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http://dx.doi.org/10.5352/JLS.2013.23.11.1325

Bioinformatic Analysis of the Canine Genes Related to Phenotypes for the Working Dogs  

Kwon, Yun-Jeong (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Eo, Jungwoo (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Choi, Bong-Hwan (Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, Rural Development Administration)
Choi, Yuri (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Gim, Jeong-An (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Kim, Dahee (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Kim, Tae-Hun (Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, Rural Development Administration)
Seong, Hwan-Hoo (Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, Rural Development Administration)
Kim, Heui-Soo (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Publication Information
Journal of Life Science / v.23, no.11, 2013 , pp. 1325-1335 More about this Journal
Abstract
Working dogs, such as rescue dogs, military watch dogs, guide dogs, and search dogs, are selected by in-training examination of desired traits, including concentration, possessiveness, and boldness. In recent years, genetic information has been considered to be an important factor for the outstanding abilities of working dogs. To characterize the molecular features of the canine genes related to phenotypes for working dogs, we investigated the 24 previously reported genes (AR, BDNF, DAT, DBH, DGCR2, DRD4, MAOA, MAOB, SLC6A4, TH, TPH2, IFT88, KCNA3, TBR2, TRKB, ACE, GNB1, MSTN, PLCL1, SLC25A22, WFIKKN2, APOE, GRIN2B, and PIK3CG) that were categorized to personality, olfactory sense, and athletic/learning ability. We analyzed the chromosomal location, gene-gene interactions, Gene Ontology, and expression patterns of these genes using bioinformatic tools. In addition, variable numbers of tandem repeat (VNTR) or microsatellite (MS) polymorphism in the AR, MAOA, MAOB, TH, DAT, DBH, and DRD4 genes were reviewed. Taken together, we suggest that the genetic background of the canine genes associated with various working dog behaviors and skill performance attributes could be used for proper selection of superior working dogs.
Keywords
Chromosomal location; expression; gene-gene network; Gene Ontology; working dogs;
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1 Hashizume, C., Suzuki, M., Masuda, K., Momozawa, Y., Kikusui, T., Takeuchi, Y. and Mori, Y. 2003. Molecular cloning of canine monoamine oxidase subtypes A (MAOA) and B (MAOB) cDNAs and their expression in the brain. J Vet Med Sci 65, 893-898.   DOI   ScienceOn
2 Hejjas, K., Vas, J., Kubinyi, E., Sasvari-Szekely, M., Miklosi, A. and Ronai, Z. 2007. Novel repeat polymorphisms of the dopaminergic neurotransmitter genes among dogs and wolves. Mamm Genome 18, 871-879.   DOI
3 Hepper, P. G. and Wells, D. L. 2006. Perinatal olfactory learning in the domestic dog. Chem Senses 31, 207-212.   DOI
4 Jones, A., Montgomery, H. E. and Woods, D. R. 2002. Human performance: a role for the ACE genotype? Exerc Sport Sci Rev 30, 184-190.   DOI   ScienceOn
5 Kim, J. I., Lee, H. R., Sim, S. E., Baek, J., Yu, N. K., Choi, J. H., Ko, H. G., Lee, Y. S., Park, S. W., Kwak, C., Ahn, S. J., Choi, S. Y., Kim, H., Kim, K. H., Backx, P. H., Bradley, C. A., Kim, E., Jang, D. J., Lee, K., Kim, S. J., Zhuo, M., Collingridge, G. L. and Kaang, B. K. 2011. PI3K$\gamma$ is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nat Neurosci 14, 1447-1454.   DOI   ScienceOn
6 Kimura, N., Mizokami, A., Oonuma, T., Sasano, H. and Nagura, H. 1993. Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin- embedded human tissues. J Histochem Cytochem 41, 671-678.   DOI   ScienceOn
7 Konno, A., Inoue-Murayama, M. and Hasegawa, T. 2011. Androgen receptor gene polymorphisms are associated with aggression in Japanese Akita Inu. Biol Lett 7, 658-660.   DOI   ScienceOn
8 Kubinyi, E., Vas, J., Hejjas, K., Ronai, Z., Brúder, I., Turcsán, B., Sasvari-Szekely, M. and Miklósi, A. 2012. Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs. PLoS One 7, e30271.   DOI
9 Kumar, P., Kumar, S. and Singh, Y. 1994. Histology of nasal turbinates in dog. Indian J Anim Sci 64, 1050-1053.
10 Leal, G., Comprido, D. and Duarte, C. B. 2013. BDNF-induced local protein synthesis and synaptic plasticity. Neuropharmacology doi: 10.1016/j.neuropharm.2013.04.005.   DOI   ScienceOn
11 Lee, S. J. 2010. Extracellular Regulation of Myostatin: A Molecular Rheostat for Muscle Mass. Immunol Endocr Metab Agents Med Chem 10, 183-194.   DOI
12 Lit, L., Belanger, J. M., Boehm, D., Lybarger, N., Haverbeke, A., Diederich, C. and Oberbauer, A. M. 2013. Characterization of a dopamine transporter polymorphism and behavior in Belgian Malinois. BMC Genet doi: 10.1186/1471-2156-14-45.   DOI   ScienceOn
13 Ludwig, K. U., Roeske, D., Herms, S., Schumacher, J., Warnke, A., Plume, E., Neuhoff, N., Bruder, J., Remschmidt, H., Schulte-Körne, G., Müller-Myhsok, B., Nöthen, M. M. and Hoffmann, P. 2010. Variation in GRIN2B contributes to weak performance in verbal short-term memory in children with dyslexia. Am J Med Genet B Neuropsychiatr Genet 153B, 503-511.   DOI
14 Martínez-Moreno, A., Rodríguez-Durán, L. F. and Escobar, M. L. 2011. Late protein synthesis-dependent phases in CTA long-term memory: BDNF requirement. Front Behav Neurosci 5, 61.
15 Takeuchi, Y., Hashizume, C., Arata, S., Inoue-Murayama, M., Maki, T., Hart, B. L. and Mori, Y. 2009. An approach to canine behavioral genetics employing guidedogs for the blind. Anim Genet 40, 217-224.   DOI   ScienceOn
16 Wahlsten, D., Metten, P., Phillips, T. J., Boehm, S. L. 2nd, Burkhart-Kasch, S., Dorow, J., Doerksen, S., Downing, C., Fogarty, J., Rodd-Henricks, K., Hen, R., McKinnon, C. S., Merrill, C. M., Nolte, C., Schalomon, M., Schlumbohm, J. P., Sibert, J. R., Wenger, C. D., Dudek, B. C. and Crabbe, J. C. 2003. Different data from different labs: lessons from studies of gene-environment interaction. J Neurobiol 54, 283-311.   DOI   ScienceOn
17 Wang, R., Macmillan, L. B., Fremeau, R. T. Jr, Magnuson, M. A., Lindner, J. and Limbird, L. E. 1996. Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals. Neuroscience 74, 199-218.   DOI   ScienceOn
18 Schmack, K., Sekutowicz, M., Rössler, H., Brandl, E. J., Muller, D. J. and Sterzer, P. 2013. The influence of dopamine-related genes on perceptual stability. Eur J Neurosci doi: 10.1111/ejn.12339.   DOI   ScienceOn
19 Schultz, W. 2002. Getting formal with dopamine and reward. Neuron 36, 241-263.   DOI   ScienceOn
20 Shimada, S., Kitayama, S., Walther, D. and Uhl, G. 1992. Dopamine transporter mRNA: dense expression in ventral midbrain neurons. Brain Res Mol Brain Res 13, 359-362.   DOI   ScienceOn
21 Takeuchi, Y., Hashizume, C., Chon, E. M., Momozawa, Y., Masuda, K., Kikusui, T. and Mori, Y. 2005. Canine tyrosine hydroxylase (TH) gene and dopamine beta-hydroxylase (DBH) gene: their sequences, genetic polymorphisms, and diversities among five different dog breeds. J Vet Med Sci 67, 861-867.   DOI   ScienceOn
22 Vaughan, D., Huber-Abel, F. A., Graber, F., Hoppeler, H. and Flück, M. 2013. The angiotensin converting enzyme insertion/deletion polymorphism alters the response of muscle energy supply lines to exercise. Eur J Appl Physiol 113, 1719-1729.   DOI   ScienceOn
23 Rodriguez, G. A., Burns, M. P., Weeber, E. J. and Rebeck, G. W. 2013. Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex. Learn Mem 20, 256-266.   DOI   ScienceOn
24 Sartori, C. R., Pelágio, F. C., Teixeira, S. A., Valentinuzzi, V. S., Nascimento, A. L., Rogério, F., Muscará, M. N., Ferrari, E. A. and Langone, F. 2009. Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus. Behav Brain Res 203, 165-172   DOI   ScienceOn
25 Nieoullon, A. and Amalric, M. 2002. Dopaminergic receptors: structural features and functional implications. Rev Neurol 158, S59-68.
26 Nagappan, G., Zaitsev, E., Senatorov, V. V. Jr, Yang, J., Hempstead, B. L. and Lu, B. 2009. Control of extracellular cleavage of ProBDNF by high frequency neuronal activity. Proc Natl Acad Sci USA 106, 1267-1272.   DOI   ScienceOn
27 Naragoni, S., Sankella, S., Harris, K. and Gray, W. G. 2009. Phytoestrogens regulate mRNA and protein levels of guanine nucleotide-binding protein, beta-1 subunit (GNB1) in MCF-7 cells. J Cell Physiol 219, 584-594.   DOI   ScienceOn
28 Nieoullon, A. 2002. Dopamine and the regulation of cognition and attention. Prog Neurobiol 67, 53-83.   DOI   ScienceOn
29 Ou, L. C., Yeh, S. H. and Gean, P. W. 2010. Late expression of brain-derived neurotrophic factor in the amygdala is required for persistence of fear memory. Neurobiol Learn Mem 93, 372-382.   DOI   ScienceOn
30 Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W. H., Hempstead, B. L. and Lu, B. 2004. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 306, 487-491.   DOI
31 Purves-Tyson, T. D., Handelsman. D. J., Double, K. L., Owens, S. J., Bustamante, S. and Weickert, C. S. 2012. Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra. BMC Neurosci 13, 95.   DOI
32 Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P. and Soubrier, F. 1990. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86, 1343-1346.   DOI   ScienceOn
33 Mizuguchi, R., Naritsuka, H., Mori, K., Mao, C. A., Klein, W. H. and Yoshihara, Y. 2012. Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb. J Neurosci 32, 8831-8844.   DOI
34 Robinson, G. E. and Ben-Shahar, Y. 2002. Social behavior and comparative genomics: new genes or new gene regulation? Genes Brain Behav 1, 197-203.   DOI   ScienceOn
35 McIntyre, J. C., Davis, E. E., Joiner, A., Williams, C. L., Tsai, I. C., Jenkins, P. M., McEwen, D. P., Zhang, L., Escobado, J., Thomas, S., Szymanska, K., Johnson, C. A., Beales, P. L., Green, E. D., Mullikin, J. C.; NISC Comparative Sequencing Program, Sabo, A., Muzny, D. M., Gibbs, R. A., Attie-Bitach, T., Yoder, B. K., Reed, R. R., Katsanis, N. and Martens, J. R. 2012. Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model. Nat Med 18, 1423-1428.   DOI   ScienceOn
36 Mercerón-Martínez, D., Almaguer-Melian, W., Serrano, T., Lorigados, L., Pavón, N. and Bergado, J. A. 2013. Hippocampal neurotrophins after stimulation of the basolateral amygdala, and memory improvement in lesioned rats. Restor Neurol Neurosci 31, 189-197.
37 Mizuno, K., Dempster, E., Mill, J. and Giese, K. P. 2012. Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning. Genes Brain Behav 11, 651-659   DOI   ScienceOn
38 Mong, J., Easton, A., Kow, L. M. and Pfaff, D. 2003. Neural, hormonal and genetic mechanisms for the activation of brain and behavior. Eur J Pharmacol 7, 229-231.
39 Myerson, S., Hemingway, H., Budget, R., Martin, J., Humphries, S. and Montgomery, H. 1999. Human angiotensin I-converting enzyme gene and endurance performance. J Appl Physiol 87, 1313-1316.   DOI
40 Mong, J. A., Devidze, N., Frail, D. E., O'Connor, L. T., Samuel, M., Choleris, E., Ogawa, S. and Pfaff, D. W. 2003. Estradiol differentially regulates lipocalin-type prostaglandin D synthase transcript levels in the rodent brain: evidence from high-density oligonucleotide arrays and in situhybridization. Proc Natl Acad Sci USA 100, 318-323.   DOI   ScienceOn
41 White, D. M. and Van Cott, A. C. 2007. Clozapine (Clozaril), seizures, and EEG abnormalities. Am J Electroneurodiagnostic Technol 47, 190-197.
42 Zhang, Y., Zhang, C., Yuan, G., Yao, J., Cheng, Z., Liu, C., Liu, Q., Wan, G., Shi, G., Cheng, Y., Ling, Y. and Li, K. 2010. Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression. Behav Brain Funct 6, 49.   DOI   ScienceOn
43 Zhou, Q., Nie, R., Prins, G. S., Saunders, P. T., Katzenellenbogen, B. S. and Hess, R. A. 2002. Localization of androgen and estrogen receptors in adult male mouse reproductive tract. J Androl 23, 870-881.
44 Whitfield, C. W., Cziko, A. M. and Robinson, G. E. 2003. Gene expression profiles in the brain predict behavior in individual honey bees. Science 302, 296-299.   DOI   ScienceOn
45 Almeida, S. S., Barros, C. C., Moraes, M. R., Russo, F. J., Haro, A. S., Rosa, T. S., Alves, M. F., Pesquero, J. B., Carmona, A. K., Bacurau, R. F. and Araujo, R. C. 2010. Plasma Kallikrein and Angiotensin I-converting enzyme Nand C-terminal domain activities are modulated by the insertion/ deletion polymorphism. Neuropeptides 44, 139-143.   DOI   ScienceOn
46 Balestri, M., Calati, R., Serretti, A. and De Ronchi, D. 2013. Genetic modulation of personality traits: a systematic review of the literature. Int Clin Psychopharmacol [Epub ahead of print].
47 Alvarez, R., Terrados, N., Ortolano, R., Iglesias-Cubero, G., Reguero, J. R., Batalla, A., Cortina, A., Fernandez-Garcia, B., Rodriguez, C., Braga, S., Alvarez, V. and Coto, E. 2000. Genetic variation in the reninangiotensin system and athletic performance. Eur J Appl Physiol 82, 117-120.   DOI   ScienceOn
48 Auerbach, J. G., Benjamin, J., Faroy, M., Geller, V. and Ebstein, R. 2001. DRD4 related to infant attention and information processing: a developmental link to ADHD? Psychiatr Genet 11, 31-35.   DOI
49 Baek, K. H., Hong, M. E., Jung, Y. Y., Lee, C. H., Lee, T. J., Park, E. S., Kim, M. K., Yoo, J. H. and Lee, S. W. 2012. Correlation of AR, EGFR, and HER2 Expression Levels in Prostate Cancer: Immunohistochemical Analysis and Chromogenic In Situ Hybridization. Cancer Res Treat 44, 50-56.   DOI   ScienceOn
50 Adams, D. R. and Hotchkiss, D. K. 1983. The canine nasal mucosa. Anat Histol Embryol 12, 109-125.   DOI   ScienceOn
51 Alia-Klein, N., Goldstein, R. Z., Kriplani, A., Logan, J., Tomasi, D., Williams, B., Telang, F., Shumay, E., Biegon, A., Craig, I. W., Henn, F., Wang, G. J., Volkow, N. D. and Fowler, J. S. 2008. Brain monoamine oxidase A activity predicts trait aggression. J Neurosci 28, 5099-5104.   DOI   ScienceOn
52 Bekinschtein, P., Cammarota, M., Igaz, L. M., Bevilaqua, L. R., Izquierdo, I. and Medina, J. H. 2007. Persistence of long-term memory storage requires a late protein synthesisand BDNF- dependent phase in the hippocampus. Neuron 53, 261-277.   DOI   ScienceOn
53 Comings, D. E., Chen, C., Wu, S. and Muhleman, D. 1999. Association of the androgen receptor gene (AR) with ADHD and conduct disorder. Neuroreport 10, 1589-1592.   DOI   ScienceOn
54 Bekinschtein, P., Cammarota, M. and Medina, J. H. 2013. BDNF and memory processing. Neuropharmacology doi:10.1016/j.neuropharm.2013.04.024.   DOI   ScienceOn
55 Chan, D. K., Mellick, G. D., Hung, W. T. and Woo, J. 2003. Genetic and environmental risk factors and their interactions for Parkinson's disease in a Chinese population. J Clin Neurosci 10, 313-315.   DOI   ScienceOn
56 Christie, A. E., Fontanilla, T. M., Roncalli, V., Cieslak, M. C. and Lenz, P. H. 2013. Identification and developmental expression of the enzymes responsible for dopamine, histamine, octopamine and serotonin biosynthesis in the copepod crustacean Calanus finmarchicus. Gen Comp Endocrinol doi: 10.1016/j.ygcen.2013.10.003.   DOI   ScienceOn
57 Baik, J. H. 2013. Dopamine signaling in reward-related behaviors. Front Neural Circuits 7, 152.
58 Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A. and Poulton, R. 2002. Role of genotype in the cycle of violence in maltreated children. Science 297, 851-854.   DOI   ScienceOn
59 Cavallaro, S., Dagata, V. and Alkon, D. L. 2002. Programs of gene expression during the laying down of memory formation as revealed by DNA microarrays. Neurochem Res 27, 1201-1207.   DOI   ScienceOn
60 Chamberlain, N. L., Driver, E. D. and Miesfeld, R. L. 1994. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res 22, 3181-3186.   DOI   ScienceOn
61 Gainetdinov, R. R., Jones, S. R. and Caron, M. G. 1999. Functional hyperdopaminergia in dopamine transporter knock-out mice. Biol Psychiatry 46, 303-311.   DOI   ScienceOn
62 Colley, B., Tucker, K. and Fadool, D. A. 2004. Comparison of modulation of Kv1.3 channel by two receptor tyrosine kinases in olfactory bulb neurons of rodents. Receptors Channels 10, 25-36.   DOI   ScienceOn
63 Fahnestock, M., Marchese, M., Head, E., Pop, V., Michalski, B., Milgram, W. N. and Cotman, C. W. 2010. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging 33, 546-554.
64 Faraone, S. V., Spencer, T. J., Madras, B. K., Zhang-James, Y. and Biederman, J. 2013. Functional effects of dopamine transporter gene genotypes on in vivo dopamine transporter functioning: a meta-analysis. Mol Psychiatry doi: 10.1038/ mp.2013.126.   DOI   ScienceOn
65 Giros, B. and Caron, M. G. 1993. Molecular characterization of the dopamine transporter. Trends Pharmacol Sci 14, 43-49.   DOI   ScienceOn
66 Gong, P., Xi, S., Shen, G., Li, S., Zhang, P., Cao, G., Zhang, F., Shen, Y., Feng, T. and Ma, H. 2013. The effects of DBH, MAOA, and MAOB on attentional biases for facial expressions. J Mol Neurosci 49, 606-613.   DOI   ScienceOn
67 Haddad, P. M. and Dursun, S. M. 2008. Neurological complications of psychiatric drugs: clinical features and management. Hum Psychopharmacol 23, 15-26.   DOI   ScienceOn
68 Hall, J., Thomas, K. L. and Everitt, B. J. 2000. Rapid and selective induction of BDNF expression in the hippocampus during contextual learning. Nat Neurosci 3, 533-535.   DOI   ScienceOn
69 Hejjas, K., Kubinyi, E., Ronai, Z., Szekely, A., Vas, J., Miklosi, A., Sasvari-Szekely, M. and Kereszturi, E. 2009. Molecular and behavioral analysis of the intron 2 repeat polymorphism in the canine dopamine D4 receptor gene. Genes Brain Behav 8, 330-336.   DOI   ScienceOn