• Reproductive and Developmental Biology
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• v.30 no.1
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• pp.13-19
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• 2006

To search of new porcine pheromonal odorants for biostimulation control system technologies to improve reproductive efficiency in livestock species, the comparative molecular field analysis (CoMFA) for binding affinity constant $(p(Od)_{50})$ between porcine odorant binding protein (pOBP) and ligands of odorant 2-(cyclohexyloxy) tetrahydrofurane derivatives as substrate molecule was conducted and discussed. In the optimized CoMFA model AIV with chirality $(C_1'(R),\;C_2(S))$ in substrate molecule and atom based fit alignment (A) of odorants, the statistical results showed the best predictability of the binding affinities $(p(Od)_{50})$ based on the LOO cross-validated value $r^2_{cv}.\;(q^2=0.886)$ and non-cross-validated conventional coefficient $(r^2_{ncv}.=0.984)$. the binding affinity constants exhibited a good correlation with steric (40.8%), electrostatic (14.6%) and hydrophobic (44.6%) factors of the substrate molecules. from the analytical results of the contour maps, which may give us some valuable informations to the modification of odorants for effective binding affinity.

• Animal Systematics, Evolution and Diversity
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• no.nspc5
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• pp.29-46
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• 2005

As a commemorative joint survey for the 20th anniversary of the Korean Society of Systematic Zoology, molluscan fauna of Jindo Island was investigated from the materials collected from 3 localities of Jindo Island from 29th to 30th of June, 2004. A total of 77 species of 37 families were identified. Among them, 26 species of 18 families are reported for the first time in this area, including Onchidella kurodai (Taki, 1935) that is new to Korean fauna. For O. kurodai, external morphologies were described in detail with illustrations. Combining the present data with those of the previous works revealed that a total of 115 species from 43 families have been recorded in Jindo Island and its adjacent areas thus far. From a biogeographic point of view, some gastropod species (Bittium craticulatum, Mocroschisma dilatatum, Cantharidus japonicus, C. callichroa, Homalopoma sangarense, and Crepidula onyx) encountered from Jindo Island were the species previously recorded in the southern and/or eastern offshores of Korean peninsula, including Jeju Island (Choe, 1992). Along with the fact that Jindo Island contains a large number of molluscan species ranging over the Yellow Sea coast, this finding is another line of evidence supporting the Kim and Kwon (1983)'s idea that this area is an overtopping zone of marine organisms which dwell in both the Yellow sea and southern part of Korean sea waters. No comprehensive faunistic survey was not made in the present study. We expect that further supplementary study would generate more biogeographic and faunistic knowledges than what we understand through the present study.

• Journal of Life Science
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• v.29 no.1
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• pp.105-111
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• 2019

In recent years, progress has been made in the search for the development of new anti-cancer agents by employing specific inhibitors of histone deacetylase (HDAC)-6 to block signal transduction pathways in cancer cells. This study examined the effects of tubastatin A (TubA), an HDAC-6 inhibitor, on the growth and development of immature oocytes in murine ovaries using RNA sequencing analysis. The results from a gene set enrichment analysis (GSEA) indicated that the expression of most of the gene sets involved in the cell cycle and control and progression of meiosis decreased in the TubA-treated group as compared with that in germinal vesicle (GV) stage oocytes. In addition, an ingenuity pathway analysis (IPA) suggested that TubA not only caused increased expression of p53 and pRB and decreased expression of CDK4/6 and cyclin D but also caused elevated expression of genes involved in the control of the DNA check point in G2/M stage oocytes. These results suggest that TubA may induce cell cycle arrest and apoptosis through the induction of changes in the expression of genes involved in signal transduction pathways associated with DNA damage and the cell cycle of immature oocytes in the ovary.

• Journal of Life Science
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• v.23 no.11
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• pp.1325-1335
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• 2013

Working dogs, such as rescue dogs, military watch dogs, guide dogs, and search dogs, are selected by in-training examination of desired traits, including concentration, possessiveness, and boldness. In recent years, genetic information has been considered to be an important factor for the outstanding abilities of working dogs. To characterize the molecular features of the canine genes related to phenotypes for working dogs, we investigated the 24 previously reported genes (AR, BDNF, DAT, DBH, DGCR2, DRD4, MAOA, MAOB, SLC6A4, TH, TPH2, IFT88, KCNA3, TBR2, TRKB, ACE, GNB1, MSTN, PLCL1, SLC25A22, WFIKKN2, APOE, GRIN2B, and PIK3CG) that were categorized to personality, olfactory sense, and athletic/learning ability. We analyzed the chromosomal location, gene-gene interactions, Gene Ontology, and expression patterns of these genes using bioinformatic tools. In addition, variable numbers of tandem repeat (VNTR) or microsatellite (MS) polymorphism in the AR, MAOA, MAOB, TH, DAT, DBH, and DRD4 genes were reviewed. Taken together, we suggest that the genetic background of the canine genes associated with various working dog behaviors and skill performance attributes could be used for proper selection of superior working dogs.

• Journal of the Korean Association of Geographic Information Studies
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• v.18 no.1
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• pp.48-63
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• 2015

In this study, we introduce various hyperspectral data processing techniques for the monitoring of shallow and coastal waters to enlarge the application range and to improve the accuracy of the end results in Korea. Unlike land, more accurate atmospheric correction is needed in coastal region showing relatively low reflectance in visible wavelengths. Sun-glint which occurs due to a geometry of sun-sea surface-sensor is another issue for the data processing in the ocean application of hyperspectal imagery. After the preprocessing of the hyperspectral data, a semi-analytical algorithm based on a radiative transfer model and a spectral library can be used for bathymetry mapping in coastal area, type classification and status monitoring of benthos or substrate classification. In general, semi-analytical algorithms using spectral information obtained from hyperspectral imagey shows higher accuracy than an empirical method using multispectral data. The water depth and quality are constraint factors in the ocean application of optical data. Although a radiative transfer model suggests the theoretical limit of about 25m in depth for bathymetry and bottom classification, hyperspectral data have been used practically at depths of up to 10 m in shallow and coastal waters. It means we have to focus on the maximum depth of water and water quality conditions that affect the coastal applicability of hyperspectral data, and to define the spectral library of coastal waters to classify the types of benthos and substrates.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.08a
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• pp.3-3
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• 2020

최근 지구온난화로 인한 기후변화로 인해 지리적 분포가 한정적인 한반도 구과식물들은 점점 서식지 내 생육에 위협을 받고 있다. 이러한 구과식물의 지속이용가능한 보전을 위해서는 각 종별 형질 특성 및 분포, 생육정보 등의 기초정보 구축이 필요할 것이다. 구과식물(Pinidae, Conifers)은 전 세계적으로 나자식물(Gymnosperms)의 3/5정도인 630여분류군이 분포하는 것으로 알려져 있다(Farjon, 2008). 은행나무나 소철나무류 등 다른 나자식물과 비교하여 여러 복잡한 구조로 이루어진 구과(웅성, 자성 구과)를 형성하고, 잎은 대부분 바늘형으로 단순하며, 상록성인 특징 등으로 구분된다. 우리나라에 분포 및 식재되고 있는 나자식물 중 은행나무와 소철나무를 제외한 모든 나자식물이 구과식물에 속한다. 구과식물이 전 세계적으로 넓은 분포역을 갖지만, 종별로는 제한적인 분포를 갖는 것들이 많이 나타난다. 우리나라에 자생하는 구과식물 대부분도 동북아시아에만 분포하는 종들이 대다수이다. 한반도 구과식물은 총 5과 12속 23종 5변종 총 28분류군으로 확인되었다. 소나무과는 5속 12분류군으로 구상나무와 분비나무의 형태적 중복형질이 확인되었으며, 측백나무과는 3속 9분류군으로 눈향나무를 변종에서 종 수준으로 적용하였고, 어청도에서 해변노간주의 분포를 확인하였다. 개비자나무과는 1속 3분류군으로 수형에 따라 큰개비자나무, 눈개비자나무, 개비자나무로 구분하였다. 주목과는 비자나무속을 포함하여 2속 3분류군으로 설악눈주목에 대한 세부적인 분류학적 재검토가 필요할 것으로 판단한다. 나한송과는 1속 1분류군으로 신안군 가거도에서 나한송의 자생지를 확인하였다. 구상나무와 분비나무의 형태적 구분형질이 모호함에 따라 집단별 유전정보 분석을 통한 계통지리학적 연구를 수행하였다. 분석을 통해 구상나무는 빙하기에 북부지역의 조상종이 남하하여 분화되고, 후빙기에 중부지역까지 분포확장이 이루어진 것으로 판단된다.

• Journal of the Korean Society of Radiology
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• v.10 no.5
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• pp.299-305
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• 2016

Despite of the development of medical equipments and technology. Pancreatic cancer has maked high false positive rate and low survival rate compared to other cancers. Therefore, early catch of pancreatic cancer is the only way to enhance the viability. It is important to find the exact location of the pancreas cancer in early stage. The method of optimum scan for early detection of pancreatic cancer on PET/CT exam is proposed. Examined the anatomical region that potentially can be missing from the supine position of ordinary pet/ct exam. The characteristics and usefulness of angle variation ($0^{\circ}$, $30^{\circ}$, $45^{\circ}$, $60^{\circ}$, $90^{\circ}$) of patients scan position is analyzed. The proposed scan method (named JJ-projection) is bringing advantage of anatomical discrimination by separating stomach, liver, gallbladder duodenum and pancreas. ROC curve analysis is shows to advantage of the JJ-Projection method. The sensitivity has increased 4.6% than the supine delay scan method, the results sensitivity has increased from 91% to 95.2%. The specificity has increased from 75.1% to 84%. Compared with the results observed in cancer by biological biopsy, The accuracy has increased from 86.8% to 94.1%.

• Journal of Life Science
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• v.29 no.2
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• pp.181-190
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• 2019

The purpose of this study was to acquire the active compounds of Anisi stellati fructus (ASF) and to analyze the genes and diseases it targets, focusing on its antibacterial effects using a system pharmacological analysis approach. Active compounds of ASF were obtained through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database and Analysis Platform. This contains the pharmacokinetic properties of active compounds and related drug-target-disease networks, which is a breakthrough in silico approach possible at the network level. Gene information of targets was gathered from the UnitProt Database, and gene ontology analysis was performed using the David 6.8 Gene Functional Classification Tool. A total of 201 target genes were collected, which corresponded to the nine screened active compounds, and 47 genes were found to act on biological processes related to antimicrobial activity. The representative active compounds involved in antibacterial action were luteolin, kaempferol, and quercetin. Among their targets, Chemokine ligand2, Interleukin-10, Interleukin-6, and Tumor Necrosis Factor were associated with more than three antimicrobial biological processes. This study has provided accurate evidence while saving time and effort to select future laboratory research materials. The data obtained has provided important data for infection prevention and treatment strategies.

• The Journal of the Korea Contents Association
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• v.10 no.6
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• pp.49-54
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• 2010

As information on gene sequences is not only diverse but also extremely huge in volume, high-performance computer and information technology techniques are required to build and analyze gene sequence databases. This has given rise to the discipline of bioinformatics, a field of research where computers are utilized to collect, to manage, to save, to evaluate, and to analyze biological data. In line with such continued development in bioinformatics, the Korea Institute of Science and Technology Information (KISTI) has built an infrastructure for the biological information, based on the information technology, and provided the information for researchers of bioscience. This paper analyzes the reference fields of Genbank, the most frequently used gene database by the global researchers among the life information databases, and proposes the interface method to NDSL which is the science and technology information integrated service provided by KISTI. For these, after collecting Genbank data from NCBI FTP site, we rebuilt the database by separating Genbank text files into the basic gene data and the reference data. So new tables are generated through extracting the paper and patent information from Genbank reference fields. Then we suggest the method of connection with the paper DB and the patent DB operated by KISTI.

• Journal of the Korean Association of Geographic Information Studies
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• v.18 no.2
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• pp.174-189
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• 2015

The objective of this study was to reconstruct spatial information using the results of the investigation and evaluation of the health of the living organisms, habitat, and water quality at the investigation points for the aquatic ecosystem health of the Nakdong River basin, to support the rational decision making of the aquatic ecosystem preservation and restoration policies of the Nakdong River basin using spatial analysis techniques, and to present efficient management methods. To analyze the aquatic ecosystem health of the Nakdong River basin, punctiform data were constructed based on the position information of each point with the aquatic ecosystem health investigation and evaluation results of 250 investigation sections. To apply the spatial analysis technique, the data need to be reconstructed into areal data. For this purpose, spatial influence and trends were analyzed using the Kriging interpolation(ArcGIS 10.1, Geostatistical Analysis), and were reconstructed into areal data. To analyze the spatial distribution characteristics of the Nakdong River basin health based on these analytical results, hotspot(Getis-Ord Gi, $G^*_i$), LISA(Local Indicator of Spatial Association), and standard deviational ellipse analyses were used. The hotspot analysis results showed that the hotspot basins of the biotic indices(TDI, BMI, FAI) were the Andong Dam upstream, Wangpicheon, and the Imha Dam basin, and that the health grades of their biotic indices were good. The coldspot basins were Nakdong River Namhae, the Nakdong River mouth, and the Suyeong River basin. The LISA analysis results showed that the exceptional areas were Gahwacheon, the Hapcheon Dam, and the Yeong River upstream basin. These areas had high bio-health indices, but their surrounding basins were low and required management for aquatic ecosystem health. The hotspot basins of the physicochemical factor(BOD) were the Nakdong River downstream basin, Suyeong River, Hoeya River, and the Nakdong River Namhae basin, whereas the coldspot basins were the upstream basins of the Nakdong River tributaries, including Andong Dam, Imha Dam, and Yeong River. The hotspots of the habitat and riverside environment factor(HRI) were different from the hotspots and coldspots of each factor in the LISA analysis results. In general, the habitat and riverside environment of the Nakdong River mainstream and tributaries, including the Nakdong river upstream, Andong Dam, Imha Dam, and the Hapcheon Dam basin, had good health. The coldspot basins of the habitat and riverside environment also showed low health indices of the biotic indices and physicochemical factors, thus requiring management of the habitat and riverside environment. As a result of the time-series analysis with a standard deviation ellipsoid, the areas with good aquatic ecosystem health of the organisms, habitat, and riverside environment showed a tendency to move northward, and the BOD results showed different directions and concentrations by the year of investigation. These aquatic ecosystem health analysis results can provide not only the health management information for each investigation spot but also information for managing the aquatic ecosystem in the catchment unit for the working research staff as well as for the water environment researchers in the future, based on spatial information.