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http://dx.doi.org/10.5352/JLS.2019.29.2.181

Systemic Analysis of Antibacterial and Pharmacological Functions of Anisi Stellati Fructus  

Han, Jeong A (School of Korean Medicine, Pusan National University)
Choo, Ji Eun (School of Korean Medicine, Pusan National University)
Shon, Jee Won (School of Korean Medicine, Pusan National University)
Kim, Youn Sook (School of Medicine, Pusan National University)
Suh, Su Yeon (Okpo Korean Medicine Clinic)
An, Won Gun (School of Korean Medicine, Pusan National University)
Publication Information
Journal of Life Science / v.29, no.2, 2019 , pp. 181-190 More about this Journal
Abstract
The purpose of this study was to acquire the active compounds of Anisi stellati fructus (ASF) and to analyze the genes and diseases it targets, focusing on its antibacterial effects using a system pharmacological analysis approach. Active compounds of ASF were obtained through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database and Analysis Platform. This contains the pharmacokinetic properties of active compounds and related drug-target-disease networks, which is a breakthrough in silico approach possible at the network level. Gene information of targets was gathered from the UnitProt Database, and gene ontology analysis was performed using the David 6.8 Gene Functional Classification Tool. A total of 201 target genes were collected, which corresponded to the nine screened active compounds, and 47 genes were found to act on biological processes related to antimicrobial activity. The representative active compounds involved in antibacterial action were luteolin, kaempferol, and quercetin. Among their targets, Chemokine ligand2, Interleukin-10, Interleukin-6, and Tumor Necrosis Factor were associated with more than three antimicrobial biological processes. This study has provided accurate evidence while saving time and effort to select future laboratory research materials. The data obtained has provided important data for infection prevention and treatment strategies.
Keywords
Anisi Stellati Fructus; antibacterial action; gene ontology analysis; system pharmacological analysis;
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  • Reference
1 Abbas, A. K., Lichtman, A. H. and Pillai, S. 2018. Cellular and Molecular Immunology, pp. 43-44, 9th ed., Elsevier, Philadelphia, USA.
2 Boots, A. W., Haenen, G. R. and Bast, A. 2008. Health effects of quercetin: from antioxidant to nutraceutical. Eur. J. Pharmacol. 585, 325-337.   DOI
3 Chun, B. C. 2001. Epidermiological characteristics and ecological perspectives of zoonoses. J. Agri. Med. Community Health 26, 123-144.
4 Donadio, S., Maffioli, S., Monciardini, P., Sosio, M. and Jabes, D. 2010. Antibiotic discovery in the twenty-first century: current trends and future perspectives. J. Antibiotics 63, 423-430.   DOI
5 Goldbout, J. P. and Glaser, R. 2006. Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer. J. Neuroimmune. Pharm. 1, 421-427.   DOI
6 Huang, D. W., Sherman, B. T. and Lempicki, R. A. 2009. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57.   DOI
7 Huang, D. W., Sherman, B. T. and Lempicki, R. A. 2009. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37, 1-13.   DOI
8 Huang, Y., Zhao, J., Zhou, L., Wang, J., Gong, y., Chen, X., Guo, Z., Wang, Q. and Jiang, W. 2010. Antifungal activity of the essential oil of Illicium verum fruit and its main component trans-anethole. Molecules 15, 7558-7569.   DOI
9 Kang, C. I. 2011. Therapeutic strategy for the management of multi-resistant gram-negative bacterial infections. J. Kor. Med. Assoc. 54, 325-331.   DOI
10 Kataoka, M., Hirata, K., Kunikata, T., Ushio, S., Iwaki, K., Ohashi, K., Ikeda, M. and Kurimoto, M. 2001. Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils. J. Gastroenterol. 36, 5-9.   DOI
11 Kim, A., Im, M. and Ma, J. Y. 2014. Anisi stellati fructus extract attenuates the in vitro and in vivo metastatic and angiogenic potential of malignant cancer cells by down regulating proteolytic activity and pro-angiogenic factors. Int. J. Oncol. 45, 1937-1948.   DOI
12 Ghosh, S., Chisti, Y. and Banerjee, U. C. 2012. Production of shikimic acid. Biotechnol. Adv. 30, 1425-1431.   DOI
13 Kint, T. J., Goldsby, R. A., Osborne, B. A. and Kuby, J. 2006. Immunology, pp. 307, A-28, A-31, 6th ed., Macmillan, New York, USA.
14 Lee, J. Y., Kim, Y. J., Kim, H. J., Lee, M. W. and Park, W. S. 2012. Effect of Anisi Stellati Fructus extract on hydrogen peroxide production in RAW 264.7 mouse macrophage. J. Physiol. Pathol. Kor. Med. 26, 301-305.
15 Lee, S. H. 2008. Epidemics, Human Security, and National Security. Int. Area Studies 12, 229-246.   DOI
16 Wang, G. W., Hu, W. T., Huang, B. K. and Qin, L. P. 2011. Illicium verum: a review on its botany, traditional use, chemistry and pharmacology. J. Ethnopharmacol. 136, 10-20.   DOI
17 Lim, Y. H., Kim, I. H. and Seo, J. J. 2007. In vitro activity of kaempferol isolated from the impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes. J. Microbiol. 45, 473-477.
18 Nabavi, S. F., Braidy, N., Gortzi, O., Sobarzo-Sanchez, E., Daglia, M., Skalicka-Woźniak, K. and Nabavi, S. M. 2015. Luteolin as an anti-inflammatory and neuroprotective agent: A brief review. Brain Res. Bull. 119, 1-11.   DOI
19 Suh, S. Y. and An, W. G. 2017. Systems pharmacological approach of Pulsatillae Radix on treating Crohn's Disease. Evid. Based Complement Alternat. Med. 2017, 4198035.
20 Wang, Q. and Xie, M. 2010. Antibacterial activity and mechanism of luteolin on Staphylococcus aureus. Wei Sheng Wu Xue Bao 50, 1180-1184.
21 Yang, X., Zhang, W., Zhao, Z., Li, N., Mou, Z., Sun, D., Cai, Y., Wang, W. and Lin, Y. 2017. Quercetin loading CdSe/ZnS nanoparticles as efficient antibacterial and anticancer materials. J. Inorg. Biochem. 167, 36-48.   DOI