• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.3
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• pp.132-142
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• 2008

Purpose: This research was designed to study that VEGA DFM 722 is proper index in postpartum women. Methods: The subjects were 81 postpartum women who admitted for postpartum care in Oriental Hospital of Woosuk University from 20, May 2005 to 28, October 2005 and 83 general women who taken Medical Health Examination from 29, January 2005 to 22, July 2006. The women took the test of VEGA DFM 722 and CBC. The SPSS 12.0 for windows was used to analyse the data and the independent samples t-test and paired samples t-test were used to verify the results. Results: The following results were obtained 1. The heights of zone 1, 2, 3 of postpartum women group significantly higher than that of general women group. The height of zone 6 of postpartum women group significantly higher than that of general women group. But, there were no significant differences in the heights of zone 4, 5, 7. 2. The heights of zone 1, 2, 3 of second test significantly lower than that of first test in postpartum women. But, there were no significant differences in the heights of zone 4, 5, 6, 7. Conclusion: The results suggest that postpartum women has upper heat and lower cold compared with general women. And after oriental postpartum care, disparity in upper heat and lower cold was decreased in postpartum women.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.4
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• pp.97-108
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• 2014

Objectives: This study is to report the clinical effect of oriental medicine on a patient suffering from postabortal syndrome with somatic pain disorder, Qi deficiency and depression. Methods: The patient had a miscarriage by cervical incompetence in 24 weeks' gestation even though she had operated cervical cerclage in 20 weeks' gestation. The patient received herbal medication, acupuncture, moxibustion during 20 days of outpatient treatment. The clinical effects were evaluated through VAS (Visual Analogue Scale) and EPDS (Edinburgh Postnatal Depression Scale Test). Results: The clinical symptoms of somatic pain and Qi deficiency were reduced during the treatment. The EPDS score also decreased from 19 points (high risk level) to 8 points (low risk level). Conclusions: This case study showed that herbal medicine, acupuncture and moxibustion treatment appeared to effectively reduce postabortal syndrome. Since patients previously experienced cervical incompetence tend to have habitual abortion for next pregnancy, further long term observation and preventive treatment are needed in this case for next safe pregnancy and childbirth.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.4
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• pp.43-56
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• 2014

Objectives: The purpose of this study is to review the trend of chinese clinical studies of herbal treatment for infertility caused by Polycystic Ovary Syndrome (PCOS). Methods: We searched the clinical studies published from 1979 to 2013 through CAJ (Chinese Academic Journal) with keywords of "PCOS and 不孕" or "多囊卵 巢綜合證 and 不孕". We analyzed the intervention type of clinical studies. In addition, We researched randomized controlled trials (RCTs) published from 2009 to 2013, assessed the quality of RCTs using the Jadad Scale and reanalyzed the intervention type of RCTs. Results: One hundred and seventeen clinical studies were finally selected. Clinical studies of herbal treatment for infertility caused by PCOS increased remarkably after the 2000s in China. Combined herbal medicine and western medicine was used the most frequently. RCTs published from 2009 to 2013 were fifty. Average of Jadad score of RCTs was 1.2. Combined herbal medicine and western medicine was also the most frequently used as intervention in RCTs. Conclusions: Clinical studies on effect of combined herbal medicine and western medicine for infertility caused by PCOS were mostly published in China. But Quality of studies was generally low. Further research on effect of herbal treatment for infertility caused by PCOS is needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.4
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• pp.15-24
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• 2014

Objectives: There were only small studies about the difference of the quality of life depending on blood stasis. We investigated that the blood stasis made the differences of quality of life. Methods: We recruited the participants stratified according to age and gender. The participants were assessed independently by two Korean medicine doctors more than 7 years of clinical experiences whether or not with blood stasis. And they responded at the questionnaire associated with blood stasis and SF-36. The analysis was done with IBM SPSS Statistics (ver. 21). Results: Total 101 participants were checked for with/without blood stasis. 40 participants were accord in the diagnosis with blood stasis by two doctors. Two researchers coincided in diagnosis with non-blood stasis in 42 participants. 19 participants showed the discrepancy between the assessment of blood stasis and they were classified as non-blood stasis. The mean age in group of blood stasis was $44.07{\pm}11.65$, it was not shown the significant difference comparing non-blood stasis group. The subscale of physical function (PF), role-physical (RP), bodily pain (BP), general health (GH), vitality (VT), mental health (MH) and role emotional (RE) in SF-36 were significantly low in the group of blood stasis. Blood test including biochemistry, fibrinogen, prothrombin time and D-dimer was not in abnormal range according to blood stasis without CRP. Conclusions: The patients that diagnosed of blood stasis showed the bad physical health status, and partially bad mental health. It is necessary to investigate whether Korean traditional treatment for blood stasis would be made improvement for quality of life. Moreover, the standardization of diagnosis on blood stasis would be needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.1
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• pp.140-151
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• 2014

Objectives: Cold hypersensitivity has been regarded to be associated with digestive function. This study is aims to evaluate the correlation between digestive function and coldness of hands. Methods: We made a research of 80 women who is in ${\bigcirc}{\bigcirc}$ University. The patients were subjected to thermometer, and those with thermal difference between upper arm and palm were diagnosed with cold hypersensitivity. The patients were divided into two group by cold hypersensitivity group (n=20), and non-cold hypersensitivity group (n=19), and 39 women are mesured by Nepean dyspepsia index-Korean version (NDI-K) to evaluate the severity of functional dyspepsia. Results: There was no difference between two groups on age, height, weight. In functional dyspepsia symptom score, 6 symptoms (Pain in upper abdomen, Burning in upper abdomen, Cramps in upper abdomen, Pressure in upper abdomen, Vomiting, Bad breath) out of 15 were significantly increased in cold hypersensitivity group compared with non-cold hypersensitivity group. And in quality of life score, 3 domains (Tension/sleep, Interference with daily activities, Knowledge/control) out of 5, and total quality of life score were significantly decreased in cold hypersensitivity group compared with non-cold hypersensitivity group. Conclusions: This study shows the correlation between cold hypersensitivity and digestive function.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.1
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• pp.17-27
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• 2014

Objectives: This study was conducted to evaluate the inhibitory effect of polygoni cuspidati radix (PCR) extract on osteoclast differentiation. Methods: MTT-assay was performed to estimate cytotoxicity of PCR extract in BMMs stimulated with RANKL. Tartrate resistant acid phosphatase (TRAP) staining, TRAP activity and RT-PCR were performed to know the inhibitory effect on osteoclast differentiation. actin ring formation were analysed to observe the effect of PCR extract. Results: PCR decreased the number of TRAP positive cells and TRAP activities in BMMs stimulated with RANKL and M-CSF. PCR restrained the formation of actin ring. PCR down regulated the induction of NFATc1, c-Fos, TRAP and OSCAR by RANKL. PCR inhibited NF-${\kappa}B$ activity by inducing degradation of $I{\kappa}B{\alpha}$. Conclusions: We suggest that PCR Extracts can be an effective therapeutic agent on osteoclast differentiation caused by diseases such as osteoporosis.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.1
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• pp.1-16
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• 2014

Objectives: The purpose of this study was to investigate the effects of Gardeniae Fructus Water Extract (GF) on the production of inflammatory mediators in RAW 264.7 cell treated with lipopolysaccharide (LPS). Methods: Gradeniae Fructus was extracted with distilled water (2,000 ml) for 2 hours. In order to evaluate cytotoxicity of GF, 3 - (4,5-dimethylthiazol-2-yl) - 2,5 - diphenyltetrazolium bromide (MTT) assay was performed. To investigate antiinflammatory effects, the concentration of nitric oxide (NO) was measured with No assay, calcium (Ca) was measured with Fluo-4 Ca assay, and cytokine was measured by Bio-Plex cytokine assay in RAW 264.7 cell. And when p-value is below 0.05, it is judged to have the significant difference statistically. Results: 1. GF did not show any cytotoxicity. 2. GF suppressed the production of NO and Ca at the concentration of 25, 50, 100 and $200{\mu}g/ml$. 3. GF suppressed the production of interleukin (IL)-$1{\beta}$, IL-10, IL-12p40, macrophage-colony stimulating factor (M-CSF), macrophage inflammatory protein (MIP)-$1{\beta}$ and keratinocyte chemoattractant(KC) at the concentration of 25, 50, 100 and $200{\mu}g/ml$. 4. GF suppressed the production of vascular endothelial growth factor (VEGF), granulocyte-colony stimulating factor (G-CSF) and monocyte cheomattractant protein (MCP)-1 at the concentration of 25, 50 and $100{\mu}g/ml$. 5. GF suppressed the production of granulocyte macrophage-colony stimulating factor (GM-CSF) and regulated on activation, normal T cell expressed and secreted (RANTES) at the concentration of 25 and $50{\mu}g/ml$. 6. GF suppressed the production of MIP-2 at the concentration of 50 and $100{\mu}g/ml$, and tumor necrosis factor (TNF)-${\alpha}$ at the concentration of 50 and $200{\mu}g/ml$. Conclusions: These results suggest that GF has anti-inflammatory effect and immuno-modulating activity.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.1
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• pp.185-192
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• 2014

Purpose: The purpose of this study is to report the effect on cold hypersensitivity of hands, feet and low abdomen by Sasang constitutional treatment. For this purpose, the effects of a treatment were measured quantitatively using Digital Infrared Thermographic Imaging (DITI). Methods: It was a case of report, the patient was a 25-year-old female whose chief complaint was cold hypersensitivity of hands and feet and low abdomem. We treated the patient with Sasang constitutional treatment, and the effect of a treatment was evaluated by DITI. Results: After Sasang constitutional treatment, the differences of temperature of hands, feet and low abdomem were decreased on DITI screening, respectively. Conclusions: Sasang constitutional treatment on cold hypersensitivity of hands, feet and low abdomen is effective. Further studies on diagnosis tools of low abdomen cold hypersensitivity are needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.1
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• pp.176-184
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• 2014

Objectives: The purpose of this study is to understand current situation of acupuncture and moxibustion for male infertility. Methods: We searched all relevant studies of male infertility patients treated with acupuncture and moxibustion. Electronic searches were conducted in Pubmed, the Cochrane Library, EMBASE and 4 Korean databases until October 2013. Results: A total of 10 reports were included in the review. Two case reports, one case series, three before and after studies, one cohort study, one non-randomized controlled study and two randomized controlled studies were reviewed. Although the majority of studies suggested a positive effect of acupuncture on male infertility, the quality of studies was low. Data on adverse effects were lacking. Conclusions: We found a benefit from acupuncture for poor semen quality in male infertility. These findings should be treated with caution as the evidence was low or very low quality. To further evaluate the effects of acupuncture and moxibustion in male infertility, well-designed randomized controlled studies are needed.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.3
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• pp.175-188
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• 2014

Objectives: The study was implemented to observe how Oriental Medicine Music Therapy (Korean Medicine Music Therapy) influences on curing the symptoms of anger and depression. Methods: Study conducted an experiment with an age of 43 female who usually suffers from headache and dizziness, and frequently gets angry at her daughter. The Study was conducted for an hour, 1 times a week. In the present study, the whole program consisted of 7 sessions. Other than the Oriental Medicine Music Therapy, the patient had never been cured by other treatments. Results: 1. According to the result of STAXI analysis, the patient with anger scale of 36 (before treatment) became to have anger scale of 31 after the treatment, indicating that the therapy had positive effect on curing the anger symptom. 2. Moreover, the analysis result of BDI showed that the patient with depression scale of 17 (before treatment) turned out to be non-depression state, which he had the depression scale of 8. Regarding the results above, it was observed that the treatment cured the depression symptom. 3. Based on the result of SEI analysis, the patient with a SEI score of 139 (higher the SEI score, more the self-esteem one has) became to have score of 142 after the treatment. Conclusions: From the research, it was observed that Korean Medicine Music Therapy has positive influence on improving one's anger or depression control and self-esteem. Clinical trial is needed to verify statistical significance.