• Title/Summary/Keyword: 비선형 계획

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Feasibility study of using Halcyon LINAC for Double-target spine stereotactic body radiation therapy (이중 표적 척추 전이암의 체부정위방사선치료 시 Halcyon LINAC의 치료 유용성 평가)

  • Jeong Hee Ju;An Ye Chan;Park Byung Suk;Park Myung Hwan;Park Yong Chul
    • The Journal of Korean Society for Radiation Therapy
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    • v.34
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    • pp.51-60
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    • 2022
  • Objectives: The purpose is to evaluate dosimetric performance and delivery efficiency of VMAT with Halcyon LINAC for double target spine SBRT Materials and Methods: 12 patients with spine oligometastases were retrospectively studied. Single-isocenter spine SBRT plans was established using Halcyon® with Dual Layer MLC and Truebeam® with High Definition MLC. All patients' plans were created in Eclipse TPS through the identical conditions and optimization. C.I, H.I, G.I (Gradient Index), maximal and volumetric doses to spinal cord and low dose area were evaluated for comparison of both plans. Also, total MU and BOT(Beam On Time) were evaluated. Results: Halcyon plans was no Statistical differences in C.I and H.I. However, the average of G.I was 4.64 for Halcyon, which decreased to 5.5% compared to Truebeam (P<0.001). Halcyon plans demonstrated statistically significant reduced G.I. The average of 50% and 25% isodose volume was 487.56 cc (-3.82%, P<0.001), 1859.45 cc (-4.75%, P<0.001) in Halcyon, respectively. Significantly reduced low dose spill were observed in Halcyon plans. In the evaluation of the spinal cord, the average of Dmean and V10 of Halcyon plans in the sample group with an overlap volume of less than 1 cc was 6.802 Gy (-3.504%, P=0.067), 5.766±1.683 cc (-8.199%, P=0.002), respectively. Halcyon plans demonstrated statistically significant reduced Dmean and V10. For delivery efficiency, MU and BOT(maximum dose rate for each machine), on average, increased in Halcyon plans. However, the average of BOT(800MU/min for each machine) was 648.33 sec for Halcyon (-1.74%, P<0.001). Conclusion: Halcyon plan for double-target spine SBRT demonstrated advantages in the low dose area with a steep dose gradient, while having dosimetrically equivalent target dose distribution and spinal cord protective effect. As a result, Halcyon LINAC produced a dosimetrically improved plan for double-target spine SBRT.

Decomposition Characteristics of Fungicides(Benomyl) using a Design of Experiment(DOE) in an E-beam Process and Acute Toxicity Assessment (전자빔 공정에서 실험계획법을 이용한 살균제 Benomyl의 제거특성 및 독성평가)

  • Yu, Seung-Ho;Cho, Il-Hyoung;Chang, Soon-Woong;Lee, Si-Jin;Chun, Suk-Young;Kim, Han-Lae
    • Journal of Korean Society of Environmental Engineers
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    • v.30 no.9
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    • pp.955-960
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    • 2008
  • We investigated and estimated at the characteristics of decomposition and mineralization of benomyl using a design of experiment(DOE) based on the general factorial design in an E-beam process, and also the main factors(variables) with benomyl concentration(X$_1$) and E-beam irradiation(X$_2$) which consisted of 5 levels in each factor was set up to estimate the prediction model and the optimization conditions. At frist, the benomyl in all treatment combinations except 17 and 18 trials was almost degraded and the difference in the decomposition of benomyl in the 3 blocks was not significant(p > 0.05, one-way ANOVA). However, the % of benomyl mineralization was 46%(block 1), 36.7%(block 2) and 22%(block 3) and showed the significant difference of the % that between each block(p < 0.05). The linear regression equations of benomyl mineralization in each block were also estimated as followed; block 1(Y$_1$ = 0.024X$_1$ + 34.1(R$^2$ = 0.929)), block 2(Y$_2$ = 0.026X$_2$ + 23.1(R$^2$ = 0.976)) and block 3(Y$_3$ = 0.034X$_3$ + 6.2(R$^2$ = 0.98)). The normality of benomyl mineralization obtained from Anderson-Darling test in all treatment conditions was satisfied(p > 0.05). The results of prediction model and optimization point using the canonical analysis in order to obtain the optimal operation conditions were Y = 39.96 - 9.36X$_1$ + 0.03X$_2$ - 10.67X$_1{^2}$ - 0.001X$_2{^2}$ + 0.011X$_1$X$_2$(R$^2$ = 96.3%, Adjusted R$^2$ = 94.8%) and 57.3% at 0.55 mg/L and 950 Gy, respectively. A Microtox test using V. fischeri showed that the toxicity, expressed as the inhibition(%), was reduced almost completely after an E-beam irradiation, whereas the inhibition(%) for 0.5 mg/L, 1 mg/L and 1.5 mg/L was 10.25%, 20.14% and 26.2% in the initial reactions in the absence of an E-beam illumination.

A Study on the Evaluation of 3D Dose Distribution using Normoxic Polymer Gel (정상산소 중합체 겔 선량계를 이용한 3차원 방사선량 평가에 관한 연구)

  • Chung, Se-Young;Kim, Young-Bum;Kwon, Young-Ho;Lee, Suk
    • The Journal of Korean Society for Radiation Therapy
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    • v.19 no.1
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    • pp.7-17
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    • 2007
  • Purpose: As increasing complexity of modern radiotherapy technique, more developing dosimetry is required. Polymer gel dosimeters offer a wide range of potential applications with high resolution and assured quality in the thee-dimensional verification of complex dose distribution such as intensity-modulated radiotherapy (IMRT). The purpose of this study is to find the most sensitive and suitable gel as a dosimeter by varying its composition ratio and its condition such as temperature during manufacturing. Materials and Methods: Each polymer gel with various ratio of composition was irradiated with the same amount of photon beam accordingly. Various polymer gels were analyzed and compared using a dedicated software written in visual C++ which converts TE images to R2 map images. Their sensitivities to the photon beam depending on their composition ratio were investigated. Results: There is no dependence on beam energy nor dose rate, and calibration curve is linear. Conclusion: The polymer gel dosimeter developed by using anti-oxidant in this study proved to be suitable for dosimetry.

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A comparative analysis of terminal efficiency on Northeast Asia and America container ports (동북아 지역과 미국 주요 컨테이너항만간의 효율성 비교 - DEA 기법을 중심으로 -)

  • Ha, Myun-Shin
    • Journal of Korea Port Economic Association
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    • v.25 no.3
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    • pp.229-250
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    • 2009
  • This paper aims to implement an empirical research about the efficiency of America and Northeast Asia pots, and to suggest an effective strategy which can operate these ports more well. This study tries to apply the Data Envelopment Analysis(DEA) model to America and Northeast Asia ports. DEA is a methodology of comparing the relative efficiency of each decision making unit(DMU) by comparing it with other DMUs having similar input and output structure, and is specially very useful when a form of production function of each DMU such as a port is not known. DEA provides the extent of inefficiency of DMUs, which is practically useful information (like the efficiency score and reference sets) required to improve efficiency. This paper analyzed the relative efficiency of 35 ports in America and Northeast Asia for 3 years from 2005 to 2007 through DEA-CCR, DEA-BCC model and scale efficiency. Accordingly, this paper evaluates the efficiency of America and Northeast Asia ports, grasps the position at the present time, and suggests an advanced direction in future.

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Evaluation of Shear Strength by Experiment and Finite Element Analysis of SFRC Hollow Members (SFRC 중공 부재의 실험 및 유한요소 해석에 의한 전단강도 평가)

  • Kim, Seong-Eun;Jeong, Jae-Won;Kim, Seung-Hun
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.23 no.4
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    • pp.78-85
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    • 2019
  • This study targets SFRC hollow members with small depth under shear force and bending. To evaluate the effect of web width on shear strength of SFRC members, experiment and finite element analysis were conducted and compared with existing equations. The web width was planned to be 1/2 times and 2/3 times, and the shear span ratio was planned to be 1.5 times. In the shear test results, the maximum shear strength increased by 10.3 to 28.0% with the web width increased by 33%. When the overall depth of specimens was increased by 1.5 times, the shear strength of the specimen with a web width of 100mm was increased by 29.2%. On the other hand, specimen with the 150mm only increased by 11.3%. These results indicate that the smaller the web width, the greater the shear strength increase with the increase of depth. Also, the smaller the web width, the greater the contribution of steel fiber. It has been shown that the KCI code evaluates the shear strength of experiments as very safe side, and that the proposed formula of Shin et al. predicts the experimental strength relatively well. As the web width increases by 2, 3, and 6 times, the mean shear strength by FEA appears to be 1.18, 1.80, and 2.19 times respectively. This indicates that the shear strength does not increase in proportion to the increase in web width.

Verification of Clinical Usefulness of Jaw Tracking in IMRT (IMRT에 있어 Jaw Tracking 의 임상적 유용성 검증)

  • Kim, Jin-young;Kim, Ki-Hwan
    • Journal of the Korean Society of Radiology
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    • v.14 no.2
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    • pp.105-109
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    • 2020
  • Intensity-modulated radiotherapy(IMRT) has disadvantages such as increasing the low doses of irradiation to normal tissues and accumulated dose for the whole volume by leakage and transmission of the Multi Leaf Collimator (MLC). The accumulated dose and low dose may increase the occurrence of secondary malignant neoplasms. For this reasons, the jaw tracking function of the TrueBeam (Varian Medical Systems, Palo Alto, CA) was developed to reduce the leakage and transmission dose of the MLC with existing linear accelerators. But quantitative analysis of the dose reduction has not been verified. Therefore, in the present study, we intended to verify the clinical possibility of utilizing the jaw tracking function in brain tumor with comparison of treatment plans. To accomplish this, 3 types of original treatment plans were made using Eclipse11 (Varian Medical Systems, Palo Alto, CA): 1) beyond 2 cm distance from the Organs At Risk (OARs); 2) within 2 cm distance from the OARs; and 3) intersecting with the OARs. Jaw tracking treatment plans were also made with copies of the original treatment planning using Smart LMC Version 11.0.31 (Varian Medical Systems, Palo Alto, CA). A comparison between the 2 types of treatment planning methods was performed using the difference of the mean dose and maximum dose to the OARs in cumulative Dose Volume Histogram (DVH). In the DVH comparison, the maximum difference of 0.5 % was observed between the planning methods in the case of over 2 cm distance, and the maximum of 0.6 % was obtained for within the 2 cm distance. For the case intersecting with the OAR, the maximum difference of 2 % was achieved. According to these results, it could be realized that the differences of mean dose and maximum dose to the OARs was larger when the OARs and PTV were closer. Therefore, treatment plans with the jaw tracking function consistently affected the dose reduction and the clinical possibility could be verified.

Comparison of Experimental and Radiation Therapy Planning (RTP) Dose Distributions on Air Cavity (공동(air cavity)의 존재 시 실험적 선량분포와 치료계획상의 선량분포 비교)

  • Kim, Yon-Lae;Suh, Tae-Suk;Ko, Shin-Gwan;Lee, Jeong-Woo
    • Journal of radiological science and technology
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    • v.33 no.3
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    • pp.261-268
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    • 2010
  • This study is compared that the dose distribution by experimentation and radiation therapy planning (RTP) when the air cavity region was treated high energy photon. The dose measurements were performed with a 6 MV photon beam of linear accelerator. The polystyrene and self made acyl phantom were similar to tissue density of the human body. A parallel plate chamber was connected to an electrometer. The measurement setup was SCD (Source Chamber Distance) 100 cm and the distance of surface from air cavity was 3 cm. Absorbed dose of interface were measured by area and height. The percent depth dose were measured presence and absence of air cavity, depth according to a ratio of field size and air cavity size. The dose distribution on planning was expressed to do the inhomogeneity correction. As the area of air cavity was increased, the absorbed dose were gradually reduced. It was slightly increased, when the height of air cavity was changed from 0 cm to 0.5 cm. After the point, dose was decreased. In case of presence of air cavity, dose after distal air cavity interface was more great than absence of air cavity. The rebuild up by field size and area of air cavity occurred for field size, $4{\times}4\;cm^2$, $5{\times}5\;cm^2$ and $6{\times}6\;cm^2$, with fixed on area of air cavity, $5{\times}5\;cm^2$. But it didn't occur at $10{\times}10\;cm^2$ field size. On the contrary, the field size was fixed on $5{\times}5\;cm^2$, rebuild up occurred in area of air cavity, $4{\times}4\;cm^2$, $5{\times}5\;cm^2$. but, it did not occur for air cavity, $2{\times}2\;cm^2$, $3{\times}3\;cm^2$. All of the radiation therapy planning were not occurred rebuild up. It was required to pay attention to treat tumor in air cavity because the dose distribution of planning was different from the dose distribution of patient.

Shape Scheme and Size Discrete Optimum Design of Plane Steel Trusses Using Improved Genetic Algorithm (개선된 유전자 알고리즘을 이용한 평면 철골트러스의 형상계획 및 단면 이산화 최적설계)

  • Kim, Soo-Won;Yuh, Baeg-Youh;Park, Choon-Wok;Kang, Moon-Myung
    • Journal of Korean Association for Spatial Structures
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    • v.4 no.2 s.12
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    • pp.89-97
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    • 2004
  • The objective of this study is the development of a scheme and discrete optimum design algorithm, which is based on the genetic algorithm. The algorithm can perform both scheme and size optimum designs of plane trusses. The developed Scheme genetic algorithm was implemented in a computer program. For the optimum design, the objective function is the weight of structures and the constraints are limits on loads and serviceability. The basic search method for the optimum design is the genetic algorithm. The algorithm is known to be very efficient for the discrete optimization. However, its application to the complicated structures has been limited because of the extreme time need for a number of structural analyses. This study solves the problem by introducing the size & scheme genetic algorithm operators into the genetic algorithm. The genetic process virtually takes no time. However, the evolutionary process requires a tremendous amount of time for a number of structural analyses. Therefore, the application of the genetic algorithm to the complicated structures is extremely difficult, if not impossible. The scheme genetic algorithm operators was introduced to overcome the problem and to complement the evolutionary process. It is very efficient in the approximate analyses and scheme and size optimization of plane trusses structures and considerably reduces structural analysis time. Scheme and size discrete optimum combined into the genetic algorithm is what makes the practical discrete optimum design of plane fusses structures possible. The efficiency and validity of the developed discrete optimum design algorithm was verified by applying the algorithm to various optimum design examples: plane pratt, howe and warren truss.

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Ball end milling of sculptured surface models by considering machinability (절삭성을 고려한 자유곡면 모형의 볼 엔드 밀링가공에 관한 연구)

  • 박천경;맹희영
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.15 no.6
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    • pp.2048-2061
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    • 1991
  • As compared with other cutting types, the ball end milling process causes a complexity in cutting system and a falling-off of machinability. In order to increase the productivity and efficiency in th NC machining of sculptured surfaces, this study carried out the qualitative linearized evaluation about the ball end milling system and applied their practical expressions to the technological processor at the cutter path planning stage. The evaluated expressions were proved to be adequate for practical use from an accuracy point of view and the estimation models were applied to sculptured surface machining processes for finding variable machining conditions. Consequently, it was recognized that variable machining conditions bring about the dispersion of force system and the reduction of machining time by more than 50%.

An Analysis of Choice Behavior for Tour Type of Commercial Vehicle using Decision Tree (의사결정나무를 이용한 화물자동차 투어유형 선택행태 분석)

  • Kim, Han-Su;Park, Dong-Ju;Kim, Chan-Seong;Choe, Chang-Ho;Kim, Gyeong-Su
    • Journal of Korean Society of Transportation
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    • v.28 no.6
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    • pp.43-54
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    • 2010
  • In recent years there have been studies on tour based approaches for freight travel demand modelling. The purpose of this paper is to analyze tour type choice behavior of commercial vehicles which are divided into round trips and chained tours. The methods of the study are based on the decision tree and the logit model. The results indicates that the explanation variables for classifying tour types of commercial vehicles are loading factor, average goods quantity, and total goods quantity. The results of the decision tree method are similar to those of logit model. In addition, the explanation variables for tour type classification of small trucks are not different from those for medium trucks', implying that the most important factor on the vehicle tour planning is how to load goods such as shipment size and total quantity.