• Journal of The Korean Society of Integrative Medicine
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• v.9 no.4
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• pp.251-259
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• 2021

Purpose : This descriptive study examined the correlation between college life stress, self-leadership, sociality, and the three variables of nursing students. Methods : This study surveyed 225 college students majoring in nursing at City B from May to June 2021. The collected data were analyzed for frequency, percentage ratio, mean, and standard deviation using SPSS/WIN 22.0. For the analysis, t-test, analysis of variance, Scheffé's test, and Pearson's correlation coefficient were used. Results : The college life stress of nursing students was 2.12±0.67, self-leadership was 3.41±0.59, and sociality was 3.19±0.42. College life stress as measured by grade (F=3.49, p=.016), major satisfaction(F=3.83, p=.005), happiness index(F=6.38, p=.000), and health status(F=4.61, p<.001) showed significant differences. Self-leadership showed a significant difference in satisfaction with college majors(F=7.02, p=.000). Sociality showed significant differences in college satisfaction(F=3.88, p=.005), happiness index(F=2.72, p=.031), and health status (F=2.92, p=.022). Self-leadership and sociality were positively correlated(r=.147, p=.028). Conclusion : Based on the results of this study, repeated research on college life stress, self-leadership, and sociality of nursing students is required, and attention and effort are needed to develop programs that can reduce college life stress and foster self-direction.

• Journal of the Korea Convergence Society
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• v.12 no.1
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• pp.361-368
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• 2021

This study was conducted to analyze the effects of smoking and drinking on quality of life in Adults. The content was analyzed for aged 30 years or older using data from the 7th National Health and Nutrition Survey(2017). The total number of subjects of this study was 5,465. Socio-demographic characteristics, health-related variables and EQ-5D index scores were used for the analysis. Statistical analysis was performed using the IBM SPSS ver.23 program. As a result of the analysis, there were statistically significant differences in smoking status, binge drinking, subjective health status and stress perception with quality of life. In the regression after adjusting the control variables, 'the amount of alcohol consumed at once(β=.106)' was statistically significant. However smoking status and binge drinking were not statistically significant. Therefore, it is necessary to develop Convergence drinking intervention program to improve the quality of life in adults.

• Journal of The Korean Society of Integrative Medicine
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• v.8 no.4
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• pp.241-251
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• 2020

Purpose : This study examined the effect of locomotive syndrome on stress index and lifestyle patterns among elderly Koreans aged 65 years and older, and analyzed its correlation with stress index and lifestyle patterns. The purpose of this study was to provide basic data for the management and prevention of locomotive syndrome in the elderly. Methods : Using the "25-Question Geriatric Locomotive Function Scale (GLFS-25)", the study evaluated locomotive syndrome in 123 elderly Koreans aged 65 years and older. Of them, 85 patients were assigned to the locomotive syndrome group and 38 patients were assigned to the normal group. The questionnaire measured and investigated the participants' stress index and lifestyle patterns. Statistical analysis was performed using SPSS 22.0 ver. Results : Results showed the locomotive syndrome group displayed a higher stress index than the normal group, with a statistically significant difference between the two groups. The group also scored lower in the lifestyle pattern survey than the normal group did, with a statistically significant difference in high-intensity work performance ratio and average daily performance time between them. The GLFS-25 score showed a significant positive correlation with the stress index and sitting and lying down time, and a significant negative correlation with medium-intensity working time, walking, and cycling time. Conclusion : In conclusion, Locomotive syndrome in elderly Koreans is closely related to stress and lifestyle patterns, especially high-intensity work. We recommend active prevention and management of locomotive syndrome and further research into the effects of various lifestyle factors on the illness.

• Journal of Life Science
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• v.29 no.2
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• pp.265-271
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• 2019

In general, specific gravity (SG) and urinary creatinine (CR) have been used to adjust urinary cadmium (Cd) concentrations. However, the validity of correction methods has been controversial. We compared the two adjustments to evaluate associations between urinary Cd and various renal damage markers and to evaluate the relationship between urinary Cd concentration and renal disease markers, such as estimated glomerular filtration rate (eGFR), in a relatively large general population sample. Among the 1,086 volunteers who were enrolled in this study, 862 healthy volunteers who did not have kidney disease were included in the final analysis. Urinary Cd, malondialdehyde (MDA), and N-acetyl-${\beta}$-D-glucosaminidase (NAG) concentrations were measured, the creatinine-based eGFR was calculated, and the relationships between these markers were subsequently analyzed. This study showed the use of urinary Cd concentration adjusted with SG rather than with urinary creatinine may be appropriate in studies evaluating renal function based on Cd exposure. Urinary Cd concentration adjusted with SG had a positive correlation with urinary MDA levels and a negative correlation with eGFR. This relationship was relatively stronger in women than in men. This study showed that urinary Cd level was associated with decreased eGFR in the general population, and oxidative stress was likely to act as an intermediator in this process. These results suggest that eGFR can be a very good indicator of kidney damage caused by Cd exposure in the general population.

• Journal of Life Science
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• v.29 no.2
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• pp.173-180
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• 2019

Amyloid ${\beta}$-protein ($A{\beta}$) is the principal component of senile plaques characteristic of Alzheimer's disease (AD) and elicits a toxic effect on neurons in vitro and in vivo. Many environmental factors, including antioxidants and proteoglycans, modify $A{\beta}$ toxicity. It is worthwhile to isolate novel natural compounds that could prove therapeutic for patients with AD without causing detrimental side effects. In this study, we investigated the in vitro neuroprotective effects of the ethyl acetate fraction of methanol extract of Ophiophogon japonicas (OJEA fraction). We used an MTT reduction assay to detect protective effects of the OJEA fraction on $A{\beta}_{25-35}$-induced cytotoxicity to PC12 cells. We also used a cell-based ${\beta}$-secretase assay system to investigate the inhibitory effect of the OJEA fraction on ${\beta}$-secretase activity. In addition, we performed an in vitro lipid peroxidation assay to evaluate the protective effect of the OJEA fraction against oxidative stress induced by $A{\beta}_{25-35}$ in PC12 cells. The OJEA fraction had strong protective effects against $A{\beta}_{25-35}$-induced cytotoxicity to PC12 cells and was strongly inhibitory to ${\beta}$-secretase activity, which resulted in the attenuation of $A{\beta}$ generation. In addition, the OJEA fraction significantly decreased malondialdehyde (MDA) content, which is induced by the exposure of PC12 cells to $A{\beta}_{25-35}$. Our results suggested that the OJEA fraction contained active compounds exhibiting a neuroprotective effect on $A{\beta}$ toxicity.

• Korean Journal of Health Education and Promotion
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• v.21 no.3
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• pp.195-211
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• 2004

Stress is a primary health promotion issue in worksite research because psychological distress is closely related not only to workers' health status but also to their job performance. This study identified the significant health behaviors affecting workers' job-related stress in Korean manufacturing industry with the national survey data conducted by the Korean Occupational Safety and Health Agency in 2003. A total of 7,818 factory workers in 1,562 manufacturing companies participated in the Korean nation-wide occupational health survey and 3,390 workers answered that they had any stressors in their workplace among the 7,818 workers finally participated in the analysis. Participants were selected by the stratified proportional sampling process by manufacturing industry classification, company size, and company locations (8 metropolitan and 8 non-metropolitan regions) in Korea. Trained interviewers visited the target companies and interviewed the factory workers randomly selected in each company. Smoking, drinking, weight control, exercise, sleeping, break time at work, and perceived fatigue were included in the health behavior construct. Stress symptoms was consisted of physical and psychological stress with 8 items. All survey responses were anonymously coded into the SPSS statistical program and testified using stepwise multiple regression analysis. Male workers were 73.5% and the 30s were 40.0% among the age groups. The married and the high school graduate were majority with 52.1% and 61.8% each. Current smokers were 44.7% and More than 50% of the participants drank alcohol sometimes. No exercise group was 59.3% and the participants who dissatisfied with their daily sleeping hours were 43.5%. In t-test and analysis of variance, the significant general characteristics associated with physical and psychological job stress were young age (p<0.001), single marital status (p<0.001), and short working period at the present company (p<0.001). The health behaviors related to physical job stress were current smoking, weight change during the past one year (p<0.001), weight control effort (p<0.001), exercise (p<0.001), daily sleeping dissatisfaction (p<0.001), break time, and perceived fatigue (p<0.001). All 10 health behavior factors were significantly associated with psychological job stress (p<0.05). Weight change, weight control effort, exercise, daily sleeping dissatisfaction, little break at work, and high perceived fatigue were significant factors affecting job stress. Daily sleeping dissatisfaction, little break at work, little exercise, weight change for the past one year and young age were selected as the significant health behavior and general factors affecting physical job stress symptoms in stepwise multiple regression analysis. The five factors explained 18.9% of the physical stress score variance. Six factors were selected as the significant health behaviors affecting psychological job stress: daily sleeping dissatisfaction, little exercise, frequent drinking alcohol, high perceived fatigue, little break at work, and little weight control effort. The six factors explained 10.6% of the psychological stress score variance.

• Journal of Korean Academy of Oral Health
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• v.41 no.4
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• pp.243-249
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• 2017

Objectives: Stress is a psychological reaction to stimuli such as anxiety or threat felt by a person either physically or mentally when placed in a difficult situation. Although a relationship between stress and dry mouth has been reported, it remains understudied. The purpose of this study was to investigate the association between stress and subjective dry mouth among the elderly living in a rural region. Methods: A total of 214 people aged ${\geq}60years$ living in a rural area were recruited with an informed consent for a cross-sectional analysis. Information about stress and subjective dry mouth was obtained by an interview survey with a constructed questionnaire. Data on other potential confounding factors (including oral factors) such as socio-demographic data, health-related behaviors, the number of remaining teeth, and subjective chewing ability were also gathered at the same time. Logistic regression models were used to analyze the relationship of stress and dry mouth using SPSS. Results: The Crude odds ratio (OR) of stress awareness affecting subjective dry mouth was 2.59 (95% confidence interval: 1.43-4.68). After adjusting for sex, education, income, smoking, and alcohol intake, the adjusted OR was 2.52 (95% confidence interval: 1.30-4.87) which was statistically significant. Conclusions: Elderly people who were stressed had an approximately 2-fold increase in experiencing subjective dry mouth when compared to their stress-free counterparts.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.29 no.2
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• pp.251-258
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• 2019

Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Inflammation and oxidative stress are associated with COPD. The aim of this study was to evaluate the relationship among inflammation, oxidative stress, and airflow limitation severity in retired miners with COPD. Methods: The levels of serum high-sensitivity C-reactive protein(hsCRP) as a biomarker for inflammation, degree of reactive oxygen metabolites(dROMs) and biological antioxidants potential(BAP) in plasma as biomarkers for oxidative stress were measured in 211 male subjects with COPD. Degree of airflow limitation severity as determined by spirometry was divided into three grades grouped according to the classification of the Global Initiatives for Obstructive Lung Disease(GOLD)(1, mild; 2, moderate; $3{\leq}$, severe or more) using a fixed ratio, post- bronchodilator $FEV_1/FVC$ < 0.7. Results: Mean levels of dROMs significantly increased in relation to airflow limitation severity(GOLD 1, 317.8 U.CARR vs. GOLD 2, 320.3 U.CARR vs. GOLD $3{\leq}$, 350.9 U.CARR, p=0.047) and dROMs levels were correlated with serum hsCRP levels(r=0.514, p<0.001). Mean levels of hsCRP were higher in current smokers(non-smoker, 1.47 mg/L vs. smoker, 2.34 mg/L, p=0.006), and tended to increase with degree of airflow limitation severity(p=0.071). Mean levels of BAP were lower in current smokers(non-smoker, $1873{\mu}mol/L$ vs. smoker, $1754{\mu}mol/L$, p=0.006). Conclusions: These results suggest that inflammation and oxidative stress are related to airflow limitation severity in retired miners with COPD, and there was a correlation between inflammation and oxidative stress.

• Proceedings of the KAIS Fall Conference
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• 2010.11b
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• pp.915-918
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• 2010

12주간의 유산소 운동 및 복합성 운동이 중년여성의 신체 구성 및 혈중 지질에 미치는 영향을 규명하기 위해 2009년 3월부터 9월까지 일개 D광역시 소재 일개 S구 보건소 12주 운동프로그램에 참가한 40~50대 중년 여성 78명을 대상으로 비만그룹과 정상그룹으로 나누어 주3회, 회당 80분의 유산소 운동과 유산소운동/근력 운동을 병행한 복합성 운동을 목표 심박수 40~60%에서 실시하였다. 1. WHO 기준 적용 시, 정상군의 경우 운동의 유형에 상관없이 유의한 차이가 나타났다. 2. WHO 기준 적용 시, 비만군의 경우 유산소 운동의 근육량, 체지방량, 체지방률을 제외하고 운동의 유형에 상관없이 유의한 차이가 나타났다. 3. 아시아-태평양 기준 적용 시, 정상군의 경우 일부 항목에서만 유의한 차이가 나타났다. 4. 아시아-태평양 기준 적용 시, 비만군의 경우 유산소 운동의 근육량을 제외하고 운동의 유형에 상관 없이 유의한 차이가 나타났다. 상기 결론에서 볼 수 있듯이, 12주간의 운동 프로그램은 WHO 기준 적용 시 일부 항목을 제외하고 운동 유형에 상관없이 40~50대 중년여성의 신체조성 및 혈중지질에 긍정적 효과를 미치는 것으로 판단된다. 그러나 비만에 대해 더 엄격한 아시아 - 태평양 기준 적용 시 특히 정상 군에서 유의한 차이를 보이지 않는 항목이 많이 나타났는데 이것은 우리나라 비만기준을 아시아태평양기준에서 세계 기준으로 바꿀 필요가 있다는 주장을 뒷받침하고 있다. 세계보건기구 WHO는 2004년에 이미 우리나라에 세계비만기준을 따를 것을 권고했는데, 실제 위험성이 정확하게 평가돼야지 정확한 대책이나 관리가 나올 수 있기 때문이다. WHO 기준에 의거 시 질병의 발생 위험도가 낮은 경도비만이 엄격한 아시아-태평양 지역 기준 적용 시 비만으로 분류되어 불필요하게 체형에 대한 부정적인 이미지나 스트레스를 받을 가능성도 있다.

• Journal of Life Science
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• v.31 no.6
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• pp.568-573
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• 2021

This study identified genomic factors associated with endoplasmic reticulum protein (ERp)29 gene expression in a genome-wide association study (GWAS) of genetic variants, including single-nucleotide polymorphisms (SNPs). In total, 373 European genes from the 1000 Genomes Project were analyzed. SNPs with an allelic frequency of less than or more than 5% were removed, resulting in 5,913,563 SNPs including in the analysis. The following expression quantitative trait loci (eQTL) from the long noncoding RNA LOC105372577 were strongly associated with ERp29 expression: rs6138266 (p<4.172e10), rs62193420 (p<1.173e10), and rs6138267 (p<2.041e10). These were strongly expressed in the testis and in the brain. The three eQTL were identified through a transcriptome-wide association study (TWAS) and showed a significant association with ERp29 and osteosarcoma amplified 9 (OS9) expression. Upstream sequences of rs6138266 were recognized by ChIP-seq data, while HaploReg was used to demonstrate how its regulatory DNA binds upstream of transcription factor 1 (USF1). There were no changes in the expression of OS9 or USF1 following ER stress.