitor (PLX4032) in metastatic melanoma, the treatment response of ATC is reported to be low. The purpose of this study is to investigate the innate resistance mechanism responsible for this low treatment response to BRAF inhibitor and its effect on epithelial-mesenchymal transition(EMT). Materials and Methods : Two ATP cell lines, 8505C and FRO were selected and treated with PLX4032 and its drug sensitivity and effects on cell migration and EMT were examined and compared. Further investigation on the changes in signals responsible for the different treatment response to PLX4032 was carried out and the same experiment was performed on both orthotopic and ectopic xenograft mouse models. Results : FRO cell line was more sensitive to PLX4032 treatment compared to 8505C cell line. The resistance to BRAF inhibition in 8505C was due to increased expression of EGFR. Effective inhibition of both EGFR and p-AKT was achieved after dual treatment with BRAF inhibitor(PLX4032) and EGFR inhibitor(Erlotinib). Similar results were confirmed on in vivo study. Conclusion : EGFR-mediated reactivation of the PI3K/AKT pathway and MAPK pathway contributes to the relative insensitivity of BRAF(V600E) mutant ATC cells to PLX4032. Dual inhibition of BRAF and EGFR leads to sustained treatment response including cell invasiveness.