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http://dx.doi.org/10.15188/kjopp.2019.02.33.1.48

Immunostimulatory Effects of Blueberry Yeast Fermented Powder Against Cyclophosphamide-induced Immunosuppressed Model  

Jeong, Do Youn (Microbial Institute for Fermentation Industry (MIFI))
Yang, Hee Jong (Microbial Institute for Fermentation Industry (MIFI))
Jeong, Su Ji (Microbial Institute for Fermentation Industry (MIFI))
Kim, Min Guk (Christian Medical Research Center, Presbyterian Medical Center)
Yun, Chi Young (Christian Medical Research Center, Presbyterian Medical Center)
Lee, Hak Yong (INVIVO Co. Ltd.)
Lee, Yang Hee (INVIVO Co. Ltd.)
Shin, Dong Yeop (INVIVO Co. Ltd.)
Yang, Yea gin (INVIVO Co. Ltd.)
Lee, Hae Seong (INVIVO Co. Ltd.)
Park, Young Mi (INVIVO Co. Ltd.)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.33, no.1, 2019 , pp. 48-55 More about this Journal
Abstract
Current studies have been reported that fruits such as berries may contain both antioxidant and antitumor polyphenols that may be important in this regard. We investigated the immunostimulatory effect of fermented blueberry (Vaccinium corymbosum L.) on cyclophosphamide-induced immunosuppression in animal model. Rats were administered blueberry yeast fermented powder (BYFP) at doses 30, 100, and 300 mg/kg for 4 weeks after cyclophosphamide (Cy) treatment, respectively. The immunomodulatory effect of BYFP were measured both in vitro and in vivo, and the changes of blood components were also analyzed. We found that BYFP recovered immunosuppression-mediated decreased liver, spleen, and thymus weights as well as up regulation of white blood cell, lymphocyte, and neutrophil in blood. Moreover, BYFP up-regulated IL-2, TNF-${\alpha}$, and IFN-${\gamma}$ pro-inflammatory cytokine production compared to immune suppressed control group, respectively. According to histological studies, BYFP regenerated significantly on Cy-mediated injured spleen at the high doses (BYFP 300) comparison with Cy-treated groups (immunosuppression). Collectively, these findings suggest that BYFP may have the potential as a dietary immunostimulatory agent.
Keywords
Blueberry; Immunomodulatory effect; Cyclophosphamide; Cytokines; Dietary immunostimulator;
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