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http://dx.doi.org/10.15188/kjopp.2021.02.35.2.64

Anti-Colitic Effects of Herbal Medicine HPL-01 on Dextran Sulfate Sodium Induced Ulcerative Colitis in Rat  

Jo, Hyoung-Kwon (Central Research and Development, Hanpoong Pharm & Foods)
Kim, Dae-Sung (Central Research and Development, Hanpoong Pharm & Foods)
Cho, Seong-Wan (Department of Pharmaceutics & Biotechnology, Konyang University)
Shin, Na-Rae (INVIVO Co. Ltd.)
Park, Young Mi (INVIVO Co. Ltd.)
Lee, Hak Yong (INVIVO Co. Ltd.)
Shin, Dong-Yeop (INVIVO Co. Ltd.)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.35, no.2, 2021 , pp. 64-70 More about this Journal
Abstract
This study aimed to investigate the anti-inflammatory effects of herbal complex HPL-01 on dextran sodium sulfate(DSS) induced ulcerative colitis in rat. Adult male Sprague-Dawley rats were randomized and divided into six groups. Five groups, excluding the normal group, were orally administered orally HPL-01(50, 100, or 200 mg/kg) for 21 days, and acute colitis was induced during the last 7 days by 4% DSS in the drinking water. The HPL-01 administered DSS-treated rats exhibited significantly reduced colon macroscopic damage index and increased body weight and colonic length 7 days after DSS treatment. Additionally, these rats showed lower serum levels of the pro-inflammatory cytokines TNF-α and IL-6 than those treated only with DSS. HPL-01(100 or 200 mg/kg) also attenuated the DSS-induced increase in the number of white blood cells, granulocytes, and mid cells and improved intestinal damage. Taken together, these results suggest that HPL-01 is a promising anti-inflammatory agent that may be in the treatment of colitis.
Keywords
Herbal complex HPL-01; Ulcerative colitis; Dextran sulfate sodium; Colon length; $TNF-{\alpha}$; IL-6;
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