• 생물정신의학
• /
• 제13권3호
• /
• pp.170-177
• /
• 2006

Objectives : Disturbances of serotonergic system might be related to the possible mechanism of social phobia. This study was to investigate the association of serotonin transporter gene and social phobia. Methods : Sixty nine patients with social phobia(51 male(73.9%), mean age $35.17{\pm}11.89$ years) and seventy four normal controls(54 male(73.0%), mean age $33.46{\pm}9.63$ years) were tested for serotonin transporter gene-linked polymorphic region(5-HTTLPR) polymorphism. Additionally, patients were grouped into 46 generalized(GEN) and 23 nongeneralized(NGEN) subgroups and 5-HTTLPR polymorphism was compared with that of normal controls. The genotypes and allele frequencies of the 5-HTTLPR polymorphism between social phobia and the control group were compared. Genomic DNA was extracted from their blood and 5-HTTLPR polymorphisms were determined by using polymerase chain reaction. Results : Significant association was observed between the S(ss) genotype and social phobia, by functional classification(p=.010). In allele frequency analysis, a significant association was also observed between the short allele and social phobia(p=.030). A significant associations between S genotype and each subgroup were observed(GEN p=.045 ; NGEN p=.033), but there were no differences in allele frequency. And, no differences in genotype and allele distribution between two subgroups were found. Conclusion : The results in our Korean sample suggest that S genotype of 5-HTTLPR may be associated with social phobia and s allele may be an important genetic factor that activates social phobic symptoms. But, further studies including large number of samples are necessary to elucidate these present findings.

• 생물정신의학
• /
• 제11권2호
• /
• pp.165-172
• /
• 2004

Objective:Although polymorphism of dopamine transporter gene(DAT1) has been considered to be implicated in the pathogenesis of social phobia, previous investigations have been inconsistent and controversial. The authors investigated the relationship between DAT1 polymorphism and social phobia in Koreans. Methods:DAT1 and alleles of fifty subjects who met DSM-IV criterion of social phobia, and those of age- & sex- matched fifty normal controls in Korea were compared. Additionally, patients were grouped into generalized(33) and nongeneralized(17) types and DAT1 polymorphism was compared with that of age- & sex- matched controls. DAT1 with variable number of tandem repeats(VNTR) were determined by using polymerase chain reaction. To compare the distribution of the DAT1 polymorphism between different groups, Fisher's exact test was used. Results:There were no significant differences in either genotypic(p=0.451) or allelic(p=0.452) distributions between the social phobia patients and the controls. There also were no differences in genotypic distribution between subtypes of social phobia patients and the controls. Conclusion:We couldn't find any association between DAT1 polymorphism and social phobia. Further studies including larger number of samples and diverse clinical variables should be conducted to elucidate the present findings.

• 대한불안의학회지
• /
• 제10권1호
• /
• pp.37-43
• /
• 2014

Objective : Social Phobia is associated with extensive disability and reduced quality of life. The concept of 'social self' is a representation of the self-reflected in the eyes of others, and is recruited during self-face recognition, which is closely related to self-esteem. The aim of this study was to identify the relationship of face recognition for self and others using measures of social anxiety and self-esteem in patients with social phobia. Methods : Twenty-seven patients with social phobia and twenty-three normal controls were evaluated with scales of self-esteem, depression, anxiety and other psychiatric symptoms. All participants completed the self-face recognition task. Nine self-faces, nine other faces and eighty-one morphed faces were presented randomly for each trial. The participants were instructed to make a decision as to whether the stimuli were self-face or not. The responses and reaction times were recorded during the task. Results : There were no group differences of the morphing composition at the recognition start point as self-face. In patients with social phobia, the mean reaction time at the start point of recognizing as a self-face was 1,037.6 ms, which was significantly longer than that of normal controls (911.3 ms, p<0.05). Patients with social phobia showed a significant negative correlation between the mean reaction time and the severity of depression when the stimuli were recognized as a self-face (r=-0.421, p<0.05). Conclusion : A difficulty in attention rather than avoidance may be an important factor of face recognition in patients with social phobia. When considering self-face recognition in such patients, many factors, such as anxiety, depression, working memory and theory of mind, need to be considered.

• 생물정신의학
• /
• 제14권2호
• /
• pp.106-114
• /
• 2007

Objective : It is suggested that disturbance of dopaminergic system might be related to the possible mechanism of social phobia. The aim of this study was to investigate the possible association of DRD2 TaqI polymorphism and social phobia. Method : Fifty-one patients with social phobia and 200 comparison subjects were tested for DRD2 TaqI A polymorphism. The severity of social phobic symptoms was measured by self-report version of the Liebowitz Social Anxiety Scale(LSAS-SR) and Hamilton anxiety scale(HAM-A). Results : There was no signigicant difference in the genotype, allele frequency, A1 carrier frequency, and heterozygote frequency DRD2 TaqI A polymorphism between the social phobia patients and the control groups. However, we found significant decrease in somatic anxiety of the HAM-A in the patients having A2A2 homozygotes(p=0.014). In addition, patients having A1A2 heterozygotes showed more anxiety in two subscales (p=0.042 in anxiety, p=0.019 in performance) of the LSAS-SR. Conclusion : These results suggest that DRD2 A2 homozygote might have a protective role against somatic anxiety, and molecular heterosis of DRD2 TaqI A polymorphism might be related with more severe anxiety in social phobia.

• 대한불안의학회지
• /
• 제4권1호
• /
• pp.62-67
• /
• 2008

Objectives : Gender differences in demographic characteristics, symptom presentation, and severity may influence the selection of target behaviors as well as the course and outcome of therapeutic interventions for patients with social phobia. The purpose of this study was to explore the gender differences in the symptomatic characteristics of Korean patients with social phobia. Methods : A total of 256 outpatients with social phobia at Kangbuk Samsung Hospital were included in this study. All subjects were evaluated using the Korean version of the MINI International Neuropsychiatric Interview Plus. Potential differences in demographic characteristics, severity of anxiety, and situational fear and avoidance were examined. Self-report questionnaires and interviewer-administered instruments, including the Social Phobia Scale (SPS), Social Phobia subscale of the Fear Questionnaire (FQ-social), Appraisal of Social Concerns (ASC), and Liebowitz Social Anxiety Scale (LSAS), were used to evaluate the severity of the patients' symptoms. Results : There were no gender differences in demographic characteristics, age, age at onset of social phobia, total SPS score, FQ-Social score, ASC score, and LSAS score. In addition, there was no gender difference in the severity of fear in specific social situations. However, women reported significantly higher total scores on the social helplessness category of the ASC than men (p=0.009). Conclusion : Previous studies reported that the severity of social phobia symptoms is greater in women than in men, but our results suggest that there are no significant gender differences in the severity of social phobia symptoms. Thus, gender differences among patients with social phobia are discussed in the context of traditional sex-role expectations.

• 생물정신의학
• /
• 제16권1호
• /
• pp.37-45
• /
• 2009

Objectives : It is reported that panic disorder is frequently comorbid with other psychiatric illnesses. The aim of this study was to investigate differences of psychiatric comorbidity according to age of onset of panic disorder. Methods : Three hundred-two patients participated in the study. All the patients were evaluated by clinical instruments for the assessment the presence of other comorbid psychiatric disorders and various clinical features; Korean version of Mini International Neuropsychiatric Interview, Self-report questionnaires(Beck Anxiety Inventory, Beck Depression Inventory, Anxiety Sensitivity Index and State-Trait Anxiety Inventory) and clinical rating scale (Hamilton Anxiety Scale, Hamilton Depression Scale and Global Assessment of Functional score). Chi-square test was used to determine the difference between early onset and late onset panic disorder. Results : Forty percent of panic patients were found to have at least one comorbid psychiatric diagnosis. There were no differences among the groups divided by number of comorbidity in sex, agoraphobia comorbidity, duration of panic disorder, except onset age of panic disorder. Early onset group had more comorbidy with social phobia, agoraphobia, PTSD. We also found that Early onset panic disorder patients were more likely to experience derealization, nausea, parethesia than late onset panic disorder patients. Conclusion : The results of our study are in keeping with previous data from other parts of the world. Our finding suggest that earier onset of panic disorder related to more psychiatric comorbidity.

• 한국콘텐츠학회논문지
• /
• 제11권9호
• /
• pp.225-237
• /
• 2011

본 연구에서는 청소년의 자아정체감, 사회적지지와 정신건강과의 관계를 검증하였다. 연구대상은 경기도 지역 K시에 소재한 중 고등학교 각 2개 학교의 중학생 169명, 고등학생 178명으로 총 347명을 대상으로 상관계수와 중다회귀분석을 실시하였다. 그 결과는 다음과 같다. 첫째, 청소년의 자아정체감, 사회적지지, 정신건강 간의 관계를 살펴보면, 청소년의 자아정체감, 사회적지지의 하위변인에서 정신건강의 하위변인 중 강박증과 친구지지, 적대감 및 공포증과 교사지지, 신체화와 미래확신성, 친밀성, 교사지지, 친구지지, 우울증과 미래확신성, 정신증과 미래확신성을 제외한 모든 하위영역에서 상관이 있는 것으로 나타났다. 둘째, 중다회귀분석 결과, 정신건강에 영향을 미치는 가장 높은 변인은 자기수용성, 목표지향성, 부모지지, 친밀성, 주체성 순으로 나타난 반면, 미래확신성, 주도성, 교사지지, 친구지지는 통계적으로 유의미한 예측변인이 아닌 것으로 나타났다. 본 연구의 결과는 자기수용성, 목표지향성, 친밀성, 주체성 수준이 높은 청소년과 부모지지를 높게 지각하는 청소년의 정신건강 수준이 높음을 나타내고 있다.

• 한국노년학
• /
• 제29권3호
• /
• pp.805-822
• /
• 2009

본 연구는 독거노인의 정신건강 수준이 어느 정도인지를 조사하고, 사회인구학적 변인들이 정신건강 수준에 어떤 차이를 가져오는지를 살펴보며, 정신건강의 영향요인을 분석하는 것이다. 이를 위해 G시에 거주하는 65세 이상의 독거노인 131명에 대해 면접조사를 실시하고, 간이정신진단검사(SCL-90-R)를 활용하여 정신건강 수준을 측정하였다. 주요 분석결과는 다음과 같다. 첫째, 본 조사대상자의 정신건강 수준은 3.53점(5점 척도)로서 상당히 심각한 수준인 것으로 나타났으며, 이는 독거노인의 정신건강 수준이 일반노인에 비해 훨씬 열악하다는 것을 보여주는 결과이다. 정신건강의 하위영역별로 우울증이 가장 심각했으며, 신체화 증상도 매우 심각한 수준인 것으로 나타났다. 공포불안, 강박증, 불안증 등의 증상도 심각한 수준이었다. 둘째, 사회인구학적 변인이 정신건강 수준에 어떤 차이를 가져오는지를 살펴보기 위한 변량분석 결과에 의하면, 성별과 교육수준이 유의한 변수로 나타났다. 셋째, 독거노인 정신건강 수준의 영향요인을 예측하기 위한 위계적 회귀분석 결과에 의하면, 본 연구에서 설정한 독립변수 13개를 모두 투입한 최종모델에서 독거노인의 정신건강 수준에 영향을 미치는 변수는 8개였으며, 설명력은 생활만족도, ADL, IADL, 복지서비스 지원, 비공식적 지지 등 사회적 지원 변수의 순서로 높게 나타났다. 본 연구에서는 위의 결과를 토대로 하여 거시적, 미시적 차원의 함의를 제시하였다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제8권2호
• /
• pp.266-272
• /
• 1997

본 연구의 목적은 선택적 함구증 환자에게 강력한 세로토닌 재흡수 억제제인 fluoxetine을 투여한 후에 임상효과를 검증하고자 하였다. 대상은 선택적 함구증 환아 17명으로 8주간 fluoxetine $20{\sim}60mg$을 투약하였고, Clinical Global Impression(CGI), Children’s Depression Inventory(CDI), Revised Children’s Manifest Anxiety Scale(RCMAS) 척도의 변화를 통해 치료효과를 평가함과 아울러 선택적 함구증의 동반병리 및 fluoxetine의 부작용을 조사하였다. Fluoxetine 치료후의 CGI 척도 점수는 치료전의 4.3(${\pm}0.6$)점에서 1.9(${\pm}0.9$)점으로, CDI는 치료전 17.8(${\pm}5.6$)점에서 11.6(${\pm}3.9$)점으로, RCMAS는 치료전 13.2(${\pm}4.2$)점에서 9.6(${\pm}3.6$)점으로 유의한 감소를 보였고, 8주 치료기간 중 치료 4주 이후에 58.8%의 환자가, 치료 8주 시기에는 76.5%의 환자가 임상적 호전을 보고하였다. 선택적 함구증 환자들은 가족 관계의 문제, 사회공포증, 경계성 지능, 언어문제 등의 정신과적 질환이 동반되어 있었으며, 8주간의 fluoxetine투여기간동안 식욕감퇴, 흥분/탈억제, 입면곤란, 구역질, 입마름 등의 부작용이 나타났으나 대체로 내약성을 유지하였다. 이 연구를 통해서 선택적 함구증 환아의 치료에 선택적 세로토닌 재흡수 억제제가 효과적임이 시사된다.

• 한국정보처리학회:학술대회논문집
• /
• 한국정보처리학회 2017년도 추계학술발표대회
• /
• pp.997-1000
• /
• 2017

가상현실이 심리학에 확대 적용되며 주목할 만한 많은 연구결과들이 발표되고 있다. 이와 더불어 현대사회에서 필수적으로 갖춰야할 능력 중 하나는 바로 발표능력이다. 하지만 제대로 연습을 할 수 있는 조건을 갖추기가 힘들고, 발표 연습 현장은 실제 발표 상황과 많이 다르기 때문에 크게 도움이 되지 않을 수도 있다. 따라서 본 논문에서는 좀 더 현실감 있고, 실제 상황을 반영할 수 있는 발표연습 프로그램을 제안한다. 제안 시스템은 VR기기를 통해 사용자가 실제로 발표하는 느낌을 받도록 환경을 제공하며, 라이프 풍선요소를 배치하여, 사용자의 시선처리 능력을 향상시킬 수 있도록 이끌어 주며, 직접 PPT자료를 업로드 함으로써, 제한적인 공간에서도 PPT이용 발표를 할 수 있도록 도와준다. 마지막으로 본 제안 시스템에서는 사용자 음성 피치와 채점, 침묵시간의 분석을 통해 발표 흐름을 피드백할 수 있는 기능을 제공하였다.