• The Journal of the Korea institute of electronic communication sciences
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• v.13 no.6
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• pp.1397-1404
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• 2018

Due to the technical difficulties and high cost for obtaining 3-dimensional structure data, sequence-based approaches in proteins have not been widely acknowledged. A motif can be defined as any segments in protein or gene sequences. With this simplicity, motifs have been actively and widely used in various areas. However, the motif itself has not been studied comprehensively. The value of this study can be categorized in three fields in order to analyze the human proteins using artificial intelligence method: (1) Based on our best knowledge, this research is the first comprehensive motif analysis by analyzing motifs with all human proteins in Protein Data Bank (PDB) associated with the database of Enzyme Commission (EC) number and Structural Classification of Proteins (SCOP). (2) We deeply analyze the motif in three different categories: pattern, statistical, and functional analysis of clusters. (3) At the last and most importantly, we proposed random motif frequency(RMF) matric that can efficiently distinct the characteristics of proteins by identifying interface residues from non-interface residues and clustering protein functions based on big data while varying the size of random motif.

• Journal of Navigation and Port Research
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• v.43 no.3
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• pp.219-230
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• 2019

The objective of this study is to suggest the evaluation method, the evaluation index and items, and evaluation criteria for rational and systematic evaluation of the thalassotherapy complex site. Evaluation items and indicators are determined based on overseas cases of thalassotherapy complex, the central governments' thalassotherapy business policy, and the local governments business plan. 3 major evaluation items, 8 middle evaluation items, 5 small evaluation items and 26 evaluation indexes are selected as evaluation items. The evaluation criterion for each evaluation index is then determined. As per the evaluation process, first, weights are assigned to the evaluation items by an evaluation committee composed of experts. Secondly, each committee member assigns a weight and a score to each evaluation indicator for evaluation score calculation. This score is then multiplied by the weight of the evaluation item to determine the final score for each evaluation index. The ultimate scores of all the evaluation indexes are then added to the evaluation score of each committee member. Lastly, the arithmetic mean of the evaluation scores of all committee members becomes the final evaluation result of a site.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.47-47
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• 2019

미얀마 Indo-Burma 지역은 13,500종의 식물종이 분포하고 있는 생물다양성 핫스팟이다. 북부 산악지역에서 남부의 망그로브 지역에 이르는 다양한 특성의 생태계로 구성되어있다. 그러나, 풍부한 생물 다양성은 인간에 의해 인위적인 간섭, 개발, 모노크림 재배와 같은 지속적인 삼림 벌채로 위협 받고 있다. Dprovidedc와 Krupnick (2018년)은 123과 472종의 미얀마 약용식물을 학명, 영명, 미얀마 식물명 그리고 미얀마 현지에서 쓰이고 있는 약용식물의 활용 및 보존 상태를 종합적으로 정리했다. 이 중 약 13%가 보존 상태에 대한 평가를 받았으며 IUCN의 멸종 위기 종 목록(IUCN2017)에 등재되었다. 비록, 전국에 다양한 식물 및 생물 다양성이 분포되어 있지만, 미얀마는 여전히 지속 가능한 관리와 사용을 위한 인적자원과 시설이 부족하다. 국립수목원(KNA)은 2013년부터 미얀마 천연자원환경보전부(MINISTRY OF NATURAL RESOURCES AND ENVIRONMENTAL CONSERVATION, MONREC)와 미얀마 산림과학원(Forest Research Institute, FRI)과 함께 미얀마 보호지역 및 Saggaing 지역 내 식물 다양성 보존을 위한 공동 현장조사, 연구 및 출판 등의 협력사업을 진행하고 있다. 또한 국립수목원(KNA)는 약용으로 가치가 있는 미얀마 식물 생체를 수집, 현지외 보전 중이며 이중 65과 326종의 식물 생체를 국립수목원(KNA)에 있는 열대식물자원연구센터에 보존과 교육 목적으로 전시 중이다. 이 기증은 미얀마에서 식물생체를 국외로 반출한 첫 번째 사례이며 국립수목원(KNA)은 2008년 독일에서 열대식물을 기증받은 사례 다음으로 두 번째로 외국 정부의 공식적인 대량 식물 도입 사례이다. 도입한 식물 중 Santalum album L. 과 Amorphopallus paeoniifolius (Dennst.) Nicolson. 은 IUCN Red List of Threated Spiences (IUCN2017)에 취약(Vulnerable, VU), 관심필요(Least Concern, LC)로 분류되어 있다. 국립수목원 (KNA)는 2019년 6월 17일 개최된 "2019 아태지역 산림주간 및 28차 아태지역 산림위원회"에 참가하여 미얀마 도입식물 전시회를 개최 하였고, 국내 최초로 Amorphopallus paeoniifolius (Dennst.) Nicolson.의 Leaf Cycle을 타임랩스 촬영하여 국립수목원 웹진(10월 호) 과 YouTube에 연구성과를 홍보하고 있다. 또한 국립수목원 열대식물자원연구센터는 2,700여종의 미얀마, 라오스 등 무한한 가치를 지닌 열대식물의 수집 보전으로 기초 응용 연구기반을 구축하여 국민들에게 열대식물의 중요성과 잠재적인 자원가치를 알리는 역할을 하고 있다.

• Journal of the Korean Society of Radiology
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• v.16 no.3
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• pp.357-363
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• 2022

This study aims to improve the safety inspection awareness of occupational exposure and help radiation safety management by analyzing radiation exposure doses by occupational type of radiation related-workers and radiation workers. Radiation-related workers and radiation workers were classified into three occupations (radiological technologist, doctors, and nurses). A nominal risk coefficient based on ICRP 103 was used to calculate the probability of causing side effects of the lungs due to exposure doses. As a result of analyzing the exposure dose of all workers for one year, the exposure dose of radiological technologist among radiation-related workers was 1.63 ± 2.84 mSv, doctors 0.12 ± 0.22 mSv, and nurses 0.59 ± 1.08 mSv. The one-year deep dose for radiation workers was 2.44 ± 3.30 mSv for radiological technologists, 0.19 ± 0.26 mSv for doctors, and 0.12 ± 0.00 mSv for nurses. Due to this dose, the probability of causing side effects in the lungs was 1.2 per 100,000 radiological technologist, 0.096 doctors, and 0.06 nurses. In this study, it is believed that the probability of side effects on lungs by occupation of radiation exposure dose will be studied and used as useful data for radiation safety management in relation to probabilistic effects in the future.

• Analytical Science and Technology
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• v.35 no.3
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• pp.93-115
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• 2022

Potential impurities in pharmaceuticals could be produced during manufacture, distribution, and storage and affect quality and safety of pharmaceuticals. In particular, highly reactive impurities could result in carcinogenic (mutagenic) effects on human body. International Conference on Harmonisation (ICH) has provided M7(R1) guideline for "Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk" and recommended an adoption of this guideline to the authorities. ICH M7(R1) guideline provides classification, accepted intakes, and controls of potential impurities in pharmaceuticals. However, since appropriate and unified analytical methods for impurities in pharmaceuticals have not been provided in this guideline, most potential impurities in pharmaceuticals are still difficult to manage and supervise by pharmaceutical companies and regulatory authorities, respectively. In this review, we briefly described definition of unintended mutagenic impurities, basic information in ICH M7(R1) guideline, and analytical methods to determine potential impurities. This review would be helpful to manage and supervise potential impurities in pharmaceuticals by pharmaceutical companies and regulatory authorities.

• Journal of the Korean Regional Science Association
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• v.38 no.2
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• pp.43-57
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• 2022

The Land Suitability Assessment is mandatory by National Land Planning and Utilization Act and the results are considered in the establishment of urban master plan and urban management plan. The study aims to examine whether the application of Land Suitability Assessment in developed urban areas is appropriate. A simulation analysis based on the Seoul's data of environmental ecological, physical, and spatial characteristics was conducted on urban green, the only applicable land for the assessment in Seoul. The results of the assessment shows that all pieces of lands in urban green is suitable for 'development'. This conflicts to the purpose of land use of urban green which needs to be conserved to protect the natural environment and landscape, animals and plants, environmental pollution, and urban sprawl. In the analysis applying optional indicators such as the distance from the area of Biotope Class 1 to prevent this conflict, the results shows little difference. This supports the necessity to review this regulation including an option to exclude developed urban areas such as Seoul in the assessment.

• The Journal of KAIRB
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• v.4 no.2
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• pp.36-41
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• 2022

Purpose: The purpose of this study is to evaluate how university hospital Institutional Review Boards (IRBs) in Korea classify risk when reviewing clinical trial protocols. Methods: IRB experts (IRB chairman, vice chairman, IRB administrator) in the university hospitals obtaining a Human research protection program (HRPP) or IRB accreditation in Korea were asked to fill out the Google Survey from September 1, 2020 to October 10, 2020. Result: Among the 23 responder hospitals, 8 were accredited by the American Association for Human Research Protection Program (AAHRPP) and 8 were accredited by the HRPP of Ministry of Food and Drug Safety (MFDS). Seven were accredited by Forum for Ethical Review Committees in Asia and the Western Pacific or Korea National Institution for Bioethics Policy. Thirteen of 23 hospitals (56.5%) had 4 levels (less than minimal, low, moderate, high risk), 4 hospitals had 3 levels (less than, slightly over, over than minimal risk), 1 hospital had 5 levels (4 levels plus required data safety monitoring board), and 1 hospital had 2 levels (less than, over than minimal risk) risk classification system. Thirteen of 23 hospitals (56.5%) had difficulty classifying the risk levels of research protocols. Fourteen hospitals (60.9%) responded that different standards among hospitals for risk level determination associated with clinical trials will affect the subject protection. Six hospitals (26.1%) responded that it will not. Three hospitals (13.0%) responded that it will affect the beginning of the clinical trial. To resolve differences in standards between hospitals, 14 hospitals (60.9%) responded that either the Korean Association of IRB or MFDS needs to provide a guideline for risk level determination in clinical trials: 5 hospitals (21.7%) responded education for IRB members and researchers is needed; 3 hospitals (13.0%) responded that difference among institutions needs to be acknowledged; and 1 hospital (4.3%) responded that there needs to be communication among IRB, investigator, and sponsor. Conclusion: After conducting a nationwide survey on how IRB in university hospital determines risk during review of clinical trials, it is reasonable to use 4-level risk classification (less than minimal, low, moderate, high risk); the most utilized method among hospitals. Moreover, personal information and conflict of interest associated with clinical trials have to be considered when reviewing clinical trial protocols.

• Korean Journal of Culture and Social Issue
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• v.29 no.1
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• pp.125-146
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• 2023

The aims of this study was to investigate the effect of workplace support and access to workplace counseling on the depression level of employees who are workplace bullying victims and then find cross-level interaction effects between individual and group factors. A multi-level analysis was conducted using data from 642 individuals who reported experiencing workplace bullying in the 2017 National Human Rights Commission survey. The findings indicate that a worker's perceived safety of their workplace is negatively associated with depression levels. Additionally, higher perceived workplace support and access to workplace counseling were associated with lower depression levels. Lastly, a positive interaction effect was observed between access to workplace counseling and perceived workplace support in relation to depression levels. That is, higher access to workplace counseling increases the negative effect of workplace support on depression levels of employees. These results highlight the importance of creating protective factors such as a safe and supportive organizational culture to combat workplace bullying of coworkers or supervisors, and implementation of counseling and support services to assist victims in coping with workplace bullying and reducing depression symptoms.

• Journal of the Korean Institute of Landscape Architecture
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• v.51 no.1
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• pp.85-97
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• 2023

Seoul Boramae Park was opened on May 5, 1986, after the Republic of Korea Air Force Academy relocated to Cheongju City in 1985. This study aims to examine the birth and evolution of Seoul Boramae Park and diagnose the park's value being transformed from the former site of the Air Force Academy. Policy reports and newspaper data were analyzed as a research method, focusing on Seoul public records. The study results are as follows. First, Seoul Boramae Park is a large-scale park created before the policy for parks on relocated sites we enacted. Second, Seoul Boramae Park has historical value as an urban park where memories and traces of the Air Force Academy overlap. Third, Seou Boramae Park contributed to regional change by promoting the public value of parks created on the relocated sites with an urban planning method. Seoul Boramae Park has implications for Korean landscape history as a case of securing large green areas in Seoul and presenting its function and roles as a park created on a relocated site.

• Korean Journal of Heritage: History & Science
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• v.56 no.1
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• pp.162-180
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• 2023

The World Heritage Committee decided to make "cultural landscapes" a world heritage category in the 16th Session of the UNESCO General Conference. The decision was made from a recognition of the importance of interactions between human beings and the natural environment or between cultural heritage and natural heritage. Many countries have created policies and institutions to protect their own cultural landscapes along with the changing times. Korea, however, has not obviously defined the concepts and categories of its cultural landscapes, but manages policies and institutions based on the concept of a scenic spot, which has some similar meanings. In addition, it even borrows the "list of landscape adjectives," one of the representative methods for managing landscapes, from foreign countries. With this background, this paper suggested how to define cultural landscapes according to the global development flow. It created a list of cultural landscape adjectives by gathering the adjectives that can properly express local cultural landscapes in Korea. In particular, it collected 4,556 articles from a local newspaper by focusing on the case of Shinan-gun, Jeollanam-do, and analyzed key words and adjectives included in them by using big data analysis. The results suggested by this paper, such as the "classification table of cultural landscape types," "list of cultural landscape adjectives" and "network map of nouns/adjectives" can be applied to research on other localities, and furthermore, used as basic data for finding and protecting the characteristics of local cultural landscapes in Korea.